Amino acid dipepetide frequency for Streptomyces asterosporus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.738AlaAla: 21.738 ± 0.181	1.09AlaCys: 1.09 ± 0.025	8.888AlaAsp: 8.888 ± 0.079	8.972AlaGlu: 8.972 ± 0.099	3.448AlaPhe: 3.448 ± 0.047	13.411AlaGly: 13.411 ± 0.1	3.038AlaHis: 3.038 ± 0.047	2.924AlaIle: 2.924 ± 0.041	2.543AlaLys: 2.543 ± 0.048	14.684AlaLeu: 14.684 ± 0.132	2.362AlaMet: 2.362 ± 0.034	1.784AlaAsn: 1.784 ± 0.033	7.457AlaPro: 7.457 ± 0.092	3.651AlaGln: 3.651 ± 0.04	10.962AlaArg: 10.962 ± 0.094	5.626AlaSer: 5.626 ± 0.055	6.856AlaThr: 6.856 ± 0.07	12.844AlaVal: 12.844 ± 0.116	1.837AlaTrp: 1.837 ± 0.031	2.734AlaTyr: 2.734 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.101CysAla: 1.101 ± 0.024	0.09CysCys: 0.09 ± 0.007	0.479CysAsp: 0.479 ± 0.017	0.385CysGlu: 0.385 ± 0.015	0.214CysPhe: 0.214 ± 0.01	0.927CysGly: 0.927 ± 0.025	0.19CysHis: 0.19 ± 0.01	0.141CysIle: 0.141 ± 0.008	0.106CysLys: 0.106 ± 0.008	0.729CysLeu: 0.729 ± 0.023	0.11CysMet: 0.11 ± 0.008	0.134CysAsn: 0.134 ± 0.007	0.443CysPro: 0.443 ± 0.013	0.143CysGln: 0.143 ± 0.009	0.625CysArg: 0.625 ± 0.018	0.428CysSer: 0.428 ± 0.016	0.509CysThr: 0.509 ± 0.017	0.645CysVal: 0.645 ± 0.018	0.123CysTrp: 0.123 ± 0.008	0.15CysTyr: 0.15 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.246AspAla: 8.246 ± 0.083	0.437AspCys: 0.437 ± 0.017	3.976AspAsp: 3.976 ± 0.055	3.971AspGlu: 3.971 ± 0.044	1.676AspPhe: 1.676 ± 0.031	7.084AspGly: 7.084 ± 0.077	1.465AspHis: 1.465 ± 0.024	1.841AspIle: 1.841 ± 0.036	1.113AspLys: 1.113 ± 0.028	6.39AspLeu: 6.39 ± 0.055	0.826AspMet: 0.826 ± 0.022	0.976AspAsn: 0.976 ± 0.024	4.758AspPro: 4.758 ± 0.058	1.36AspGln: 1.36 ± 0.028	5.381AspArg: 5.381 ± 0.06	2.511AspSer: 2.511 ± 0.037	3.581AspThr: 3.581 ± 0.048	4.903AspVal: 4.903 ± 0.05	1.069AspTrp: 1.069 ± 0.021	1.088AspTyr: 1.088 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.468GluAla: 7.468 ± 0.084	0.365GluCys: 0.365 ± 0.012	3.041GluAsp: 3.041 ± 0.037	3.784GluGlu: 3.784 ± 0.055	1.474GluPhe: 1.474 ± 0.03	4.282GluGly: 4.282 ± 0.049	1.55GluHis: 1.55 ± 0.03	2.167GluIle: 2.167 ± 0.041	1.434GluLys: 1.434 ± 0.032	6.754GluLeu: 6.754 ± 0.075	0.864GluMet: 0.864 ± 0.024	1.039GluAsn: 1.039 ± 0.022	3.641GluPro: 3.641 ± 0.058	2.307GluGln: 2.307 ± 0.037	5.842GluArg: 5.842 ± 0.057	2.517GluSer: 2.517 ± 0.038	2.923GluThr: 2.923 ± 0.037	4.547GluVal: 4.547 ± 0.051	0.747GluTrp: 0.747 ± 0.018	1.092GluTyr: 1.092 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.641PheAla: 3.641 ± 0.042	0.254PheCys: 0.254 ± 0.013	1.97PheAsp: 1.97 ± 0.032	1.414PheGlu: 1.414 ± 0.025	0.846PhePhe: 0.846 ± 0.019	2.939PheGly: 2.939 ± 0.039	0.606PheHis: 0.606 ± 0.018	0.598PheIle: 0.598 ± 0.017	0.453PheLys: 0.453 ± 0.017	2.557PheLeu: 2.557 ± 0.039	0.403PheMet: 0.403 ± 0.014	0.537PheAsn: 0.537 ± 0.016	1.351PhePro: 1.351 ± 0.026	0.645PheGln: 0.645 ± 0.017	1.933PheArg: 1.933 ± 0.031	1.379PheSer: 1.379 ± 0.026	1.999PheThr: 1.999 ± 0.032	2.291PheVal: 2.291 ± 0.036	0.414PheTrp: 0.414 ± 0.015	0.547PheTyr: 0.547 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.102GlyAla: 11.102 ± 0.088	0.798GlyCys: 0.798 ± 0.021	5.502GlyAsp: 5.502 ± 0.059	5.217GlyGlu: 5.217 ± 0.048	2.818GlyPhe: 2.818 ± 0.039	8.914GlyGly: 8.914 ± 0.089	2.397GlyHis: 2.397 ± 0.036	3.31GlyIle: 3.31 ± 0.044	2.133GlyLys: 2.133 ± 0.042	9.292GlyLeu: 9.292 ± 0.081	1.915GlyMet: 1.915 ± 0.032	1.704GlyAsn: 1.704 ± 0.027	5.554GlyPro: 5.554 ± 0.065	2.539GlyGln: 2.539 ± 0.04	8.473GlyArg: 8.473 ± 0.071	5.231GlySer: 5.231 ± 0.055	6.882GlyThr: 6.882 ± 0.075	7.538GlyVal: 7.538 ± 0.079	1.65GlyTrp: 1.65 ± 0.03	2.157GlyTyr: 2.157 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.823HisAla: 2.823 ± 0.041	0.202HisCys: 0.202 ± 0.011	1.429HisAsp: 1.429 ± 0.029	1.212HisGlu: 1.212 ± 0.028	0.655HisPhe: 0.655 ± 0.019	2.484HisGly: 2.484 ± 0.036	0.69HisHis: 0.69 ± 0.02	0.635HisIle: 0.635 ± 0.017	0.325HisLys: 0.325 ± 0.013	2.455HisLeu: 2.455 ± 0.04	0.329HisMet: 0.329 ± 0.014	0.362HisAsn: 0.362 ± 0.014	1.868HisPro: 1.868 ± 0.034	0.582HisGln: 0.582 ± 0.015	2.267HisArg: 2.267 ± 0.039	1.006HisSer: 1.006 ± 0.025	1.419HisThr: 1.419 ± 0.026	1.767HisVal: 1.767 ± 0.03	0.381HisTrp: 0.381 ± 0.016	0.459HisTyr: 0.459 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.311IleAla: 4.311 ± 0.053	0.261IleCys: 0.261 ± 0.01	2.088IleAsp: 2.088 ± 0.036	1.829IleGlu: 1.829 ± 0.034	0.635IlePhe: 0.635 ± 0.02	3.311IleGly: 3.311 ± 0.045	0.564IleHis: 0.564 ± 0.017	0.718IleIle: 0.718 ± 0.02	0.658IleLys: 0.658 ± 0.019	2.174IleLeu: 2.174 ± 0.033	0.418IleMet: 0.418 ± 0.014	0.612IleAsn: 0.612 ± 0.018	1.578IlePro: 1.578 ± 0.03	0.603IleGln: 0.603 ± 0.019	2.118IleArg: 2.118 ± 0.032	1.467IleSer: 1.467 ± 0.03	2.043IleThr: 2.043 ± 0.033	2.59IleVal: 2.59 ± 0.035	0.33IleTrp: 0.33 ± 0.013	0.45IleTyr: 0.45 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.651LysAla: 2.651 ± 0.057	0.098LysCys: 0.098 ± 0.007	1.321LysAsp: 1.321 ± 0.028	1.181LysGlu: 1.181 ± 0.03	0.404LysPhe: 0.404 ± 0.015	1.711LysGly: 1.711 ± 0.034	0.386LysHis: 0.386 ± 0.014	0.739LysIle: 0.739 ± 0.021	0.832LysLys: 0.832 ± 0.029	1.828LysLeu: 1.828 ± 0.032	0.349LysMet: 0.349 ± 0.012	0.487LysAsn: 0.487 ± 0.018	1.195LysPro: 1.195 ± 0.028	0.645LysGln: 0.645 ± 0.02	1.354LysArg: 1.354 ± 0.031	1.034LysSer: 1.034 ± 0.026	1.148LysThr: 1.148 ± 0.031	1.774LysVal: 1.774 ± 0.04	0.238LysTrp: 0.238 ± 0.01	0.419LysTyr: 0.419 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.999LeuAla: 14.999 ± 0.138	0.828LeuCys: 0.828 ± 0.021	6.888LeuAsp: 6.888 ± 0.061	4.852LeuGlu: 4.852 ± 0.054	2.576LeuPhe: 2.576 ± 0.041	9.069LeuGly: 9.069 ± 0.071	2.343LeuHis: 2.343 ± 0.038	2.939LeuIle: 2.939 ± 0.047	1.932LeuLys: 1.932 ± 0.039	11.37LeuLeu: 11.37 ± 0.124	1.577LeuMet: 1.577 ± 0.03	1.624LeuAsn: 1.624 ± 0.029	6.626LeuPro: 6.626 ± 0.061	2.026LeuGln: 2.026 ± 0.033	8.937LeuArg: 8.937 ± 0.072	5.022LeuSer: 5.022 ± 0.046	7.002LeuThr: 7.002 ± 0.071	8.94LeuVal: 8.94 ± 0.079	1.315LeuTrp: 1.315 ± 0.029	1.834LeuTyr: 1.834 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.143MetAla: 2.143 ± 0.035	0.126MetCys: 0.126 ± 0.007	0.877MetAsp: 0.877 ± 0.018	0.734MetGlu: 0.734 ± 0.022	0.439MetPhe: 0.439 ± 0.014	1.26MetGly: 1.26 ± 0.027	0.344MetHis: 0.344 ± 0.014	0.613MetIle: 0.613 ± 0.017	0.396MetLys: 0.396 ± 0.015	1.562MetLeu: 1.562 ± 0.032	0.265MetMet: 0.265 ± 0.012	0.405MetAsn: 0.405 ± 0.015	1.053MetPro: 1.053 ± 0.022	0.427MetGln: 0.427 ± 0.014	1.37MetArg: 1.37 ± 0.023	1.263MetSer: 1.263 ± 0.022	1.511MetThr: 1.511 ± 0.029	1.235MetVal: 1.235 ± 0.025	0.216MetTrp: 0.216 ± 0.01	0.319MetTyr: 0.319 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.126AsnAla: 2.126 ± 0.034	0.157AsnCys: 0.157 ± 0.009	0.931AsnAsp: 0.931 ± 0.021	0.815AsnGlu: 0.815 ± 0.022	0.473AsnPhe: 0.473 ± 0.015	1.921AsnGly: 1.921 ± 0.04	0.376AsnHis: 0.376 ± 0.014	0.6AsnIle: 0.6 ± 0.016	0.374AsnLys: 0.374 ± 0.016	1.565AsnLeu: 1.565 ± 0.03	0.277AsnMet: 0.277 ± 0.011	0.424AsnAsn: 0.424 ± 0.017	1.277AsnPro: 1.277 ± 0.025	0.493AsnGln: 0.493 ± 0.017	1.255AsnArg: 1.255 ± 0.025	0.89AsnSer: 0.89 ± 0.023	1.062AsnThr: 1.062 ± 0.023	1.351AsnVal: 1.351 ± 0.026	0.284AsnTrp: 0.284 ± 0.013	0.397AsnTyr: 0.397 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.369ProAla: 9.369 ± 0.111	0.336ProCys: 0.336 ± 0.012	4.951ProAsp: 4.951 ± 0.061	4.5ProGlu: 4.5 ± 0.059	1.515ProPhe: 1.515 ± 0.027	6.838ProGly: 6.838 ± 0.068	1.47ProHis: 1.47 ± 0.03	1.104ProIle: 1.104 ± 0.023	1.069ProLys: 1.069 ± 0.025	5.405ProLeu: 5.405 ± 0.051	0.959ProMet: 0.959 ± 0.022	0.842ProAsn: 0.842 ± 0.019	3.812ProPro: 3.812 ± 0.07	1.69ProGln: 1.69 ± 0.032	4.159ProArg: 4.159 ± 0.053	3.16ProSer: 3.16 ± 0.048	3.131ProThr: 3.131 ± 0.05	5.775ProVal: 5.775 ± 0.068	0.885ProTrp: 0.885 ± 0.022	1.437ProTyr: 1.437 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.523GlnAla: 3.523 ± 0.043	0.157GlnCys: 0.157 ± 0.007	1.471GlnAsp: 1.471 ± 0.028	1.488GlnGlu: 1.488 ± 0.028	0.615GlnPhe: 0.615 ± 0.016	2.231GlnGly: 2.231 ± 0.036	0.604GlnHis: 0.604 ± 0.016	0.945GlnIle: 0.945 ± 0.02	0.58GlnLys: 0.58 ± 0.017	2.827GlnLeu: 2.827 ± 0.037	0.441GlnMet: 0.441 ± 0.015	0.494GlnAsn: 0.494 ± 0.018	1.622GlnPro: 1.622 ± 0.037	1.209GlnGln: 1.209 ± 0.03	2.287GlnArg: 2.287 ± 0.034	1.167GlnSer: 1.167 ± 0.025	1.23GlnThr: 1.23 ± 0.026	2.281GlnVal: 2.281 ± 0.034	0.46GlnTrp: 0.46 ± 0.015	0.609GlnTyr: 0.609 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.496ArgAla: 10.496 ± 0.091	0.589ArgCys: 0.589 ± 0.016	4.632ArgAsp: 4.632 ± 0.056	4.96ArgGlu: 4.96 ± 0.058	2.4ArgPhe: 2.4 ± 0.032	6.015ArgGly: 6.015 ± 0.057	2.269ArgHis: 2.269 ± 0.036	3.258ArgIle: 3.258 ± 0.045	1.562ArgLys: 1.562 ± 0.031	9.367ArgLeu: 9.367 ± 0.081	1.721ArgMet: 1.721 ± 0.031	1.4ArgAsn: 1.4 ± 0.026	5.502ArgPro: 5.502 ± 0.058	2.312ArgGln: 2.312 ± 0.032	8.353ArgArg: 8.353 ± 0.084	4.033ArgSer: 4.033 ± 0.044	5.906ArgThr: 5.906 ± 0.053	6.112ArgVal: 6.112 ± 0.061	1.364ArgTrp: 1.364 ± 0.027	1.782ArgTyr: 1.782 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.552SerAla: 6.552 ± 0.058	0.384SerCys: 0.384 ± 0.014	2.663SerAsp: 2.663 ± 0.042	2.37SerGlu: 2.37 ± 0.038	1.423SerPhe: 1.423 ± 0.029	5.877SerGly: 5.877 ± 0.064	0.98SerHis: 0.98 ± 0.023	1.231SerIle: 1.231 ± 0.026	0.908SerLys: 0.908 ± 0.024	4.592SerLeu: 4.592 ± 0.054	0.96SerMet: 0.96 ± 0.023	0.812SerAsn: 0.812 ± 0.024	3.064SerPro: 3.064 ± 0.039	1.137SerGln: 1.137 ± 0.021	3.673SerArg: 3.673 ± 0.045	2.652SerSer: 2.652 ± 0.043	2.954SerThr: 2.954 ± 0.041	4.24SerVal: 4.24 ± 0.046	0.812SerTrp: 0.812 ± 0.02	1.153SerTyr: 1.153 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.389ThrAla: 9.389 ± 0.085	0.406ThrCys: 0.406 ± 0.014	3.896ThrAsp: 3.896 ± 0.047	3.321ThrGlu: 3.321 ± 0.04	1.583ThrPhe: 1.583 ± 0.031	7.155ThrGly: 7.155 ± 0.077	1.239ThrHis: 1.239 ± 0.024	1.452ThrIle: 1.452 ± 0.029	1.023ThrLys: 1.023 ± 0.028	5.694ThrLeu: 5.694 ± 0.054	0.873ThrMet: 0.873 ± 0.017	0.957ThrAsn: 0.957 ± 0.02	4.207ThrPro: 4.207 ± 0.063	1.257ThrGln: 1.257 ± 0.026	4.098ThrArg: 4.098 ± 0.046	3.021ThrSer: 3.021 ± 0.045	3.932ThrThr: 3.932 ± 0.059	6.447ThrVal: 6.447 ± 0.061	0.904ThrTrp: 0.904 ± 0.022	1.399ThrTyr: 1.399 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	10.784ValAla: 10.784 ± 0.106	0.78ValCys: 0.78 ± 0.021	5.216ValAsp: 5.216 ± 0.048	4.849ValGlu: 4.849 ± 0.053	2.461ValPhe: 2.461 ± 0.034	6.357ValGly: 6.357 ± 0.057	2.091ValHis: 2.091 ± 0.032	2.587ValIle: 2.587 ± 0.039	1.656ValLys: 1.656 ± 0.034	9.76ValLeu: 9.76 ± 0.097	1.376ValMet: 1.376 ± 0.027	1.629ValAsn: 1.629 ± 0.029	5.62ValPro: 5.62 ± 0.059	2.041ValGln: 2.041 ± 0.034	7.745ValArg: 7.745 ± 0.059	4.186ValSer: 4.186 ± 0.043	5.95ValThr: 5.95 ± 0.053	8.312ValVal: 8.312 ± 0.08	1.197ValTrp: 1.197 ± 0.022	1.59ValTyr: 1.59 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.617TrpAla: 1.617 ± 0.028	0.143TrpCys: 0.143 ± 0.009	0.857TrpAsp: 0.857 ± 0.022	0.74TrpGlu: 0.74 ± 0.019	0.493TrpPhe: 0.493 ± 0.016	1.039TrpGly: 1.039 ± 0.025	0.354TrpHis: 0.354 ± 0.014	0.517TrpIle: 0.517 ± 0.015	0.342TrpLys: 0.342 ± 0.014	1.715TrpLeu: 1.715 ± 0.032	0.286TrpMet: 0.286 ± 0.013	0.423TrpAsn: 0.423 ± 0.014	0.777TrpPro: 0.777 ± 0.02	0.626TrpGln: 0.626 ± 0.015	1.355TrpArg: 1.355 ± 0.027	0.92TrpSer: 0.92 ± 0.023	1.055TrpThr: 1.055 ± 0.023	0.95TrpVal: 0.95 ± 0.023	0.319TrpTrp: 0.319 ± 0.013	0.361TrpTyr: 0.361 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.772TyrAla: 2.772 ± 0.036	0.172TyrCys: 0.172 ± 0.008	1.576TyrAsp: 1.576 ± 0.041	1.242TyrGlu: 1.242 ± 0.028	0.631TyrPhe: 0.631 ± 0.017	2.302TyrGly: 2.302 ± 0.038	0.396TyrHis: 0.396 ± 0.014	0.44TyrIle: 0.44 ± 0.014	0.354TyrLys: 0.354 ± 0.014	1.977TyrLeu: 1.977 ± 0.029	0.245TyrMet: 0.245 ± 0.011	0.4TyrAsn: 0.4 ± 0.016	1.005TyrPro: 1.005 ± 0.021	0.548TyrGln: 0.548 ± 0.018	1.848TyrArg: 1.848 ± 0.033	0.923TyrSer: 0.923 ± 0.022	1.16TyrThr: 1.16 ± 0.028	1.644TyrVal: 1.644 ± 0.029	0.345TyrTrp: 0.345 ± 0.013	0.453TyrTyr: 0.453 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6358 proteins (2202986 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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