Amino acid dipepetide frequency for Acidipropionibacterium acidipropionici (strain ATCC 4875 / DSM 20272 / JCM 6432 / NBRC 12425 / NCIMB 8070) (Propionibacterium acidipropionici)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.923AlaAla: 16.923 ± 0.202
1.062AlaCys: 1.062 ± 0.033
8.314AlaAsp: 8.314 ± 0.096
7.499AlaGlu: 7.499 ± 0.11
3.013AlaPhe: 3.013 ± 0.066
12.283AlaGly: 12.283 ± 0.112
2.485AlaHis: 2.485 ± 0.055
4.877AlaIle: 4.877 ± 0.078
2.739AlaLys: 2.739 ± 0.067
11.736AlaLeu: 11.736 ± 0.129
3.2AlaMet: 3.2 ± 0.056
2.126AlaAsn: 2.126 ± 0.046
5.623AlaPro: 5.623 ± 0.086
3.641AlaGln: 3.641 ± 0.064
9.076AlaArg: 9.076 ± 0.116
6.938AlaSer: 6.938 ± 0.09
7.049AlaThr: 7.049 ± 0.085
10.581AlaVal: 10.581 ± 0.121
1.969AlaTrp: 1.969 ± 0.046
1.949AlaTyr: 1.949 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.92CysAla: 0.92 ± 0.032
0.146CysCys: 0.146 ± 0.012
0.56CysAsp: 0.56 ± 0.024
0.406CysGlu: 0.406 ± 0.02
0.251CysPhe: 0.251 ± 0.016
0.987CysGly: 0.987 ± 0.034
0.226CysHis: 0.226 ± 0.014
0.279CysIle: 0.279 ± 0.017
0.099CysLys: 0.099 ± 0.01
0.824CysLeu: 0.824 ± 0.028
0.146CysMet: 0.146 ± 0.012
0.133CysAsn: 0.133 ± 0.011
0.551CysPro: 0.551 ± 0.03
0.268CysGln: 0.268 ± 0.016
0.639CysArg: 0.639 ± 0.026
0.555CysSer: 0.555 ± 0.024
0.503CysThr: 0.503 ± 0.025
0.576CysVal: 0.576 ± 0.024
0.146CysTrp: 0.146 ± 0.014
0.186CysTyr: 0.186 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.739AspAla: 7.739 ± 0.093
0.415AspCys: 0.415 ± 0.022
4.262AspAsp: 4.262 ± 0.086
4.222AspGlu: 4.222 ± 0.07
1.59AspPhe: 1.59 ± 0.044
5.729AspGly: 5.729 ± 0.093
1.629AspHis: 1.629 ± 0.04
2.28AspIle: 2.28 ± 0.046
1.297AspLys: 1.297 ± 0.042
6.866AspLeu: 6.866 ± 0.076
1.064AspMet: 1.064 ± 0.033
1.03AspAsn: 1.03 ± 0.034
4.811AspPro: 4.811 ± 0.071
2.111AspGln: 2.111 ± 0.048
4.838AspArg: 4.838 ± 0.081
3.161AspSer: 3.161 ± 0.059
2.834AspThr: 2.834 ± 0.054
5.268AspVal: 5.268 ± 0.077
0.984AspTrp: 0.984 ± 0.03
1.234AspTyr: 1.234 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.803GluAla: 6.803 ± 0.1
0.33GluCys: 0.33 ± 0.016
2.878GluAsp: 2.878 ± 0.054
3.251GluGlu: 3.251 ± 0.069
1.51GluPhe: 1.51 ± 0.043
4.188GluGly: 4.188 ± 0.061
1.39GluHis: 1.39 ± 0.039
2.63GluIle: 2.63 ± 0.049
1.602GluLys: 1.602 ± 0.039
5.643GluLeu: 5.643 ± 0.082
1.235GluMet: 1.235 ± 0.034
1.142GluAsn: 1.142 ± 0.035
2.995GluPro: 2.995 ± 0.058
2.064GluGln: 2.064 ± 0.051
3.972GluArg: 3.972 ± 0.072
2.812GluSer: 2.812 ± 0.058
2.764GluThr: 2.764 ± 0.055
4.372GluVal: 4.372 ± 0.074
0.76GluTrp: 0.76 ± 0.029
1.055GluTyr: 1.055 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.163PheAla: 3.163 ± 0.06
0.312PheCys: 0.312 ± 0.019
2.034PheAsp: 2.034 ± 0.041
1.337PheGlu: 1.337 ± 0.04
0.937PhePhe: 0.937 ± 0.039
3.031PheGly: 3.031 ± 0.066
0.62PheHis: 0.62 ± 0.026
1.358PheIle: 1.358 ± 0.041
0.624PheLys: 0.624 ± 0.029
2.524PheLeu: 2.524 ± 0.059
0.614PheMet: 0.614 ± 0.028
0.77PheAsn: 0.77 ± 0.029
1.303PhePro: 1.303 ± 0.041
0.767PheGln: 0.767 ± 0.027
1.542PheArg: 1.542 ± 0.046
1.86PheSer: 1.86 ± 0.045
2.023PheThr: 2.023 ± 0.044
2.126PheVal: 2.126 ± 0.05
0.472PheTrp: 0.472 ± 0.026
0.568PheTyr: 0.568 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
9.951GlyAla: 9.951 ± 0.118
0.89GlyCys: 0.89 ± 0.032
4.974GlyAsp: 4.974 ± 0.073
4.476GlyGlu: 4.476 ± 0.064
2.948GlyPhe: 2.948 ± 0.055
7.477GlyGly: 7.477 ± 0.104
2.291GlyHis: 2.291 ± 0.053
4.506GlyIle: 4.506 ± 0.069
2.418GlyLys: 2.418 ± 0.06
9.48GlyLeu: 9.48 ± 0.111
2.284GlyMet: 2.284 ± 0.046
1.702GlyAsn: 1.702 ± 0.047
4.561GlyPro: 4.561 ± 0.074
3.062GlyGln: 3.062 ± 0.067
7.353GlyArg: 7.353 ± 0.094
6.0GlySer: 6.0 ± 0.095
5.524GlyThr: 5.524 ± 0.085
7.85GlyVal: 7.85 ± 0.101
1.834GlyTrp: 1.834 ± 0.045
2.28GlyTyr: 2.28 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.1HisAla: 2.1 ± 0.051
0.194HisCys: 0.194 ± 0.013
1.623HisAsp: 1.623 ± 0.041
1.154HisGlu: 1.154 ± 0.033
0.58HisPhe: 0.58 ± 0.027
2.064HisGly: 2.064 ± 0.049
0.728HisHis: 0.728 ± 0.031
0.94HisIle: 0.94 ± 0.031
0.38HisLys: 0.38 ± 0.019
2.306HisLeu: 2.306 ± 0.049
0.437HisMet: 0.437 ± 0.019
0.439HisAsn: 0.439 ± 0.02
1.684HisPro: 1.684 ± 0.041
0.759HisGln: 0.759 ± 0.024
2.0HisArg: 2.0 ± 0.041
1.128HisSer: 1.128 ± 0.031
1.156HisThr: 1.156 ± 0.035
1.61HisVal: 1.61 ± 0.035
0.361HisTrp: 0.361 ± 0.018
0.477HisTyr: 0.477 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.685IleAla: 5.685 ± 0.086
0.499IleCys: 0.499 ± 0.021
3.38IleAsp: 3.38 ± 0.061
2.397IleGlu: 2.397 ± 0.053
1.243IlePhe: 1.243 ± 0.044
4.896IleGly: 4.896 ± 0.072
0.91IleHis: 0.91 ± 0.028
2.003IleIle: 2.003 ± 0.053
0.928IleLys: 0.928 ± 0.033
3.705IleLeu: 3.705 ± 0.067
0.826IleMet: 0.826 ± 0.027
1.13IleAsn: 1.13 ± 0.038
2.504IlePro: 2.504 ± 0.051
0.961IleGln: 0.961 ± 0.028
2.838IleArg: 2.838 ± 0.051
2.666IleSer: 2.666 ± 0.045
2.987IleThr: 2.987 ± 0.056
3.874IleVal: 3.874 ± 0.068
0.627IleTrp: 0.627 ± 0.024
0.823IleTyr: 0.823 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
3.127LysAla: 3.127 ± 0.069
0.109LysCys: 0.109 ± 0.01
1.41LysAsp: 1.41 ± 0.042
1.186LysGlu: 1.186 ± 0.034
0.571LysPhe: 0.571 ± 0.023
1.988LysGly: 1.988 ± 0.049
0.446LysHis: 0.446 ± 0.023
1.111LysIle: 1.111 ± 0.033
1.088LysLys: 1.088 ± 0.044
2.11LysLeu: 2.11 ± 0.057
0.538LysMet: 0.538 ± 0.026
0.665LysAsn: 0.665 ± 0.029
1.174LysPro: 1.174 ± 0.041
0.732LysGln: 0.732 ± 0.031
1.326LysArg: 1.326 ± 0.034
1.233LysSer: 1.233 ± 0.042
1.416LysThr: 1.416 ± 0.045
2.217LysVal: 2.217 ± 0.052
0.282LysTrp: 0.282 ± 0.018
0.576LysTyr: 0.576 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
13.447LeuAla: 13.447 ± 0.133
0.776LeuCys: 0.776 ± 0.027
6.727LeuAsp: 6.727 ± 0.085
4.969LeuGlu: 4.969 ± 0.078
2.43LeuPhe: 2.43 ± 0.054
8.943LeuGly: 8.943 ± 0.107
1.922LeuHis: 1.922 ± 0.043
4.365LeuIle: 4.365 ± 0.075
2.01LeuLys: 2.01 ± 0.043
8.975LeuLeu: 8.975 ± 0.115
2.056LeuMet: 2.056 ± 0.048
1.941LeuAsn: 1.941 ± 0.045
5.353LeuPro: 5.353 ± 0.077
2.108LeuGln: 2.108 ± 0.046
6.757LeuArg: 6.757 ± 0.086
5.871LeuSer: 5.871 ± 0.075
6.171LeuThr: 6.171 ± 0.077
8.913LeuVal: 8.913 ± 0.116
1.262LeuTrp: 1.262 ± 0.038
1.47LeuTyr: 1.47 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.025MetAla: 3.025 ± 0.056
0.198MetCys: 0.198 ± 0.013
1.169MetAsp: 1.169 ± 0.033
0.912MetGlu: 0.912 ± 0.034
0.577MetPhe: 0.577 ± 0.026
1.947MetGly: 1.947 ± 0.045
0.405MetHis: 0.405 ± 0.019
1.143MetIle: 1.143 ± 0.034
0.586MetLys: 0.586 ± 0.025
2.051MetLeu: 2.051 ± 0.046
0.528MetMet: 0.528 ± 0.024
0.588MetAsn: 0.588 ± 0.021
1.353MetPro: 1.353 ± 0.039
0.457MetGln: 0.457 ± 0.019
1.577MetArg: 1.577 ± 0.037
1.819MetSer: 1.819 ± 0.039
1.995MetThr: 1.995 ± 0.043
1.909MetVal: 1.909 ± 0.043
0.321MetTrp: 0.321 ± 0.019
0.333MetTyr: 0.333 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.312AsnAla: 2.312 ± 0.054
0.188AsnCys: 0.188 ± 0.012
1.106AsnAsp: 1.106 ± 0.034
0.935AsnGlu: 0.935 ± 0.03
0.66AsnPhe: 0.66 ± 0.024
1.987AsnGly: 1.987 ± 0.045
0.491AsnHis: 0.491 ± 0.023
0.856AsnIle: 0.856 ± 0.026
0.495AsnLys: 0.495 ± 0.023
2.064AsnLeu: 2.064 ± 0.042
0.416AsnMet: 0.416 ± 0.023
0.484AsnAsn: 0.484 ± 0.023
1.67AsnPro: 1.67 ± 0.039
0.694AsnGln: 0.694 ± 0.026
1.524AsnArg: 1.524 ± 0.046
1.09AsnSer: 1.09 ± 0.034
1.179AsnThr: 1.179 ± 0.033
1.513AsnVal: 1.513 ± 0.039
0.34AsnTrp: 0.34 ± 0.02
0.546AsnTyr: 0.546 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.792ProAla: 6.792 ± 0.086
0.347ProCys: 0.347 ± 0.019
4.466ProAsp: 4.466 ± 0.066
3.865ProGlu: 3.865 ± 0.064
1.522ProPhe: 1.522 ± 0.037
5.916ProGly: 5.916 ± 0.081
1.144ProHis: 1.144 ± 0.035
1.878ProIle: 1.878 ± 0.043
1.238ProLys: 1.238 ± 0.041
4.468ProLeu: 4.468 ± 0.068
1.169ProMet: 1.169 ± 0.034
1.017ProAsn: 1.017 ± 0.032
2.246ProPro: 2.246 ± 0.062
1.767ProGln: 1.767 ± 0.037
3.735ProArg: 3.735 ± 0.072
3.441ProSer: 3.441 ± 0.066
3.288ProThr: 3.288 ± 0.062
5.083ProVal: 5.083 ± 0.078
0.933ProTrp: 0.933 ± 0.032
1.079ProTyr: 1.079 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.912GlnAla: 3.912 ± 0.078
0.192GlnCys: 0.192 ± 0.013
1.469GlnAsp: 1.469 ± 0.037
1.461GlnGlu: 1.461 ± 0.039
0.844GlnPhe: 0.844 ± 0.026
2.446GlnGly: 2.446 ± 0.048
0.571GlnHis: 0.571 ± 0.025
1.729GlnIle: 1.729 ± 0.039
0.819GlnLys: 0.819 ± 0.033
2.821GlnLeu: 2.821 ± 0.053
0.787GlnMet: 0.787 ± 0.028
0.68GlnAsn: 0.68 ± 0.027
1.516GlnPro: 1.516 ± 0.043
1.194GlnGln: 1.194 ± 0.041
2.175GlnArg: 2.175 ± 0.044
1.489GlnSer: 1.489 ± 0.039
1.616GlnThr: 1.616 ± 0.042
2.862GlnVal: 2.862 ± 0.054
0.489GlnTrp: 0.489 ± 0.022
0.643GlnTyr: 0.643 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
8.393ArgAla: 8.393 ± 0.098
0.604ArgCys: 0.604 ± 0.025
4.193ArgAsp: 4.193 ± 0.068
3.7ArgGlu: 3.7 ± 0.061
2.18ArgPhe: 2.18 ± 0.05
5.36ArgGly: 5.36 ± 0.081
1.874ArgHis: 1.874 ± 0.043
4.043ArgIle: 4.043 ± 0.069
1.628ArgLys: 1.628 ± 0.045
7.32ArgLeu: 7.32 ± 0.105
2.03ArgMet: 2.03 ± 0.042
1.557ArgAsn: 1.557 ± 0.04
4.363ArgPro: 4.363 ± 0.078
2.418ArgGln: 2.418 ± 0.045
7.651ArgArg: 7.651 ± 0.113
4.479ArgSer: 4.479 ± 0.077
4.443ArgThr: 4.443 ± 0.07
5.318ArgVal: 5.318 ± 0.081
1.29ArgTrp: 1.29 ± 0.035
1.601ArgTyr: 1.601 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
7.198SerAla: 7.198 ± 0.102
0.455SerCys: 0.455 ± 0.021
3.297SerAsp: 3.297 ± 0.06
2.615SerGlu: 2.615 ± 0.052
1.774SerPhe: 1.774 ± 0.043
6.578SerGly: 6.578 ± 0.101
1.263SerHis: 1.263 ± 0.035
2.384SerIle: 2.384 ± 0.063
1.299SerLys: 1.299 ± 0.042
5.219SerLeu: 5.219 ± 0.079
1.581SerMet: 1.581 ± 0.043
1.135SerAsn: 1.135 ± 0.035
3.464SerPro: 3.464 ± 0.07
1.982SerGln: 1.982 ± 0.044
4.552SerArg: 4.552 ± 0.069
4.129SerSer: 4.129 ± 0.102
4.022SerThr: 4.022 ± 0.075
4.617SerVal: 4.617 ± 0.075
1.196SerTrp: 1.196 ± 0.034
1.336SerTyr: 1.336 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
7.167ThrAla: 7.167 ± 0.092
0.458ThrCys: 0.458 ± 0.022
3.779ThrAsp: 3.779 ± 0.061
2.755ThrGlu: 2.755 ± 0.049
1.783ThrPhe: 1.783 ± 0.048
6.228ThrGly: 6.228 ± 0.094
1.148ThrHis: 1.148 ± 0.035
2.664ThrIle: 2.664 ± 0.056
1.228ThrLys: 1.228 ± 0.036
5.609ThrLeu: 5.609 ± 0.076
1.312ThrMet: 1.312 ± 0.04
1.232ThrAsn: 1.232 ± 0.038
3.864ThrPro: 3.864 ± 0.06
1.458ThrGln: 1.458 ± 0.043
4.209ThrArg: 4.209 ± 0.072
3.97ThrSer: 3.97 ± 0.065
4.109ThrThr: 4.109 ± 0.071
5.766ThrVal: 5.766 ± 0.087
1.032ThrTrp: 1.032 ± 0.031
1.148ThrTyr: 1.148 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
10.71ValAla: 10.71 ± 0.11
0.84ValCys: 0.84 ± 0.031
5.621ValAsp: 5.621 ± 0.075
4.631ValGlu: 4.631 ± 0.065
2.286ValPhe: 2.286 ± 0.051
6.806ValGly: 6.806 ± 0.094
1.784ValHis: 1.784 ± 0.044
4.397ValIle: 4.397 ± 0.072
1.976ValLys: 1.976 ± 0.049
8.781ValLeu: 8.781 ± 0.112
1.947ValMet: 1.947 ± 0.041
1.868ValAsn: 1.868 ± 0.046
4.446ValPro: 4.446 ± 0.069
1.927ValGln: 1.927 ± 0.047
5.575ValArg: 5.575 ± 0.079
5.239ValSer: 5.239 ± 0.077
5.667ValThr: 5.667 ± 0.082
8.313ValVal: 8.313 ± 0.111
1.193ValTrp: 1.193 ± 0.035
1.391ValTyr: 1.391 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.735TrpAla: 1.735 ± 0.044
0.196TrpCys: 0.196 ± 0.016
0.828TrpAsp: 0.828 ± 0.031
0.677TrpGlu: 0.677 ± 0.023
0.603TrpPhe: 0.603 ± 0.026
1.192TrpGly: 1.192 ± 0.037
0.37TrpHis: 0.37 ± 0.019
0.771TrpIle: 0.771 ± 0.027
0.403TrpLys: 0.403 ± 0.02
1.787TrpLeu: 1.787 ± 0.044
0.384TrpMet: 0.384 ± 0.018
0.454TrpAsn: 0.454 ± 0.021
0.79TrpPro: 0.79 ± 0.029
0.655TrpGln: 0.655 ± 0.025
1.402TrpArg: 1.402 ± 0.035
1.048TrpSer: 1.048 ± 0.033
1.072TrpThr: 1.072 ± 0.034
1.143TrpVal: 1.143 ± 0.034
0.462TrpTrp: 0.462 ± 0.023
0.309TrpTyr: 0.309 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.979TyrAla: 1.979 ± 0.044
0.188TyrCys: 0.188 ± 0.013
1.272TyrAsp: 1.272 ± 0.031
0.949TyrGlu: 0.949 ± 0.031
0.684TyrPhe: 0.684 ± 0.026
1.814TyrGly: 1.814 ± 0.042
0.425TyrHis: 0.425 ± 0.021
0.67TyrIle: 0.67 ± 0.026
0.447TyrLys: 0.447 ± 0.021
2.177TyrLeu: 2.177 ± 0.049
0.34TyrMet: 0.34 ± 0.02
0.459TyrAsn: 0.459 ± 0.022
1.122TyrPro: 1.122 ± 0.037
0.69TyrGln: 0.69 ± 0.026
1.702TyrArg: 1.702 ± 0.042
1.17TyrSer: 1.17 ± 0.039
1.101TyrThr: 1.101 ± 0.038
1.489TyrVal: 1.489 ± 0.042
0.327TyrTrp: 0.327 ± 0.018
0.45TyrTyr: 0.45 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3316 proteins (1065160 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski