Amino acid dipepetide frequency for Arthrobacter phage RcigaStruga

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.336AlaAla: 11.336 ± 1.422
0.502AlaCys: 0.502 ± 0.182
5.668AlaAsp: 5.668 ± 0.533
7.533AlaGlu: 7.533 ± 0.916
2.583AlaPhe: 2.583 ± 0.395
8.968AlaGly: 8.968 ± 0.977
1.435AlaHis: 1.435 ± 0.261
5.883AlaIle: 5.883 ± 0.745
6.098AlaLys: 6.098 ± 0.671
8.681AlaLeu: 8.681 ± 1.095
2.87AlaMet: 2.87 ± 0.468
3.444AlaAsn: 3.444 ± 0.39
4.018AlaPro: 4.018 ± 0.562
4.377AlaGln: 4.377 ± 0.537
5.381AlaArg: 5.381 ± 0.533
6.098AlaSer: 6.098 ± 0.792
6.601AlaThr: 6.601 ± 0.901
7.103AlaVal: 7.103 ± 0.863
1.794AlaTrp: 1.794 ± 0.348
2.726AlaTyr: 2.726 ± 0.412
0.0AlaXaa: 0.0 ± 0.0
Cys
0.359CysAla: 0.359 ± 0.165
0.072CysCys: 0.072 ± 0.081
0.359CysAsp: 0.359 ± 0.156
0.359CysGlu: 0.359 ± 0.173
0.072CysPhe: 0.072 ± 0.071
1.291CysGly: 1.291 ± 0.398
0.143CysHis: 0.143 ± 0.106
0.502CysIle: 0.502 ± 0.172
0.502CysLys: 0.502 ± 0.178
0.43CysLeu: 0.43 ± 0.176
0.0CysMet: 0.0 ± 0.0
0.215CysAsn: 0.215 ± 0.115
0.287CysPro: 0.287 ± 0.139
0.646CysGln: 0.646 ± 0.272
0.502CysArg: 0.502 ± 0.208
0.502CysSer: 0.502 ± 0.207
0.502CysThr: 0.502 ± 0.227
0.215CysVal: 0.215 ± 0.124
0.143CysTrp: 0.143 ± 0.111
0.143CysTyr: 0.143 ± 0.093
0.0CysXaa: 0.0 ± 0.0
Asp
5.166AspAla: 5.166 ± 0.637
0.646AspCys: 0.646 ± 0.232
3.3AspAsp: 3.3 ± 0.592
4.592AspGlu: 4.592 ± 0.638
1.722AspPhe: 1.722 ± 0.31
5.381AspGly: 5.381 ± 0.664
1.22AspHis: 1.22 ± 0.383
2.439AspIle: 2.439 ± 0.33
2.152AspLys: 2.152 ± 0.343
5.453AspLeu: 5.453 ± 0.642
1.363AspMet: 1.363 ± 0.36
1.578AspAsn: 1.578 ± 0.28
4.018AspPro: 4.018 ± 0.56
2.081AspGln: 2.081 ± 0.414
3.803AspArg: 3.803 ± 0.494
3.3AspSer: 3.3 ± 0.595
2.942AspThr: 2.942 ± 0.341
2.368AspVal: 2.368 ± 0.384
1.578AspTrp: 1.578 ± 0.349
1.435AspTyr: 1.435 ± 0.341
0.0AspXaa: 0.0 ± 0.0
Glu
8.394GluAla: 8.394 ± 0.988
0.717GluCys: 0.717 ± 0.227
3.803GluAsp: 3.803 ± 0.711
5.166GluGlu: 5.166 ± 0.532
2.296GluPhe: 2.296 ± 0.433
4.95GluGly: 4.95 ± 0.72
1.076GluHis: 1.076 ± 0.269
3.3GluIle: 3.3 ± 0.491
2.87GluLys: 2.87 ± 0.562
6.457GluLeu: 6.457 ± 0.745
1.363GluMet: 1.363 ± 0.378
1.865GluAsn: 1.865 ± 0.276
2.655GluPro: 2.655 ± 0.486
3.587GluGln: 3.587 ± 0.607
3.444GluArg: 3.444 ± 0.541
2.152GluSer: 2.152 ± 0.46
3.444GluThr: 3.444 ± 0.454
4.448GluVal: 4.448 ± 0.624
1.578GluTrp: 1.578 ± 0.37
1.865GluTyr: 1.865 ± 0.342
0.0GluXaa: 0.0 ± 0.0
Phe
2.798PheAla: 2.798 ± 0.438
0.215PheCys: 0.215 ± 0.118
2.296PheAsp: 2.296 ± 0.384
2.081PheGlu: 2.081 ± 0.353
1.22PhePhe: 1.22 ± 0.515
3.3PheGly: 3.3 ± 0.77
0.789PheHis: 0.789 ± 0.26
0.502PheIle: 0.502 ± 0.189
1.507PheLys: 1.507 ± 0.295
2.224PheLeu: 2.224 ± 0.345
0.861PheMet: 0.861 ± 0.284
0.933PheAsn: 0.933 ± 0.259
0.789PhePro: 0.789 ± 0.23
1.076PheGln: 1.076 ± 0.238
2.081PheArg: 2.081 ± 0.366
2.511PheSer: 2.511 ± 0.598
2.224PheThr: 2.224 ± 0.623
1.507PheVal: 1.507 ± 0.393
0.359PheTrp: 0.359 ± 0.154
0.646PheTyr: 0.646 ± 0.242
0.0PheXaa: 0.0 ± 0.0
Gly
8.681GlyAla: 8.681 ± 0.96
0.861GlyCys: 0.861 ± 0.31
4.879GlyAsp: 4.879 ± 0.68
4.807GlyGlu: 4.807 ± 0.508
3.013GlyPhe: 3.013 ± 0.504
6.744GlyGly: 6.744 ± 0.642
1.865GlyHis: 1.865 ± 0.441
4.735GlyIle: 4.735 ± 0.779
4.09GlyLys: 4.09 ± 0.431
7.175GlyLeu: 7.175 ± 0.97
2.009GlyMet: 2.009 ± 0.388
3.372GlyAsn: 3.372 ± 0.508
4.018GlyPro: 4.018 ± 0.473
3.372GlyGln: 3.372 ± 0.488
4.664GlyArg: 4.664 ± 0.502
5.955GlySer: 5.955 ± 0.709
6.027GlyThr: 6.027 ± 0.803
6.314GlyVal: 6.314 ± 0.695
2.152GlyTrp: 2.152 ± 0.358
2.511GlyTyr: 2.511 ± 0.408
0.0GlyXaa: 0.0 ± 0.0
His
1.65HisAla: 1.65 ± 0.39
0.215HisCys: 0.215 ± 0.12
1.076HisAsp: 1.076 ± 0.253
1.363HisGlu: 1.363 ± 0.374
0.717HisPhe: 0.717 ± 0.268
1.722HisGly: 1.722 ± 0.323
0.646HisHis: 0.646 ± 0.196
0.646HisIle: 0.646 ± 0.206
1.148HisLys: 1.148 ± 0.291
1.722HisLeu: 1.722 ± 0.442
0.287HisMet: 0.287 ± 0.132
0.287HisAsn: 0.287 ± 0.157
0.717HisPro: 0.717 ± 0.229
0.43HisGln: 0.43 ± 0.208
0.717HisArg: 0.717 ± 0.216
1.722HisSer: 1.722 ± 0.303
1.076HisThr: 1.076 ± 0.305
1.722HisVal: 1.722 ± 0.413
0.502HisTrp: 0.502 ± 0.184
0.933HisTyr: 0.933 ± 0.318
0.0HisXaa: 0.0 ± 0.0
Ile
4.879IleAla: 4.879 ± 0.565
0.215IleCys: 0.215 ± 0.105
2.726IleAsp: 2.726 ± 0.458
4.233IleGlu: 4.233 ± 0.51
1.363IlePhe: 1.363 ± 0.365
4.807IleGly: 4.807 ± 0.604
0.789IleHis: 0.789 ± 0.22
2.368IleIle: 2.368 ± 0.537
2.511IleLys: 2.511 ± 0.448
3.372IleLeu: 3.372 ± 0.477
0.574IleMet: 0.574 ± 0.277
2.152IleAsn: 2.152 ± 0.405
2.439IlePro: 2.439 ± 0.388
2.081IleGln: 2.081 ± 0.419
3.516IleArg: 3.516 ± 0.414
3.157IleSer: 3.157 ± 0.511
3.946IleThr: 3.946 ± 0.482
4.233IleVal: 4.233 ± 0.726
0.933IleTrp: 0.933 ± 0.234
1.004IleTyr: 1.004 ± 0.275
0.0IleXaa: 0.0 ± 0.0
Lys
5.955LysAla: 5.955 ± 0.902
0.359LysCys: 0.359 ± 0.151
3.013LysAsp: 3.013 ± 0.597
2.583LysGlu: 2.583 ± 0.467
1.435LysPhe: 1.435 ± 0.365
4.233LysGly: 4.233 ± 0.383
1.291LysHis: 1.291 ± 0.424
3.013LysIle: 3.013 ± 0.43
2.152LysLys: 2.152 ± 0.477
4.305LysLeu: 4.305 ± 0.533
1.507LysMet: 1.507 ± 0.321
1.435LysAsn: 1.435 ± 0.291
2.798LysPro: 2.798 ± 0.525
1.291LysGln: 1.291 ± 0.29
3.3LysArg: 3.3 ± 0.582
2.942LysSer: 2.942 ± 0.447
3.157LysThr: 3.157 ± 0.466
4.018LysVal: 4.018 ± 0.529
0.502LysTrp: 0.502 ± 0.17
1.004LysTyr: 1.004 ± 0.268
0.0LysXaa: 0.0 ± 0.0
Leu
8.538LeuAla: 8.538 ± 0.749
0.646LeuCys: 0.646 ± 0.225
5.524LeuAsp: 5.524 ± 0.591
4.161LeuGlu: 4.161 ± 0.558
2.583LeuPhe: 2.583 ± 0.537
7.318LeuGly: 7.318 ± 0.865
1.363LeuHis: 1.363 ± 0.312
4.52LeuIle: 4.52 ± 0.573
3.372LeuLys: 3.372 ± 0.475
6.314LeuLeu: 6.314 ± 0.804
1.865LeuMet: 1.865 ± 0.36
4.161LeuAsn: 4.161 ± 0.52
5.166LeuPro: 5.166 ± 0.572
3.659LeuGln: 3.659 ± 0.444
4.735LeuArg: 4.735 ± 0.652
4.592LeuSer: 4.592 ± 0.585
5.524LeuThr: 5.524 ± 0.57
6.242LeuVal: 6.242 ± 0.727
1.507LeuTrp: 1.507 ± 0.365
1.937LeuTyr: 1.937 ± 0.394
0.0LeuXaa: 0.0 ± 0.0
Met
2.224MetAla: 2.224 ± 0.385
0.072MetCys: 0.072 ± 0.076
1.435MetAsp: 1.435 ± 0.372
1.794MetGlu: 1.794 ± 0.348
0.287MetPhe: 0.287 ± 0.127
1.148MetGly: 1.148 ± 0.345
0.215MetHis: 0.215 ± 0.128
1.507MetIle: 1.507 ± 0.362
1.076MetLys: 1.076 ± 0.274
1.65MetLeu: 1.65 ± 0.31
0.287MetMet: 0.287 ± 0.175
1.291MetAsn: 1.291 ± 0.311
2.009MetPro: 2.009 ± 0.357
0.861MetGln: 0.861 ± 0.341
0.646MetArg: 0.646 ± 0.184
1.722MetSer: 1.722 ± 0.346
1.937MetThr: 1.937 ± 0.381
1.794MetVal: 1.794 ± 0.326
0.215MetTrp: 0.215 ± 0.129
0.574MetTyr: 0.574 ± 0.176
0.0MetXaa: 0.0 ± 0.0
Asn
3.587AsnAla: 3.587 ± 0.466
0.072AsnCys: 0.072 ± 0.067
1.363AsnAsp: 1.363 ± 0.345
1.65AsnGlu: 1.65 ± 0.305
0.502AsnPhe: 0.502 ± 0.212
4.233AsnGly: 4.233 ± 0.566
0.502AsnHis: 0.502 ± 0.228
1.937AsnIle: 1.937 ± 0.348
1.722AsnLys: 1.722 ± 0.326
3.229AsnLeu: 3.229 ± 0.467
0.502AsnMet: 0.502 ± 0.213
1.148AsnAsn: 1.148 ± 0.331
2.152AsnPro: 2.152 ± 0.491
1.794AsnGln: 1.794 ± 0.412
1.578AsnArg: 1.578 ± 0.337
2.726AsnSer: 2.726 ± 0.597
2.798AsnThr: 2.798 ± 0.464
2.296AsnVal: 2.296 ± 0.424
0.861AsnTrp: 0.861 ± 0.228
0.502AsnTyr: 0.502 ± 0.212
0.0AsnXaa: 0.0 ± 0.0
Pro
6.027ProAla: 6.027 ± 0.707
0.287ProCys: 0.287 ± 0.157
3.013ProAsp: 3.013 ± 0.45
3.946ProGlu: 3.946 ± 0.552
0.933ProPhe: 0.933 ± 0.309
5.237ProGly: 5.237 ± 0.586
0.502ProHis: 0.502 ± 0.204
2.798ProIle: 2.798 ± 0.391
3.085ProLys: 3.085 ± 0.53
2.798ProLeu: 2.798 ± 0.412
1.076ProMet: 1.076 ± 0.293
1.722ProAsn: 1.722 ± 0.342
2.081ProPro: 2.081 ± 0.473
0.861ProGln: 0.861 ± 0.225
2.368ProArg: 2.368 ± 0.404
3.874ProSer: 3.874 ± 0.46
3.803ProThr: 3.803 ± 0.571
4.161ProVal: 4.161 ± 0.498
1.435ProTrp: 1.435 ± 0.356
1.004ProTyr: 1.004 ± 0.275
0.0ProXaa: 0.0 ± 0.0
Gln
3.659GlnAla: 3.659 ± 0.448
0.143GlnCys: 0.143 ± 0.135
2.009GlnAsp: 2.009 ± 0.462
2.296GlnGlu: 2.296 ± 0.323
1.076GlnPhe: 1.076 ± 0.225
2.942GlnGly: 2.942 ± 0.57
0.574GlnHis: 0.574 ± 0.228
2.439GlnIle: 2.439 ± 0.414
2.224GlnLys: 2.224 ± 0.366
5.022GlnLeu: 5.022 ± 0.667
0.359GlnMet: 0.359 ± 0.147
1.578GlnAsn: 1.578 ± 0.458
1.937GlnPro: 1.937 ± 0.377
1.65GlnGln: 1.65 ± 0.332
1.794GlnArg: 1.794 ± 0.394
1.794GlnSer: 1.794 ± 0.366
2.152GlnThr: 2.152 ± 0.346
3.3GlnVal: 3.3 ± 0.543
0.717GlnTrp: 0.717 ± 0.224
0.717GlnTyr: 0.717 ± 0.208
0.0GlnXaa: 0.0 ± 0.0
Arg
5.166ArgAla: 5.166 ± 0.466
0.502ArgCys: 0.502 ± 0.207
3.516ArgAsp: 3.516 ± 0.595
3.587ArgGlu: 3.587 ± 0.488
1.291ArgPhe: 1.291 ± 0.344
4.233ArgGly: 4.233 ± 0.633
1.22ArgHis: 1.22 ± 0.265
2.511ArgIle: 2.511 ± 0.354
3.874ArgLys: 3.874 ± 0.695
4.735ArgLeu: 4.735 ± 0.527
1.65ArgMet: 1.65 ± 0.377
2.368ArgAsn: 2.368 ± 0.44
2.726ArgPro: 2.726 ± 0.503
1.865ArgGln: 1.865 ± 0.369
3.946ArgArg: 3.946 ± 0.57
3.516ArgSer: 3.516 ± 0.533
2.583ArgThr: 2.583 ± 0.357
4.448ArgVal: 4.448 ± 0.652
0.861ArgTrp: 0.861 ± 0.367
1.435ArgTyr: 1.435 ± 0.338
0.0ArgXaa: 0.0 ± 0.0
Ser
5.453SerAla: 5.453 ± 1.254
0.43SerCys: 0.43 ± 0.194
2.798SerAsp: 2.798 ± 0.412
3.731SerGlu: 3.731 ± 0.558
2.87SerPhe: 2.87 ± 0.505
6.744SerGly: 6.744 ± 0.792
1.65SerHis: 1.65 ± 0.354
3.3SerIle: 3.3 ± 0.545
2.726SerLys: 2.726 ± 0.384
5.524SerLeu: 5.524 ± 0.696
1.507SerMet: 1.507 ± 0.358
2.081SerAsn: 2.081 ± 0.562
2.655SerPro: 2.655 ± 0.395
2.511SerGln: 2.511 ± 0.57
3.013SerArg: 3.013 ± 0.468
3.157SerSer: 3.157 ± 0.447
3.516SerThr: 3.516 ± 0.512
4.735SerVal: 4.735 ± 0.475
1.076SerTrp: 1.076 ± 0.314
2.152SerTyr: 2.152 ± 0.512
0.0SerXaa: 0.0 ± 0.0
Thr
7.677ThrAla: 7.677 ± 0.808
0.574ThrCys: 0.574 ± 0.201
2.87ThrAsp: 2.87 ± 0.421
4.305ThrGlu: 4.305 ± 0.547
2.081ThrPhe: 2.081 ± 0.427
4.95ThrGly: 4.95 ± 0.911
1.291ThrHis: 1.291 ± 0.303
2.726ThrIle: 2.726 ± 0.575
3.659ThrLys: 3.659 ± 0.445
5.74ThrLeu: 5.74 ± 0.675
1.148ThrMet: 1.148 ± 0.285
1.937ThrAsn: 1.937 ± 0.394
4.664ThrPro: 4.664 ± 0.527
2.368ThrGln: 2.368 ± 0.497
3.157ThrArg: 3.157 ± 0.532
4.161ThrSer: 4.161 ± 0.586
5.166ThrThr: 5.166 ± 0.746
4.448ThrVal: 4.448 ± 0.569
0.646ThrTrp: 0.646 ± 0.208
1.363ThrTyr: 1.363 ± 0.287
0.0ThrXaa: 0.0 ± 0.0
Val
7.39ValAla: 7.39 ± 0.818
0.287ValCys: 0.287 ± 0.13
3.372ValAsp: 3.372 ± 0.465
4.807ValGlu: 4.807 ± 0.488
2.081ValPhe: 2.081 ± 0.416
5.309ValGly: 5.309 ± 0.746
1.865ValHis: 1.865 ± 0.366
3.874ValIle: 3.874 ± 0.848
3.013ValLys: 3.013 ± 0.517
6.098ValLeu: 6.098 ± 0.582
2.511ValMet: 2.511 ± 0.437
2.439ValAsn: 2.439 ± 0.484
3.659ValPro: 3.659 ± 0.475
3.013ValGln: 3.013 ± 0.453
4.09ValArg: 4.09 ± 0.491
5.166ValSer: 5.166 ± 0.569
4.305ValThr: 4.305 ± 0.579
4.879ValVal: 4.879 ± 0.589
1.578ValTrp: 1.578 ± 0.365
1.65ValTyr: 1.65 ± 0.388
0.0ValXaa: 0.0 ± 0.0
Trp
2.296TrpAla: 2.296 ± 0.362
0.072TrpCys: 0.072 ± 0.082
1.937TrpAsp: 1.937 ± 0.443
0.717TrpGlu: 0.717 ± 0.253
0.717TrpPhe: 0.717 ± 0.217
1.578TrpGly: 1.578 ± 0.383
0.43TrpHis: 0.43 ± 0.156
1.076TrpIle: 1.076 ± 0.241
0.933TrpLys: 0.933 ± 0.308
1.076TrpLeu: 1.076 ± 0.241
0.717TrpMet: 0.717 ± 0.194
0.646TrpAsn: 0.646 ± 0.198
0.933TrpPro: 0.933 ± 0.341
0.287TrpGln: 0.287 ± 0.142
1.076TrpArg: 1.076 ± 0.302
1.363TrpSer: 1.363 ± 0.285
1.004TrpThr: 1.004 ± 0.276
2.009TrpVal: 2.009 ± 0.361
0.717TrpTrp: 0.717 ± 0.2
0.43TrpTyr: 0.43 ± 0.17
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.865TyrAla: 1.865 ± 0.429
0.359TyrCys: 0.359 ± 0.157
1.578TyrAsp: 1.578 ± 0.329
1.722TyrGlu: 1.722 ± 0.375
1.076TyrPhe: 1.076 ± 0.231
2.152TyrGly: 2.152 ± 0.349
0.43TyrHis: 0.43 ± 0.158
1.22TyrIle: 1.22 ± 0.296
1.65TyrLys: 1.65 ± 0.307
1.722TyrLeu: 1.722 ± 0.296
0.215TyrMet: 0.215 ± 0.129
0.502TyrAsn: 0.502 ± 0.197
1.291TyrPro: 1.291 ± 0.307
0.574TyrGln: 0.574 ± 0.187
2.224TyrArg: 2.224 ± 0.402
1.22TyrSer: 1.22 ± 0.307
2.224TyrThr: 2.224 ± 0.401
1.148TyrVal: 1.148 ± 0.274
0.861TyrTrp: 0.861 ± 0.267
0.574TyrTyr: 0.574 ± 0.205
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (13939 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski