Amino acid dipepetide frequency for Halopenitus malekzadehii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.586AlaAla: 14.586 ± 0.203
0.775AlaCys: 0.775 ± 0.034
11.449AlaAsp: 11.449 ± 0.144
8.518AlaGlu: 8.518 ± 0.119
3.861AlaPhe: 3.861 ± 0.077
10.008AlaGly: 10.008 ± 0.137
1.78AlaHis: 1.78 ± 0.047
5.937AlaIle: 5.937 ± 0.08
1.709AlaLys: 1.709 ± 0.045
9.392AlaLeu: 9.392 ± 0.111
1.983AlaMet: 1.983 ± 0.053
2.284AlaAsn: 2.284 ± 0.051
3.782AlaPro: 3.782 ± 0.065
1.838AlaGln: 1.838 ± 0.052
5.818AlaArg: 5.818 ± 0.105
5.391AlaSer: 5.391 ± 0.076
7.505AlaThr: 7.505 ± 0.126
10.407AlaVal: 10.407 ± 0.121
1.008AlaTrp: 1.008 ± 0.033
2.677AlaTyr: 2.677 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.643CysAla: 0.643 ± 0.03
0.086CysCys: 0.086 ± 0.01
0.579CysAsp: 0.579 ± 0.03
0.54CysGlu: 0.54 ± 0.03
0.196CysPhe: 0.196 ± 0.014
0.929CysGly: 0.929 ± 0.043
0.177CysHis: 0.177 ± 0.015
0.259CysIle: 0.259 ± 0.017
0.113CysLys: 0.113 ± 0.012
0.58CysLeu: 0.58 ± 0.023
0.089CysMet: 0.089 ± 0.011
0.169CysAsn: 0.169 ± 0.015
0.545CysPro: 0.545 ± 0.027
0.155CysGln: 0.155 ± 0.014
0.518CysArg: 0.518 ± 0.025
0.438CysSer: 0.438 ± 0.03
0.455CysThr: 0.455 ± 0.025
0.491CysVal: 0.491 ± 0.025
0.076CysTrp: 0.076 ± 0.009
0.178CysTyr: 0.178 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
11.342AspAla: 11.342 ± 0.175
0.609AspCys: 0.609 ± 0.029
8.128AspAsp: 8.128 ± 0.118
7.039AspGlu: 7.039 ± 0.095
1.796AspPhe: 1.796 ± 0.044
8.346AspGly: 8.346 ± 0.134
2.309AspHis: 2.309 ± 0.056
2.621AspIle: 2.621 ± 0.055
0.868AspLys: 0.868 ± 0.037
7.483AspLeu: 7.483 ± 0.101
1.012AspMet: 1.012 ± 0.033
1.137AspAsn: 1.137 ± 0.042
5.674AspPro: 5.674 ± 0.092
1.707AspGln: 1.707 ± 0.049
8.703AspArg: 8.703 ± 0.138
3.466AspSer: 3.466 ± 0.06
4.193AspThr: 4.193 ± 0.076
8.804AspVal: 8.804 ± 0.123
0.969AspTrp: 0.969 ± 0.038
1.602AspTyr: 1.602 ± 0.045
0.001AspXaa: 0.001 ± 0.001
Glu
8.556GluAla: 8.556 ± 0.122
0.544GluCys: 0.544 ± 0.034
5.644GluAsp: 5.644 ± 0.099
6.365GluGlu: 6.365 ± 0.112
2.76GluPhe: 2.76 ± 0.057
5.138GluGly: 5.138 ± 0.086
1.938GluHis: 1.938 ± 0.051
4.025GluIle: 4.025 ± 0.08
1.654GluLys: 1.654 ± 0.052
7.063GluLeu: 7.063 ± 0.094
1.844GluMet: 1.844 ± 0.049
2.245GluAsn: 2.245 ± 0.052
3.873GluPro: 3.873 ± 0.067
2.215GluGln: 2.215 ± 0.061
6.726GluArg: 6.726 ± 0.1
5.051GluSer: 5.051 ± 0.081
7.287GluThr: 7.287 ± 0.101
5.036GluVal: 5.036 ± 0.083
1.095GluTrp: 1.095 ± 0.033
2.739GluTyr: 2.739 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.429PheAla: 3.429 ± 0.07
0.262PheCys: 0.262 ± 0.018
3.005PheAsp: 3.005 ± 0.069
3.183PheGlu: 3.183 ± 0.075
1.016PhePhe: 1.016 ± 0.037
3.025PheGly: 3.025 ± 0.063
0.627PheHis: 0.627 ± 0.031
1.215PheIle: 1.215 ± 0.043
0.489PheLys: 0.489 ± 0.021
2.999PheLeu: 2.999 ± 0.076
0.421PheMet: 0.421 ± 0.021
0.705PheAsn: 0.705 ± 0.027
1.321PhePro: 1.321 ± 0.039
0.735PheGln: 0.735 ± 0.029
1.797PheArg: 1.797 ± 0.038
1.578PheSer: 1.578 ± 0.046
1.943PheThr: 1.943 ± 0.053
2.812PheVal: 2.812 ± 0.069
0.359PheTrp: 0.359 ± 0.023
0.795PheTyr: 0.795 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
8.033GlyAla: 8.033 ± 0.11
0.681GlyCys: 0.681 ± 0.028
7.029GlyAsp: 7.029 ± 0.111
6.58GlyGlu: 6.58 ± 0.096
3.086GlyPhe: 3.086 ± 0.074
7.757GlyGly: 7.757 ± 0.142
1.653GlyHis: 1.653 ± 0.047
4.848GlyIle: 4.848 ± 0.081
1.687GlyLys: 1.687 ± 0.044
7.029GlyLeu: 7.029 ± 0.115
1.68GlyMet: 1.68 ± 0.05
2.121GlyAsn: 2.121 ± 0.072
3.497GlyPro: 3.497 ± 0.061
1.826GlyGln: 1.826 ± 0.048
4.918GlyArg: 4.918 ± 0.085
5.78GlySer: 5.78 ± 0.097
6.519GlyThr: 6.519 ± 0.099
7.549GlyVal: 7.549 ± 0.115
1.099GlyTrp: 1.099 ± 0.033
2.621GlyTyr: 2.621 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
2.134HisAla: 2.134 ± 0.05
0.18HisCys: 0.18 ± 0.02
1.948HisAsp: 1.948 ± 0.051
1.809HisGlu: 1.809 ± 0.051
0.538HisPhe: 0.538 ± 0.027
1.973HisGly: 1.973 ± 0.05
0.555HisHis: 0.555 ± 0.025
0.727HisIle: 0.727 ± 0.03
0.333HisLys: 0.333 ± 0.02
1.721HisLeu: 1.721 ± 0.05
0.253HisMet: 0.253 ± 0.02
0.486HisAsn: 0.486 ± 0.025
1.284HisPro: 1.284 ± 0.04
0.442HisGln: 0.442 ± 0.022
1.42HisArg: 1.42 ± 0.041
0.841HisSer: 0.841 ± 0.034
1.184HisThr: 1.184 ± 0.04
1.911HisVal: 1.911 ± 0.043
0.225HisTrp: 0.225 ± 0.015
0.546HisTyr: 0.546 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.984IleAla: 5.984 ± 0.094
0.281IleCys: 0.281 ± 0.019
5.132IleAsp: 5.132 ± 0.074
4.711IleGlu: 4.711 ± 0.079
0.81IlePhe: 0.81 ± 0.035
4.496IleGly: 4.496 ± 0.08
0.987IleHis: 0.987 ± 0.034
1.413IleIle: 1.413 ± 0.045
0.754IleLys: 0.754 ± 0.031
3.179IleLeu: 3.179 ± 0.075
0.444IleMet: 0.444 ± 0.025
1.02IleAsn: 1.02 ± 0.035
2.272IlePro: 2.272 ± 0.044
1.125IleGln: 1.125 ± 0.038
2.867IleArg: 2.867 ± 0.059
2.095IleSer: 2.095 ± 0.053
2.726IleThr: 2.726 ± 0.055
4.484IleVal: 4.484 ± 0.085
0.323IleTrp: 0.323 ± 0.018
0.899IleTyr: 0.899 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
1.57LysAla: 1.57 ± 0.046
0.111LysCys: 0.111 ± 0.011
0.996LysAsp: 0.996 ± 0.037
1.181LysGlu: 1.181 ± 0.043
0.464LysPhe: 0.464 ± 0.024
1.242LysGly: 1.242 ± 0.046
0.46LysHis: 0.46 ± 0.023
0.75LysIle: 0.75 ± 0.031
0.471LysLys: 0.471 ± 0.027
1.506LysLeu: 1.506 ± 0.042
0.321LysMet: 0.321 ± 0.021
0.53LysAsn: 0.53 ± 0.027
0.945LysPro: 0.945 ± 0.031
0.709LysGln: 0.709 ± 0.032
1.741LysArg: 1.741 ± 0.05
1.09LysSer: 1.09 ± 0.037
1.281LysThr: 1.281 ± 0.044
1.034LysVal: 1.034 ± 0.036
0.248LysTrp: 0.248 ± 0.017
0.555LysTyr: 0.555 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
10.474LeuAla: 10.474 ± 0.128
0.606LeuCys: 0.606 ± 0.03
6.88LeuAsp: 6.88 ± 0.095
7.314LeuGlu: 7.314 ± 0.107
2.956LeuPhe: 2.956 ± 0.061
7.304LeuGly: 7.304 ± 0.108
1.53LeuHis: 1.53 ± 0.038
3.483LeuIle: 3.483 ± 0.072
1.476LeuLys: 1.476 ± 0.047
8.173LeuLeu: 8.173 ± 0.129
1.191LeuMet: 1.191 ± 0.041
1.734LeuAsn: 1.734 ± 0.05
4.072LeuPro: 4.072 ± 0.065
2.008LeuGln: 2.008 ± 0.056
5.456LeuArg: 5.456 ± 0.084
5.447LeuSer: 5.447 ± 0.083
5.222LeuThr: 5.222 ± 0.079
7.746LeuVal: 7.746 ± 0.111
0.821LeuTrp: 0.821 ± 0.034
1.993LeuTyr: 1.993 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
1.762MetAla: 1.762 ± 0.044
0.114MetCys: 0.114 ± 0.011
1.208MetAsp: 1.208 ± 0.039
1.005MetGlu: 1.005 ± 0.035
0.431MetPhe: 0.431 ± 0.023
1.35MetGly: 1.35 ± 0.044
0.316MetHis: 0.316 ± 0.018
0.677MetIle: 0.677 ± 0.027
0.391MetLys: 0.391 ± 0.021
1.257MetLeu: 1.257 ± 0.038
0.273MetMet: 0.273 ± 0.019
0.581MetAsn: 0.581 ± 0.027
0.78MetPro: 0.78 ± 0.032
0.488MetGln: 0.488 ± 0.025
0.994MetArg: 0.994 ± 0.032
1.447MetSer: 1.447 ± 0.035
1.563MetThr: 1.563 ± 0.046
1.254MetVal: 1.254 ± 0.039
0.141MetTrp: 0.141 ± 0.015
0.346MetTyr: 0.346 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.709AsnAla: 2.709 ± 0.061
0.186AsnCys: 0.186 ± 0.015
1.777AsnAsp: 1.777 ± 0.047
1.773AsnGlu: 1.773 ± 0.052
0.569AsnPhe: 0.569 ± 0.025
2.245AsnGly: 2.245 ± 0.068
0.471AsnHis: 0.471 ± 0.023
0.839AsnIle: 0.839 ± 0.031
0.417AsnLys: 0.417 ± 0.026
1.904AsnLeu: 1.904 ± 0.056
0.362AsnMet: 0.362 ± 0.019
0.546AsnAsn: 0.546 ± 0.028
1.491AsnPro: 1.491 ± 0.041
0.608AsnGln: 0.608 ± 0.029
1.619AsnArg: 1.619 ± 0.043
0.977AsnSer: 0.977 ± 0.041
1.388AsnThr: 1.388 ± 0.045
2.232AsnVal: 2.232 ± 0.052
0.289AsnTrp: 0.289 ± 0.018
0.634AsnTyr: 0.634 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
4.933ProAla: 4.933 ± 0.087
0.256ProCys: 0.256 ± 0.018
5.4ProAsp: 5.4 ± 0.079
4.478ProGlu: 4.478 ± 0.077
1.63ProPhe: 1.63 ± 0.04
3.918ProGly: 3.918 ± 0.062
0.879ProHis: 0.879 ± 0.03
2.427ProIle: 2.427 ± 0.06
0.786ProLys: 0.786 ± 0.03
3.299ProLeu: 3.299 ± 0.066
0.823ProMet: 0.823 ± 0.029
1.205ProAsn: 1.205 ± 0.033
2.198ProPro: 2.198 ± 0.051
0.917ProGln: 0.917 ± 0.03
2.287ProArg: 2.287 ± 0.057
2.857ProSer: 2.857 ± 0.056
3.536ProThr: 3.536 ± 0.069
4.226ProVal: 4.226 ± 0.067
0.491ProTrp: 0.491 ± 0.025
1.118ProTyr: 1.118 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.171GlnAla: 2.171 ± 0.048
0.155GlnCys: 0.155 ± 0.014
1.259GlnAsp: 1.259 ± 0.04
1.67GlnGlu: 1.67 ± 0.059
0.926GlnPhe: 0.926 ± 0.035
1.622GlnGly: 1.622 ± 0.046
0.521GlnHis: 0.521 ± 0.024
1.098GlnIle: 1.098 ± 0.044
0.51GlnLys: 0.51 ± 0.024
2.198GlnLeu: 2.198 ± 0.057
0.426GlnMet: 0.426 ± 0.021
0.659GlnAsn: 0.659 ± 0.031
1.122GlnPro: 1.122 ± 0.033
0.894GlnGln: 0.894 ± 0.042
1.88GlnArg: 1.88 ± 0.056
1.337GlnSer: 1.337 ± 0.044
1.477GlnThr: 1.477 ± 0.045
1.63GlnVal: 1.63 ± 0.044
0.313GlnTrp: 0.313 ± 0.022
0.767GlnTyr: 0.767 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
6.152ArgAla: 6.152 ± 0.086
0.497ArgCys: 0.497 ± 0.026
5.318ArgAsp: 5.318 ± 0.091
6.5ArgGlu: 6.5 ± 0.111
2.447ArgPhe: 2.447 ± 0.048
4.508ArgGly: 4.508 ± 0.081
1.341ArgHis: 1.341 ± 0.047
3.737ArgIle: 3.737 ± 0.074
1.367ArgLys: 1.367 ± 0.043
6.285ArgLeu: 6.285 ± 0.101
1.336ArgMet: 1.336 ± 0.038
1.746ArgAsn: 1.746 ± 0.046
2.572ArgPro: 2.572 ± 0.06
1.645ArgGln: 1.645 ± 0.045
5.102ArgArg: 5.102 ± 0.083
4.279ArgSer: 4.279 ± 0.07
4.474ArgThr: 4.474 ± 0.084
5.288ArgVal: 5.288 ± 0.096
0.787ArgTrp: 0.787 ± 0.035
1.978ArgTyr: 1.978 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
5.401SerAla: 5.401 ± 0.086
0.382SerCys: 0.382 ± 0.025
4.552SerAsp: 4.552 ± 0.069
4.205SerGlu: 4.205 ± 0.081
1.848SerPhe: 1.848 ± 0.048
5.402SerGly: 5.402 ± 0.084
1.034SerHis: 1.034 ± 0.035
3.049SerIle: 3.049 ± 0.057
1.162SerLys: 1.162 ± 0.037
4.633SerLeu: 4.633 ± 0.075
1.036SerMet: 1.036 ± 0.035
1.372SerAsn: 1.372 ± 0.038
2.686SerPro: 2.686 ± 0.053
1.176SerGln: 1.176 ± 0.046
3.41SerArg: 3.41 ± 0.065
2.834SerSer: 2.834 ± 0.067
3.89SerThr: 3.89 ± 0.072
4.848SerVal: 4.848 ± 0.084
0.594SerTrp: 0.594 ± 0.027
1.341SerTyr: 1.341 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
7.599ThrAla: 7.599 ± 0.105
0.41ThrCys: 0.41 ± 0.028
6.475ThrAsp: 6.475 ± 0.106
4.787ThrGlu: 4.787 ± 0.076
2.187ThrPhe: 2.187 ± 0.054
6.198ThrGly: 6.198 ± 0.097
1.295ThrHis: 1.295 ± 0.044
3.714ThrIle: 3.714 ± 0.067
1.034ThrLys: 1.034 ± 0.036
5.671ThrLeu: 5.671 ± 0.084
1.019ThrMet: 1.019 ± 0.032
1.565ThrAsn: 1.565 ± 0.044
3.617ThrPro: 3.617 ± 0.076
1.375ThrGln: 1.375 ± 0.044
3.667ThrArg: 3.667 ± 0.071
3.039ThrSer: 3.039 ± 0.067
4.761ThrThr: 4.761 ± 0.092
7.155ThrVal: 7.155 ± 0.096
0.643ThrTrp: 0.643 ± 0.03
1.822ThrTyr: 1.822 ± 0.047
0.001ThrXaa: 0.001 ± 0.001
Val
9.648ValAla: 9.648 ± 0.119
0.729ValCys: 0.729 ± 0.033
7.816ValAsp: 7.816 ± 0.101
7.131ValGlu: 7.131 ± 0.11
2.957ValPhe: 2.957 ± 0.069
7.479ValGly: 7.479 ± 0.124
1.767ValHis: 1.767 ± 0.045
3.784ValIle: 3.784 ± 0.072
1.239ValLys: 1.239 ± 0.036
7.97ValLeu: 7.97 ± 0.125
1.285ValMet: 1.285 ± 0.043
1.95ValAsn: 1.95 ± 0.05
4.235ValPro: 4.235 ± 0.074
1.76ValGln: 1.76 ± 0.046
5.667ValArg: 5.667 ± 0.074
5.185ValSer: 5.185 ± 0.079
6.385ValThr: 6.385 ± 0.102
8.478ValVal: 8.478 ± 0.13
0.848ValTrp: 0.848 ± 0.031
2.12ValTyr: 2.12 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.825TrpAla: 0.825 ± 0.031
0.106TrpCys: 0.106 ± 0.013
0.769TrpAsp: 0.769 ± 0.036
0.748TrpGlu: 0.748 ± 0.033
0.454TrpPhe: 0.454 ± 0.026
0.798TrpGly: 0.798 ± 0.03
0.242TrpHis: 0.242 ± 0.017
0.584TrpIle: 0.584 ± 0.026
0.281TrpLys: 0.281 ± 0.018
1.095TrpLeu: 1.095 ± 0.039
0.236TrpMet: 0.236 ± 0.016
0.361TrpAsn: 0.361 ± 0.02
0.466TrpPro: 0.466 ± 0.026
0.333TrpGln: 0.333 ± 0.021
0.839TrpArg: 0.839 ± 0.031
0.595TrpSer: 0.595 ± 0.026
0.74TrpThr: 0.74 ± 0.03
0.807TrpVal: 0.807 ± 0.031
0.19TrpTrp: 0.19 ± 0.016
0.374TrpTyr: 0.374 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.757TyrAla: 2.757 ± 0.054
0.245TyrCys: 0.245 ± 0.018
2.444TyrAsp: 2.444 ± 0.053
2.263TyrGlu: 2.263 ± 0.053
0.787TyrPhe: 0.787 ± 0.03
2.253TyrGly: 2.253 ± 0.05
0.628TyrHis: 0.628 ± 0.027
0.817TyrIle: 0.817 ± 0.037
0.46TyrLys: 0.46 ± 0.024
2.446TyrLeu: 2.446 ± 0.059
0.345TyrMet: 0.345 ± 0.018
0.619TyrAsn: 0.619 ± 0.028
1.234TyrPro: 1.234 ± 0.039
0.678TyrGln: 0.678 ± 0.029
1.93TyrArg: 1.93 ± 0.049
1.125TyrSer: 1.125 ± 0.044
1.508TyrThr: 1.508 ± 0.037
2.241TyrVal: 2.241 ± 0.046
0.322TyrTrp: 0.322 ± 0.022
0.809TyrTyr: 0.809 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.001
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.001XaaLys: 0.001 ± 0.001
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.007XaaXaa: 0.007 ± 0.005
Statistics based on 3119 proteins (899592 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski