Amino acid dipepetide frequency for Circovirus-like genome DCCV-6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.754AlaAla: 5.754 ± 5.406
1.151AlaCys: 1.151 ± 1.418
3.452AlaAsp: 3.452 ± 1.555
6.904AlaGlu: 6.904 ± 1.824
4.603AlaPhe: 4.603 ± 1.58
10.357AlaGly: 10.357 ± 3.021
0.0AlaHis: 0.0 ± 0.0
0.0AlaIle: 0.0 ± 0.0
5.754AlaLys: 5.754 ± 3.672
5.754AlaLeu: 5.754 ± 1.601
1.151AlaMet: 1.151 ± 0.734
2.301AlaAsn: 2.301 ± 1.294
2.301AlaPro: 2.301 ± 1.294
3.452AlaGln: 3.452 ± 0.863
2.301AlaArg: 2.301 ± 1.294
5.754AlaSer: 5.754 ± 2.254
5.754AlaThr: 5.754 ± 3.672
4.603AlaVal: 4.603 ± 2.059
0.0AlaTrp: 0.0 ± 0.0
2.301AlaTyr: 2.301 ± 1.294
0.0AlaXaa: 0.0 ± 0.0
Cys
2.301CysAla: 2.301 ± 1.469
1.151CysCys: 1.151 ± 1.101
0.0CysAsp: 0.0 ± 0.0
2.301CysGlu: 2.301 ± 2.202
1.151CysPhe: 1.151 ± 1.418
1.151CysGly: 1.151 ± 1.418
0.0CysHis: 0.0 ± 0.0
1.151CysIle: 1.151 ± 1.101
0.0CysLys: 0.0 ± 0.0
2.301CysLeu: 2.301 ± 0.749
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
1.151CysPro: 1.151 ± 1.101
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
2.301CysSer: 2.301 ± 0.749
1.151CysThr: 1.151 ± 0.734
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.603AspAla: 4.603 ± 2.059
0.0AspCys: 0.0 ± 0.0
0.0AspAsp: 0.0 ± 0.0
1.151AspGlu: 1.151 ± 1.418
2.301AspPhe: 2.301 ± 1.294
2.301AspGly: 2.301 ± 0.749
1.151AspHis: 1.151 ± 0.734
2.301AspIle: 2.301 ± 0.749
1.151AspLys: 1.151 ± 0.734
2.301AspLeu: 2.301 ± 1.294
1.151AspMet: 1.151 ± 0.79
1.151AspAsn: 1.151 ± 0.734
4.603AspPro: 4.603 ± 1.499
2.301AspGln: 2.301 ± 2.202
2.301AspArg: 2.301 ± 0.749
1.151AspSer: 1.151 ± 1.418
6.904AspThr: 6.904 ± 1.625
3.452AspVal: 3.452 ± 0.995
3.452AspTrp: 3.452 ± 2.614
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
3.452GluAla: 3.452 ± 1.734
0.0GluCys: 0.0 ± 0.0
2.301GluAsp: 2.301 ± 1.507
4.603GluGlu: 4.603 ± 1.496
4.603GluPhe: 4.603 ± 0.545
0.0GluGly: 0.0 ± 0.0
0.0GluHis: 0.0 ± 0.0
2.301GluIle: 2.301 ± 0.749
2.301GluLys: 2.301 ± 0.749
4.603GluLeu: 4.603 ± 2.589
1.151GluMet: 1.151 ± 0.734
2.301GluAsn: 2.301 ± 0.749
1.151GluPro: 1.151 ± 0.734
0.0GluGln: 0.0 ± 0.0
0.0GluArg: 0.0 ± 0.0
5.754GluSer: 5.754 ± 2.481
4.603GluThr: 4.603 ± 1.499
4.603GluVal: 4.603 ± 2.225
0.0GluTrp: 0.0 ± 0.0
1.151GluTyr: 1.151 ± 1.418
0.0GluXaa: 0.0 ± 0.0
Phe
1.151PheAla: 1.151 ± 1.101
0.0PheCys: 0.0 ± 0.0
0.0PheAsp: 0.0 ± 0.0
1.151PheGlu: 1.151 ± 1.418
1.151PhePhe: 1.151 ± 1.418
5.754PheGly: 5.754 ± 2.254
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
2.301PheLys: 2.301 ± 1.294
1.151PheLeu: 1.151 ± 1.101
3.452PheMet: 3.452 ± 2.206
3.452PheAsn: 3.452 ± 0.995
1.151PhePro: 1.151 ± 1.418
0.0PheGln: 0.0 ± 0.0
3.452PheArg: 3.452 ± 2.203
2.301PheSer: 2.301 ± 1.294
2.301PheThr: 2.301 ± 0.749
1.151PheVal: 1.151 ± 1.418
2.301PheTrp: 2.301 ± 0.749
4.603PheTyr: 4.603 ± 2.589
0.0PheXaa: 0.0 ± 0.0
Gly
5.754GlyAla: 5.754 ± 2.672
1.151GlyCys: 1.151 ± 1.101
3.452GlyAsp: 3.452 ± 0.863
1.151GlyGlu: 1.151 ± 1.101
0.0GlyPhe: 0.0 ± 0.0
3.452GlyGly: 3.452 ± 2.203
1.151GlyHis: 1.151 ± 1.418
4.603GlyIle: 4.603 ± 1.58
1.151GlyLys: 1.151 ± 0.734
6.904GlyLeu: 6.904 ± 0.204
4.603GlyMet: 4.603 ± 4.404
5.754GlyAsn: 5.754 ± 2.672
2.301GlyPro: 2.301 ± 1.469
4.603GlyGln: 4.603 ± 2.059
4.603GlyArg: 4.603 ± 1.499
9.206GlySer: 9.206 ± 1.459
3.452GlyThr: 3.452 ± 2.614
3.452GlyVal: 3.452 ± 1.555
1.151GlyTrp: 1.151 ± 1.101
3.452GlyTyr: 3.452 ± 1.555
0.0GlyXaa: 0.0 ± 0.0
His
2.301HisAla: 2.301 ± 0.749
0.0HisCys: 0.0 ± 0.0
1.151HisAsp: 1.151 ± 0.734
1.151HisGlu: 1.151 ± 0.734
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
0.0HisLys: 0.0 ± 0.0
1.151HisLeu: 1.151 ± 0.734
0.0HisMet: 0.0 ± 0.0
1.151HisAsn: 1.151 ± 0.734
1.151HisPro: 1.151 ± 1.418
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
0.0HisThr: 0.0 ± 0.0
1.151HisVal: 1.151 ± 0.734
2.301HisTrp: 2.301 ± 1.294
1.151HisTyr: 1.151 ± 1.418
0.0HisXaa: 0.0 ± 0.0
Ile
1.151IleAla: 1.151 ± 0.734
0.0IleCys: 0.0 ± 0.0
0.0IleAsp: 0.0 ± 0.0
1.151IleGlu: 1.151 ± 0.734
2.301IlePhe: 2.301 ± 2.837
3.452IleGly: 3.452 ± 2.226
2.301IleHis: 2.301 ± 1.469
3.452IleIle: 3.452 ± 1.555
4.603IleLys: 4.603 ± 0.545
6.904IleLeu: 6.904 ± 3.469
0.0IleMet: 0.0 ± 0.0
5.754IleAsn: 5.754 ± 2.254
4.603IlePro: 4.603 ± 3.014
1.151IleGln: 1.151 ± 0.734
0.0IleArg: 0.0 ± 0.0
3.452IleSer: 3.452 ± 0.995
2.301IleThr: 2.301 ± 1.469
0.0IleVal: 0.0 ± 0.0
1.151IleTrp: 1.151 ± 1.418
1.151IleTyr: 1.151 ± 0.734
0.0IleXaa: 0.0 ± 0.0
Lys
10.357LysAla: 10.357 ± 2.2
0.0LysCys: 0.0 ± 0.0
3.452LysAsp: 3.452 ± 1.734
2.301LysGlu: 2.301 ± 2.837
3.452LysPhe: 3.452 ± 2.203
4.603LysGly: 4.603 ± 4.002
1.151LysHis: 1.151 ± 0.734
6.904LysIle: 6.904 ± 1.625
11.507LysLys: 11.507 ± 3.603
0.0LysLeu: 0.0 ± 0.0
1.151LysMet: 1.151 ± 1.101
0.0LysAsn: 0.0 ± 0.0
3.452LysPro: 3.452 ± 1.555
2.301LysGln: 2.301 ± 0.749
4.603LysArg: 4.603 ± 1.499
3.452LysSer: 3.452 ± 3.303
2.301LysThr: 2.301 ± 1.294
6.904LysVal: 6.904 ± 1.989
0.0LysTrp: 0.0 ± 0.0
2.301LysTyr: 2.301 ± 1.469
0.0LysXaa: 0.0 ± 0.0
Leu
5.754LeuAla: 5.754 ± 2.254
2.301LeuCys: 2.301 ± 0.749
5.754LeuAsp: 5.754 ± 2.254
4.603LeuGlu: 4.603 ± 2.807
4.603LeuPhe: 4.603 ± 2.938
2.301LeuGly: 2.301 ± 1.507
1.151LeuHis: 1.151 ± 1.418
4.603LeuIle: 4.603 ± 1.496
5.754LeuLys: 5.754 ± 2.481
5.754LeuLeu: 5.754 ± 3.895
2.301LeuMet: 2.301 ± 1.308
1.151LeuAsn: 1.151 ± 1.101
6.904LeuPro: 6.904 ± 6.606
3.452LeuGln: 3.452 ± 1.734
2.301LeuArg: 2.301 ± 0.749
10.357LeuSer: 10.357 ± 6.7
9.206LeuThr: 9.206 ± 2.992
1.151LeuVal: 1.151 ± 0.734
2.301LeuTrp: 2.301 ± 1.507
2.301LeuTyr: 2.301 ± 0.749
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
1.151MetHis: 1.151 ± 1.418
1.151MetIle: 1.151 ± 0.734
3.452MetLys: 3.452 ± 0.863
2.301MetLeu: 2.301 ± 2.202
1.151MetMet: 1.151 ± 0.734
2.301MetAsn: 2.301 ± 0.749
1.151MetPro: 1.151 ± 1.418
0.0MetGln: 0.0 ± 0.0
2.301MetArg: 2.301 ± 2.202
5.754MetSer: 5.754 ± 1.601
3.452MetThr: 3.452 ± 0.995
2.301MetVal: 2.301 ± 1.507
0.0MetTrp: 0.0 ± 0.0
2.301MetTyr: 2.301 ± 0.749
0.0MetXaa: 0.0 ± 0.0
Asn
5.754AsnAla: 5.754 ± 2.672
0.0AsnCys: 0.0 ± 0.0
4.603AsnAsp: 4.603 ± 2.059
4.603AsnGlu: 4.603 ± 2.938
4.603AsnPhe: 4.603 ± 0.545
0.0AsnGly: 0.0 ± 0.0
0.0AsnHis: 0.0 ± 0.0
1.151AsnIle: 1.151 ± 0.734
4.603AsnLys: 4.603 ± 1.58
6.904AsnLeu: 6.904 ± 1.989
0.0AsnMet: 0.0 ± 0.0
3.452AsnAsn: 3.452 ± 2.203
1.151AsnPro: 1.151 ± 1.101
1.151AsnGln: 1.151 ± 1.101
2.301AsnArg: 2.301 ± 1.469
3.452AsnSer: 3.452 ± 1.734
3.452AsnThr: 3.452 ± 2.203
4.603AsnVal: 4.603 ± 1.496
0.0AsnTrp: 0.0 ± 0.0
1.151AsnTyr: 1.151 ± 0.734
0.0AsnXaa: 0.0 ± 0.0
Pro
5.754ProAla: 5.754 ± 3.63
0.0ProCys: 0.0 ± 0.0
2.301ProAsp: 2.301 ± 0.749
1.151ProGlu: 1.151 ± 1.418
3.452ProPhe: 3.452 ± 0.863
1.151ProGly: 1.151 ± 0.734
0.0ProHis: 0.0 ± 0.0
0.0ProIle: 0.0 ± 0.0
3.452ProLys: 3.452 ± 0.995
5.754ProLeu: 5.754 ± 5.505
1.151ProMet: 1.151 ± 1.101
2.301ProAsn: 2.301 ± 0.749
1.151ProPro: 1.151 ± 1.101
4.603ProGln: 4.603 ± 1.58
3.452ProArg: 3.452 ± 1.555
0.0ProSer: 0.0 ± 0.0
6.904ProThr: 6.904 ± 0.204
3.452ProVal: 3.452 ± 2.226
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
1.151GlnAla: 1.151 ± 0.734
1.151GlnCys: 1.151 ± 0.734
1.151GlnAsp: 1.151 ± 1.101
1.151GlnGlu: 1.151 ± 1.101
1.151GlnPhe: 1.151 ± 1.418
2.301GlnGly: 2.301 ± 1.507
1.151GlnHis: 1.151 ± 0.734
5.754GlnIle: 5.754 ± 0.775
3.452GlnLys: 3.452 ± 0.863
2.301GlnLeu: 2.301 ± 2.202
1.151GlnMet: 1.151 ± 0.734
2.301GlnAsn: 2.301 ± 0.749
1.151GlnPro: 1.151 ± 0.734
2.301GlnGln: 2.301 ± 1.469
5.754GlnArg: 5.754 ± 0.964
1.151GlnSer: 1.151 ± 1.101
5.754GlnThr: 5.754 ± 2.254
1.151GlnVal: 1.151 ± 0.734
2.301GlnTrp: 2.301 ± 0.749
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
1.151ArgAla: 1.151 ± 0.734
0.0ArgCys: 0.0 ± 0.0
2.301ArgAsp: 2.301 ± 0.749
1.151ArgGlu: 1.151 ± 0.734
1.151ArgPhe: 1.151 ± 1.101
3.452ArgGly: 3.452 ± 1.555
2.301ArgHis: 2.301 ± 0.749
0.0ArgIle: 0.0 ± 0.0
4.603ArgLys: 4.603 ± 1.496
4.603ArgLeu: 4.603 ± 1.58
1.151ArgMet: 1.151 ± 0.734
3.452ArgAsn: 3.452 ± 2.203
1.151ArgPro: 1.151 ± 1.418
3.452ArgGln: 3.452 ± 0.863
3.452ArgArg: 3.452 ± 2.226
10.357ArgSer: 10.357 ± 2.416
6.904ArgThr: 6.904 ± 0.204
9.206ArgVal: 9.206 ± 1.459
1.151ArgTrp: 1.151 ± 0.734
1.151ArgTyr: 1.151 ± 0.734
0.0ArgXaa: 0.0 ± 0.0
Ser
4.603SerAla: 4.603 ± 0.545
2.301SerCys: 2.301 ± 0.749
4.603SerAsp: 4.603 ± 0.545
2.301SerGlu: 2.301 ± 2.202
0.0SerPhe: 0.0 ± 0.0
10.357SerGly: 10.357 ± 5.648
0.0SerHis: 0.0 ± 0.0
1.151SerIle: 1.151 ± 0.734
4.603SerLys: 4.603 ± 1.58
6.904SerLeu: 6.904 ± 3.535
2.301SerMet: 2.301 ± 2.202
3.452SerAsn: 3.452 ± 1.734
3.452SerPro: 3.452 ± 1.734
6.904SerGln: 6.904 ± 1.824
14.96SerArg: 14.96 ± 0.817
5.754SerSer: 5.754 ± 5.505
1.151SerThr: 1.151 ± 1.101
5.754SerVal: 5.754 ± 2.254
1.151SerTrp: 1.151 ± 1.101
2.301SerTyr: 2.301 ± 0.749
0.0SerXaa: 0.0 ± 0.0
Thr
6.904ThrAla: 6.904 ± 3.335
4.603ThrCys: 4.603 ± 1.496
3.452ThrAsp: 3.452 ± 0.863
2.301ThrGlu: 2.301 ± 1.294
0.0ThrPhe: 0.0 ± 0.0
10.357ThrGly: 10.357 ± 3.823
1.151ThrHis: 1.151 ± 0.734
1.151ThrIle: 1.151 ± 1.418
4.603ThrLys: 4.603 ± 1.58
11.507ThrLeu: 11.507 ± 4.554
1.151ThrMet: 1.151 ± 1.101
2.301ThrAsn: 2.301 ± 1.294
4.603ThrPro: 4.603 ± 1.58
2.301ThrGln: 2.301 ± 1.469
3.452ThrArg: 3.452 ± 2.614
6.904ThrSer: 6.904 ± 4.989
2.301ThrThr: 2.301 ± 1.469
3.452ThrVal: 3.452 ± 2.203
1.151ThrTrp: 1.151 ± 0.734
2.301ThrTyr: 2.301 ± 0.749
0.0ThrXaa: 0.0 ± 0.0
Val
4.603ValAla: 4.603 ± 2.589
1.151ValCys: 1.151 ± 0.734
2.301ValAsp: 2.301 ± 1.294
0.0ValGlu: 0.0 ± 0.0
2.301ValPhe: 2.301 ± 1.294
5.754ValGly: 5.754 ± 2.254
0.0ValHis: 0.0 ± 0.0
4.603ValIle: 4.603 ± 1.496
6.904ValLys: 6.904 ± 3.314
4.603ValLeu: 4.603 ± 1.499
1.151ValMet: 1.151 ± 0.734
2.301ValAsn: 2.301 ± 1.469
3.452ValPro: 3.452 ± 0.995
2.301ValGln: 2.301 ± 0.749
4.603ValArg: 4.603 ± 2.225
5.754ValSer: 5.754 ± 2.254
3.452ValThr: 3.452 ± 3.303
0.0ValVal: 0.0 ± 0.0
1.151ValTrp: 1.151 ± 1.418
2.301ValTyr: 2.301 ± 1.294
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.151TrpAsp: 1.151 ± 1.418
1.151TrpGlu: 1.151 ± 0.734
0.0TrpPhe: 0.0 ± 0.0
1.151TrpGly: 1.151 ± 0.734
0.0TrpHis: 0.0 ± 0.0
2.301TrpIle: 2.301 ± 1.294
0.0TrpLys: 0.0 ± 0.0
1.151TrpLeu: 1.151 ± 1.101
2.301TrpMet: 2.301 ± 1.507
4.603TrpAsn: 4.603 ± 0.545
0.0TrpPro: 0.0 ± 0.0
1.151TrpGln: 1.151 ± 1.418
2.301TrpArg: 2.301 ± 1.294
1.151TrpSer: 1.151 ± 1.101
1.151TrpThr: 1.151 ± 1.101
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.151TyrAla: 1.151 ± 0.734
1.151TyrCys: 1.151 ± 1.101
2.301TyrAsp: 2.301 ± 1.469
4.603TyrGlu: 4.603 ± 0.545
1.151TyrPhe: 1.151 ± 1.101
3.452TyrGly: 3.452 ± 2.203
0.0TyrHis: 0.0 ± 0.0
2.301TyrIle: 2.301 ± 1.294
0.0TyrLys: 0.0 ± 0.0
1.151TyrLeu: 1.151 ± 1.418
1.151TyrMet: 1.151 ± 1.418
3.452TyrAsn: 3.452 ± 2.203
0.0TyrPro: 0.0 ± 0.0
2.301TyrGln: 2.301 ± 1.469
0.0TyrArg: 0.0 ± 0.0
0.0TyrSer: 0.0 ± 0.0
3.452TyrThr: 3.452 ± 0.863
2.301TyrVal: 2.301 ± 2.837
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (870 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski