Amino acid dipepetide frequency for Williamsia sterculiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.636AlaAla: 18.636 ± 0.181	0.83AlaCys: 0.83 ± 0.028	9.328AlaAsp: 9.328 ± 0.101	7.074AlaGlu: 7.074 ± 0.085	3.278AlaPhe: 3.278 ± 0.053	11.462AlaGly: 11.462 ± 0.113	2.58AlaHis: 2.58 ± 0.043	5.105AlaIle: 5.105 ± 0.069	2.419AlaLys: 2.419 ± 0.058	12.146AlaLeu: 12.146 ± 0.1	2.678AlaMet: 2.678 ± 0.05	2.166AlaAsn: 2.166 ± 0.048	5.833AlaPro: 5.833 ± 0.079	3.719AlaGln: 3.719 ± 0.05	8.73AlaArg: 8.73 ± 0.085	5.953AlaSer: 5.953 ± 0.07	7.931AlaThr: 7.931 ± 0.091	12.212AlaVal: 12.212 ± 0.103	1.462AlaTrp: 1.462 ± 0.032	2.188AlaTyr: 2.188 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.993CysAla: 0.993 ± 0.028	0.087CysCys: 0.087 ± 0.008	0.498CysAsp: 0.498 ± 0.023	0.318CysGlu: 0.318 ± 0.017	0.207CysPhe: 0.207 ± 0.013	0.872CysGly: 0.872 ± 0.026	0.177CysHis: 0.177 ± 0.013	0.23CysIle: 0.23 ± 0.015	0.095CysLys: 0.095 ± 0.009	0.618CysLeu: 0.618 ± 0.024	0.125CysMet: 0.125 ± 0.009	0.145CysAsn: 0.145 ± 0.011	0.415CysPro: 0.415 ± 0.017	0.14CysGln: 0.14 ± 0.009	0.529CysArg: 0.529 ± 0.022	0.428CysSer: 0.428 ± 0.016	0.441CysThr: 0.441 ± 0.018	0.634CysVal: 0.634 ± 0.024	0.107CysTrp: 0.107 ± 0.01	0.151CysTyr: 0.151 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.262AspAla: 8.262 ± 0.1	0.412AspCys: 0.412 ± 0.019	5.622AspAsp: 5.622 ± 0.083	4.246AspGlu: 4.246 ± 0.069	1.795AspPhe: 1.795 ± 0.043	6.376AspGly: 6.376 ± 0.075	1.935AspHis: 1.935 ± 0.04	2.635AspIle: 2.635 ± 0.042	1.338AspLys: 1.338 ± 0.033	6.866AspLeu: 6.866 ± 0.087	0.942AspMet: 0.942 ± 0.025	1.271AspAsn: 1.271 ± 0.03	4.787AspPro: 4.787 ± 0.066	1.922AspGln: 1.922 ± 0.041	5.637AspArg: 5.637 ± 0.071	3.117AspSer: 3.117 ± 0.05	3.965AspThr: 3.965 ± 0.058	5.823AspVal: 5.823 ± 0.081	0.943AspTrp: 0.943 ± 0.03	1.309AspTyr: 1.309 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.116GluAla: 5.116 ± 0.072	0.303GluCys: 0.303 ± 0.018	2.087GluAsp: 2.087 ± 0.042	2.131GluGlu: 2.131 ± 0.05	1.685GluPhe: 1.685 ± 0.041	3.009GluGly: 3.009 ± 0.055	1.436GluHis: 1.436 ± 0.032	2.492GluIle: 2.492 ± 0.045	1.24GluLys: 1.24 ± 0.037	6.135GluLeu: 6.135 ± 0.094	0.98GluMet: 0.98 ± 0.028	1.131GluAsn: 1.131 ± 0.032	2.712GluPro: 2.712 ± 0.046	2.009GluGln: 2.009 ± 0.044	4.361GluArg: 4.361 ± 0.061	2.885GluSer: 2.885 ± 0.052	2.688GluThr: 2.688 ± 0.043	4.511GluVal: 4.511 ± 0.076	0.746GluTrp: 0.746 ± 0.028	1.044GluTyr: 1.044 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.841PheAla: 3.841 ± 0.066	0.289PheCys: 0.289 ± 0.015	2.395PheAsp: 2.395 ± 0.052	1.316PheGlu: 1.316 ± 0.033	0.962PhePhe: 0.962 ± 0.03	3.484PheGly: 3.484 ± 0.055	0.605PheHis: 0.605 ± 0.02	1.016PheIle: 1.016 ± 0.03	0.432PheLys: 0.432 ± 0.019	2.445PheLeu: 2.445 ± 0.051	0.412PheMet: 0.412 ± 0.017	0.606PheAsn: 0.606 ± 0.023	1.337PhePro: 1.337 ± 0.029	0.604PheGln: 0.604 ± 0.022	1.774PheArg: 1.774 ± 0.034	1.607PheSer: 1.607 ± 0.035	2.154PheThr: 2.154 ± 0.044	2.683PheVal: 2.683 ± 0.056	0.42PheTrp: 0.42 ± 0.019	0.656PheTyr: 0.656 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.287GlyAla: 10.287 ± 0.11	0.764GlyCys: 0.764 ± 0.026	5.762GlyAsp: 5.762 ± 0.068	4.316GlyGlu: 4.316 ± 0.056	3.064GlyPhe: 3.064 ± 0.049	8.037GlyGly: 8.037 ± 0.136	2.068GlyHis: 2.068 ± 0.04	3.969GlyIle: 3.969 ± 0.062	2.114GlyLys: 2.114 ± 0.041	8.661GlyLeu: 8.661 ± 0.094	2.036GlyMet: 2.036 ± 0.04	1.807GlyAsn: 1.807 ± 0.041	4.321GlyPro: 4.321 ± 0.058	2.636GlyGln: 2.636 ± 0.061	6.835GlyArg: 6.835 ± 0.078	5.777GlySer: 5.777 ± 0.074	5.703GlyThr: 5.703 ± 0.076	8.42GlyVal: 8.42 ± 0.102	1.636GlyTrp: 1.636 ± 0.038	2.304GlyTyr: 2.304 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.323HisAla: 2.323 ± 0.043	0.177HisCys: 0.177 ± 0.011	1.642HisAsp: 1.642 ± 0.034	1.053HisGlu: 1.053 ± 0.029	0.609HisPhe: 0.609 ± 0.022	2.136HisGly: 2.136 ± 0.042	0.788HisHis: 0.788 ± 0.028	0.823HisIle: 0.823 ± 0.023	0.302HisLys: 0.302 ± 0.015	2.216HisLeu: 2.216 ± 0.043	0.342HisMet: 0.342 ± 0.016	0.463HisAsn: 0.463 ± 0.02	1.753HisPro: 1.753 ± 0.037	0.655HisGln: 0.655 ± 0.024	2.116HisArg: 2.116 ± 0.042	1.068HisSer: 1.068 ± 0.028	1.289HisThr: 1.289 ± 0.032	1.711HisVal: 1.711 ± 0.03	0.335HisTrp: 0.335 ± 0.017	0.462HisTyr: 0.462 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.376IleAla: 6.376 ± 0.076	0.399IleCys: 0.399 ± 0.021	3.545IleAsp: 3.545 ± 0.057	2.246IleGlu: 2.246 ± 0.051	1.007IlePhe: 1.007 ± 0.028	4.644IleGly: 4.644 ± 0.064	0.694IleHis: 0.694 ± 0.02	1.531IleIle: 1.531 ± 0.04	0.7IleLys: 0.7 ± 0.023	3.094IleLeu: 3.094 ± 0.049	0.545IleMet: 0.545 ± 0.02	0.99IleAsn: 0.99 ± 0.028	2.335IlePro: 2.335 ± 0.041	0.757IleGln: 0.757 ± 0.025	2.829IleArg: 2.829 ± 0.049	2.366IleSer: 2.366 ± 0.044	3.019IleThr: 3.019 ± 0.05	3.847IleVal: 3.847 ± 0.052	0.483IleTrp: 0.483 ± 0.018	0.714IleTyr: 0.714 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.223LysAla: 2.223 ± 0.049	0.087LysCys: 0.087 ± 0.007	1.008LysAsp: 1.008 ± 0.028	0.784LysGlu: 0.784 ± 0.027	0.521LysPhe: 0.521 ± 0.023	1.427LysGly: 1.427 ± 0.029	0.378LysHis: 0.378 ± 0.018	0.94LysIle: 0.94 ± 0.032	0.749LysLys: 0.749 ± 0.035	1.801LysLeu: 1.801 ± 0.039	0.362LysMet: 0.362 ± 0.015	0.526LysAsn: 0.526 ± 0.024	1.151LysPro: 1.151 ± 0.026	0.697LysGln: 0.697 ± 0.027	1.367LysArg: 1.367 ± 0.04	1.219LysSer: 1.219 ± 0.035	1.283LysThr: 1.283 ± 0.035	1.754LysVal: 1.754 ± 0.038	0.25LysTrp: 0.25 ± 0.014	0.447LysTyr: 0.447 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	12.814LeuAla: 12.814 ± 0.118	0.787LeuCys: 0.787 ± 0.027	6.934LeuAsp: 6.934 ± 0.089	3.835LeuGlu: 3.835 ± 0.06	2.595LeuPhe: 2.595 ± 0.05	8.649LeuGly: 8.649 ± 0.112	2.055LeuHis: 2.055 ± 0.039	4.287LeuIle: 4.287 ± 0.065	1.471LeuLys: 1.471 ± 0.037	9.43LeuLeu: 9.43 ± 0.116	1.626LeuMet: 1.626 ± 0.037	1.832LeuAsn: 1.832 ± 0.04	5.338LeuPro: 5.338 ± 0.071	2.539LeuGln: 2.539 ± 0.045	7.831LeuArg: 7.831 ± 0.087	5.717LeuSer: 5.717 ± 0.066	6.563LeuThr: 6.563 ± 0.072	8.665LeuVal: 8.665 ± 0.094	1.169LeuTrp: 1.169 ± 0.03	1.587LeuTyr: 1.587 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.241MetAla: 2.241 ± 0.046	0.148MetCys: 0.148 ± 0.01	0.87MetAsp: 0.87 ± 0.027	0.589MetGlu: 0.589 ± 0.021	0.612MetPhe: 0.612 ± 0.025	1.377MetGly: 1.377 ± 0.038	0.35MetHis: 0.35 ± 0.016	0.883MetIle: 0.883 ± 0.028	0.369MetLys: 0.369 ± 0.017	1.726MetLeu: 1.726 ± 0.045	0.37MetMet: 0.37 ± 0.017	0.507MetAsn: 0.507 ± 0.02	1.102MetPro: 1.102 ± 0.027	0.509MetGln: 0.509 ± 0.021	1.483MetArg: 1.483 ± 0.033	1.677MetSer: 1.677 ± 0.034	1.92MetThr: 1.92 ± 0.038	1.698MetVal: 1.698 ± 0.036	0.246MetTrp: 0.246 ± 0.013	0.339MetTyr: 0.339 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.378AsnAla: 2.378 ± 0.042	0.162AsnCys: 0.162 ± 0.011	1.163AsnAsp: 1.163 ± 0.028	0.879AsnGlu: 0.879 ± 0.025	0.509AsnPhe: 0.509 ± 0.019	2.04AsnGly: 2.04 ± 0.048	0.418AsnHis: 0.418 ± 0.018	0.846AsnIle: 0.846 ± 0.029	0.423AsnLys: 0.423 ± 0.02	1.894AsnLeu: 1.894 ± 0.036	0.333AsnMet: 0.333 ± 0.017	0.549AsnAsn: 0.549 ± 0.022	1.607AsnPro: 1.607 ± 0.033	0.578AsnGln: 0.578 ± 0.024	1.536AsnArg: 1.536 ± 0.035	1.148AsnSer: 1.148 ± 0.031	1.325AsnThr: 1.325 ± 0.033	1.663AsnVal: 1.663 ± 0.04	0.314AsnTrp: 0.314 ± 0.014	0.48AsnTyr: 0.48 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.663ProAla: 6.663 ± 0.075	0.239ProCys: 0.239 ± 0.014	4.853ProAsp: 4.853 ± 0.078	3.216ProGlu: 3.216 ± 0.063	1.498ProPhe: 1.498 ± 0.037	5.451ProGly: 5.451 ± 0.065	1.245ProHis: 1.245 ± 0.037	2.057ProIle: 2.057 ± 0.041	0.982ProLys: 0.982 ± 0.033	4.407ProLeu: 4.407 ± 0.063	1.045ProMet: 1.045 ± 0.027	1.078ProAsn: 1.078 ± 0.026	2.931ProPro: 2.931 ± 0.058	1.714ProGln: 1.714 ± 0.039	3.715ProArg: 3.715 ± 0.061	3.172ProSer: 3.172 ± 0.051	4.037ProThr: 4.037 ± 0.061	5.233ProVal: 5.233 ± 0.071	0.764ProTrp: 0.764 ± 0.025	1.043ProTyr: 1.043 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.137GlnAla: 3.137 ± 0.047	0.182GlnCys: 0.182 ± 0.012	1.157GlnAsp: 1.157 ± 0.029	0.973GlnGlu: 0.973 ± 0.027	0.92GlnPhe: 0.92 ± 0.025	2.063GlnGly: 2.063 ± 0.048	0.644GlnHis: 0.644 ± 0.023	1.482GlnIle: 1.482 ± 0.037	0.612GlnLys: 0.612 ± 0.026	3.193GlnLeu: 3.193 ± 0.053	0.583GlnMet: 0.583 ± 0.022	0.638GlnAsn: 0.638 ± 0.025	1.564GlnPro: 1.564 ± 0.04	1.347GlnGln: 1.347 ± 0.039	2.686GlnArg: 2.686 ± 0.05	1.628GlnSer: 1.628 ± 0.036	1.733GlnThr: 1.733 ± 0.043	2.671GlnVal: 2.671 ± 0.046	0.495GlnTrp: 0.495 ± 0.02	0.639GlnTyr: 0.639 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.462ArgAla: 8.462 ± 0.086	0.591ArgCys: 0.591 ± 0.023	5.073ArgAsp: 5.073 ± 0.066	3.935ArgGlu: 3.935 ± 0.057	2.447ArgPhe: 2.447 ± 0.045	5.666ArgGly: 5.666 ± 0.072	1.893ArgHis: 1.893 ± 0.046	3.499ArgIle: 3.499 ± 0.055	1.399ArgLys: 1.399 ± 0.035	7.376ArgLeu: 7.376 ± 0.081	1.895ArgMet: 1.895 ± 0.043	1.563ArgAsn: 1.563 ± 0.035	4.305ArgPro: 4.305 ± 0.061	2.149ArgGln: 2.149 ± 0.041	7.45ArgArg: 7.45 ± 0.102	4.739ArgSer: 4.739 ± 0.06	4.89ArgThr: 4.89 ± 0.056	6.24ArgVal: 6.24 ± 0.071	1.465ArgTrp: 1.465 ± 0.032	1.76ArgTyr: 1.76 ± 0.042	0.001ArgXaa: 0.001 ± 0.001
Ser	7.308SerAla: 7.308 ± 0.074	0.356SerCys: 0.356 ± 0.016	3.734SerAsp: 3.734 ± 0.058	2.509SerGlu: 2.509 ± 0.045	1.592SerPhe: 1.592 ± 0.039	6.234SerGly: 6.234 ± 0.085	1.028SerHis: 1.028 ± 0.034	2.16SerIle: 2.16 ± 0.048	1.052SerLys: 1.052 ± 0.035	4.976SerLeu: 4.976 ± 0.064	1.355SerMet: 1.355 ± 0.031	1.084SerAsn: 1.084 ± 0.032	3.173SerPro: 3.173 ± 0.046	1.498SerGln: 1.498 ± 0.039	4.082SerArg: 4.082 ± 0.057	3.669SerSer: 3.669 ± 0.069	4.205SerThr: 4.205 ± 0.063	5.244SerVal: 5.244 ± 0.071	0.921SerTrp: 0.921 ± 0.026	1.143SerTyr: 1.143 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	8.801ThrAla: 8.801 ± 0.085	0.369ThrCys: 0.369 ± 0.019	4.671ThrAsp: 4.671 ± 0.072	3.235ThrGlu: 3.235 ± 0.051	1.829ThrPhe: 1.829 ± 0.042	6.478ThrGly: 6.478 ± 0.07	1.342ThrHis: 1.342 ± 0.032	2.686ThrIle: 2.686 ± 0.044	1.162ThrLys: 1.162 ± 0.032	5.813ThrLeu: 5.813 ± 0.078	1.15ThrMet: 1.15 ± 0.033	1.143ThrAsn: 1.143 ± 0.029	4.243ThrPro: 4.243 ± 0.07	1.49ThrGln: 1.49 ± 0.038	4.319ThrArg: 4.319 ± 0.051	3.786ThrSer: 3.786 ± 0.058	4.824ThrThr: 4.824 ± 0.091	6.908ThrVal: 6.908 ± 0.089	0.823ThrTrp: 0.823 ± 0.03	1.258ThrTyr: 1.258 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	12.193ValAla: 12.193 ± 0.115	0.722ValCys: 0.722 ± 0.026	6.789ValAsp: 6.789 ± 0.098	4.444ValGlu: 4.444 ± 0.068	2.677ValPhe: 2.677 ± 0.054	8.148ValGly: 8.148 ± 0.095	1.894ValHis: 1.894 ± 0.037	4.255ValIle: 4.255 ± 0.059	1.433ValLys: 1.433 ± 0.036	9.161ValLeu: 9.161 ± 0.098	1.648ValMet: 1.648 ± 0.035	1.885ValAsn: 1.885 ± 0.034	4.642ValPro: 4.642 ± 0.067	2.193ValGln: 2.193 ± 0.049	6.429ValArg: 6.429 ± 0.079	5.208ValSer: 5.208 ± 0.062	6.297ValThr: 6.297 ± 0.078	10.135ValVal: 10.135 ± 0.099	1.122ValTrp: 1.122 ± 0.033	1.586ValTyr: 1.586 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.435TrpAla: 1.435 ± 0.034	0.137TrpCys: 0.137 ± 0.01	0.777TrpAsp: 0.777 ± 0.025	0.65TrpGlu: 0.65 ± 0.023	0.553TrpPhe: 0.553 ± 0.022	1.008TrpGly: 1.008 ± 0.029	0.328TrpHis: 0.328 ± 0.016	0.62TrpIle: 0.62 ± 0.021	0.32TrpLys: 0.32 ± 0.015	1.562TrpLeu: 1.562 ± 0.033	0.344TrpMet: 0.344 ± 0.018	0.391TrpAsn: 0.391 ± 0.016	0.697TrpPro: 0.697 ± 0.022	0.564TrpGln: 0.564 ± 0.023	1.231TrpArg: 1.231 ± 0.031	1.022TrpSer: 1.022 ± 0.027	0.908TrpThr: 0.908 ± 0.027	1.188TrpVal: 1.188 ± 0.029	0.383TrpTrp: 0.383 ± 0.019	0.298TrpTyr: 0.298 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.242TyrAla: 2.242 ± 0.042	0.17TyrCys: 0.17 ± 0.012	1.293TyrAsp: 1.293 ± 0.039	0.955TyrGlu: 0.955 ± 0.031	0.68TyrPhe: 0.68 ± 0.027	1.958TyrGly: 1.958 ± 0.043	0.406TyrHis: 0.406 ± 0.015	0.604TyrIle: 0.604 ± 0.024	0.361TyrLys: 0.361 ± 0.019	2.201TyrLeu: 2.201 ± 0.045	0.245TyrMet: 0.245 ± 0.014	0.471TyrAsn: 0.471 ± 0.022	1.096TyrPro: 1.096 ± 0.031	0.628TyrGln: 0.628 ± 0.023	1.858TyrArg: 1.858 ± 0.039	1.134TyrSer: 1.134 ± 0.031	1.155TyrThr: 1.155 ± 0.032	1.621TyrVal: 1.621 ± 0.036	0.332TyrTrp: 0.332 ± 0.015	0.431TyrTyr: 0.431 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.002

Statistics based on 4105 proteins (1340898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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