Amino acid dipepetide frequency for Phytoactinopolyspora halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.68AlaAla: 18.68 ± 0.153	0.972AlaCys: 0.972 ± 0.02	9.012AlaAsp: 9.012 ± 0.073	8.723AlaGlu: 8.723 ± 0.075	3.44AlaPhe: 3.44 ± 0.042	12.512AlaGly: 12.512 ± 0.088	2.485AlaHis: 2.485 ± 0.036	4.563AlaIle: 4.563 ± 0.051	1.936AlaLys: 1.936 ± 0.036	12.321AlaLeu: 12.321 ± 0.097	2.716AlaMet: 2.716 ± 0.034	1.97AlaAsn: 1.97 ± 0.032	5.625AlaPro: 5.625 ± 0.052	3.538AlaGln: 3.538 ± 0.045	9.252AlaArg: 9.252 ± 0.085	6.272AlaSer: 6.272 ± 0.056	6.974AlaThr: 6.974 ± 0.053	11.569AlaVal: 11.569 ± 0.102	1.929AlaTrp: 1.929 ± 0.031	2.523AlaTyr: 2.523 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.818CysAla: 0.818 ± 0.021	0.081CysCys: 0.081 ± 0.006	0.477CysAsp: 0.477 ± 0.016	0.369CysGlu: 0.369 ± 0.013	0.204CysPhe: 0.204 ± 0.01	0.835CysGly: 0.835 ± 0.02	0.2CysHis: 0.2 ± 0.011	0.191CysIle: 0.191 ± 0.009	0.082CysLys: 0.082 ± 0.005	0.585CysLeu: 0.585 ± 0.016	0.111CysMet: 0.111 ± 0.007	0.126CysAsn: 0.126 ± 0.008	0.43CysPro: 0.43 ± 0.016	0.164CysGln: 0.164 ± 0.009	0.556CysArg: 0.556 ± 0.017	0.397CysSer: 0.397 ± 0.014	0.437CysThr: 0.437 ± 0.018	0.586CysVal: 0.586 ± 0.017	0.105CysTrp: 0.105 ± 0.008	0.151CysTyr: 0.151 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.848AspAla: 8.848 ± 0.075	0.345AspCys: 0.345 ± 0.013	5.862AspAsp: 5.862 ± 0.072	5.15AspGlu: 5.15 ± 0.059	1.583AspPhe: 1.583 ± 0.032	7.736AspGly: 7.736 ± 0.082	1.625AspHis: 1.625 ± 0.032	2.281AspIle: 2.281 ± 0.034	0.758AspLys: 0.758 ± 0.019	6.336AspLeu: 6.336 ± 0.054	0.94AspMet: 0.94 ± 0.023	1.043AspAsn: 1.043 ± 0.021	4.607AspPro: 4.607 ± 0.051	1.866AspGln: 1.866 ± 0.034	5.026AspArg: 5.026 ± 0.052	2.797AspSer: 2.797 ± 0.045	3.286AspThr: 3.286 ± 0.045	6.617AspVal: 6.617 ± 0.057	1.018AspTrp: 1.018 ± 0.024	1.341AspTyr: 1.341 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.88GluAla: 6.88 ± 0.074	0.366GluCys: 0.366 ± 0.015	2.987GluAsp: 2.987 ± 0.044	3.327GluGlu: 3.327 ± 0.048	1.787GluPhe: 1.787 ± 0.03	3.75GluGly: 3.75 ± 0.048	1.859GluHis: 1.859 ± 0.034	2.765GluIle: 2.765 ± 0.035	1.091GluLys: 1.091 ± 0.027	7.237GluLeu: 7.237 ± 0.068	1.132GluMet: 1.132 ± 0.021	1.29GluAsn: 1.29 ± 0.03	3.944GluPro: 3.944 ± 0.049	2.502GluGln: 2.502 ± 0.039	5.811GluArg: 5.811 ± 0.055	3.069GluSer: 3.069 ± 0.039	3.175GluThr: 3.175 ± 0.04	4.653GluVal: 4.653 ± 0.046	0.91GluTrp: 0.91 ± 0.021	1.319GluTyr: 1.319 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.603PheAla: 3.603 ± 0.046	0.234PheCys: 0.234 ± 0.01	2.292PheAsp: 2.292 ± 0.037	1.596PheGlu: 1.596 ± 0.032	0.954PhePhe: 0.954 ± 0.022	3.05PheGly: 3.05 ± 0.041	0.634PheHis: 0.634 ± 0.017	1.015PheIle: 1.015 ± 0.024	0.365PheLys: 0.365 ± 0.012	2.619PheLeu: 2.619 ± 0.037	0.465PheMet: 0.465 ± 0.018	0.657PheAsn: 0.657 ± 0.019	1.328PhePro: 1.328 ± 0.027	0.742PheGln: 0.742 ± 0.019	1.937PheArg: 1.937 ± 0.033	1.643PheSer: 1.643 ± 0.028	2.001PheThr: 2.001 ± 0.033	2.503PheVal: 2.503 ± 0.042	0.458PheTrp: 0.458 ± 0.014	0.689PheTyr: 0.689 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.062GlyAla: 10.062 ± 0.075	0.776GlyCys: 0.776 ± 0.019	6.03GlyAsp: 6.03 ± 0.075	5.357GlyGlu: 5.357 ± 0.052	2.944GlyPhe: 2.944 ± 0.035	8.097GlyGly: 8.097 ± 0.077	2.173GlyHis: 2.173 ± 0.034	3.719GlyIle: 3.719 ± 0.045	1.673GlyLys: 1.673 ± 0.031	8.715GlyLeu: 8.715 ± 0.072	2.099GlyMet: 2.099 ± 0.025	1.788GlyAsn: 1.788 ± 0.036	4.486GlyPro: 4.486 ± 0.047	2.542GlyGln: 2.542 ± 0.035	7.286GlyArg: 7.286 ± 0.067	5.331GlySer: 5.331 ± 0.063	5.788GlyThr: 5.788 ± 0.057	7.778GlyVal: 7.778 ± 0.064	1.768GlyTrp: 1.768 ± 0.034	2.421GlyTyr: 2.421 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.764HisAla: 2.764 ± 0.038	0.161HisCys: 0.161 ± 0.009	1.631HisAsp: 1.631 ± 0.028	1.299HisGlu: 1.299 ± 0.023	0.56HisPhe: 0.56 ± 0.016	2.409HisGly: 2.409 ± 0.039	0.665HisHis: 0.665 ± 0.017	0.742HisIle: 0.742 ± 0.019	0.264HisLys: 0.264 ± 0.011	2.211HisLeu: 2.211 ± 0.034	0.368HisMet: 0.368 ± 0.013	0.393HisAsn: 0.393 ± 0.013	1.651HisPro: 1.651 ± 0.031	0.652HisGln: 0.652 ± 0.017	2.018HisArg: 2.018 ± 0.032	0.945HisSer: 0.945 ± 0.021	1.215HisThr: 1.215 ± 0.028	2.096HisVal: 2.096 ± 0.032	0.354HisTrp: 0.354 ± 0.014	0.503HisTyr: 0.503 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.3IleAla: 5.3 ± 0.053	0.31IleCys: 0.31 ± 0.013	3.198IleAsp: 3.198 ± 0.039	2.586IleGlu: 2.586 ± 0.036	1.018IlePhe: 1.018 ± 0.021	3.959IleGly: 3.959 ± 0.045	0.736IleHis: 0.736 ± 0.018	1.327IleIle: 1.327 ± 0.025	0.594IleLys: 0.594 ± 0.018	3.01IleLeu: 3.01 ± 0.04	0.631IleMet: 0.631 ± 0.018	0.787IleAsn: 0.787 ± 0.02	2.132IlePro: 2.132 ± 0.033	0.884IleGln: 0.884 ± 0.02	2.756IleArg: 2.756 ± 0.038	2.069IleSer: 2.069 ± 0.03	2.429IleThr: 2.429 ± 0.034	3.576IleVal: 3.576 ± 0.043	0.482IleTrp: 0.482 ± 0.017	0.728IleTyr: 0.728 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	1.831LysAla: 1.831 ± 0.036	0.062LysCys: 0.062 ± 0.006	0.835LysAsp: 0.835 ± 0.023	0.824LysGlu: 0.824 ± 0.023	0.344LysPhe: 0.344 ± 0.014	1.113LysGly: 1.113 ± 0.026	0.369LysHis: 0.369 ± 0.012	0.679LysIle: 0.679 ± 0.019	0.423LysLys: 0.423 ± 0.019	1.605LysLeu: 1.605 ± 0.028	0.276LysMet: 0.276 ± 0.012	0.366LysAsn: 0.366 ± 0.014	1.008LysPro: 1.008 ± 0.026	0.526LysGln: 0.526 ± 0.017	1.224LysArg: 1.224 ± 0.029	0.834LysSer: 0.834 ± 0.023	0.982LysThr: 0.982 ± 0.022	1.36LysVal: 1.36 ± 0.03	0.202LysTrp: 0.202 ± 0.01	0.336LysTyr: 0.336 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	13.981LeuAla: 13.981 ± 0.119	0.661LeuCys: 0.661 ± 0.018	7.069LeuAsp: 7.069 ± 0.06	5.009LeuGlu: 5.009 ± 0.05	2.69LeuPhe: 2.69 ± 0.039	8.783LeuGly: 8.783 ± 0.074	2.073LeuHis: 2.073 ± 0.03	3.894LeuIle: 3.894 ± 0.045	1.377LeuLys: 1.377 ± 0.028	9.858LeuLeu: 9.858 ± 0.091	1.639LeuMet: 1.639 ± 0.029	1.908LeuAsn: 1.908 ± 0.034	5.562LeuPro: 5.562 ± 0.056	2.357LeuGln: 2.357 ± 0.034	7.934LeuArg: 7.934 ± 0.079	5.442LeuSer: 5.442 ± 0.051	6.161LeuThr: 6.161 ± 0.06	8.604LeuVal: 8.604 ± 0.08	1.211LeuTrp: 1.211 ± 0.025	1.779LeuTyr: 1.779 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.379MetAla: 2.379 ± 0.036	0.13MetCys: 0.13 ± 0.008	0.933MetAsp: 0.933 ± 0.021	0.803MetGlu: 0.803 ± 0.02	0.578MetPhe: 0.578 ± 0.017	1.309MetGly: 1.309 ± 0.028	0.416MetHis: 0.416 ± 0.015	0.833MetIle: 0.833 ± 0.02	0.34MetLys: 0.34 ± 0.014	2.065MetLeu: 2.065 ± 0.031	0.393MetMet: 0.393 ± 0.016	0.48MetAsn: 0.48 ± 0.016	1.223MetPro: 1.223 ± 0.022	0.499MetGln: 0.499 ± 0.014	1.602MetArg: 1.602 ± 0.027	1.4MetSer: 1.4 ± 0.024	1.603MetThr: 1.603 ± 0.027	1.629MetVal: 1.629 ± 0.027	0.272MetTrp: 0.272 ± 0.012	0.377MetTyr: 0.377 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.218AsnAla: 2.218 ± 0.038	0.132AsnCys: 0.132 ± 0.01	1.265AsnAsp: 1.265 ± 0.027	1.028AsnGlu: 1.028 ± 0.021	0.515AsnPhe: 0.515 ± 0.018	1.939AsnGly: 1.939 ± 0.036	0.426AsnHis: 0.426 ± 0.014	0.72AsnIle: 0.72 ± 0.02	0.278AsnLys: 0.278 ± 0.014	1.783AsnLeu: 1.783 ± 0.032	0.309AsnMet: 0.309 ± 0.011	0.43AsnAsn: 0.43 ± 0.016	1.476AsnPro: 1.476 ± 0.024	0.547AsnGln: 0.547 ± 0.018	1.425AsnArg: 1.425 ± 0.024	0.97AsnSer: 0.97 ± 0.025	1.163AsnThr: 1.163 ± 0.023	1.704AsnVal: 1.704 ± 0.03	0.317AsnTrp: 0.317 ± 0.012	0.476AsnTyr: 0.476 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.026ProAla: 7.026 ± 0.064	0.293ProCys: 0.293 ± 0.013	5.05ProAsp: 5.05 ± 0.057	4.273ProGlu: 4.273 ± 0.047	1.624ProPhe: 1.624 ± 0.026	5.673ProGly: 5.673 ± 0.054	1.304ProHis: 1.304 ± 0.023	1.842ProIle: 1.842 ± 0.031	0.786ProLys: 0.786 ± 0.021	4.578ProLeu: 4.578 ± 0.043	1.131ProMet: 1.131 ± 0.023	1.06ProAsn: 1.06 ± 0.026	3.143ProPro: 3.143 ± 0.04	1.494ProGln: 1.494 ± 0.027	3.552ProArg: 3.552 ± 0.046	3.403ProSer: 3.403 ± 0.04	3.198ProThr: 3.198 ± 0.046	4.898ProVal: 4.898 ± 0.052	0.934ProTrp: 0.934 ± 0.022	1.29ProTyr: 1.29 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.676GlnAla: 3.676 ± 0.041	0.136GlnCys: 0.136 ± 0.008	1.379GlnAsp: 1.379 ± 0.028	1.447GlnGlu: 1.447 ± 0.031	0.775GlnPhe: 0.775 ± 0.022	1.971GlnGly: 1.971 ± 0.032	0.709GlnHis: 0.709 ± 0.019	1.287GlnIle: 1.287 ± 0.025	0.43GlnLys: 0.43 ± 0.014	3.081GlnLeu: 3.081 ± 0.039	0.581GlnMet: 0.581 ± 0.018	0.57GlnAsn: 0.57 ± 0.017	1.768GlnPro: 1.768 ± 0.035	1.144GlnGln: 1.144 ± 0.028	2.736GlnArg: 2.736 ± 0.04	1.272GlnSer: 1.272 ± 0.021	1.5GlnThr: 1.5 ± 0.029	2.502GlnVal: 2.502 ± 0.035	0.477GlnTrp: 0.477 ± 0.015	0.627GlnTyr: 0.627 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.068ArgAla: 9.068 ± 0.083	0.554ArgCys: 0.554 ± 0.018	4.731ArgAsp: 4.731 ± 0.052	4.554ArgGlu: 4.554 ± 0.05	2.405ArgPhe: 2.405 ± 0.033	5.462ArgGly: 5.462 ± 0.052	2.073ArgHis: 2.073 ± 0.037	3.486ArgIle: 3.486 ± 0.039	1.283ArgLys: 1.283 ± 0.025	8.381ArgLeu: 8.381 ± 0.085	1.929ArgMet: 1.929 ± 0.029	1.468ArgAsn: 1.468 ± 0.029	4.478ArgPro: 4.478 ± 0.051	2.413ArgGln: 2.413 ± 0.04	8.283ArgArg: 8.283 ± 0.085	4.409ArgSer: 4.409 ± 0.047	4.633ArgThr: 4.633 ± 0.052	6.086ArgVal: 6.086 ± 0.058	1.489ArgTrp: 1.489 ± 0.029	1.973ArgTyr: 1.973 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.708SerAla: 6.708 ± 0.069	0.359SerCys: 0.359 ± 0.012	3.444SerAsp: 3.444 ± 0.044	2.902SerGlu: 2.902 ± 0.039	1.657SerPhe: 1.657 ± 0.031	5.971SerGly: 5.971 ± 0.06	1.085SerHis: 1.085 ± 0.023	2.026SerIle: 2.026 ± 0.03	0.842SerLys: 0.842 ± 0.019	4.721SerLeu: 4.721 ± 0.045	1.242SerMet: 1.242 ± 0.024	1.022SerAsn: 1.022 ± 0.023	3.082SerPro: 3.082 ± 0.043	1.293SerGln: 1.293 ± 0.027	3.775SerArg: 3.775 ± 0.043	3.272SerSer: 3.272 ± 0.044	3.53SerThr: 3.53 ± 0.045	4.606SerVal: 4.606 ± 0.042	1.053SerTrp: 1.053 ± 0.024	1.213SerTyr: 1.213 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	7.411ThrAla: 7.411 ± 0.066	0.372ThrCys: 0.372 ± 0.012	3.848ThrAsp: 3.848 ± 0.049	3.222ThrGlu: 3.222 ± 0.04	1.912ThrPhe: 1.912 ± 0.033	6.05ThrGly: 6.05 ± 0.059	1.219ThrHis: 1.219 ± 0.024	2.321ThrIle: 2.321 ± 0.033	0.867ThrLys: 0.867 ± 0.021	5.747ThrLeu: 5.747 ± 0.049	1.182ThrMet: 1.182 ± 0.026	1.051ThrAsn: 1.051 ± 0.021	3.588ThrPro: 3.588 ± 0.046	1.378ThrGln: 1.378 ± 0.028	3.815ThrArg: 3.815 ± 0.043	3.446ThrSer: 3.446 ± 0.041	4.005ThrThr: 4.005 ± 0.059	6.155ThrVal: 6.155 ± 0.063	1.023ThrTrp: 1.023 ± 0.023	1.424ThrTyr: 1.424 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.558ValAla: 11.558 ± 0.088	0.655ValCys: 0.655 ± 0.018	6.51ValAsp: 6.51 ± 0.055	5.349ValGlu: 5.349 ± 0.052	2.573ValPhe: 2.573 ± 0.042	7.126ValGly: 7.126 ± 0.065	1.971ValHis: 1.971 ± 0.035	3.498ValIle: 3.498 ± 0.044	1.25ValLys: 1.25 ± 0.027	9.082ValLeu: 9.082 ± 0.08	1.473ValMet: 1.473 ± 0.028	1.765ValAsn: 1.765 ± 0.028	4.951ValPro: 4.951 ± 0.057	2.228ValGln: 2.228 ± 0.029	6.742ValArg: 6.742 ± 0.057	4.725ValSer: 4.725 ± 0.049	5.692ValThr: 5.692 ± 0.055	9.119ValVal: 9.119 ± 0.085	1.194ValTrp: 1.194 ± 0.025	1.683ValTyr: 1.683 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.58TrpAla: 1.58 ± 0.03	0.143TrpCys: 0.143 ± 0.008	0.941TrpAsp: 0.941 ± 0.025	0.787TrpGlu: 0.787 ± 0.021	0.569TrpPhe: 0.569 ± 0.017	1.01TrpGly: 1.01 ± 0.021	0.412TrpHis: 0.412 ± 0.016	0.657TrpIle: 0.657 ± 0.017	0.301TrpLys: 0.301 ± 0.011	1.801TrpLeu: 1.801 ± 0.033	0.357TrpMet: 0.357 ± 0.012	0.501TrpAsn: 0.501 ± 0.016	0.869TrpPro: 0.869 ± 0.022	0.587TrpGln: 0.587 ± 0.017	1.414TrpArg: 1.414 ± 0.027	1.075TrpSer: 1.075 ± 0.025	1.065TrpThr: 1.065 ± 0.021	1.143TrpVal: 1.143 ± 0.024	0.401TrpTrp: 0.401 ± 0.015	0.403TrpTyr: 0.403 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.623TyrAla: 2.623 ± 0.034	0.161TyrCys: 0.161 ± 0.009	1.568TyrAsp: 1.568 ± 0.03	1.253TyrGlu: 1.253 ± 0.024	0.654TyrPhe: 0.654 ± 0.018	2.079TyrGly: 2.079 ± 0.03	0.467TyrHis: 0.467 ± 0.016	0.666TyrIle: 0.666 ± 0.02	0.257TyrLys: 0.257 ± 0.012	2.256TyrLeu: 2.256 ± 0.039	0.292TyrMet: 0.292 ± 0.012	0.448TyrAsn: 0.448 ± 0.018	1.2TyrPro: 1.2 ± 0.025	0.711TyrGln: 0.711 ± 0.02	2.014TyrArg: 2.014 ± 0.034	1.032TyrSer: 1.032 ± 0.023	1.201TyrThr: 1.201 ± 0.027	1.96TyrVal: 1.96 ± 0.031	0.415TyrTrp: 0.415 ± 0.014	0.525TyrTyr: 0.525 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6265 proteins (2132900 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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