Amino acid dipepetide frequency for Pseudodesulfovibrio profundus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.389AlaAla: 8.389 ± 0.11	1.178AlaCys: 1.178 ± 0.034	5.005AlaAsp: 5.005 ± 0.06	6.059AlaGlu: 6.059 ± 0.075	3.507AlaPhe: 3.507 ± 0.059	6.801AlaGly: 6.801 ± 0.094	1.68AlaHis: 1.68 ± 0.04	5.129AlaIle: 5.129 ± 0.078	4.646AlaLys: 4.646 ± 0.062	9.014AlaLeu: 9.014 ± 0.089	2.966AlaMet: 2.966 ± 0.051	2.635AlaAsn: 2.635 ± 0.045	3.146AlaPro: 3.146 ± 0.06	2.936AlaGln: 2.936 ± 0.046	4.645AlaArg: 4.645 ± 0.071	4.701AlaSer: 4.701 ± 0.07	4.181AlaThr: 4.181 ± 0.067	6.392AlaVal: 6.392 ± 0.074	1.069AlaTrp: 1.069 ± 0.028	2.362AlaTyr: 2.362 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.019CysAla: 1.019 ± 0.03	0.209CysCys: 0.209 ± 0.015	0.696CysAsp: 0.696 ± 0.027	0.735CysGlu: 0.735 ± 0.029	0.512CysPhe: 0.512 ± 0.02	1.3CysGly: 1.3 ± 0.037	0.407CysHis: 0.407 ± 0.026	0.726CysIle: 0.726 ± 0.023	0.555CysLys: 0.555 ± 0.02	1.169CysLeu: 1.169 ± 0.033	0.341CysMet: 0.341 ± 0.018	0.42CysAsn: 0.42 ± 0.02	0.77CysPro: 0.77 ± 0.026	0.33CysGln: 0.33 ± 0.017	0.769CysArg: 0.769 ± 0.028	0.833CysSer: 0.833 ± 0.027	0.596CysThr: 0.596 ± 0.025	0.82CysVal: 0.82 ± 0.03	0.154CysTrp: 0.154 ± 0.01	0.319CysTyr: 0.319 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.799AspAla: 4.799 ± 0.065	0.729AspCys: 0.729 ± 0.028	3.433AspAsp: 3.433 ± 0.076	4.278AspGlu: 4.278 ± 0.071	2.744AspPhe: 2.744 ± 0.052	4.318AspGly: 4.318 ± 0.067	1.21AspHis: 1.21 ± 0.029	4.071AspIle: 4.071 ± 0.068	3.115AspLys: 3.115 ± 0.05	5.736AspLeu: 5.736 ± 0.065	1.868AspMet: 1.868 ± 0.043	2.065AspAsn: 2.065 ± 0.054	2.749AspPro: 2.749 ± 0.06	1.835AspGln: 1.835 ± 0.045	3.231AspArg: 3.231 ± 0.06	3.196AspSer: 3.196 ± 0.05	2.95AspThr: 2.95 ± 0.055	4.243AspVal: 4.243 ± 0.064	0.826AspTrp: 0.826 ± 0.026	1.907AspTyr: 1.907 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.438GluAla: 6.438 ± 0.091	0.718GluCys: 0.718 ± 0.027	3.741GluAsp: 3.741 ± 0.071	5.287GluGlu: 5.287 ± 0.105	2.513GluPhe: 2.513 ± 0.051	4.461GluGly: 4.461 ± 0.074	1.445GluHis: 1.445 ± 0.036	4.186GluIle: 4.186 ± 0.065	4.218GluLys: 4.218 ± 0.067	6.874GluLeu: 6.874 ± 0.081	2.12GluMet: 2.12 ± 0.038	2.58GluAsn: 2.58 ± 0.051	2.505GluPro: 2.505 ± 0.053	2.775GluGln: 2.775 ± 0.055	4.185GluArg: 4.185 ± 0.067	3.802GluSer: 3.802 ± 0.059	3.566GluThr: 3.566 ± 0.059	4.753GluVal: 4.753 ± 0.073	0.743GluTrp: 0.743 ± 0.023	1.992GluTyr: 1.992 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.282PheAla: 3.282 ± 0.05	0.586PheCys: 0.586 ± 0.022	2.737PheAsp: 2.737 ± 0.051	2.542PheGlu: 2.542 ± 0.047	2.06PhePhe: 2.06 ± 0.052	3.195PheGly: 3.195 ± 0.055	0.934PheHis: 0.934 ± 0.029	2.501PheIle: 2.501 ± 0.052	1.981PheLys: 1.981 ± 0.045	4.015PheLeu: 4.015 ± 0.062	1.199PheMet: 1.199 ± 0.031	1.53PheAsn: 1.53 ± 0.038	1.715PhePro: 1.715 ± 0.041	1.205PheGln: 1.205 ± 0.033	2.068PheArg: 2.068 ± 0.042	2.839PheSer: 2.839 ± 0.057	2.375PheThr: 2.375 ± 0.04	2.83PheVal: 2.83 ± 0.053	0.569PheTrp: 0.569 ± 0.022	1.264PheTyr: 1.264 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.864GlyAla: 5.864 ± 0.081	1.155GlyCys: 1.155 ± 0.036	4.16GlyAsp: 4.16 ± 0.067	4.86GlyGlu: 4.86 ± 0.077	3.407GlyPhe: 3.407 ± 0.056	5.721GlyGly: 5.721 ± 0.107	1.713GlyHis: 1.713 ± 0.036	4.898GlyIle: 4.898 ± 0.071	4.642GlyLys: 4.642 ± 0.063	7.718GlyLeu: 7.718 ± 0.091	2.632GlyMet: 2.632 ± 0.05	2.45GlyAsn: 2.45 ± 0.051	2.42GlyPro: 2.42 ± 0.048	2.583GlyGln: 2.583 ± 0.058	4.044GlyArg: 4.044 ± 0.066	4.175GlySer: 4.175 ± 0.063	4.076GlyThr: 4.076 ± 0.061	5.891GlyVal: 5.891 ± 0.078	1.034GlyTrp: 1.034 ± 0.029	2.515GlyTyr: 2.515 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.65HisAla: 1.65 ± 0.04	0.319HisCys: 0.319 ± 0.015	1.266HisAsp: 1.266 ± 0.033	1.333HisGlu: 1.333 ± 0.036	0.995HisPhe: 0.995 ± 0.031	1.777HisGly: 1.777 ± 0.038	0.548HisHis: 0.548 ± 0.024	1.188HisIle: 1.188 ± 0.032	0.973HisLys: 0.973 ± 0.028	2.07HisLeu: 2.07 ± 0.044	0.556HisMet: 0.556 ± 0.023	0.738HisAsn: 0.738 ± 0.026	1.281HisPro: 1.281 ± 0.035	0.729HisGln: 0.729 ± 0.022	1.147HisArg: 1.147 ± 0.034	1.231HisSer: 1.231 ± 0.034	1.064HisThr: 1.064 ± 0.027	1.372HisVal: 1.372 ± 0.036	0.298HisTrp: 0.298 ± 0.017	0.665HisTyr: 0.665 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.252IleAla: 5.252 ± 0.072	0.799IleCys: 0.799 ± 0.029	3.663IleAsp: 3.663 ± 0.063	3.98IleGlu: 3.98 ± 0.063	2.241IlePhe: 2.241 ± 0.053	4.58IleGly: 4.58 ± 0.073	1.259IleHis: 1.259 ± 0.032	3.601IleIle: 3.601 ± 0.07	2.967IleLys: 2.967 ± 0.051	5.682IleLeu: 5.682 ± 0.082	1.595IleMet: 1.595 ± 0.038	2.364IleAsn: 2.364 ± 0.05	3.05IlePro: 3.05 ± 0.054	1.912IleGln: 1.912 ± 0.043	3.497IleArg: 3.497 ± 0.057	3.809IleSer: 3.809 ± 0.067	3.261IleThr: 3.261 ± 0.058	4.384IleVal: 4.384 ± 0.06	0.659IleTrp: 0.659 ± 0.023	1.575IleTyr: 1.575 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	5.006LysAla: 5.006 ± 0.072	0.516LysCys: 0.516 ± 0.023	3.146LysAsp: 3.146 ± 0.06	4.038LysGlu: 4.038 ± 0.063	1.461LysPhe: 1.461 ± 0.04	4.027LysGly: 4.027 ± 0.06	1.094LysHis: 1.094 ± 0.032	2.926LysIle: 2.926 ± 0.053	3.591LysLys: 3.591 ± 0.075	4.745LysLeu: 4.745 ± 0.07	1.522LysMet: 1.522 ± 0.038	1.988LysAsn: 1.988 ± 0.042	2.416LysPro: 2.416 ± 0.054	2.065LysGln: 2.065 ± 0.046	3.412LysArg: 3.412 ± 0.055	2.963LysSer: 2.963 ± 0.054	2.937LysThr: 2.937 ± 0.05	3.62LysVal: 3.62 ± 0.061	0.586LysTrp: 0.586 ± 0.024	1.527LysTyr: 1.527 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	9.414LeuAla: 9.414 ± 0.098	1.265LeuCys: 1.265 ± 0.036	6.143LeuAsp: 6.143 ± 0.08	6.659LeuGlu: 6.659 ± 0.085	4.192LeuPhe: 4.192 ± 0.069	7.49LeuGly: 7.49 ± 0.099	1.967LeuHis: 1.967 ± 0.047	5.484LeuIle: 5.484 ± 0.076	5.538LeuLys: 5.538 ± 0.075	9.471LeuLeu: 9.471 ± 0.116	2.664LeuMet: 2.664 ± 0.053	3.479LeuAsn: 3.479 ± 0.055	4.739LeuPro: 4.739 ± 0.066	3.082LeuGln: 3.082 ± 0.05	5.317LeuArg: 5.317 ± 0.067	6.449LeuSer: 6.449 ± 0.089	5.347LeuThr: 5.347 ± 0.069	6.669LeuVal: 6.669 ± 0.089	1.003LeuTrp: 1.003 ± 0.032	2.419LeuTyr: 2.419 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.035MetAla: 3.035 ± 0.054	0.309MetCys: 0.309 ± 0.018	2.002MetAsp: 2.002 ± 0.045	2.0MetGlu: 2.0 ± 0.042	0.979MetPhe: 0.979 ± 0.03	2.285MetGly: 2.285 ± 0.051	0.569MetHis: 0.569 ± 0.023	1.568MetIle: 1.568 ± 0.042	1.584MetLys: 1.584 ± 0.038	2.777MetLeu: 2.777 ± 0.047	0.73MetMet: 0.73 ± 0.026	1.156MetAsn: 1.156 ± 0.034	1.412MetPro: 1.412 ± 0.043	1.066MetGln: 1.066 ± 0.032	1.65MetArg: 1.65 ± 0.039	1.942MetSer: 1.942 ± 0.043	1.782MetThr: 1.782 ± 0.036	2.086MetVal: 2.086 ± 0.047	0.234MetTrp: 0.234 ± 0.016	0.617MetTyr: 0.617 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	2.942AsnAla: 2.942 ± 0.054	0.469AsnCys: 0.469 ± 0.018	2.01AsnAsp: 2.01 ± 0.045	2.21AsnGlu: 2.21 ± 0.052	1.303AsnPhe: 1.303 ± 0.033	2.695AsnGly: 2.695 ± 0.054	0.778AsnHis: 0.778 ± 0.026	2.25AsnIle: 2.25 ± 0.041	1.82AsnLys: 1.82 ± 0.039	3.417AsnLeu: 3.417 ± 0.054	1.039AsnMet: 1.039 ± 0.031	1.258AsnAsn: 1.258 ± 0.033	2.007AsnPro: 2.007 ± 0.045	1.117AsnGln: 1.117 ± 0.032	2.094AsnArg: 2.094 ± 0.041	1.887AsnSer: 1.887 ± 0.042	1.75AsnThr: 1.75 ± 0.04	2.464AsnVal: 2.464 ± 0.046	0.478AsnTrp: 0.478 ± 0.023	1.032AsnTyr: 1.032 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.507ProAla: 3.507 ± 0.065	0.505ProCys: 0.505 ± 0.021	3.119ProAsp: 3.119 ± 0.058	4.063ProGlu: 4.063 ± 0.071	1.927ProPhe: 1.927 ± 0.04	3.566ProGly: 3.566 ± 0.06	0.995ProHis: 0.995 ± 0.028	2.324ProIle: 2.324 ± 0.045	2.247ProLys: 2.247 ± 0.044	4.053ProLeu: 4.053 ± 0.062	1.226ProMet: 1.226 ± 0.034	1.44ProAsn: 1.44 ± 0.038	1.75ProPro: 1.75 ± 0.049	1.413ProGln: 1.413 ± 0.034	1.84ProArg: 1.84 ± 0.039	2.449ProSer: 2.449 ± 0.043	2.103ProThr: 2.103 ± 0.036	3.642ProVal: 3.642 ± 0.057	0.582ProTrp: 0.582 ± 0.026	1.338ProTyr: 1.338 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.329GlnAla: 3.329 ± 0.058	0.387GlnCys: 0.387 ± 0.021	1.778GlnAsp: 1.778 ± 0.039	2.386GlnGlu: 2.386 ± 0.05	1.364GlnPhe: 1.364 ± 0.03	2.405GlnGly: 2.405 ± 0.043	0.718GlnHis: 0.718 ± 0.026	1.831GlnIle: 1.831 ± 0.039	1.732GlnLys: 1.732 ± 0.04	3.257GlnLeu: 3.257 ± 0.064	1.04GlnMet: 1.04 ± 0.031	1.139GlnAsn: 1.139 ± 0.035	1.4GlnPro: 1.4 ± 0.038	1.383GlnGln: 1.383 ± 0.043	2.032GlnArg: 2.032 ± 0.044	2.043GlnSer: 2.043 ± 0.046	1.787GlnThr: 1.787 ± 0.038	2.353GlnVal: 2.353 ± 0.051	0.441GlnTrp: 0.441 ± 0.02	0.977GlnTyr: 0.977 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.984ArgAla: 3.984 ± 0.061	0.647ArgCys: 0.647 ± 0.026	3.113ArgAsp: 3.113 ± 0.048	4.142ArgGlu: 4.142 ± 0.062	2.576ArgPhe: 2.576 ± 0.048	3.221ArgGly: 3.221 ± 0.054	1.289ArgHis: 1.289 ± 0.036	3.764ArgIle: 3.764 ± 0.059	3.39ArgLys: 3.39 ± 0.057	5.956ArgLeu: 5.956 ± 0.073	1.787ArgMet: 1.787 ± 0.036	1.978ArgAsn: 1.978 ± 0.043	2.264ArgPro: 2.264 ± 0.052	2.167ArgGln: 2.167 ± 0.044	3.273ArgArg: 3.273 ± 0.063	3.219ArgSer: 3.219 ± 0.061	2.787ArgThr: 2.787 ± 0.058	3.54ArgVal: 3.54 ± 0.048	0.648ArgTrp: 0.648 ± 0.026	1.68ArgTyr: 1.68 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.536SerAla: 4.536 ± 0.07	0.695SerCys: 0.695 ± 0.025	3.278SerAsp: 3.278 ± 0.051	3.723SerGlu: 3.723 ± 0.06	2.64SerPhe: 2.64 ± 0.05	5.261SerGly: 5.261 ± 0.07	1.233SerHis: 1.233 ± 0.033	3.81SerIle: 3.81 ± 0.062	2.896SerLys: 2.896 ± 0.045	6.117SerLeu: 6.117 ± 0.079	1.889SerMet: 1.889 ± 0.045	1.94SerAsn: 1.94 ± 0.045	2.585SerPro: 2.585 ± 0.05	1.964SerGln: 1.964 ± 0.042	3.227SerArg: 3.227 ± 0.065	3.595SerSer: 3.595 ± 0.07	3.016SerThr: 3.016 ± 0.053	4.109SerVal: 4.109 ± 0.066	0.71SerTrp: 0.71 ± 0.025	1.627SerTyr: 1.627 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	4.447ThrAla: 4.447 ± 0.066	0.646ThrCys: 0.646 ± 0.025	2.935ThrAsp: 2.935 ± 0.058	2.999ThrGlu: 2.999 ± 0.066	2.124ThrPhe: 2.124 ± 0.048	4.623ThrGly: 4.623 ± 0.071	1.079ThrHis: 1.079 ± 0.034	3.448ThrIle: 3.448 ± 0.07	2.272ThrLys: 2.272 ± 0.047	5.443ThrLeu: 5.443 ± 0.068	1.543ThrMet: 1.543 ± 0.037	1.762ThrAsn: 1.762 ± 0.037	3.01ThrPro: 3.01 ± 0.049	1.533ThrGln: 1.533 ± 0.039	2.665ThrArg: 2.665 ± 0.05	2.965ThrSer: 2.965 ± 0.049	2.875ThrThr: 2.875 ± 0.06	4.143ThrVal: 4.143 ± 0.065	0.552ThrTrp: 0.552 ± 0.023	1.452ThrTyr: 1.452 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.313ValAla: 6.313 ± 0.077	0.97ValCys: 0.97 ± 0.032	4.557ValAsp: 4.557 ± 0.073	5.032ValGlu: 5.032 ± 0.083	3.08ValPhe: 3.08 ± 0.05	5.147ValGly: 5.147 ± 0.078	1.432ValHis: 1.432 ± 0.038	4.245ValIle: 4.245 ± 0.058	3.413ValLys: 3.413 ± 0.065	7.045ValLeu: 7.045 ± 0.092	1.985ValMet: 1.985 ± 0.049	2.604ValAsn: 2.604 ± 0.042	2.967ValPro: 2.967 ± 0.053	2.257ValGln: 2.257 ± 0.044	3.955ValArg: 3.955 ± 0.069	4.379ValSer: 4.379 ± 0.071	3.909ValThr: 3.909 ± 0.058	5.716ValVal: 5.716 ± 0.09	0.819ValTrp: 0.819 ± 0.026	1.83ValTyr: 1.83 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.948TrpAla: 0.948 ± 0.028	0.156TrpCys: 0.156 ± 0.011	0.728TrpAsp: 0.728 ± 0.022	0.798TrpGlu: 0.798 ± 0.025	0.513TrpPhe: 0.513 ± 0.021	0.87TrpGly: 0.87 ± 0.025	0.249TrpHis: 0.249 ± 0.014	0.678TrpIle: 0.678 ± 0.026	0.671TrpLys: 0.671 ± 0.024	1.296TrpLeu: 1.296 ± 0.04	0.337TrpMet: 0.337 ± 0.018	0.473TrpAsn: 0.473 ± 0.023	0.55TrpPro: 0.55 ± 0.026	0.502TrpGln: 0.502 ± 0.021	0.695TrpArg: 0.695 ± 0.025	0.649TrpSer: 0.649 ± 0.022	0.641TrpThr: 0.641 ± 0.027	0.781TrpVal: 0.781 ± 0.025	0.2TrpTrp: 0.2 ± 0.016	0.313TrpTyr: 0.313 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.286TyrAla: 2.286 ± 0.048	0.421TyrCys: 0.421 ± 0.018	1.793TyrAsp: 1.793 ± 0.038	1.778TyrGlu: 1.778 ± 0.041	1.29TyrPhe: 1.29 ± 0.032	2.218TyrGly: 2.218 ± 0.041	0.6TyrHis: 0.6 ± 0.021	1.502TyrIle: 1.502 ± 0.04	1.336TyrLys: 1.336 ± 0.033	2.941TyrLeu: 2.941 ± 0.051	0.74TyrMet: 0.74 ± 0.022	1.021TyrAsn: 1.021 ± 0.032	1.352TyrPro: 1.352 ± 0.037	0.926TyrGln: 0.926 ± 0.03	1.68TyrArg: 1.68 ± 0.037	1.727TyrSer: 1.727 ± 0.043	1.513TyrThr: 1.513 ± 0.038	1.846TyrVal: 1.846 ± 0.038	0.441TyrTrp: 0.441 ± 0.02	0.991TyrTyr: 0.991 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3808 proteins (1187153 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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