Amino acid dipepetide frequency for Candidatus Planktophila sulfonica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.43AlaAla: 12.43 ± 0.263
0.705AlaCys: 0.705 ± 0.045
5.688AlaAsp: 5.688 ± 0.129
6.064AlaGlu: 6.064 ± 0.157
3.786AlaPhe: 3.786 ± 0.12
8.837AlaGly: 8.837 ± 0.132
2.17AlaHis: 2.17 ± 0.079
7.626AlaIle: 7.626 ± 0.16
5.665AlaLys: 5.665 ± 0.136
11.872AlaLeu: 11.872 ± 0.217
2.791AlaMet: 2.791 ± 0.081
2.982AlaAsn: 2.982 ± 0.089
4.519AlaPro: 4.519 ± 0.115
3.772AlaGln: 3.772 ± 0.093
5.618AlaArg: 5.618 ± 0.144
6.335AlaSer: 6.335 ± 0.126
6.645AlaThr: 6.645 ± 0.129
7.802AlaVal: 7.802 ± 0.153
1.089AlaTrp: 1.089 ± 0.046
2.222AlaTyr: 2.222 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.797CysAla: 0.797 ± 0.044
0.045CysCys: 0.045 ± 0.01
0.51CysAsp: 0.51 ± 0.037
0.421CysGlu: 0.421 ± 0.03
0.219CysPhe: 0.219 ± 0.025
0.87CysGly: 0.87 ± 0.046
0.158CysHis: 0.158 ± 0.02
0.353CysIle: 0.353 ± 0.029
0.315CysLys: 0.315 ± 0.026
0.442CysLeu: 0.442 ± 0.028
0.099CysMet: 0.099 ± 0.013
0.207CysAsn: 0.207 ± 0.021
0.419CysPro: 0.419 ± 0.033
0.167CysGln: 0.167 ± 0.018
0.315CysArg: 0.315 ± 0.032
0.473CysSer: 0.473 ± 0.039
0.428CysThr: 0.428 ± 0.03
0.536CysVal: 0.536 ± 0.033
0.082CysTrp: 0.082 ± 0.015
0.143CysTyr: 0.143 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.836AspAla: 5.836 ± 0.14
0.397AspCys: 0.397 ± 0.029
2.514AspAsp: 2.514 ± 0.087
3.779AspGlu: 3.779 ± 0.11
2.22AspPhe: 2.22 ± 0.067
4.745AspGly: 4.745 ± 0.116
1.072AspHis: 1.072 ± 0.051
3.482AspIle: 3.482 ± 0.083
2.215AspLys: 2.215 ± 0.081
5.937AspLeu: 5.937 ± 0.123
0.884AspMet: 0.884 ± 0.049
1.35AspAsn: 1.35 ± 0.06
2.758AspPro: 2.758 ± 0.082
1.747AspGln: 1.747 ± 0.066
3.125AspArg: 3.125 ± 0.09
3.569AspSer: 3.569 ± 0.085
2.319AspThr: 2.319 ± 0.084
4.461AspVal: 4.461 ± 0.104
0.687AspTrp: 0.687 ± 0.037
1.371AspTyr: 1.371 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
6.013GluAla: 6.013 ± 0.136
0.404GluCys: 0.404 ± 0.032
2.864GluAsp: 2.864 ± 0.1
3.703GluGlu: 3.703 ± 0.108
2.229GluPhe: 2.229 ± 0.073
4.042GluGly: 4.042 ± 0.104
1.19GluHis: 1.19 ± 0.054
4.842GluIle: 4.842 ± 0.119
3.588GluLys: 3.588 ± 0.107
6.415GluLeu: 6.415 ± 0.132
1.538GluMet: 1.538 ± 0.052
2.213GluAsn: 2.213 ± 0.08
2.072GluPro: 2.072 ± 0.063
1.707GluGln: 1.707 ± 0.061
3.664GluArg: 3.664 ± 0.108
3.593GluSer: 3.593 ± 0.086
3.005GluThr: 3.005 ± 0.086
5.206GluVal: 5.206 ± 0.122
0.698GluTrp: 0.698 ± 0.042
1.303GluTyr: 1.303 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
4.171PheAla: 4.171 ± 0.11
0.308PheCys: 0.308 ± 0.029
2.387PheAsp: 2.387 ± 0.078
2.201PheGlu: 2.201 ± 0.073
1.519PhePhe: 1.519 ± 0.072
3.619PheGly: 3.619 ± 0.112
0.696PheHis: 0.696 ± 0.037
2.488PheIle: 2.488 ± 0.087
1.458PheLys: 1.458 ± 0.065
3.353PheLeu: 3.353 ± 0.103
0.729PheMet: 0.729 ± 0.038
1.256PheAsn: 1.256 ± 0.055
1.54PhePro: 1.54 ± 0.06
0.884PheGln: 0.884 ± 0.051
1.552PheArg: 1.552 ± 0.064
2.544PheSer: 2.544 ± 0.082
2.594PheThr: 2.594 ± 0.08
2.589PheVal: 2.589 ± 0.091
0.508PheTrp: 0.508 ± 0.04
0.875PheTyr: 0.875 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
8.512GlyAla: 8.512 ± 0.176
0.63GlyCys: 0.63 ± 0.04
4.289GlyAsp: 4.289 ± 0.114
4.477GlyGlu: 4.477 ± 0.093
3.447GlyPhe: 3.447 ± 0.113
6.506GlyGly: 6.506 ± 0.157
1.679GlyHis: 1.679 ± 0.06
5.733GlyIle: 5.733 ± 0.133
4.345GlyLys: 4.345 ± 0.096
7.541GlyLeu: 7.541 ± 0.156
1.933GlyMet: 1.933 ± 0.068
2.274GlyAsn: 2.274 ± 0.082
2.845GlyPro: 2.845 ± 0.099
2.116GlyGln: 2.116 ± 0.07
4.193GlyArg: 4.193 ± 0.099
5.469GlySer: 5.469 ± 0.109
4.792GlyThr: 4.792 ± 0.117
6.798GlyVal: 6.798 ± 0.127
1.159GlyTrp: 1.159 ± 0.058
2.253GlyTyr: 2.253 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
1.858HisAla: 1.858 ± 0.068
0.181HisCys: 0.181 ± 0.02
1.082HisAsp: 1.082 ± 0.042
1.253HisGlu: 1.253 ± 0.052
0.724HisPhe: 0.724 ± 0.04
1.695HisGly: 1.695 ± 0.058
0.513HisHis: 0.513 ± 0.038
1.166HisIle: 1.166 ± 0.065
0.665HisLys: 0.665 ± 0.041
1.987HisLeu: 1.987 ± 0.068
0.353HisMet: 0.353 ± 0.027
0.609HisAsn: 0.609 ± 0.042
1.227HisPro: 1.227 ± 0.056
0.708HisGln: 0.708 ± 0.038
1.152HisArg: 1.152 ± 0.052
1.122HisSer: 1.122 ± 0.047
1.035HisThr: 1.035 ± 0.053
1.477HisVal: 1.477 ± 0.056
0.27HisTrp: 0.27 ± 0.023
0.475HisTyr: 0.475 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
8.573IleAla: 8.573 ± 0.162
0.529IleCys: 0.529 ± 0.031
4.209IleAsp: 4.209 ± 0.1
4.463IleGlu: 4.463 ± 0.108
2.391IlePhe: 2.391 ± 0.071
5.42IleGly: 5.42 ± 0.147
1.225IleHis: 1.225 ± 0.054
3.405IleIle: 3.405 ± 0.108
2.831IleLys: 2.831 ± 0.076
5.279IleLeu: 5.279 ± 0.141
0.95IleMet: 0.95 ± 0.052
2.248IleAsn: 2.248 ± 0.076
3.163IlePro: 3.163 ± 0.086
1.597IleGln: 1.597 ± 0.054
3.381IleArg: 3.381 ± 0.095
5.07IleSer: 5.07 ± 0.122
4.273IleThr: 4.273 ± 0.096
4.581IleVal: 4.581 ± 0.096
0.691IleTrp: 0.691 ± 0.042
1.533IleTyr: 1.533 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
5.335LysAla: 5.335 ± 0.142
0.266LysCys: 0.266 ± 0.027
2.497LysAsp: 2.497 ± 0.07
3.033LysGlu: 3.033 ± 0.104
1.646LysPhe: 1.646 ± 0.063
3.311LysGly: 3.311 ± 0.092
0.757LysHis: 0.757 ± 0.04
3.038LysIle: 3.038 ± 0.096
3.466LysLys: 3.466 ± 0.13
3.8LysLeu: 3.8 ± 0.105
1.312LysMet: 1.312 ± 0.053
1.804LysAsn: 1.804 ± 0.064
2.356LysPro: 2.356 ± 0.083
1.227LysGln: 1.227 ± 0.059
2.801LysArg: 2.801 ± 0.08
3.661LysSer: 3.661 ± 0.098
2.695LysThr: 2.695 ± 0.084
3.972LysVal: 3.972 ± 0.108
0.63LysTrp: 0.63 ± 0.042
1.324LysTyr: 1.324 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
10.972LeuAla: 10.972 ± 0.196
0.602LeuCys: 0.602 ± 0.035
5.608LeuAsp: 5.608 ± 0.13
5.702LeuGlu: 5.702 ± 0.136
3.457LeuPhe: 3.457 ± 0.111
8.108LeuGly: 8.108 ± 0.137
1.919LeuHis: 1.919 ± 0.074
6.278LeuIle: 6.278 ± 0.137
4.291LeuLys: 4.291 ± 0.107
9.34LeuLeu: 9.34 ± 0.235
2.048LeuMet: 2.048 ± 0.07
3.073LeuAsn: 3.073 ± 0.097
4.538LeuPro: 4.538 ± 0.097
2.706LeuGln: 2.706 ± 0.069
5.194LeuArg: 5.194 ± 0.125
6.711LeuSer: 6.711 ± 0.131
5.77LeuThr: 5.77 ± 0.12
7.623LeuVal: 7.623 ± 0.139
0.966LeuTrp: 0.966 ± 0.049
1.862LeuTyr: 1.862 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.662MetAla: 2.662 ± 0.088
0.153MetCys: 0.153 ± 0.018
1.072MetAsp: 1.072 ± 0.055
1.002MetGlu: 1.002 ± 0.053
0.595MetPhe: 0.595 ± 0.043
1.858MetGly: 1.858 ± 0.062
0.393MetHis: 0.393 ± 0.028
1.213MetIle: 1.213 ± 0.049
1.409MetLys: 1.409 ± 0.063
1.757MetLeu: 1.757 ± 0.058
0.433MetMet: 0.433 ± 0.029
0.778MetAsn: 0.778 ± 0.041
1.035MetPro: 1.035 ± 0.049
0.616MetGln: 0.616 ± 0.041
1.394MetArg: 1.394 ± 0.056
1.834MetSer: 1.834 ± 0.059
1.578MetThr: 1.578 ± 0.064
1.491MetVal: 1.491 ± 0.057
0.245MetTrp: 0.245 ± 0.023
0.372MetTyr: 0.372 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.057AsnAla: 3.057 ± 0.099
0.237AsnCys: 0.237 ± 0.025
1.54AsnAsp: 1.54 ± 0.062
1.905AsnGlu: 1.905 ± 0.069
1.397AsnPhe: 1.397 ± 0.054
2.535AsnGly: 2.535 ± 0.088
0.536AsnHis: 0.536 ± 0.037
1.834AsnIle: 1.834 ± 0.073
1.26AsnLys: 1.26 ± 0.053
3.2AsnLeu: 3.2 ± 0.075
0.628AsnMet: 0.628 ± 0.038
1.046AsnAsn: 1.046 ± 0.049
2.121AsnPro: 2.121 ± 0.076
0.992AsnGln: 0.992 ± 0.057
1.839AsnArg: 1.839 ± 0.064
2.114AsnSer: 2.114 ± 0.078
1.564AsnThr: 1.564 ± 0.064
2.222AsnVal: 2.222 ± 0.063
0.496AsnTrp: 0.496 ± 0.033
0.955AsnTyr: 0.955 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
4.519ProAla: 4.519 ± 0.112
0.299ProCys: 0.299 ± 0.027
2.532ProAsp: 2.532 ± 0.072
3.146ProGlu: 3.146 ± 0.09
1.585ProPhe: 1.585 ± 0.069
3.532ProGly: 3.532 ± 0.092
0.969ProHis: 0.969 ± 0.055
2.674ProIle: 2.674 ± 0.085
2.144ProLys: 2.144 ± 0.08
4.056ProLeu: 4.056 ± 0.11
0.91ProMet: 0.91 ± 0.048
1.451ProAsn: 1.451 ± 0.062
1.23ProPro: 1.23 ± 0.062
1.456ProGln: 1.456 ± 0.064
2.121ProArg: 2.121 ± 0.07
2.998ProSer: 2.998 ± 0.109
3.026ProThr: 3.026 ± 0.092
3.758ProVal: 3.758 ± 0.096
0.607ProTrp: 0.607 ± 0.044
1.108ProTyr: 1.108 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
2.993GlnAla: 2.993 ± 0.087
0.205GlnCys: 0.205 ± 0.024
1.234GlnAsp: 1.234 ± 0.055
1.82GlnGlu: 1.82 ± 0.064
1.037GlnPhe: 1.037 ± 0.049
2.217GlnGly: 2.217 ± 0.075
0.501GlnHis: 0.501 ± 0.033
2.152GlnIle: 2.152 ± 0.068
1.484GlnLys: 1.484 ± 0.064
3.165GlnLeu: 3.165 ± 0.08
0.832GlnMet: 0.832 ± 0.047
0.952GlnAsn: 0.952 ± 0.05
1.157GlnPro: 1.157 ± 0.047
0.87GlnGln: 0.87 ± 0.047
1.761GlnArg: 1.761 ± 0.062
2.135GlnSer: 2.135 ± 0.075
1.46GlnThr: 1.46 ± 0.055
2.239GlnVal: 2.239 ± 0.075
0.487GlnTrp: 0.487 ± 0.033
0.844GlnTyr: 0.844 ± 0.049
0.0GlnXaa: 0.0 ± 0.0
Arg
5.244ArgAla: 5.244 ± 0.105
0.379ArgCys: 0.379 ± 0.031
3.25ArgAsp: 3.25 ± 0.101
3.76ArgGlu: 3.76 ± 0.094
2.156ArgPhe: 2.156 ± 0.072
3.995ArgGly: 3.995 ± 0.097
1.028ArgHis: 1.028 ± 0.05
3.706ArgIle: 3.706 ± 0.093
2.697ArgLys: 2.697 ± 0.083
4.703ArgLeu: 4.703 ± 0.102
1.361ArgMet: 1.361 ± 0.056
1.935ArgAsn: 1.935 ± 0.068
2.257ArgPro: 2.257 ± 0.09
1.627ArgGln: 1.627 ± 0.064
3.224ArgArg: 3.224 ± 0.118
3.261ArgSer: 3.261 ± 0.089
3.264ArgThr: 3.264 ± 0.087
3.849ArgVal: 3.849 ± 0.084
0.705ArgTrp: 0.705 ± 0.041
1.406ArgTyr: 1.406 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
7.24SerAla: 7.24 ± 0.14
0.397SerCys: 0.397 ± 0.034
3.628SerAsp: 3.628 ± 0.089
3.84SerGlu: 3.84 ± 0.11
2.45SerPhe: 2.45 ± 0.077
5.556SerGly: 5.556 ± 0.127
1.437SerHis: 1.437 ± 0.057
4.096SerIle: 4.096 ± 0.104
3.139SerLys: 3.139 ± 0.104
6.749SerLeu: 6.749 ± 0.138
1.55SerMet: 1.55 ± 0.065
1.945SerAsn: 1.945 ± 0.07
2.817SerPro: 2.817 ± 0.092
2.323SerGln: 2.323 ± 0.073
3.633SerArg: 3.633 ± 0.102
4.313SerSer: 4.313 ± 0.11
4.035SerThr: 4.035 ± 0.108
5.098SerVal: 5.098 ± 0.122
0.952SerTrp: 0.952 ± 0.044
1.691SerTyr: 1.691 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
5.937ThrAla: 5.937 ± 0.167
0.39ThrCys: 0.39 ± 0.029
3.134ThrAsp: 3.134 ± 0.079
3.2ThrGlu: 3.2 ± 0.097
2.37ThrPhe: 2.37 ± 0.074
5.197ThrGly: 5.197 ± 0.121
1.234ThrHis: 1.234 ± 0.057
3.88ThrIle: 3.88 ± 0.116
2.692ThrLys: 2.692 ± 0.079
5.782ThrLeu: 5.782 ± 0.136
1.084ThrMet: 1.084 ± 0.055
1.768ThrAsn: 1.768 ± 0.067
3.398ThrPro: 3.398 ± 0.1
1.799ThrGln: 1.799 ± 0.064
2.775ThrArg: 2.775 ± 0.086
4.091ThrSer: 4.091 ± 0.105
3.783ThrThr: 3.783 ± 0.112
4.665ThrVal: 4.665 ± 0.11
0.712ThrTrp: 0.712 ± 0.043
1.352ThrTyr: 1.352 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
9.034ValAla: 9.034 ± 0.175
0.576ValCys: 0.576 ± 0.036
4.618ValAsp: 4.618 ± 0.107
4.581ValGlu: 4.581 ± 0.116
2.495ValPhe: 2.495 ± 0.073
6.013ValGly: 6.013 ± 0.115
1.427ValHis: 1.427 ± 0.054
5.759ValIle: 5.759 ± 0.132
3.626ValLys: 3.626 ± 0.103
7.393ValLeu: 7.393 ± 0.124
1.726ValMet: 1.726 ± 0.058
2.403ValAsn: 2.403 ± 0.076
3.062ValPro: 3.062 ± 0.08
1.959ValGln: 1.959 ± 0.065
3.953ValArg: 3.953 ± 0.1
4.997ValSer: 4.997 ± 0.113
5.171ValThr: 5.171 ± 0.118
6.892ValVal: 6.892 ± 0.142
0.736ValTrp: 0.736 ± 0.042
1.373ValTyr: 1.373 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
1.138TrpAla: 1.138 ± 0.048
0.108TrpCys: 0.108 ± 0.015
0.597TrpAsp: 0.597 ± 0.041
0.487TrpGlu: 0.487 ± 0.033
0.515TrpPhe: 0.515 ± 0.04
0.821TrpGly: 0.821 ± 0.042
0.303TrpHis: 0.303 ± 0.025
0.847TrpIle: 0.847 ± 0.046
0.595TrpLys: 0.595 ± 0.037
1.289TrpLeu: 1.289 ± 0.051
0.303TrpMet: 0.303 ± 0.026
0.538TrpAsn: 0.538 ± 0.039
0.52TrpPro: 0.52 ± 0.04
0.482TrpGln: 0.482 ± 0.038
0.741TrpArg: 0.741 ± 0.044
0.842TrpSer: 0.842 ± 0.041
0.658TrpThr: 0.658 ± 0.044
0.912TrpVal: 0.912 ± 0.044
0.23TrpTrp: 0.23 ± 0.023
0.313TrpTyr: 0.313 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.297TyrAla: 2.297 ± 0.075
0.186TyrCys: 0.186 ± 0.02
1.213TyrAsp: 1.213 ± 0.057
1.451TyrGlu: 1.451 ± 0.058
1.032TyrPhe: 1.032 ± 0.055
2.116TyrGly: 2.116 ± 0.068
0.346TyrHis: 0.346 ± 0.029
1.242TyrIle: 1.242 ± 0.05
1.044TyrLys: 1.044 ± 0.047
2.711TyrLeu: 2.711 ± 0.092
0.421TyrMet: 0.421 ± 0.034
0.647TyrAsn: 0.647 ± 0.038
1.086TyrPro: 1.086 ± 0.051
0.79TyrGln: 0.79 ± 0.042
1.373TyrArg: 1.373 ± 0.065
1.757TyrSer: 1.757 ± 0.076
1.152TyrThr: 1.152 ± 0.056
1.622TyrVal: 1.622 ± 0.064
0.287TyrTrp: 0.287 ± 0.028
0.522TyrTyr: 0.522 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1334 proteins (425275 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski