Amino acid dipepetide frequency for Corynebacterium matruchotii ATCC 14266

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.652AlaAla: 14.652 ± 0.206	0.984AlaCys: 0.984 ± 0.039	6.661AlaAsp: 6.661 ± 0.093	6.835AlaGlu: 6.835 ± 0.103	3.103AlaPhe: 3.103 ± 0.068	9.187AlaGly: 9.187 ± 0.121	2.582AlaHis: 2.582 ± 0.059	5.813AlaIle: 5.813 ± 0.097	4.058AlaLys: 4.058 ± 0.088	9.893AlaLeu: 9.893 ± 0.134	2.62AlaMet: 2.62 ± 0.06	3.022AlaAsn: 3.022 ± 0.06	4.628AlaPro: 4.628 ± 0.094	4.195AlaGln: 4.195 ± 0.084	6.198AlaArg: 6.198 ± 0.096	5.288AlaSer: 5.288 ± 0.081	7.532AlaThr: 7.532 ± 0.11	8.345AlaVal: 8.345 ± 0.119	1.442AlaTrp: 1.442 ± 0.048	2.327AlaTyr: 2.327 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.924CysAla: 0.924 ± 0.041	0.123CysCys: 0.123 ± 0.012	0.51CysAsp: 0.51 ± 0.028	0.441CysGlu: 0.441 ± 0.023	0.308CysPhe: 0.308 ± 0.02	0.862CysGly: 0.862 ± 0.035	0.223CysHis: 0.223 ± 0.018	0.388CysIle: 0.388 ± 0.023	0.16CysLys: 0.16 ± 0.014	0.706CysLeu: 0.706 ± 0.033	0.189CysMet: 0.189 ± 0.016	0.222CysAsn: 0.222 ± 0.016	0.434CysPro: 0.434 ± 0.025	0.246CysGln: 0.246 ± 0.02	0.433CysArg: 0.433 ± 0.026	0.525CysSer: 0.525 ± 0.03	0.51CysThr: 0.51 ± 0.027	0.681CysVal: 0.681 ± 0.035	0.13CysTrp: 0.13 ± 0.013	0.226CysTyr: 0.226 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	6.36AspAla: 6.36 ± 0.094	0.438AspCys: 0.438 ± 0.025	4.008AspAsp: 4.008 ± 0.1	3.598AspGlu: 3.598 ± 0.077	1.991AspPhe: 1.991 ± 0.055	4.585AspGly: 4.585 ± 0.094	1.439AspHis: 1.439 ± 0.042	3.342AspIle: 3.342 ± 0.065	2.141AspLys: 2.141 ± 0.056	5.329AspLeu: 5.329 ± 0.087	1.268AspMet: 1.268 ± 0.039	2.009AspAsn: 2.009 ± 0.055	3.783AspPro: 3.783 ± 0.081	1.946AspGln: 1.946 ± 0.045	3.27AspArg: 3.27 ± 0.061	3.199AspSer: 3.199 ± 0.075	3.584AspThr: 3.584 ± 0.085	4.524AspVal: 4.524 ± 0.081	0.825AspTrp: 0.825 ± 0.033	1.784AspTyr: 1.784 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	5.501GluAla: 5.501 ± 0.102	0.445GluCys: 0.445 ± 0.025	2.572GluAsp: 2.572 ± 0.068	3.285GluGlu: 3.285 ± 0.076	2.181GluPhe: 2.181 ± 0.053	2.97GluGly: 2.97 ± 0.067	1.418GluHis: 1.418 ± 0.041	3.188GluIle: 3.188 ± 0.07	2.475GluLys: 2.475 ± 0.062	6.462GluLeu: 6.462 ± 0.105	1.107GluMet: 1.107 ± 0.032	1.925GluAsn: 1.925 ± 0.056	2.684GluPro: 2.684 ± 0.069	2.586GluGln: 2.586 ± 0.057	3.244GluArg: 3.244 ± 0.076	3.062GluSer: 3.062 ± 0.058	3.398GluThr: 3.398 ± 0.06	4.151GluVal: 4.151 ± 0.081	0.806GluTrp: 0.806 ± 0.038	1.518GluTyr: 1.518 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.66PheAla: 3.66 ± 0.068	0.332PheCys: 0.332 ± 0.021	2.388PheAsp: 2.388 ± 0.066	1.634PheGlu: 1.634 ± 0.052	1.275PhePhe: 1.275 ± 0.044	3.162PheGly: 3.162 ± 0.066	0.753PheHis: 0.753 ± 0.035	1.749PheIle: 1.749 ± 0.049	0.811PheLys: 0.811 ± 0.033	3.081PheLeu: 3.081 ± 0.073	0.71PheMet: 0.71 ± 0.035	1.08PheAsn: 1.08 ± 0.039	1.591PhePro: 1.591 ± 0.047	0.994PheGln: 0.994 ± 0.032	1.703PheArg: 1.703 ± 0.047	2.09PheSer: 2.09 ± 0.058	2.427PheThr: 2.427 ± 0.058	2.511PheVal: 2.511 ± 0.054	0.427PheTrp: 0.427 ± 0.022	0.951PheTyr: 0.951 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.532GlyAla: 7.532 ± 0.129	0.711GlyCys: 0.711 ± 0.03	4.314GlyAsp: 4.314 ± 0.069	4.227GlyGlu: 4.227 ± 0.081	3.11GlyPhe: 3.11 ± 0.054	6.36GlyGly: 6.36 ± 0.131	1.735GlyHis: 1.735 ± 0.047	4.818GlyIle: 4.818 ± 0.077	3.342GlyLys: 3.342 ± 0.069	7.321GlyLeu: 7.321 ± 0.109	2.248GlyMet: 2.248 ± 0.055	2.483GlyAsn: 2.483 ± 0.073	2.975GlyPro: 2.975 ± 0.06	2.545GlyGln: 2.545 ± 0.072	4.367GlyArg: 4.367 ± 0.08	4.763GlySer: 4.763 ± 0.109	5.12GlyThr: 5.12 ± 0.094	6.753GlyVal: 6.753 ± 0.11	1.326GlyTrp: 1.326 ± 0.039	2.211GlyTyr: 2.211 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.222HisAla: 2.222 ± 0.05	0.241HisCys: 0.241 ± 0.019	1.524HisAsp: 1.524 ± 0.045	1.159HisGlu: 1.159 ± 0.04	0.661HisPhe: 0.661 ± 0.029	1.787HisGly: 1.787 ± 0.051	0.848HisHis: 0.848 ± 0.038	1.284HisIle: 1.284 ± 0.044	0.652HisLys: 0.652 ± 0.029	2.019HisLeu: 2.019 ± 0.051	0.542HisMet: 0.542 ± 0.023	0.914HisAsn: 0.914 ± 0.034	1.721HisPro: 1.721 ± 0.054	0.997HisGln: 0.997 ± 0.035	1.565HisArg: 1.565 ± 0.05	1.225HisSer: 1.225 ± 0.038	1.534HisThr: 1.534 ± 0.045	1.657HisVal: 1.657 ± 0.048	0.305HisTrp: 0.305 ± 0.022	0.752HisTyr: 0.752 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.867IleAla: 6.867 ± 0.102	0.486IleCys: 0.486 ± 0.025	3.84IleAsp: 3.84 ± 0.068	2.766IleGlu: 2.766 ± 0.058	1.713IlePhe: 1.713 ± 0.048	4.445IleGly: 4.445 ± 0.08	1.209IleHis: 1.209 ± 0.038	3.706IleIle: 3.706 ± 0.074	1.665IleLys: 1.665 ± 0.047	4.623IleLeu: 4.623 ± 0.087	1.426IleMet: 1.426 ± 0.042	1.89IleAsn: 1.89 ± 0.05	3.346IlePro: 3.346 ± 0.073	1.358IleGln: 1.358 ± 0.047	2.898IleArg: 2.898 ± 0.062	3.276IleSer: 3.276 ± 0.061	4.519IleThr: 4.519 ± 0.083	4.477IleVal: 4.477 ± 0.085	0.495IleTrp: 0.495 ± 0.031	1.078IleTyr: 1.078 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.541LysAla: 3.541 ± 0.089	0.177LysCys: 0.177 ± 0.015	1.918LysAsp: 1.918 ± 0.055	2.027LysGlu: 2.027 ± 0.055	1.125LysPhe: 1.125 ± 0.04	1.976LysGly: 1.976 ± 0.061	0.867LysHis: 0.867 ± 0.034	1.99LysIle: 1.99 ± 0.051	1.924LysLys: 1.924 ± 0.065	3.568LysLeu: 3.568 ± 0.07	0.74LysMet: 0.74 ± 0.032	1.462LysAsn: 1.462 ± 0.046	2.253LysPro: 2.253 ± 0.073	1.512LysGln: 1.512 ± 0.043	1.969LysArg: 1.969 ± 0.057	1.965LysSer: 1.965 ± 0.053	2.465LysThr: 2.465 ± 0.063	2.741LysVal: 2.741 ± 0.076	0.423LysTrp: 0.423 ± 0.024	0.883LysTyr: 0.883 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	11.249LeuAla: 11.249 ± 0.143	0.863LeuCys: 0.863 ± 0.038	5.657LeuAsp: 5.657 ± 0.094	4.39LeuGlu: 4.39 ± 0.084	2.972LeuPhe: 2.972 ± 0.078	8.002LeuGly: 8.002 ± 0.101	2.04LeuHis: 2.04 ± 0.047	5.299LeuIle: 5.299 ± 0.098	2.936LeuLys: 2.936 ± 0.064	8.913LeuLeu: 8.913 ± 0.122	2.076LeuMet: 2.076 ± 0.058	2.566LeuAsn: 2.566 ± 0.057	5.236LeuPro: 5.236 ± 0.086	2.832LeuGln: 2.832 ± 0.064	5.976LeuArg: 5.976 ± 0.102	5.704LeuSer: 5.704 ± 0.091	6.309LeuThr: 6.309 ± 0.091	7.997LeuVal: 7.997 ± 0.127	1.262LeuTrp: 1.262 ± 0.048	1.949LeuTyr: 1.949 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.47MetAla: 2.47 ± 0.059	0.194MetCys: 0.194 ± 0.013	1.114MetAsp: 1.114 ± 0.039	1.037MetGlu: 1.037 ± 0.033	0.831MetPhe: 0.831 ± 0.037	1.688MetGly: 1.688 ± 0.051	0.463MetHis: 0.463 ± 0.021	1.267MetIle: 1.267 ± 0.039	0.87MetLys: 0.87 ± 0.034	2.324MetLeu: 2.324 ± 0.057	0.585MetMet: 0.585 ± 0.03	0.799MetAsn: 0.799 ± 0.032	1.329MetPro: 1.329 ± 0.044	0.714MetGln: 0.714 ± 0.032	1.462MetArg: 1.462 ± 0.048	1.729MetSer: 1.729 ± 0.046	1.747MetThr: 1.747 ± 0.042	1.965MetVal: 1.965 ± 0.048	0.352MetTrp: 0.352 ± 0.025	0.421MetTyr: 0.421 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.044AsnAla: 3.044 ± 0.071	0.233AsnCys: 0.233 ± 0.019	1.78AsnAsp: 1.78 ± 0.054	1.521AsnGlu: 1.521 ± 0.048	1.017AsnPhe: 1.017 ± 0.039	2.444AsnGly: 2.444 ± 0.072	0.796AsnHis: 0.796 ± 0.029	1.848AsnIle: 1.848 ± 0.049	1.192AsnLys: 1.192 ± 0.047	3.05AsnLeu: 3.05 ± 0.063	0.751AsnMet: 0.751 ± 0.031	1.452AsnAsn: 1.452 ± 0.049	2.591AsnPro: 2.591 ± 0.06	1.352AsnGln: 1.352 ± 0.041	1.902AsnArg: 1.902 ± 0.044	1.888AsnSer: 1.888 ± 0.052	2.002AsnThr: 2.002 ± 0.056	2.237AsnVal: 2.237 ± 0.053	0.406AsnTrp: 0.406 ± 0.022	0.945AsnTyr: 0.945 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	5.876ProAla: 5.876 ± 0.13	0.301ProCys: 0.301 ± 0.022	3.548ProAsp: 3.548 ± 0.064	3.986ProGlu: 3.986 ± 0.082	1.582ProPhe: 1.582 ± 0.048	4.391ProGly: 4.391 ± 0.085	1.363ProHis: 1.363 ± 0.044	2.709ProIle: 2.709 ± 0.058	1.946ProLys: 1.946 ± 0.054	4.353ProLeu: 4.353 ± 0.074	1.075ProMet: 1.075 ± 0.039	1.851ProAsn: 1.851 ± 0.049	2.625ProPro: 2.625 ± 0.095	2.33ProGln: 2.33 ± 0.072	2.734ProArg: 2.734 ± 0.069	2.683ProSer: 2.683 ± 0.063	4.291ProThr: 4.291 ± 0.09	4.055ProVal: 4.055 ± 0.072	0.73ProTrp: 0.73 ± 0.029	1.279ProTyr: 1.279 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	4.175GlnAla: 4.175 ± 0.084	0.223GlnCys: 0.223 ± 0.017	1.564GlnAsp: 1.564 ± 0.041	2.092GlnGlu: 2.092 ± 0.056	1.089GlnPhe: 1.089 ± 0.037	2.309GlnGly: 2.309 ± 0.066	0.964GlnHis: 0.964 ± 0.031	1.854GlnIle: 1.854 ± 0.058	1.254GlnLys: 1.254 ± 0.046	4.102GlnLeu: 4.102 ± 0.073	0.747GlnMet: 0.747 ± 0.03	1.005GlnAsn: 1.005 ± 0.039	2.343GlnPro: 2.343 ± 0.075	2.064GlnGln: 2.064 ± 0.083	2.417GlnArg: 2.417 ± 0.06	1.908GlnSer: 1.908 ± 0.06	1.623GlnThr: 1.623 ± 0.046	2.951GlnVal: 2.951 ± 0.063	0.579GlnTrp: 0.579 ± 0.028	0.846GlnTyr: 0.846 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	5.463ArgAla: 5.463 ± 0.088	0.429ArgCys: 0.429 ± 0.023	3.314ArgAsp: 3.314 ± 0.069	3.343ArgGlu: 3.343 ± 0.077	1.998ArgPhe: 1.998 ± 0.053	4.164ArgGly: 4.164 ± 0.088	1.437ArgHis: 1.437 ± 0.047	3.505ArgIle: 3.505 ± 0.065	2.298ArgLys: 2.298 ± 0.054	5.513ArgLeu: 5.513 ± 0.113	1.579ArgMet: 1.579 ± 0.044	2.031ArgAsn: 2.031 ± 0.05	2.869ArgPro: 2.869 ± 0.062	2.274ArgGln: 2.274 ± 0.056	4.729ArgArg: 4.729 ± 0.106	3.162ArgSer: 3.162 ± 0.07	3.409ArgThr: 3.409 ± 0.065	4.213ArgVal: 4.213 ± 0.072	0.983ArgTrp: 0.983 ± 0.038	1.708ArgTyr: 1.708 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.822SerAla: 5.822 ± 0.095	0.423SerCys: 0.423 ± 0.026	3.338SerAsp: 3.338 ± 0.068	2.995SerGlu: 2.995 ± 0.063	1.974SerPhe: 1.974 ± 0.056	5.309SerGly: 5.309 ± 0.096	1.311SerHis: 1.311 ± 0.039	2.841SerIle: 2.841 ± 0.069	1.955SerLys: 1.955 ± 0.055	5.254SerLeu: 5.254 ± 0.083	1.537SerMet: 1.537 ± 0.046	1.849SerAsn: 1.849 ± 0.047	3.008SerPro: 3.008 ± 0.06	2.216SerGln: 2.216 ± 0.051	3.359SerArg: 3.359 ± 0.072	3.698SerSer: 3.698 ± 0.096	3.835SerThr: 3.835 ± 0.094	4.274SerVal: 4.274 ± 0.084	0.88SerTrp: 0.88 ± 0.033	1.452SerTyr: 1.452 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	6.879ThrAla: 6.879 ± 0.107	0.527ThrCys: 0.527 ± 0.024	3.936ThrAsp: 3.936 ± 0.081	3.423ThrGlu: 3.423 ± 0.066	2.012ThrPhe: 2.012 ± 0.051	5.354ThrGly: 5.354 ± 0.096	1.599ThrHis: 1.599 ± 0.042	4.318ThrIle: 4.318 ± 0.077	2.361ThrLys: 2.361 ± 0.059	5.994ThrLeu: 5.994 ± 0.086	1.637ThrMet: 1.637 ± 0.043	2.435ThrAsn: 2.435 ± 0.06	4.405ThrPro: 4.405 ± 0.095	2.143ThrGln: 2.143 ± 0.061	3.183ThrArg: 3.183 ± 0.062	4.005ThrSer: 4.005 ± 0.073	5.469ThrThr: 5.469 ± 0.132	5.354ThrVal: 5.354 ± 0.089	0.925ThrTrp: 0.925 ± 0.033	1.599ThrTyr: 1.599 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	9.377ValAla: 9.377 ± 0.122	0.723ValCys: 0.723 ± 0.031	5.085ValAsp: 5.085 ± 0.087	4.188ValGlu: 4.188 ± 0.07	2.787ValPhe: 2.787 ± 0.063	6.259ValGly: 6.259 ± 0.105	1.571ValHis: 1.571 ± 0.045	4.511ValIle: 4.511 ± 0.084	2.376ValLys: 2.376 ± 0.065	7.413ValLeu: 7.413 ± 0.12	1.776ValMet: 1.776 ± 0.043	2.238ValAsn: 2.238 ± 0.056	3.954ValPro: 3.954 ± 0.077	2.087ValGln: 2.087 ± 0.049	4.327ValArg: 4.327 ± 0.081	4.819ValSer: 4.819 ± 0.085	5.804ValThr: 5.804 ± 0.091	7.418ValVal: 7.418 ± 0.115	0.995ValTrp: 0.995 ± 0.036	1.63ValTyr: 1.63 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.386TrpAla: 1.386 ± 0.044	0.156TrpCys: 0.156 ± 0.013	0.767TrpAsp: 0.767 ± 0.032	0.746TrpGlu: 0.746 ± 0.027	0.573TrpPhe: 0.573 ± 0.024	0.942TrpGly: 0.942 ± 0.038	0.339TrpHis: 0.339 ± 0.021	0.621TrpIle: 0.621 ± 0.03	0.423TrpLys: 0.423 ± 0.024	1.718TrpLeu: 1.718 ± 0.056	0.305TrpMet: 0.305 ± 0.021	0.432TrpAsn: 0.432 ± 0.025	0.645TrpPro: 0.645 ± 0.03	0.627TrpGln: 0.627 ± 0.026	1.012TrpArg: 1.012 ± 0.038	0.792TrpSer: 0.792 ± 0.034	0.592TrpThr: 0.592 ± 0.03	1.24TrpVal: 1.24 ± 0.046	0.38TrpTrp: 0.38 ± 0.021	0.354TrpTyr: 0.354 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.364TyrAla: 2.364 ± 0.055	0.233TyrCys: 0.233 ± 0.017	1.582TyrAsp: 1.582 ± 0.049	1.282TyrGlu: 1.282 ± 0.048	1.026TyrPhe: 1.026 ± 0.036	2.061TyrGly: 2.061 ± 0.058	0.653TyrHis: 0.653 ± 0.031	1.035TyrIle: 1.035 ± 0.038	0.685TyrLys: 0.685 ± 0.032	2.592TyrLeu: 2.592 ± 0.06	0.441TyrMet: 0.441 ± 0.022	0.788TyrAsn: 0.788 ± 0.037	1.292TyrPro: 1.292 ± 0.042	1.094TyrGln: 1.094 ± 0.039	1.673TyrArg: 1.673 ± 0.045	1.548TyrSer: 1.548 ± 0.041	1.391TyrThr: 1.391 ± 0.04	1.793TyrVal: 1.793 ± 0.044	0.377TyrTrp: 0.377 ± 0.023	0.719TyrTyr: 0.719 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2619 proteins (820278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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