Amino acid dipepetide frequency for Corynebacterium phage phi674

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.604AlaAla: 10.604 ± 1.437
0.221AlaCys: 0.221 ± 0.125
4.934AlaAsp: 4.934 ± 0.722
5.376AlaGlu: 5.376 ± 0.705
2.283AlaPhe: 2.283 ± 0.268
9.794AlaGly: 9.794 ± 1.086
2.135AlaHis: 2.135 ± 0.511
4.566AlaIle: 4.566 ± 0.548
4.05AlaLys: 4.05 ± 0.714
8.247AlaLeu: 8.247 ± 1.011
2.798AlaMet: 2.798 ± 0.423
3.166AlaAsn: 3.166 ± 0.531
5.228AlaPro: 5.228 ± 1.124
4.566AlaGln: 4.566 ± 0.587
5.302AlaArg: 5.302 ± 0.679
6.186AlaSer: 6.186 ± 0.593
7.29AlaThr: 7.29 ± 0.82
7.216AlaVal: 7.216 ± 0.727
2.062AlaTrp: 2.062 ± 0.536
2.798AlaTyr: 2.798 ± 0.463
0.0AlaXaa: 0.0 ± 0.0
Cys
0.515CysAla: 0.515 ± 0.239
0.074CysCys: 0.074 ± 0.082
0.589CysAsp: 0.589 ± 0.21
0.295CysGlu: 0.295 ± 0.15
0.147CysPhe: 0.147 ± 0.101
0.368CysGly: 0.368 ± 0.165
0.074CysHis: 0.074 ± 0.089
0.295CysIle: 0.295 ± 0.158
0.295CysLys: 0.295 ± 0.174
0.295CysLeu: 0.295 ± 0.155
0.147CysMet: 0.147 ± 0.103
0.147CysAsn: 0.147 ± 0.097
0.0CysPro: 0.0 ± 0.0
0.221CysGln: 0.221 ± 0.127
0.442CysArg: 0.442 ± 0.218
0.442CysSer: 0.442 ± 0.178
0.663CysThr: 0.663 ± 0.255
0.663CysVal: 0.663 ± 0.261
0.295CysTrp: 0.295 ± 0.155
0.295CysTyr: 0.295 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
7.29AspAla: 7.29 ± 0.735
0.442AspCys: 0.442 ± 0.166
4.05AspAsp: 4.05 ± 0.537
3.461AspGlu: 3.461 ± 0.503
2.504AspPhe: 2.504 ± 0.324
5.965AspGly: 5.965 ± 0.705
1.178AspHis: 1.178 ± 0.327
3.387AspIle: 3.387 ± 0.562
4.05AspLys: 4.05 ± 0.556
6.701AspLeu: 6.701 ± 0.812
3.019AspMet: 3.019 ± 0.47
2.798AspAsn: 2.798 ± 0.471
3.608AspPro: 3.608 ± 0.503
2.062AspGln: 2.062 ± 0.363
2.356AspArg: 2.356 ± 0.474
3.535AspSer: 3.535 ± 0.686
4.124AspThr: 4.124 ± 0.496
4.345AspVal: 4.345 ± 0.588
1.178AspTrp: 1.178 ± 0.306
1.399AspTyr: 1.399 ± 0.262
0.0AspXaa: 0.0 ± 0.0
Glu
5.965GluAla: 5.965 ± 0.588
0.515GluCys: 0.515 ± 0.203
3.903GluAsp: 3.903 ± 0.667
3.24GluGlu: 3.24 ± 0.558
1.915GluPhe: 1.915 ± 0.341
3.608GluGly: 3.608 ± 0.719
2.283GluHis: 2.283 ± 0.372
2.651GluIle: 2.651 ± 0.416
1.841GluLys: 1.841 ± 0.372
5.449GluLeu: 5.449 ± 0.611
1.546GluMet: 1.546 ± 0.42
2.504GluAsn: 2.504 ± 0.425
1.767GluPro: 1.767 ± 0.392
2.946GluGln: 2.946 ± 0.512
4.639GluArg: 4.639 ± 0.689
3.903GluSer: 3.903 ± 0.614
3.387GluThr: 3.387 ± 0.381
3.461GluVal: 3.461 ± 0.384
1.473GluTrp: 1.473 ± 0.292
1.62GluTyr: 1.62 ± 0.4
0.0GluXaa: 0.0 ± 0.0
Phe
2.504PheAla: 2.504 ± 0.414
0.074PheCys: 0.074 ± 0.063
2.283PheAsp: 2.283 ± 0.419
1.399PheGlu: 1.399 ± 0.391
0.663PhePhe: 0.663 ± 0.184
1.694PheGly: 1.694 ± 0.285
0.442PheHis: 0.442 ± 0.183
1.325PheIle: 1.325 ± 0.468
1.031PheLys: 1.031 ± 0.333
2.209PheLeu: 2.209 ± 0.391
0.884PheMet: 0.884 ± 0.212
1.252PheAsn: 1.252 ± 0.316
1.399PhePro: 1.399 ± 0.306
1.399PheGln: 1.399 ± 0.336
1.252PheArg: 1.252 ± 0.4
1.325PheSer: 1.325 ± 0.284
2.356PheThr: 2.356 ± 0.559
1.473PheVal: 1.473 ± 0.352
0.442PheTrp: 0.442 ± 0.216
0.442PheTyr: 0.442 ± 0.15
0.0PheXaa: 0.0 ± 0.0
Gly
7.069GlyAla: 7.069 ± 0.736
0.442GlyCys: 0.442 ± 0.235
5.744GlyAsp: 5.744 ± 0.731
4.345GlyGlu: 4.345 ± 0.441
2.946GlyPhe: 2.946 ± 0.522
8.689GlyGly: 8.689 ± 1.506
1.915GlyHis: 1.915 ± 0.417
5.155GlyIle: 5.155 ± 0.811
4.345GlyLys: 4.345 ± 0.499
6.848GlyLeu: 6.848 ± 0.962
2.356GlyMet: 2.356 ± 0.483
3.387GlyAsn: 3.387 ± 0.74
1.694GlyPro: 1.694 ± 0.31
2.283GlyGln: 2.283 ± 0.42
4.05GlyArg: 4.05 ± 0.589
5.081GlySer: 5.081 ± 0.643
6.038GlyThr: 6.038 ± 0.579
5.228GlyVal: 5.228 ± 0.706
2.135GlyTrp: 2.135 ± 0.42
2.798GlyTyr: 2.798 ± 0.459
0.0GlyXaa: 0.0 ± 0.0
His
2.283HisAla: 2.283 ± 0.4
0.221HisCys: 0.221 ± 0.137
1.325HisAsp: 1.325 ± 0.434
0.957HisGlu: 0.957 ± 0.362
0.515HisPhe: 0.515 ± 0.161
1.694HisGly: 1.694 ± 0.422
0.589HisHis: 0.589 ± 0.225
1.915HisIle: 1.915 ± 0.525
0.589HisLys: 0.589 ± 0.188
1.988HisLeu: 1.988 ± 0.45
0.663HisMet: 0.663 ± 0.236
0.736HisAsn: 0.736 ± 0.269
1.767HisPro: 1.767 ± 0.348
0.589HisGln: 0.589 ± 0.22
1.62HisArg: 1.62 ± 0.432
0.81HisSer: 0.81 ± 0.292
2.062HisThr: 2.062 ± 0.487
1.546HisVal: 1.546 ± 0.313
0.736HisTrp: 0.736 ± 0.288
0.663HisTyr: 0.663 ± 0.221
0.0HisXaa: 0.0 ± 0.0
Ile
4.271IleAla: 4.271 ± 0.572
0.368IleCys: 0.368 ± 0.193
4.05IleAsp: 4.05 ± 0.534
3.093IleGlu: 3.093 ± 0.634
1.105IlePhe: 1.105 ± 0.329
3.24IleGly: 3.24 ± 0.654
1.473IleHis: 1.473 ± 0.263
2.062IleIle: 2.062 ± 0.421
2.356IleLys: 2.356 ± 0.516
2.577IleLeu: 2.577 ± 0.404
0.957IleMet: 0.957 ± 0.288
2.135IleAsn: 2.135 ± 0.357
3.093IlePro: 3.093 ± 0.841
2.356IleGln: 2.356 ± 0.457
2.43IleArg: 2.43 ± 0.468
3.756IleSer: 3.756 ± 0.589
4.934IleThr: 4.934 ± 0.658
2.356IleVal: 2.356 ± 0.315
0.736IleTrp: 0.736 ± 0.179
0.884IleTyr: 0.884 ± 0.239
0.0IleXaa: 0.0 ± 0.0
Lys
4.124LysAla: 4.124 ± 0.789
0.295LysCys: 0.295 ± 0.143
2.577LysAsp: 2.577 ± 0.447
2.062LysGlu: 2.062 ± 0.357
0.957LysPhe: 0.957 ± 0.278
2.283LysGly: 2.283 ± 0.471
0.884LysHis: 0.884 ± 0.295
1.767LysIle: 1.767 ± 0.432
1.694LysLys: 1.694 ± 0.338
3.608LysLeu: 3.608 ± 0.536
1.473LysMet: 1.473 ± 0.424
1.399LysAsn: 1.399 ± 0.362
2.062LysPro: 2.062 ± 0.367
1.399LysGln: 1.399 ± 0.309
1.988LysArg: 1.988 ± 0.352
3.756LysSer: 3.756 ± 0.488
3.166LysThr: 3.166 ± 0.56
2.43LysVal: 2.43 ± 0.542
1.105LysTrp: 1.105 ± 0.339
2.209LysTyr: 2.209 ± 0.466
0.0LysXaa: 0.0 ± 0.0
Leu
8.542LeuAla: 8.542 ± 0.62
0.663LeuCys: 0.663 ± 0.278
6.627LeuAsp: 6.627 ± 0.717
4.639LeuGlu: 4.639 ± 0.43
1.988LeuPhe: 1.988 ± 0.413
7.364LeuGly: 7.364 ± 0.88
1.694LeuHis: 1.694 ± 0.374
3.166LeuIle: 3.166 ± 0.499
2.798LeuLys: 2.798 ± 0.345
5.523LeuLeu: 5.523 ± 0.746
2.062LeuMet: 2.062 ± 0.418
2.209LeuAsn: 2.209 ± 0.463
4.639LeuPro: 4.639 ± 0.564
3.314LeuGln: 3.314 ± 0.458
5.081LeuArg: 5.081 ± 0.659
5.891LeuSer: 5.891 ± 0.658
5.376LeuThr: 5.376 ± 0.504
5.744LeuVal: 5.744 ± 0.642
1.767LeuTrp: 1.767 ± 0.371
2.062LeuTyr: 2.062 ± 0.505
0.0LeuXaa: 0.0 ± 0.0
Met
3.093MetAla: 3.093 ± 0.472
0.368MetCys: 0.368 ± 0.161
2.062MetAsp: 2.062 ± 0.471
1.546MetGlu: 1.546 ± 0.348
0.515MetPhe: 0.515 ± 0.193
1.767MetGly: 1.767 ± 0.284
0.736MetHis: 0.736 ± 0.247
1.031MetIle: 1.031 ± 0.315
1.178MetLys: 1.178 ± 0.299
1.546MetLeu: 1.546 ± 0.361
0.884MetMet: 0.884 ± 0.22
0.957MetAsn: 0.957 ± 0.278
1.252MetPro: 1.252 ± 0.285
1.399MetGln: 1.399 ± 0.433
1.473MetArg: 1.473 ± 0.222
2.209MetSer: 2.209 ± 0.355
2.725MetThr: 2.725 ± 0.51
2.798MetVal: 2.798 ± 0.438
0.368MetTrp: 0.368 ± 0.138
0.515MetTyr: 0.515 ± 0.192
0.0MetXaa: 0.0 ± 0.0
Asn
3.166AsnAla: 3.166 ± 0.447
0.295AsnCys: 0.295 ± 0.194
1.252AsnAsp: 1.252 ± 0.286
2.062AsnGlu: 2.062 ± 0.36
0.81AsnPhe: 0.81 ± 0.223
2.872AsnGly: 2.872 ± 0.462
0.663AsnHis: 0.663 ± 0.265
1.988AsnIle: 1.988 ± 0.422
1.62AsnLys: 1.62 ± 0.351
3.24AsnLeu: 3.24 ± 0.578
0.736AsnMet: 0.736 ± 0.247
1.62AsnAsn: 1.62 ± 0.479
3.24AsnPro: 3.24 ± 0.43
1.694AsnGln: 1.694 ± 0.287
2.356AsnArg: 2.356 ± 0.361
1.841AsnSer: 1.841 ± 0.346
2.062AsnThr: 2.062 ± 0.433
2.504AsnVal: 2.504 ± 0.697
0.736AsnTrp: 0.736 ± 0.28
1.325AsnTyr: 1.325 ± 0.286
0.0AsnXaa: 0.0 ± 0.0
Pro
5.744ProAla: 5.744 ± 1.031
0.074ProCys: 0.074 ± 0.061
3.387ProAsp: 3.387 ± 0.671
5.744ProGlu: 5.744 ± 0.648
1.031ProPhe: 1.031 ± 0.242
4.639ProGly: 4.639 ± 0.716
1.473ProHis: 1.473 ± 0.295
2.504ProIle: 2.504 ± 0.365
2.798ProLys: 2.798 ± 0.516
3.019ProLeu: 3.019 ± 0.396
0.884ProMet: 0.884 ± 0.201
1.031ProAsn: 1.031 ± 0.313
2.577ProPro: 2.577 ± 0.5
1.915ProGln: 1.915 ± 0.537
1.988ProArg: 1.988 ± 0.467
3.608ProSer: 3.608 ± 0.701
2.356ProThr: 2.356 ± 0.413
3.756ProVal: 3.756 ± 0.487
1.178ProTrp: 1.178 ± 0.342
1.841ProTyr: 1.841 ± 0.375
0.0ProXaa: 0.0 ± 0.0
Gln
5.376GlnAla: 5.376 ± 0.835
0.295GlnCys: 0.295 ± 0.131
2.062GlnAsp: 2.062 ± 0.293
1.841GlnGlu: 1.841 ± 0.331
1.031GlnPhe: 1.031 ± 0.207
2.651GlnGly: 2.651 ± 0.511
0.884GlnHis: 0.884 ± 0.278
1.546GlnIle: 1.546 ± 0.305
0.81GlnLys: 0.81 ± 0.306
3.535GlnLeu: 3.535 ± 0.456
1.178GlnMet: 1.178 ± 0.245
1.105GlnAsn: 1.105 ± 0.393
2.135GlnPro: 2.135 ± 0.49
1.178GlnGln: 1.178 ± 0.359
2.725GlnArg: 2.725 ± 0.39
2.135GlnSer: 2.135 ± 0.386
2.135GlnThr: 2.135 ± 0.406
3.166GlnVal: 3.166 ± 0.464
1.325GlnTrp: 1.325 ± 0.392
1.031GlnTyr: 1.031 ± 0.297
0.0GlnXaa: 0.0 ± 0.0
Arg
5.744ArgAla: 5.744 ± 0.446
0.295ArgCys: 0.295 ± 0.186
4.124ArgAsp: 4.124 ± 0.552
3.608ArgGlu: 3.608 ± 0.578
1.178ArgPhe: 1.178 ± 0.262
4.197ArgGly: 4.197 ± 0.551
1.031ArgHis: 1.031 ± 0.313
2.062ArgIle: 2.062 ± 0.267
2.209ArgLys: 2.209 ± 0.496
3.976ArgLeu: 3.976 ± 0.561
1.915ArgMet: 1.915 ± 0.374
1.325ArgAsn: 1.325 ± 0.398
3.166ArgPro: 3.166 ± 0.475
1.473ArgGln: 1.473 ± 0.433
3.24ArgArg: 3.24 ± 0.67
4.05ArgSer: 4.05 ± 0.998
4.197ArgThr: 4.197 ± 0.55
3.903ArgVal: 3.903 ± 0.504
0.295ArgTrp: 0.295 ± 0.149
2.135ArgTyr: 2.135 ± 0.432
0.0ArgXaa: 0.0 ± 0.0
Ser
6.333SerAla: 6.333 ± 0.875
0.368SerCys: 0.368 ± 0.161
4.786SerAsp: 4.786 ± 0.429
3.093SerGlu: 3.093 ± 0.479
1.399SerPhe: 1.399 ± 0.257
6.186SerGly: 6.186 ± 0.732
1.399SerHis: 1.399 ± 0.33
2.577SerIle: 2.577 ± 0.417
2.946SerLys: 2.946 ± 0.546
4.713SerLeu: 4.713 ± 0.848
1.988SerMet: 1.988 ± 0.387
2.283SerAsn: 2.283 ± 0.437
3.756SerPro: 3.756 ± 0.654
1.915SerGln: 1.915 ± 0.401
3.019SerArg: 3.019 ± 0.698
4.05SerSer: 4.05 ± 0.455
4.492SerThr: 4.492 ± 0.758
6.333SerVal: 6.333 ± 0.489
1.031SerTrp: 1.031 ± 0.344
1.252SerTyr: 1.252 ± 0.329
0.0SerXaa: 0.0 ± 0.0
Thr
6.038ThrAla: 6.038 ± 0.524
0.515ThrCys: 0.515 ± 0.165
4.124ThrAsp: 4.124 ± 0.507
3.976ThrGlu: 3.976 ± 0.446
2.283ThrPhe: 2.283 ± 0.488
5.523ThrGly: 5.523 ± 0.794
1.767ThrHis: 1.767 ± 0.385
3.829ThrIle: 3.829 ± 0.603
2.283ThrLys: 2.283 ± 0.425
6.701ThrLeu: 6.701 ± 0.588
2.135ThrMet: 2.135 ± 0.502
2.577ThrAsn: 2.577 ± 0.521
5.228ThrPro: 5.228 ± 0.513
2.283ThrGln: 2.283 ± 0.384
3.608ThrArg: 3.608 ± 0.507
4.05ThrSer: 4.05 ± 0.458
4.934ThrThr: 4.934 ± 0.607
6.48ThrVal: 6.48 ± 0.715
1.399ThrTrp: 1.399 ± 0.29
1.915ThrTyr: 1.915 ± 0.353
0.0ThrXaa: 0.0 ± 0.0
Val
6.112ValAla: 6.112 ± 0.653
0.442ValCys: 0.442 ± 0.188
5.891ValAsp: 5.891 ± 0.658
5.596ValGlu: 5.596 ± 0.669
1.546ValPhe: 1.546 ± 0.456
6.038ValGly: 6.038 ± 0.619
1.546ValHis: 1.546 ± 0.328
3.461ValIle: 3.461 ± 0.64
2.798ValLys: 2.798 ± 0.428
6.259ValLeu: 6.259 ± 0.716
1.546ValMet: 1.546 ± 0.316
3.829ValAsn: 3.829 ± 0.617
3.387ValPro: 3.387 ± 0.445
3.166ValGln: 3.166 ± 0.516
3.019ValArg: 3.019 ± 0.5
3.903ValSer: 3.903 ± 0.537
5.744ValThr: 5.744 ± 0.686
6.627ValVal: 6.627 ± 0.741
1.178ValTrp: 1.178 ± 0.283
1.841ValTyr: 1.841 ± 0.446
0.0ValXaa: 0.0 ± 0.0
Trp
1.399TrpAla: 1.399 ± 0.441
0.0TrpCys: 0.0 ± 0.0
1.915TrpAsp: 1.915 ± 0.984
0.884TrpGlu: 0.884 ± 0.194
0.368TrpPhe: 0.368 ± 0.185
1.105TrpGly: 1.105 ± 0.315
0.442TrpHis: 0.442 ± 0.154
1.473TrpIle: 1.473 ± 0.374
0.736TrpLys: 0.736 ± 0.218
1.399TrpLeu: 1.399 ± 0.291
0.442TrpMet: 0.442 ± 0.174
1.105TrpAsn: 1.105 ± 0.471
0.295TrpPro: 0.295 ± 0.155
0.736TrpGln: 0.736 ± 0.201
1.325TrpArg: 1.325 ± 0.292
1.915TrpSer: 1.915 ± 0.376
1.546TrpThr: 1.546 ± 0.316
1.767TrpVal: 1.767 ± 0.42
0.368TrpTrp: 0.368 ± 0.149
0.81TrpTyr: 0.81 ± 0.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.651TyrAla: 2.651 ± 0.471
0.295TyrCys: 0.295 ± 0.167
1.767TyrAsp: 1.767 ± 0.411
1.473TyrGlu: 1.473 ± 0.253
0.663TyrPhe: 0.663 ± 0.216
2.872TyrGly: 2.872 ± 0.537
0.663TyrHis: 0.663 ± 0.198
1.473TyrIle: 1.473 ± 0.335
0.81TyrLys: 0.81 ± 0.234
3.314TyrLeu: 3.314 ± 0.485
0.736TyrMet: 0.736 ± 0.244
0.515TyrAsn: 0.515 ± 0.181
1.252TyrPro: 1.252 ± 0.386
1.252TyrGln: 1.252 ± 0.239
2.209TyrArg: 2.209 ± 0.521
1.473TyrSer: 1.473 ± 0.289
2.062TyrThr: 2.062 ± 0.398
2.135TyrVal: 2.135 ± 0.526
0.221TyrTrp: 0.221 ± 0.121
0.884TyrTyr: 0.884 ± 0.196
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (13581 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski