Amino acid dipepetide frequency for Polyangium fumosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.896AlaAla: 17.896 ± 0.121	1.977AlaCys: 1.977 ± 0.042	6.087AlaAsp: 6.087 ± 0.042	8.389AlaGlu: 8.389 ± 0.066	4.164AlaPhe: 4.164 ± 0.035	10.416AlaGly: 10.416 ± 0.059	2.448AlaHis: 2.448 ± 0.033	4.829AlaIle: 4.829 ± 0.042	3.964AlaLys: 3.964 ± 0.04	14.478AlaLeu: 14.478 ± 0.093	2.537AlaMet: 2.537 ± 0.025	2.196AlaAsn: 2.196 ± 0.026	8.371AlaPro: 8.371 ± 0.071	3.479AlaGln: 3.479 ± 0.038	11.383AlaArg: 11.383 ± 0.088	7.582AlaSer: 7.582 ± 0.052	6.413AlaThr: 6.413 ± 0.048	8.125AlaVal: 8.125 ± 0.053	1.838AlaTrp: 1.838 ± 0.022	2.397AlaTyr: 2.397 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	1.561CysAla: 1.561 ± 0.032	0.191CysCys: 0.191 ± 0.011	0.911CysAsp: 0.911 ± 0.032	0.736CysGlu: 0.736 ± 0.017	0.347CysPhe: 0.347 ± 0.009	1.38CysGly: 1.38 ± 0.036	0.284CysHis: 0.284 ± 0.012	0.396CysIle: 0.396 ± 0.011	0.411CysLys: 0.411 ± 0.012	0.883CysLeu: 0.883 ± 0.017	0.219CysMet: 0.219 ± 0.008	0.417CysAsn: 0.417 ± 0.019	0.811CysPro: 0.811 ± 0.02	0.364CysGln: 0.364 ± 0.016	0.743CysArg: 0.743 ± 0.018	0.774CysSer: 0.774 ± 0.02	0.818CysThr: 0.818 ± 0.024	0.992CysVal: 0.992 ± 0.023	0.148CysTrp: 0.148 ± 0.009	0.22CysTyr: 0.22 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.711AspAla: 7.711 ± 0.048	0.713AspCys: 0.713 ± 0.032	3.566AspAsp: 3.566 ± 0.043	4.278AspGlu: 4.278 ± 0.041	1.774AspPhe: 1.774 ± 0.022	5.604AspGly: 5.604 ± 0.066	1.13AspHis: 1.13 ± 0.018	1.923AspIle: 1.923 ± 0.023	1.739AspLys: 1.739 ± 0.025	5.875AspLeu: 5.875 ± 0.046	0.882AspMet: 0.882 ± 0.015	0.996AspAsn: 0.996 ± 0.019	4.422AspPro: 4.422 ± 0.046	1.238AspGln: 1.238 ± 0.019	4.028AspArg: 4.028 ± 0.041	1.702AspSer: 1.702 ± 0.022	2.479AspThr: 2.479 ± 0.029	5.116AspVal: 5.116 ± 0.037	0.666AspTrp: 0.666 ± 0.015	0.961AspTyr: 0.961 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	8.914GluAla: 8.914 ± 0.065	0.551GluCys: 0.551 ± 0.015	3.262GluAsp: 3.262 ± 0.034	4.17GluGlu: 4.17 ± 0.045	1.31GluPhe: 1.31 ± 0.018	5.759GluGly: 5.759 ± 0.044	1.466GluHis: 1.466 ± 0.02	2.93GluIle: 2.93 ± 0.029	2.285GluLys: 2.285 ± 0.031	6.473GluLeu: 6.473 ± 0.054	1.152GluMet: 1.152 ± 0.018	1.283GluAsn: 1.283 ± 0.021	3.783GluPro: 3.783 ± 0.031	2.061GluGln: 2.061 ± 0.032	6.178GluArg: 6.178 ± 0.054	2.687GluSer: 2.687 ± 0.027	3.063GluThr: 3.063 ± 0.033	4.747GluVal: 4.747 ± 0.036	0.615GluTrp: 0.615 ± 0.015	0.975GluTyr: 0.975 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.923PheAla: 3.923 ± 0.035	0.419PheCys: 0.419 ± 0.011	2.316PheAsp: 2.316 ± 0.026	2.297PheGlu: 2.297 ± 0.026	1.311PhePhe: 1.311 ± 0.025	3.348PheGly: 3.348 ± 0.036	0.711PheHis: 0.711 ± 0.014	0.866PheIle: 0.866 ± 0.017	0.711PheLys: 0.711 ± 0.016	3.105PheLeu: 3.105 ± 0.034	0.546PheMet: 0.546 ± 0.011	0.622PheAsn: 0.622 ± 0.013	1.632PhePro: 1.632 ± 0.022	0.897PheGln: 0.897 ± 0.016	2.254PheArg: 2.254 ± 0.027	1.93PheSer: 1.93 ± 0.024	1.724PheThr: 1.724 ± 0.021	3.212PheVal: 3.212 ± 0.037	0.443PheTrp: 0.443 ± 0.011	0.754PheTyr: 0.754 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	11.305GlyAla: 11.305 ± 0.065	1.323GlyCys: 1.323 ± 0.024	4.986GlyAsp: 4.986 ± 0.042	5.605GlyGlu: 5.605 ± 0.038	3.043GlyPhe: 3.043 ± 0.029	9.102GlyGly: 9.102 ± 0.098	1.795GlyHis: 1.795 ± 0.022	3.589GlyIle: 3.589 ± 0.036	3.709GlyLys: 3.709 ± 0.039	7.8GlyLeu: 7.8 ± 0.049	2.025GlyMet: 2.025 ± 0.025	2.061GlyAsn: 2.061 ± 0.029	4.673GlyPro: 4.673 ± 0.042	2.564GlyGln: 2.564 ± 0.029	6.494GlyArg: 6.494 ± 0.055	5.174GlySer: 5.174 ± 0.049	5.283GlyThr: 5.283 ± 0.049	6.422GlyVal: 6.422 ± 0.045	1.124GlyTrp: 1.124 ± 0.018	1.973GlyTyr: 1.973 ± 0.026	0.0GlyXaa: 0.0 ± 0.0
His	2.802HisAla: 2.802 ± 0.031	0.238HisCys: 0.238 ± 0.008	1.223HisAsp: 1.223 ± 0.019	1.433HisGlu: 1.433 ± 0.02	0.767HisPhe: 0.767 ± 0.014	1.934HisGly: 1.934 ± 0.025	0.592HisHis: 0.592 ± 0.014	0.648HisIle: 0.648 ± 0.013	0.457HisLys: 0.457 ± 0.01	2.073HisLeu: 2.073 ± 0.029	0.274HisMet: 0.274 ± 0.009	0.341HisAsn: 0.341 ± 0.01	1.444HisPro: 1.444 ± 0.022	0.45HisGln: 0.45 ± 0.013	1.558HisArg: 1.558 ± 0.022	0.676HisSer: 0.676 ± 0.015	0.879HisThr: 0.879 ± 0.016	1.947HisVal: 1.947 ± 0.021	0.272HisTrp: 0.272 ± 0.008	0.484HisTyr: 0.484 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.93IleAla: 4.93 ± 0.039	0.418IleCys: 0.418 ± 0.012	2.833IleAsp: 2.833 ± 0.029	3.181IleGlu: 3.181 ± 0.031	1.092IlePhe: 1.092 ± 0.019	3.466IleGly: 3.466 ± 0.03	0.849IleHis: 0.849 ± 0.015	0.937IleIle: 0.937 ± 0.019	0.956IleLys: 0.956 ± 0.018	3.301IleLeu: 3.301 ± 0.032	0.421IleMet: 0.421 ± 0.012	0.694IleAsn: 0.694 ± 0.017	2.068IlePro: 2.068 ± 0.029	0.961IleGln: 0.961 ± 0.016	2.54IleArg: 2.54 ± 0.027	1.743IleSer: 1.743 ± 0.022	2.198IleThr: 2.198 ± 0.026	3.517IleVal: 3.517 ± 0.034	0.36IleTrp: 0.36 ± 0.009	0.737IleTyr: 0.737 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.656LysAla: 3.656 ± 0.04	0.285LysCys: 0.285 ± 0.013	1.897LysAsp: 1.897 ± 0.027	1.817LysGlu: 1.817 ± 0.026	0.697LysPhe: 0.697 ± 0.016	2.6LysGly: 2.6 ± 0.035	0.626LysHis: 0.626 ± 0.012	1.28LysIle: 1.28 ± 0.019	1.628LysLys: 1.628 ± 0.033	3.24LysLeu: 3.24 ± 0.035	0.606LysMet: 0.606 ± 0.012	0.941LysAsn: 0.941 ± 0.02	2.266LysPro: 2.266 ± 0.032	0.944LysGln: 0.944 ± 0.018	2.453LysArg: 2.453 ± 0.027	1.554LysSer: 1.554 ± 0.02	1.824LysThr: 1.824 ± 0.023	2.225LysVal: 2.225 ± 0.031	0.308LysTrp: 0.308 ± 0.009	0.605LysTyr: 0.605 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.042LeuAla: 14.042 ± 0.087	1.152LeuCys: 1.152 ± 0.02	6.527LeuAsp: 6.527 ± 0.042	5.961LeuGlu: 5.961 ± 0.057	3.309LeuPhe: 3.309 ± 0.04	9.735LeuGly: 9.735 ± 0.066	2.024LeuHis: 2.024 ± 0.025	2.441LeuIle: 2.441 ± 0.027	2.22LeuLys: 2.22 ± 0.031	10.054LeuLeu: 10.054 ± 0.068	1.28LeuMet: 1.28 ± 0.017	1.446LeuAsn: 1.446 ± 0.02	6.191LeuPro: 6.191 ± 0.047	2.152LeuGln: 2.152 ± 0.026	8.334LeuArg: 8.334 ± 0.058	6.006LeuSer: 6.006 ± 0.042	4.414LeuThr: 4.414 ± 0.037	9.159LeuVal: 9.159 ± 0.053	1.131LeuTrp: 1.131 ± 0.02	1.935LeuTyr: 1.935 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.104MetAla: 2.104 ± 0.023	0.163MetCys: 0.163 ± 0.006	0.821MetAsp: 0.821 ± 0.015	0.879MetGlu: 0.879 ± 0.014	0.524MetPhe: 0.524 ± 0.014	1.613MetGly: 1.613 ± 0.022	0.414MetHis: 0.414 ± 0.011	0.719MetIle: 0.719 ± 0.014	0.752MetLys: 0.752 ± 0.014	1.848MetLeu: 1.848 ± 0.023	0.362MetMet: 0.362 ± 0.011	0.577MetAsn: 0.577 ± 0.012	1.313MetPro: 1.313 ± 0.021	0.629MetGln: 0.629 ± 0.013	1.686MetArg: 1.686 ± 0.021	1.266MetSer: 1.266 ± 0.017	1.17MetThr: 1.17 ± 0.018	1.152MetVal: 1.152 ± 0.017	0.164MetTrp: 0.164 ± 0.007	0.297MetTyr: 0.297 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.506AsnAla: 2.506 ± 0.029	0.286AsnCys: 0.286 ± 0.013	1.277AsnAsp: 1.277 ± 0.019	1.26AsnGlu: 1.26 ± 0.019	0.624AsnPhe: 0.624 ± 0.016	2.167AsnGly: 2.167 ± 0.033	0.446AsnHis: 0.446 ± 0.011	0.771AsnIle: 0.771 ± 0.015	0.588AsnLys: 0.588 ± 0.013	1.964AsnLeu: 1.964 ± 0.027	0.339AsnMet: 0.339 ± 0.011	0.535AsnAsn: 0.535 ± 0.016	1.588AsnPro: 1.588 ± 0.024	0.592AsnGln: 0.592 ± 0.015	1.249AsnArg: 1.249 ± 0.023	0.716AsnSer: 0.716 ± 0.016	1.103AsnThr: 1.103 ± 0.018	1.837AsnVal: 1.837 ± 0.025	0.23AsnTrp: 0.23 ± 0.009	0.437AsnTyr: 0.437 ± 0.011	0.0AsnXaa: 0.0 ± 0.0
Pro	8.013ProAla: 8.013 ± 0.067	0.644ProCys: 0.644 ± 0.017	3.73ProAsp: 3.73 ± 0.034	4.64ProGlu: 4.64 ± 0.036	2.141ProPhe: 2.141 ± 0.025	5.423ProGly: 5.423 ± 0.046	1.155ProHis: 1.155 ± 0.018	2.24ProIle: 2.24 ± 0.022	2.068ProLys: 2.068 ± 0.029	5.572ProLeu: 5.572 ± 0.047	1.391ProMet: 1.391 ± 0.02	1.433ProAsn: 1.433 ± 0.022	5.73ProPro: 5.73 ± 0.077	1.463ProGln: 1.463 ± 0.025	4.563ProArg: 4.563 ± 0.042	4.214ProSer: 4.214 ± 0.039	3.391ProThr: 3.391 ± 0.037	4.156ProVal: 4.156 ± 0.037	0.845ProTrp: 0.845 ± 0.015	1.17ProTyr: 1.17 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.442GlnAla: 3.442 ± 0.033	0.353GlnCys: 0.353 ± 0.013	1.224GlnAsp: 1.224 ± 0.018	1.375GlnGlu: 1.375 ± 0.021	0.718GlnPhe: 0.718 ± 0.014	2.38GlnGly: 2.38 ± 0.03	0.539GlnHis: 0.539 ± 0.011	1.338GlnIle: 1.338 ± 0.019	1.16GlnLys: 1.16 ± 0.02	2.075GlnLeu: 2.075 ± 0.027	0.512GlnMet: 0.512 ± 0.012	0.732GlnAsn: 0.732 ± 0.015	1.516GlnPro: 1.516 ± 0.024	0.884GlnGln: 0.884 ± 0.021	2.29GlnArg: 2.29 ± 0.025	1.427GlnSer: 1.427 ± 0.022	1.421GlnThr: 1.421 ± 0.022	1.9GlnVal: 1.9 ± 0.025	0.351GlnTrp: 0.351 ± 0.01	0.529GlnTyr: 0.529 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	10.974ArgAla: 10.974 ± 0.09	0.793ArgCys: 0.793 ± 0.016	4.1ArgAsp: 4.1 ± 0.039	4.963ArgGlu: 4.963 ± 0.041	3.082ArgPhe: 3.082 ± 0.028	6.183ArgGly: 6.183 ± 0.052	1.568ArgHis: 1.568 ± 0.021	3.778ArgIle: 3.778 ± 0.035	2.442ArgLys: 2.442 ± 0.029	8.05ArgLeu: 8.05 ± 0.061	1.746ArgMet: 1.746 ± 0.022	1.299ArgAsn: 1.299 ± 0.022	4.366ArgPro: 4.366 ± 0.039	1.808ArgGln: 1.808 ± 0.024	7.058ArgArg: 7.058 ± 0.072	4.075ArgSer: 4.075 ± 0.037	3.874ArgThr: 3.874 ± 0.032	6.3ArgVal: 6.3 ± 0.051	1.135ArgTrp: 1.135 ± 0.019	1.817ArgTyr: 1.817 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.617SerAla: 6.617 ± 0.044	0.812SerCys: 0.812 ± 0.022	2.675SerAsp: 2.675 ± 0.033	2.783SerGlu: 2.783 ± 0.026	2.254SerPhe: 2.254 ± 0.025	5.368SerGly: 5.368 ± 0.051	0.959SerHis: 0.959 ± 0.014	2.27SerIle: 2.27 ± 0.024	1.513SerLys: 1.513 ± 0.022	5.504SerLeu: 5.504 ± 0.04	1.168SerMet: 1.168 ± 0.018	1.171SerAsn: 1.171 ± 0.022	3.7SerPro: 3.7 ± 0.033	1.289SerGln: 1.289 ± 0.02	3.895SerArg: 3.895 ± 0.04	3.641SerSer: 3.641 ± 0.052	3.033SerThr: 3.033 ± 0.033	3.923SerVal: 3.923 ± 0.034	0.691SerTrp: 0.691 ± 0.014	1.139SerTyr: 1.139 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.443ThrAla: 5.443 ± 0.042	0.908ThrCys: 0.908 ± 0.03	2.534ThrAsp: 2.534 ± 0.032	2.666ThrGlu: 2.666 ± 0.03	1.976ThrPhe: 1.976 ± 0.027	4.807ThrGly: 4.807 ± 0.046	1.032ThrHis: 1.032 ± 0.018	2.234ThrIle: 2.234 ± 0.026	1.674ThrLys: 1.674 ± 0.025	5.548ThrLeu: 5.548 ± 0.047	0.994ThrMet: 0.994 ± 0.017	1.388ThrAsn: 1.388 ± 0.022	3.813ThrPro: 3.813 ± 0.034	1.41ThrGln: 1.41 ± 0.021	3.725ThrArg: 3.725 ± 0.037	3.403ThrSer: 3.403 ± 0.032	3.32ThrThr: 3.32 ± 0.039	3.709ThrVal: 3.709 ± 0.039	0.811ThrTrp: 0.811 ± 0.016	1.241ThrTyr: 1.241 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	9.538ValAla: 9.538 ± 0.061	1.004ValCys: 1.004 ± 0.026	4.727ValAsp: 4.727 ± 0.037	5.139ValGlu: 5.139 ± 0.034	2.65ValPhe: 2.65 ± 0.029	6.029ValGly: 6.029 ± 0.044	1.733ValHis: 1.733 ± 0.024	2.792ValIle: 2.792 ± 0.03	2.166ValLys: 2.166 ± 0.028	8.335ValLeu: 8.335 ± 0.061	1.346ValMet: 1.346 ± 0.016	1.51ValAsn: 1.51 ± 0.021	4.644ValPro: 4.644 ± 0.043	1.972ValGln: 1.972 ± 0.024	6.31ValArg: 6.31 ± 0.05	4.171ValSer: 4.171 ± 0.036	4.408ValThr: 4.408 ± 0.043	7.109ValVal: 7.109 ± 0.051	0.967ValTrp: 0.967 ± 0.019	1.563ValTyr: 1.563 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.26TrpAla: 1.26 ± 0.02	0.125TrpCys: 0.125 ± 0.005	0.699TrpAsp: 0.699 ± 0.016	0.678TrpGlu: 0.678 ± 0.013	0.466TrpPhe: 0.466 ± 0.013	0.959TrpGly: 0.959 ± 0.02	0.274TrpHis: 0.274 ± 0.009	0.641TrpIle: 0.641 ± 0.015	0.462TrpLys: 0.462 ± 0.012	1.447TrpLeu: 1.447 ± 0.02	0.302TrpMet: 0.302 ± 0.009	0.389TrpAsn: 0.389 ± 0.011	0.639TrpPro: 0.639 ± 0.014	0.412TrpGln: 0.412 ± 0.011	0.888TrpArg: 0.888 ± 0.016	0.855TrpSer: 0.855 ± 0.018	0.765TrpThr: 0.765 ± 0.018	0.869TrpVal: 0.869 ± 0.015	0.158TrpTrp: 0.158 ± 0.007	0.263TrpTyr: 0.263 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.331TyrAla: 2.331 ± 0.027	0.248TyrCys: 0.248 ± 0.009	1.409TyrAsp: 1.409 ± 0.027	1.412TyrGlu: 1.412 ± 0.023	0.773TyrPhe: 0.773 ± 0.016	1.777TyrGly: 1.777 ± 0.022	0.448TyrHis: 0.448 ± 0.012	0.579TyrIle: 0.579 ± 0.012	0.547TyrLys: 0.547 ± 0.012	1.887TyrLeu: 1.887 ± 0.024	0.352TyrMet: 0.352 ± 0.009	0.484TyrAsn: 0.484 ± 0.012	1.013TyrPro: 1.013 ± 0.018	0.598TyrGln: 0.598 ± 0.013	1.785TyrArg: 1.785 ± 0.023	0.81TyrSer: 0.81 ± 0.017	1.054TyrThr: 1.054 ± 0.018	1.697TyrVal: 1.697 ± 0.02	0.293TyrTrp: 0.293 ± 0.01	0.493TyrTyr: 0.493 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9827 proteins (3775618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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