Amino acid dipepetide frequency for Streptococcus satellite phage Javan63

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.653AlaAla: 2.653 ± 1.504
0.442AlaCys: 0.442 ± 0.384
5.305AlaAsp: 5.305 ± 1.321
4.421AlaGlu: 4.421 ± 1.525
3.095AlaPhe: 3.095 ± 1.384
2.653AlaGly: 2.653 ± 0.993
0.884AlaHis: 0.884 ± 0.611
6.189AlaIle: 6.189 ± 1.624
5.305AlaLys: 5.305 ± 1.205
4.863AlaLeu: 4.863 ± 1.106
1.768AlaMet: 1.768 ± 0.869
3.095AlaAsn: 3.095 ± 0.966
2.653AlaPro: 2.653 ± 0.727
1.326AlaGln: 1.326 ± 0.632
3.537AlaArg: 3.537 ± 1.051
4.421AlaSer: 4.421 ± 1.316
2.21AlaThr: 2.21 ± 0.849
2.21AlaVal: 2.21 ± 1.553
0.442AlaTrp: 0.442 ± 0.514
2.653AlaTyr: 2.653 ± 1.045
0.0AlaXaa: 0.0 ± 0.0
Cys
0.884CysAla: 0.884 ± 0.547
0.0CysCys: 0.0 ± 0.0
0.442CysAsp: 0.442 ± 0.468
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.442CysGly: 0.442 ± 0.437
0.0CysHis: 0.0 ± 0.0
0.442CysIle: 0.442 ± 0.437
0.884CysLys: 0.884 ± 0.5
0.0CysLeu: 0.0 ± 0.0
0.442CysMet: 0.442 ± 0.391
0.0CysAsn: 0.0 ± 0.0
0.442CysPro: 0.442 ± 0.391
0.884CysGln: 0.884 ± 0.63
0.442CysArg: 0.442 ± 0.397
0.0CysSer: 0.0 ± 0.0
0.442CysThr: 0.442 ± 0.514
0.0CysVal: 0.0 ± 0.0
0.442CysTrp: 0.442 ± 0.477
0.884CysTyr: 0.884 ± 0.56
0.0CysXaa: 0.0 ± 0.0
Asp
0.442AspAla: 0.442 ± 0.391
0.884AspCys: 0.884 ± 0.637
2.653AspAsp: 2.653 ± 1.206
3.979AspGlu: 3.979 ± 1.268
4.421AspPhe: 4.421 ± 1.393
4.863AspGly: 4.863 ± 1.565
0.0AspHis: 0.0 ± 0.0
6.189AspIle: 6.189 ± 1.774
8.842AspLys: 8.842 ± 1.618
5.747AspLeu: 5.747 ± 1.216
1.326AspMet: 1.326 ± 0.798
5.305AspAsn: 5.305 ± 1.971
1.768AspPro: 1.768 ± 0.8
1.768AspGln: 1.768 ± 0.604
0.442AspArg: 0.442 ± 0.499
1.326AspSer: 1.326 ± 0.916
0.884AspThr: 0.884 ± 0.52
2.653AspVal: 2.653 ± 1.119
0.0AspTrp: 0.0 ± 0.0
3.537AspTyr: 3.537 ± 1.376
0.0AspXaa: 0.0 ± 0.0
Glu
4.421GluAla: 4.421 ± 1.265
0.884GluCys: 0.884 ± 0.534
4.421GluAsp: 4.421 ± 1.365
5.747GluGlu: 5.747 ± 2.148
3.095GluPhe: 3.095 ± 1.218
2.21GluGly: 2.21 ± 1.013
0.884GluHis: 0.884 ± 0.597
6.189GluIle: 6.189 ± 1.888
10.61GluLys: 10.61 ± 1.519
12.821GluLeu: 12.821 ± 2.906
3.537GluMet: 3.537 ± 1.3
3.537GluAsn: 3.537 ± 1.362
1.326GluPro: 1.326 ± 0.893
2.653GluGln: 2.653 ± 0.844
4.863GluArg: 4.863 ± 2.405
5.305GluSer: 5.305 ± 1.399
4.863GluThr: 4.863 ± 0.966
4.863GluVal: 4.863 ± 0.944
0.884GluTrp: 0.884 ± 0.516
3.095GluTyr: 3.095 ± 0.872
0.0GluXaa: 0.0 ± 0.0
Phe
0.884PheAla: 0.884 ± 0.502
0.442PheCys: 0.442 ± 0.468
3.537PheAsp: 3.537 ± 1.215
4.421PheGlu: 4.421 ± 1.63
1.768PhePhe: 1.768 ± 0.747
2.21PheGly: 2.21 ± 0.781
0.884PheHis: 0.884 ± 0.516
3.979PheIle: 3.979 ± 0.877
3.537PheLys: 3.537 ± 1.122
3.095PheLeu: 3.095 ± 1.025
0.442PheMet: 0.442 ± 0.355
2.21PheAsn: 2.21 ± 0.942
0.884PhePro: 0.884 ± 0.626
1.768PheGln: 1.768 ± 0.778
1.326PheArg: 1.326 ± 0.912
1.768PheSer: 1.768 ± 0.74
2.21PheThr: 2.21 ± 0.858
1.768PheVal: 1.768 ± 0.63
0.442PheTrp: 0.442 ± 0.437
1.326PheTyr: 1.326 ± 0.68
0.0PheXaa: 0.0 ± 0.0
Gly
3.537GlyAla: 3.537 ± 1.235
0.0GlyCys: 0.0 ± 0.0
1.326GlyAsp: 1.326 ± 0.745
2.21GlyGlu: 2.21 ± 1.153
1.768GlyPhe: 1.768 ± 0.877
3.537GlyGly: 3.537 ± 1.379
0.442GlyHis: 0.442 ± 0.384
5.305GlyIle: 5.305 ± 1.566
5.747GlyLys: 5.747 ± 1.9
5.305GlyLeu: 5.305 ± 1.334
2.21GlyMet: 2.21 ± 1.273
2.21GlyAsn: 2.21 ± 0.936
0.0GlyPro: 0.0 ± 0.0
1.768GlyGln: 1.768 ± 0.773
0.884GlyArg: 0.884 ± 0.5
2.653GlySer: 2.653 ± 0.939
1.768GlyThr: 1.768 ± 1.181
2.653GlyVal: 2.653 ± 0.82
0.884GlyTrp: 0.884 ± 0.559
4.421GlyTyr: 4.421 ± 1.747
0.0GlyXaa: 0.0 ± 0.0
His
1.768HisAla: 1.768 ± 1.184
0.0HisCys: 0.0 ± 0.0
0.884HisAsp: 0.884 ± 0.536
0.884HisGlu: 0.884 ± 0.559
0.442HisPhe: 0.442 ± 0.443
1.326HisGly: 1.326 ± 0.745
0.884HisHis: 0.884 ± 0.886
0.884HisIle: 0.884 ± 0.527
0.442HisLys: 0.442 ± 0.499
2.653HisLeu: 2.653 ± 0.829
0.0HisMet: 0.0 ± 0.0
1.768HisAsn: 1.768 ± 1.374
0.0HisPro: 0.0 ± 0.0
0.442HisGln: 0.442 ± 0.391
0.884HisArg: 0.884 ± 0.872
0.884HisSer: 0.884 ± 0.534
0.442HisThr: 0.442 ± 0.384
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.979IleAla: 3.979 ± 1.249
0.442IleCys: 0.442 ± 0.514
7.515IleAsp: 7.515 ± 0.909
5.305IleGlu: 5.305 ± 1.634
2.21IlePhe: 2.21 ± 0.784
2.653IleGly: 2.653 ± 0.87
0.442IleHis: 0.442 ± 0.443
5.305IleIle: 5.305 ± 1.1
6.631IleLys: 6.631 ± 1.589
6.189IleLeu: 6.189 ± 1.662
3.095IleMet: 3.095 ± 1.201
3.095IleAsn: 3.095 ± 1.165
1.768IlePro: 1.768 ± 0.921
4.863IleGln: 4.863 ± 1.479
4.863IleArg: 4.863 ± 1.352
4.421IleSer: 4.421 ± 0.922
6.631IleThr: 6.631 ± 1.77
0.884IleVal: 0.884 ± 0.655
1.768IleTrp: 1.768 ± 0.734
3.095IleTyr: 3.095 ± 1.209
0.0IleXaa: 0.0 ± 0.0
Lys
8.842LysAla: 8.842 ± 1.915
0.884LysCys: 0.884 ± 0.873
3.095LysAsp: 3.095 ± 1.417
11.494LysGlu: 11.494 ± 1.9
1.768LysPhe: 1.768 ± 0.756
3.095LysGly: 3.095 ± 1.052
3.095LysHis: 3.095 ± 1.595
4.863LysIle: 4.863 ± 1.05
7.515LysLys: 7.515 ± 1.963
7.073LysLeu: 7.073 ± 1.644
3.979LysMet: 3.979 ± 1.42
5.747LysAsn: 5.747 ± 1.667
3.979LysPro: 3.979 ± 1.011
4.421LysGln: 4.421 ± 1.625
6.189LysArg: 6.189 ± 1.428
3.979LysSer: 3.979 ± 0.762
7.958LysThr: 7.958 ± 1.724
6.189LysVal: 6.189 ± 1.272
0.442LysTrp: 0.442 ± 0.397
1.326LysTyr: 1.326 ± 0.983
0.0LysXaa: 0.0 ± 0.0
Leu
7.515LeuAla: 7.515 ± 1.311
1.326LeuCys: 1.326 ± 0.937
7.515LeuAsp: 7.515 ± 1.914
13.263LeuGlu: 13.263 ± 2.829
3.979LeuPhe: 3.979 ± 1.474
5.305LeuGly: 5.305 ± 1.487
0.884LeuHis: 0.884 ± 0.536
5.747LeuIle: 5.747 ± 1.635
10.168LeuLys: 10.168 ± 2.254
10.168LeuLeu: 10.168 ± 2.602
2.21LeuMet: 2.21 ± 0.775
5.305LeuAsn: 5.305 ± 1.526
1.326LeuPro: 1.326 ± 0.683
3.537LeuGln: 3.537 ± 1.076
3.537LeuArg: 3.537 ± 1.267
5.305LeuSer: 5.305 ± 1.371
6.189LeuThr: 6.189 ± 1.546
4.421LeuVal: 4.421 ± 1.378
0.0LeuTrp: 0.0 ± 0.0
3.537LeuTyr: 3.537 ± 1.2
0.0LeuXaa: 0.0 ± 0.0
Met
3.537MetAla: 3.537 ± 1.256
0.0MetCys: 0.0 ± 0.0
1.326MetAsp: 1.326 ± 0.725
1.768MetGlu: 1.768 ± 0.674
0.442MetPhe: 0.442 ± 0.397
0.884MetGly: 0.884 ± 0.531
0.0MetHis: 0.0 ± 0.0
2.21MetIle: 2.21 ± 0.988
0.442MetLys: 0.442 ± 0.391
2.21MetLeu: 2.21 ± 1.029
0.0MetMet: 0.0 ± 0.0
4.421MetAsn: 4.421 ± 1.683
1.326MetPro: 1.326 ± 0.822
0.0MetGln: 0.0 ± 0.0
1.768MetArg: 1.768 ± 0.576
2.21MetSer: 2.21 ± 0.923
3.979MetThr: 3.979 ± 1.041
0.884MetVal: 0.884 ± 0.57
0.442MetTrp: 0.442 ± 0.468
0.884MetTyr: 0.884 ± 0.74
0.0MetXaa: 0.0 ± 0.0
Asn
2.653AsnAla: 2.653 ± 1.009
0.0AsnCys: 0.0 ± 0.0
1.768AsnAsp: 1.768 ± 0.885
7.515AsnGlu: 7.515 ± 2.536
2.21AsnPhe: 2.21 ± 0.959
5.305AsnGly: 5.305 ± 1.427
0.442AsnHis: 0.442 ± 0.391
3.095AsnIle: 3.095 ± 1.384
4.421AsnLys: 4.421 ± 1.309
3.537AsnLeu: 3.537 ± 1.417
0.884AsnMet: 0.884 ± 0.5
3.979AsnAsn: 3.979 ± 1.093
0.884AsnPro: 0.884 ± 0.561
3.095AsnGln: 3.095 ± 0.962
2.21AsnArg: 2.21 ± 1.213
3.979AsnSer: 3.979 ± 1.453
3.095AsnThr: 3.095 ± 1.332
3.095AsnVal: 3.095 ± 1.236
1.768AsnTrp: 1.768 ± 0.81
1.326AsnTyr: 1.326 ± 0.74
0.0AsnXaa: 0.0 ± 0.0
Pro
2.21ProAla: 2.21 ± 0.726
0.0ProCys: 0.0 ± 0.0
1.768ProAsp: 1.768 ± 0.959
2.21ProGlu: 2.21 ± 1.241
1.768ProPhe: 1.768 ± 0.764
0.884ProGly: 0.884 ± 0.531
0.442ProHis: 0.442 ± 0.433
0.884ProIle: 0.884 ± 0.561
2.21ProLys: 2.21 ± 1.109
0.884ProLeu: 0.884 ± 0.619
0.0ProMet: 0.0 ± 0.0
0.884ProAsn: 0.884 ± 0.559
0.0ProPro: 0.0 ± 0.0
0.884ProGln: 0.884 ± 0.547
1.326ProArg: 1.326 ± 0.814
1.768ProSer: 1.768 ± 0.658
1.768ProThr: 1.768 ± 0.609
0.884ProVal: 0.884 ± 0.547
0.0ProTrp: 0.0 ± 0.0
0.884ProTyr: 0.884 ± 0.534
0.0ProXaa: 0.0 ± 0.0
Gln
4.863GlnAla: 4.863 ± 1.48
0.0GlnCys: 0.0 ± 0.0
2.21GlnAsp: 2.21 ± 0.78
3.095GlnGlu: 3.095 ± 0.714
1.326GlnPhe: 1.326 ± 0.616
2.653GlnGly: 2.653 ± 0.849
0.0GlnHis: 0.0 ± 0.0
2.21GlnIle: 2.21 ± 0.945
3.979GlnLys: 3.979 ± 1.375
5.305GlnLeu: 5.305 ± 1.713
0.442GlnMet: 0.442 ± 0.585
2.653GlnAsn: 2.653 ± 1.064
0.0GlnPro: 0.0 ± 0.0
4.421GlnGln: 4.421 ± 1.486
1.768GlnArg: 1.768 ± 0.68
3.095GlnSer: 3.095 ± 1.121
2.653GlnThr: 2.653 ± 0.853
2.21GlnVal: 2.21 ± 0.882
0.0GlnTrp: 0.0 ± 0.0
2.653GlnTyr: 2.653 ± 0.907
0.0GlnXaa: 0.0 ± 0.0
Arg
2.21ArgAla: 2.21 ± 1.199
0.442ArgCys: 0.442 ± 0.384
2.21ArgAsp: 2.21 ± 1.044
3.979ArgGlu: 3.979 ± 1.213
0.442ArgPhe: 0.442 ± 0.384
2.21ArgGly: 2.21 ± 1.052
1.768ArgHis: 1.768 ± 0.697
6.631ArgIle: 6.631 ± 1.883
4.421ArgLys: 4.421 ± 1.017
6.189ArgLeu: 6.189 ± 1.632
0.884ArgMet: 0.884 ± 0.495
2.21ArgAsn: 2.21 ± 0.782
0.442ArgPro: 0.442 ± 0.436
3.537ArgGln: 3.537 ± 1.806
1.326ArgArg: 1.326 ± 0.915
1.768ArgSer: 1.768 ± 0.908
3.095ArgThr: 3.095 ± 1.419
1.326ArgVal: 1.326 ± 0.681
0.0ArgTrp: 0.0 ± 0.0
2.653ArgTyr: 2.653 ± 1.017
0.0ArgXaa: 0.0 ± 0.0
Ser
2.21SerAla: 2.21 ± 0.952
0.442SerCys: 0.442 ± 0.477
3.537SerAsp: 3.537 ± 0.81
4.421SerGlu: 4.421 ± 1.283
0.442SerPhe: 0.442 ± 0.437
1.326SerGly: 1.326 ± 0.631
1.326SerHis: 1.326 ± 0.587
4.863SerIle: 4.863 ± 1.108
3.979SerLys: 3.979 ± 1.71
5.305SerLeu: 5.305 ± 0.972
2.653SerMet: 2.653 ± 1.055
1.768SerAsn: 1.768 ± 0.666
0.884SerPro: 0.884 ± 0.536
0.442SerGln: 0.442 ± 0.439
4.421SerArg: 4.421 ± 0.986
2.21SerSer: 2.21 ± 0.819
5.747SerThr: 5.747 ± 1.877
4.863SerVal: 4.863 ± 1.346
0.0SerTrp: 0.0 ± 0.0
3.979SerTyr: 3.979 ± 1.433
0.0SerXaa: 0.0 ± 0.0
Thr
2.653ThrAla: 2.653 ± 0.97
0.442ThrCys: 0.442 ± 0.397
3.095ThrAsp: 3.095 ± 0.928
5.747ThrGlu: 5.747 ± 1.813
3.095ThrPhe: 3.095 ± 1.268
3.979ThrGly: 3.979 ± 1.501
1.326ThrHis: 1.326 ± 0.804
3.979ThrIle: 3.979 ± 1.468
5.747ThrLys: 5.747 ± 1.144
5.305ThrLeu: 5.305 ± 1.547
3.095ThrMet: 3.095 ± 1.267
1.768ThrAsn: 1.768 ± 0.636
1.326ThrPro: 1.326 ± 0.675
3.979ThrGln: 3.979 ± 1.401
2.653ThrArg: 2.653 ± 1.404
3.537ThrSer: 3.537 ± 1.14
3.979ThrThr: 3.979 ± 1.693
4.863ThrVal: 4.863 ± 1.627
0.442ThrTrp: 0.442 ± 0.436
2.653ThrTyr: 2.653 ± 1.177
0.0ThrXaa: 0.0 ± 0.0
Val
2.21ValAla: 2.21 ± 1.363
0.0ValCys: 0.0 ± 0.0
2.21ValAsp: 2.21 ± 0.717
3.537ValGlu: 3.537 ± 1.486
2.653ValPhe: 2.653 ± 1.04
1.768ValGly: 1.768 ± 0.836
0.0ValHis: 0.0 ± 0.0
2.21ValIle: 2.21 ± 0.986
5.747ValLys: 5.747 ± 2.443
6.631ValLeu: 6.631 ± 1.963
0.442ValMet: 0.442 ± 0.437
2.21ValAsn: 2.21 ± 0.838
1.768ValPro: 1.768 ± 0.992
3.095ValGln: 3.095 ± 1.156
2.21ValArg: 2.21 ± 1.11
3.095ValSer: 3.095 ± 0.644
3.979ValThr: 3.979 ± 1.811
0.884ValVal: 0.884 ± 0.878
0.0ValTrp: 0.0 ± 0.0
2.21ValTyr: 2.21 ± 0.921
0.0ValXaa: 0.0 ± 0.0
Trp
1.326TrpAla: 1.326 ± 0.983
0.0TrpCys: 0.0 ± 0.0
0.442TrpAsp: 0.442 ± 0.397
0.884TrpGlu: 0.884 ± 0.618
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.884TrpIle: 0.884 ± 0.63
0.0TrpLys: 0.0 ± 0.0
2.653TrpLeu: 2.653 ± 0.859
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.442TrpGln: 0.442 ± 0.391
0.442TrpArg: 0.442 ± 0.437
0.0TrpSer: 0.0 ± 0.0
0.442TrpThr: 0.442 ± 0.384
0.884TrpVal: 0.884 ± 0.72
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.326TyrAla: 1.326 ± 0.804
0.442TyrCys: 0.442 ± 0.391
1.768TyrAsp: 1.768 ± 1.27
1.326TyrGlu: 1.326 ± 0.777
3.979TyrPhe: 3.979 ± 1.447
1.326TyrGly: 1.326 ± 0.918
0.884TyrHis: 0.884 ± 0.502
3.095TyrIle: 3.095 ± 1.278
5.305TyrLys: 5.305 ± 1.965
5.305TyrLeu: 5.305 ± 1.4
0.884TyrMet: 0.884 ± 0.57
3.095TyrAsn: 3.095 ± 0.834
0.884TyrPro: 0.884 ± 0.516
2.653TyrGln: 2.653 ± 1.519
2.653TyrArg: 2.653 ± 0.764
3.095TyrSer: 3.095 ± 0.844
1.326TyrThr: 1.326 ± 0.592
1.326TyrVal: 1.326 ± 0.826
0.442TyrTrp: 0.442 ± 0.499
1.326TyrTyr: 1.326 ± 0.857
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 15 proteins (2263 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski