Amino acid dipepetide frequency for Desulfofarcimen acetoxidans (strain ATCC 49208 / DSM 771 / KCTC 5769 / VKM B-1644 / 5575) (Desulfotomaculum acetoxidans)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.521AlaAla: 7.521 ± 0.119
1.0AlaCys: 1.0 ± 0.032
3.782AlaAsp: 3.782 ± 0.071
5.192AlaGlu: 5.192 ± 0.077
2.768AlaPhe: 2.768 ± 0.059
6.713AlaGly: 6.713 ± 0.104
1.097AlaHis: 1.097 ± 0.031
5.095AlaIle: 5.095 ± 0.081
4.404AlaLys: 4.404 ± 0.08
7.56AlaLeu: 7.56 ± 0.094
1.997AlaMet: 1.997 ± 0.04
2.803AlaAsn: 2.803 ± 0.053
2.153AlaPro: 2.153 ± 0.139
2.446AlaGln: 2.446 ± 0.049
3.748AlaArg: 3.748 ± 0.061
4.027AlaSer: 4.027 ± 0.072
3.148AlaThr: 3.148 ± 0.09
6.708AlaVal: 6.708 ± 0.114
0.693AlaTrp: 0.693 ± 0.028
2.293AlaTyr: 2.293 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.846CysAla: 0.846 ± 0.03
0.305CysCys: 0.305 ± 0.017
0.583CysAsp: 0.583 ± 0.024
0.667CysGlu: 0.667 ± 0.027
0.535CysPhe: 0.535 ± 0.024
1.256CysGly: 1.256 ± 0.041
0.329CysHis: 0.329 ± 0.015
0.79CysIle: 0.79 ± 0.029
0.679CysLys: 0.679 ± 0.026
1.279CysLeu: 1.279 ± 0.038
0.282CysMet: 0.282 ± 0.015
0.529CysAsn: 0.529 ± 0.022
0.702CysPro: 0.702 ± 0.028
0.429CysGln: 0.429 ± 0.02
0.768CysArg: 0.768 ± 0.026
0.896CysSer: 0.896 ± 0.03
0.579CysThr: 0.579 ± 0.026
0.697CysVal: 0.697 ± 0.023
0.128CysTrp: 0.128 ± 0.011
0.468CysTyr: 0.468 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.317AspAla: 3.317 ± 0.059
0.672AspCys: 0.672 ± 0.025
2.251AspAsp: 2.251 ± 0.049
3.418AspGlu: 3.418 ± 0.059
2.461AspPhe: 2.461 ± 0.048
3.493AspGly: 3.493 ± 0.086
0.755AspHis: 0.755 ± 0.023
4.633AspIle: 4.633 ± 0.065
3.554AspLys: 3.554 ± 0.06
5.185AspLeu: 5.185 ± 0.073
1.44AspMet: 1.44 ± 0.035
2.507AspAsn: 2.507 ± 0.057
1.989AspPro: 1.989 ± 0.052
1.418AspGln: 1.418 ± 0.035
2.593AspArg: 2.593 ± 0.056
2.875AspSer: 2.875 ± 0.06
2.458AspThr: 2.458 ± 0.052
3.214AspVal: 3.214 ± 0.053
0.647AspTrp: 0.647 ± 0.024
2.219AspTyr: 2.219 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.19GluAla: 5.19 ± 0.083
0.65GluCys: 0.65 ± 0.025
3.274GluAsp: 3.274 ± 0.057
5.278GluGlu: 5.278 ± 0.086
2.372GluPhe: 2.372 ± 0.042
3.731GluGly: 3.731 ± 0.058
1.205GluHis: 1.205 ± 0.03
5.715GluIle: 5.715 ± 0.092
5.746GluLys: 5.746 ± 0.083
6.783GluLeu: 6.783 ± 0.097
1.893GluMet: 1.893 ± 0.046
3.466GluAsn: 3.466 ± 0.06
1.93GluPro: 1.93 ± 0.043
3.094GluGln: 3.094 ± 0.058
3.22GluArg: 3.22 ± 0.062
3.023GluSer: 3.023 ± 0.053
3.05GluThr: 3.05 ± 0.051
4.393GluVal: 4.393 ± 0.074
0.614GluTrp: 0.614 ± 0.026
2.358GluTyr: 2.358 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
2.784PheAla: 2.784 ± 0.055
0.602PheCys: 0.602 ± 0.024
2.095PheAsp: 2.095 ± 0.039
2.205PheGlu: 2.205 ± 0.045
1.832PhePhe: 1.832 ± 0.048
2.729PheGly: 2.729 ± 0.049
0.707PheHis: 0.707 ± 0.029
3.134PheIle: 3.134 ± 0.065
2.31PheLys: 2.31 ± 0.051
4.164PheLeu: 4.164 ± 0.078
0.977PheMet: 0.977 ± 0.028
2.069PheAsn: 2.069 ± 0.043
1.489PhePro: 1.489 ± 0.038
1.197PheGln: 1.197 ± 0.033
1.676PheArg: 1.676 ± 0.04
2.977PheSer: 2.977 ± 0.056
2.292PheThr: 2.292 ± 0.05
2.401PheVal: 2.401 ± 0.045
0.454PheTrp: 0.454 ± 0.02
1.532PheTyr: 1.532 ± 0.041
0.0PheXaa: 0.0 ± 0.0
Gly
4.805GlyAla: 4.805 ± 0.123
1.09GlyCys: 1.09 ± 0.031
3.275GlyAsp: 3.275 ± 0.066
4.379GlyGlu: 4.379 ± 0.074
2.926GlyPhe: 2.926 ± 0.053
5.07GlyGly: 5.07 ± 0.129
1.305GlyHis: 1.305 ± 0.03
5.971GlyIle: 5.971 ± 0.084
5.085GlyLys: 5.085 ± 0.068
7.047GlyLeu: 7.047 ± 0.09
2.005GlyMet: 2.005 ± 0.043
3.027GlyAsn: 3.027 ± 0.079
2.052GlyPro: 2.052 ± 0.215
2.666GlyGln: 2.666 ± 0.046
3.417GlyArg: 3.417 ± 0.058
4.215GlySer: 4.215 ± 0.07
4.003GlyThr: 4.003 ± 0.116
4.991GlyVal: 4.991 ± 0.072
0.76GlyTrp: 0.76 ± 0.028
2.879GlyTyr: 2.879 ± 0.051
0.0GlyXaa: 0.0 ± 0.0
His
1.121HisAla: 1.121 ± 0.03
0.283HisCys: 0.283 ± 0.015
0.879HisAsp: 0.879 ± 0.03
0.977HisGlu: 0.977 ± 0.028
0.781HisPhe: 0.781 ± 0.029
1.287HisGly: 1.287 ± 0.035
0.435HisHis: 0.435 ± 0.021
1.287HisIle: 1.287 ± 0.036
1.055HisLys: 1.055 ± 0.036
1.831HisLeu: 1.831 ± 0.041
0.418HisMet: 0.418 ± 0.02
0.859HisAsn: 0.859 ± 0.028
0.874HisPro: 0.874 ± 0.032
0.547HisGln: 0.547 ± 0.02
1.014HisArg: 1.014 ± 0.032
0.982HisSer: 0.982 ± 0.03
0.852HisThr: 0.852 ± 0.028
0.971HisVal: 0.971 ± 0.026
0.21HisTrp: 0.21 ± 0.014
0.722HisTyr: 0.722 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.642IleAla: 5.642 ± 0.078
1.011IleCys: 1.011 ± 0.03
4.095IleAsp: 4.095 ± 0.06
4.919IleGlu: 4.919 ± 0.068
3.122IlePhe: 3.122 ± 0.06
4.769IleGly: 4.769 ± 0.074
1.121IleHis: 1.121 ± 0.027
6.239IleIle: 6.239 ± 0.096
5.543IleLys: 5.543 ± 0.083
7.102IleLeu: 7.102 ± 0.098
1.876IleMet: 1.876 ± 0.044
4.366IleAsn: 4.366 ± 0.056
3.185IlePro: 3.185 ± 0.055
2.002IleGln: 2.002 ± 0.038
3.299IleArg: 3.299 ± 0.059
5.4IleSer: 5.4 ± 0.072
4.462IleThr: 4.462 ± 0.078
4.707IleVal: 4.707 ± 0.068
0.69IleTrp: 0.69 ± 0.023
2.626IleTyr: 2.626 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.681LysAla: 4.681 ± 0.064
0.711LysCys: 0.711 ± 0.036
3.746LysAsp: 3.746 ± 0.065
5.347LysGlu: 5.347 ± 0.083
2.046LysPhe: 2.046 ± 0.04
3.941LysGly: 3.941 ± 0.067
1.157LysHis: 1.157 ± 0.037
5.454LysIle: 5.454 ± 0.078
5.228LysLys: 5.228 ± 0.074
6.498LysLeu: 6.498 ± 0.082
1.832LysMet: 1.832 ± 0.042
3.655LysAsn: 3.655 ± 0.054
2.436LysPro: 2.436 ± 0.053
2.592LysGln: 2.592 ± 0.052
2.87LysArg: 2.87 ± 0.057
3.645LysSer: 3.645 ± 0.058
3.597LysThr: 3.597 ± 0.068
4.401LysVal: 4.401 ± 0.061
0.587LysTrp: 0.587 ± 0.021
2.579LysTyr: 2.579 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
8.475LeuAla: 8.475 ± 0.108
1.14LeuCys: 1.14 ± 0.032
5.135LeuAsp: 5.135 ± 0.063
6.51LeuGlu: 6.51 ± 0.1
3.698LeuPhe: 3.698 ± 0.063
6.618LeuGly: 6.618 ± 0.096
1.706LeuHis: 1.706 ± 0.039
7.018LeuIle: 7.018 ± 0.099
7.061LeuLys: 7.061 ± 0.08
10.465LeuLeu: 10.465 ± 0.135
2.359LeuMet: 2.359 ± 0.046
4.666LeuAsn: 4.666 ± 0.067
4.464LeuPro: 4.464 ± 0.072
3.6LeuGln: 3.6 ± 0.065
4.636LeuArg: 4.636 ± 0.069
7.129LeuSer: 7.129 ± 0.086
5.609LeuThr: 5.609 ± 0.08
6.602LeuVal: 6.602 ± 0.098
0.927LeuTrp: 0.927 ± 0.033
3.133LeuTyr: 3.133 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.177MetAla: 2.177 ± 0.046
0.228MetCys: 0.228 ± 0.014
1.37MetAsp: 1.37 ± 0.039
1.674MetGlu: 1.674 ± 0.042
0.864MetPhe: 0.864 ± 0.028
1.737MetGly: 1.737 ± 0.041
0.458MetHis: 0.458 ± 0.022
1.673MetIle: 1.673 ± 0.038
1.636MetLys: 1.636 ± 0.039
2.746MetLeu: 2.746 ± 0.052
0.575MetMet: 0.575 ± 0.023
1.134MetAsn: 1.134 ± 0.032
1.206MetPro: 1.206 ± 0.032
1.024MetGln: 1.024 ± 0.035
1.237MetArg: 1.237 ± 0.031
1.71MetSer: 1.71 ± 0.035
1.322MetThr: 1.322 ± 0.034
1.847MetVal: 1.847 ± 0.035
0.16MetTrp: 0.16 ± 0.011
0.657MetTyr: 0.657 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.847AsnAla: 2.847 ± 0.05
0.641AsnCys: 0.641 ± 0.027
2.172AsnAsp: 2.172 ± 0.043
2.688AsnGlu: 2.688 ± 0.052
1.838AsnPhe: 1.838 ± 0.043
3.13AsnGly: 3.13 ± 0.065
0.828AsnHis: 0.828 ± 0.025
4.185AsnIle: 4.185 ± 0.064
3.263AsnLys: 3.263 ± 0.053
4.793AsnLeu: 4.793 ± 0.067
1.231AsnMet: 1.231 ± 0.035
2.78AsnAsn: 2.78 ± 0.076
2.294AsnPro: 2.294 ± 0.042
1.757AsnGln: 1.757 ± 0.048
2.403AsnArg: 2.403 ± 0.053
2.971AsnSer: 2.971 ± 0.055
2.514AsnThr: 2.514 ± 0.056
2.662AsnVal: 2.662 ± 0.06
0.538AsnTrp: 0.538 ± 0.023
1.929AsnTyr: 1.929 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.093ProAla: 3.093 ± 0.094
0.408ProCys: 0.408 ± 0.019
2.362ProAsp: 2.362 ± 0.05
3.287ProGlu: 3.287 ± 0.053
1.549ProPhe: 1.549 ± 0.036
3.162ProGly: 3.162 ± 0.055
0.723ProHis: 0.723 ± 0.025
2.105ProIle: 2.105 ± 0.045
1.875ProLys: 1.875 ± 0.044
3.541ProLeu: 3.541 ± 0.061
0.77ProMet: 0.77 ± 0.025
1.422ProAsn: 1.422 ± 0.034
1.328ProPro: 1.328 ± 0.036
1.337ProGln: 1.337 ± 0.031
1.496ProArg: 1.496 ± 0.033
2.109ProSer: 2.109 ± 0.09
1.748ProThr: 1.748 ± 0.139
4.091ProVal: 4.091 ± 0.266
0.392ProTrp: 0.392 ± 0.018
1.326ProTyr: 1.326 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.879GlnAla: 2.879 ± 0.057
0.344GlnCys: 0.344 ± 0.021
1.693GlnAsp: 1.693 ± 0.036
2.685GlnGlu: 2.685 ± 0.056
1.159GlnPhe: 1.159 ± 0.028
2.198GlnGly: 2.198 ± 0.042
0.567GlnHis: 0.567 ± 0.02
2.745GlnIle: 2.745 ± 0.051
2.787GlnLys: 2.787 ± 0.052
3.437GlnLeu: 3.437 ± 0.058
0.938GlnMet: 0.938 ± 0.028
1.757GlnAsn: 1.757 ± 0.037
1.234GlnPro: 1.234 ± 0.035
1.571GlnGln: 1.571 ± 0.047
1.692GlnArg: 1.692 ± 0.037
1.962GlnSer: 1.962 ± 0.042
1.694GlnThr: 1.694 ± 0.042
2.674GlnVal: 2.674 ± 0.048
0.312GlnTrp: 0.312 ± 0.017
1.188GlnTyr: 1.188 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.04ArgAla: 3.04 ± 0.048
0.626ArgCys: 0.626 ± 0.024
2.444ArgAsp: 2.444 ± 0.047
3.761ArgGlu: 3.761 ± 0.066
1.991ArgPhe: 1.991 ± 0.042
2.872ArgGly: 2.872 ± 0.059
0.944ArgHis: 0.944 ± 0.028
3.524ArgIle: 3.524 ± 0.057
3.185ArgLys: 3.185 ± 0.064
5.166ArgLeu: 5.166 ± 0.085
1.306ArgMet: 1.306 ± 0.039
2.047ArgAsn: 2.047 ± 0.049
1.626ArgPro: 1.626 ± 0.04
2.17ArgGln: 2.17 ± 0.046
2.587ArgArg: 2.587 ± 0.064
2.452ArgSer: 2.452 ± 0.054
2.069ArgThr: 2.069 ± 0.045
3.427ArgVal: 3.427 ± 0.069
0.503ArgTrp: 0.503 ± 0.019
1.786ArgTyr: 1.786 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.201SerAla: 4.201 ± 0.078
0.789SerCys: 0.789 ± 0.028
3.075SerAsp: 3.075 ± 0.059
3.666SerGlu: 3.666 ± 0.061
2.8SerPhe: 2.8 ± 0.058
5.37SerGly: 5.37 ± 0.082
1.115SerHis: 1.115 ± 0.033
4.418SerIle: 4.418 ± 0.061
3.555SerLys: 3.555 ± 0.062
6.321SerLeu: 6.321 ± 0.086
1.514SerMet: 1.514 ± 0.038
2.518SerAsn: 2.518 ± 0.056
2.273SerPro: 2.273 ± 0.046
2.13SerGln: 2.13 ± 0.045
2.956SerArg: 2.956 ± 0.055
3.918SerSer: 3.918 ± 0.065
2.921SerThr: 2.921 ± 0.055
4.32SerVal: 4.32 ± 0.072
0.695SerTrp: 0.695 ± 0.027
2.084SerTyr: 2.084 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
4.358ThrAla: 4.358 ± 0.103
0.601ThrCys: 0.601 ± 0.023
2.694ThrAsp: 2.694 ± 0.064
3.046ThrGlu: 3.046 ± 0.051
1.973ThrPhe: 1.973 ± 0.048
5.384ThrGly: 5.384 ± 0.222
0.845ThrHis: 0.845 ± 0.028
3.602ThrIle: 3.602 ± 0.066
2.595ThrLys: 2.595 ± 0.051
4.647ThrLeu: 4.647 ± 0.061
1.108ThrMet: 1.108 ± 0.033
2.072ThrAsn: 2.072 ± 0.048
2.275ThrPro: 2.275 ± 0.057
1.361ThrGln: 1.361 ± 0.039
2.134ThrArg: 2.134 ± 0.045
2.948ThrSer: 2.948 ± 0.062
2.661ThrThr: 2.661 ± 0.06
4.6ThrVal: 4.6 ± 0.097
0.478ThrTrp: 0.478 ± 0.024
1.679ThrTyr: 1.679 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
5.254ValAla: 5.254 ± 0.105
0.929ValCys: 0.929 ± 0.032
3.69ValAsp: 3.69 ± 0.06
4.555ValGlu: 4.555 ± 0.081
2.981ValPhe: 2.981 ± 0.054
4.381ValGly: 4.381 ± 0.18
1.142ValHis: 1.142 ± 0.03
5.342ValIle: 5.342 ± 0.074
4.658ValLys: 4.658 ± 0.077
7.417ValLeu: 7.417 ± 0.102
1.858ValMet: 1.858 ± 0.044
3.376ValAsn: 3.376 ± 0.062
2.823ValPro: 2.823 ± 0.107
2.304ValGln: 2.304 ± 0.046
3.223ValArg: 3.223 ± 0.059
4.557ValSer: 4.557 ± 0.071
3.764ValThr: 3.764 ± 0.086
5.106ValVal: 5.106 ± 0.091
0.644ValTrp: 0.644 ± 0.027
2.421ValTyr: 2.421 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.652TrpAla: 0.652 ± 0.027
0.117TrpCys: 0.117 ± 0.011
0.525TrpAsp: 0.525 ± 0.024
0.623TrpGlu: 0.623 ± 0.024
0.394TrpPhe: 0.394 ± 0.02
0.653TrpGly: 0.653 ± 0.03
0.234TrpHis: 0.234 ± 0.013
0.577TrpIle: 0.577 ± 0.021
0.592TrpLys: 0.592 ± 0.022
1.199TrpLeu: 1.199 ± 0.03
0.24TrpMet: 0.24 ± 0.013
0.521TrpAsn: 0.521 ± 0.022
0.331TrpPro: 0.331 ± 0.016
0.573TrpGln: 0.573 ± 0.021
0.497TrpArg: 0.497 ± 0.023
0.661TrpSer: 0.661 ± 0.029
0.436TrpThr: 0.436 ± 0.023
0.674TrpVal: 0.674 ± 0.024
0.107TrpTrp: 0.107 ± 0.01
0.337TrpTyr: 0.337 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.267TyrAla: 2.267 ± 0.047
0.602TyrCys: 0.602 ± 0.025
1.957TyrAsp: 1.957 ± 0.065
2.107TyrGlu: 2.107 ± 0.048
1.537TyrPhe: 1.537 ± 0.043
2.474TyrGly: 2.474 ± 0.044
0.71TyrHis: 0.71 ± 0.029
2.668TyrIle: 2.668 ± 0.056
2.193TyrLys: 2.193 ± 0.044
3.77TyrLeu: 3.77 ± 0.065
0.816TyrMet: 0.816 ± 0.026
1.891TyrAsn: 1.891 ± 0.048
1.459TyrPro: 1.459 ± 0.036
1.298TyrGln: 1.298 ± 0.036
2.061TyrArg: 2.061 ± 0.041
2.183TyrSer: 2.183 ± 0.048
1.883TyrThr: 1.883 ± 0.051
1.937TyrVal: 1.937 ± 0.041
0.404TyrTrp: 0.404 ± 0.021
1.545TyrTyr: 1.545 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4016 proteins (1201787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski