Amino acid dipepetide frequency for Helicoverpa armigera (Cotton bollworm) (Heliothis armigera)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.88AlaAla: 7.88 ± 0.095	1.45AlaCys: 1.45 ± 0.026	3.666AlaAsp: 3.666 ± 0.032	4.424AlaGlu: 4.424 ± 0.055	2.315AlaPhe: 2.315 ± 0.026	4.411AlaGly: 4.411 ± 0.06	1.815AlaHis: 1.815 ± 0.026	3.313AlaIle: 3.313 ± 0.039	3.807AlaLys: 3.807 ± 0.042	6.957AlaLeu: 6.957 ± 0.066	1.598AlaMet: 1.598 ± 0.024	2.664AlaAsn: 2.664 ± 0.033	4.494AlaPro: 4.494 ± 0.066	2.625AlaGln: 2.625 ± 0.035	4.399AlaArg: 4.399 ± 0.052	5.138AlaSer: 5.138 ± 0.044	4.026AlaThr: 4.026 ± 0.047	4.913AlaVal: 4.913 ± 0.042	0.784AlaTrp: 0.784 ± 0.018	1.92AlaTyr: 1.92 ± 0.027	0.012AlaXaa: 0.012 ± 0.002
Cys	1.485CysAla: 1.485 ± 0.028	0.509CysCys: 0.509 ± 0.018	1.18CysAsp: 1.18 ± 0.03	1.191CysGlu: 1.191 ± 0.029	0.741CysPhe: 0.741 ± 0.018	1.427CysGly: 1.427 ± 0.03	0.504CysHis: 0.504 ± 0.013	1.037CysIle: 1.037 ± 0.022	1.083CysLys: 1.083 ± 0.023	1.798CysLeu: 1.798 ± 0.024	0.423CysMet: 0.423 ± 0.011	0.863CysAsn: 0.863 ± 0.018	1.063CysPro: 1.063 ± 0.033	0.685CysGln: 0.685 ± 0.016	1.207CysArg: 1.207 ± 0.027	1.552CysSer: 1.552 ± 0.03	1.099CysThr: 1.099 ± 0.023	1.467CysVal: 1.467 ± 0.031	0.24CysTrp: 0.24 ± 0.009	0.614CysTyr: 0.614 ± 0.019	0.001CysXaa: 0.001 ± 0.001
Asp	3.755AspAla: 3.755 ± 0.04	1.072AspCys: 1.072 ± 0.024	4.167AspAsp: 4.167 ± 0.07	4.224AspGlu: 4.224 ± 0.061	2.12AspPhe: 2.12 ± 0.03	3.172AspGly: 3.172 ± 0.045	1.183AspHis: 1.183 ± 0.02	3.364AspIle: 3.364 ± 0.035	3.627AspLys: 3.627 ± 0.048	4.744AspLeu: 4.744 ± 0.04	1.342AspMet: 1.342 ± 0.022	2.753AspAsn: 2.753 ± 0.04	2.545AspPro: 2.545 ± 0.045	1.662AspGln: 1.662 ± 0.024	2.767AspArg: 2.767 ± 0.042	4.247AspSer: 4.247 ± 0.047	3.16AspThr: 3.16 ± 0.034	3.848AspVal: 3.848 ± 0.033	0.647AspTrp: 0.647 ± 0.014	1.856AspTyr: 1.856 ± 0.026	0.002AspXaa: 0.002 ± 0.001
Glu	4.383GluAla: 4.383 ± 0.047	1.208GluCys: 1.208 ± 0.032	4.005GluAsp: 4.005 ± 0.046	5.646GluGlu: 5.646 ± 0.076	2.077GluPhe: 2.077 ± 0.028	3.074GluGly: 3.074 ± 0.038	1.57GluHis: 1.57 ± 0.024	3.592GluIle: 3.592 ± 0.046	4.84GluLys: 4.84 ± 0.087	5.907GluLeu: 5.907 ± 0.067	1.555GluMet: 1.555 ± 0.027	3.371GluAsn: 3.371 ± 0.038	3.192GluPro: 3.192 ± 0.049	2.559GluGln: 2.559 ± 0.042	4.019GluArg: 4.019 ± 0.055	4.237GluSer: 4.237 ± 0.051	3.658GluThr: 3.658 ± 0.05	3.975GluVal: 3.975 ± 0.041	0.701GluTrp: 0.701 ± 0.019	2.025GluTyr: 2.025 ± 0.029	0.001GluXaa: 0.001 ± 0.0
Phe	2.181PheAla: 2.181 ± 0.031	0.754PheCys: 0.754 ± 0.016	2.071PheAsp: 2.071 ± 0.022	2.092PheGlu: 2.092 ± 0.028	1.429PhePhe: 1.429 ± 0.025	2.322PheGly: 2.322 ± 0.034	0.873PheHis: 0.873 ± 0.018	2.096PheIle: 2.096 ± 0.032	2.158PheLys: 2.158 ± 0.027	3.226PheLeu: 3.226 ± 0.042	0.848PheMet: 0.848 ± 0.016	1.781PheAsn: 1.781 ± 0.025	1.583PhePro: 1.583 ± 0.025	1.277PheGln: 1.277 ± 0.021	1.85PheArg: 1.85 ± 0.028	2.646PheSer: 2.646 ± 0.033	2.152PheThr: 2.152 ± 0.027	2.388PheVal: 2.388 ± 0.028	0.427PheTrp: 0.427 ± 0.011	1.344PheTyr: 1.344 ± 0.023	0.001PheXaa: 0.001 ± 0.0
Gly	4.39GlyAla: 4.39 ± 0.065	1.078GlyCys: 1.078 ± 0.026	3.109GlyAsp: 3.109 ± 0.046	3.091GlyGlu: 3.091 ± 0.044	2.115GlyPhe: 2.115 ± 0.034	4.631GlyGly: 4.631 ± 0.128	1.477GlyHis: 1.477 ± 0.031	2.637GlyIle: 2.637 ± 0.037	3.107GlyLys: 3.107 ± 0.039	4.528GlyLeu: 4.528 ± 0.052	1.155GlyMet: 1.155 ± 0.02	2.332GlyAsn: 2.332 ± 0.037	2.638GlyPro: 2.638 ± 0.062	1.96GlyGln: 1.96 ± 0.033	3.198GlyArg: 3.198 ± 0.043	4.386GlySer: 4.386 ± 0.067	3.044GlyThr: 3.044 ± 0.035	3.766GlyVal: 3.766 ± 0.04	0.726GlyTrp: 0.726 ± 0.017	2.072GlyTyr: 2.072 ± 0.039	0.006GlyXaa: 0.006 ± 0.001
His	1.756HisAla: 1.756 ± 0.03	0.565HisCys: 0.565 ± 0.014	1.269HisAsp: 1.269 ± 0.024	1.369HisGlu: 1.369 ± 0.022	0.963HisPhe: 0.963 ± 0.017	1.379HisGly: 1.379 ± 0.028	1.04HisHis: 1.04 ± 0.034	1.338HisIle: 1.338 ± 0.018	1.43HisLys: 1.43 ± 0.017	2.267HisLeu: 2.267 ± 0.025	0.636HisMet: 0.636 ± 0.014	1.146HisAsn: 1.146 ± 0.02	1.365HisPro: 1.365 ± 0.025	0.938HisGln: 0.938 ± 0.02	1.481HisArg: 1.481 ± 0.021	1.91HisSer: 1.91 ± 0.029	1.433HisThr: 1.433 ± 0.019	1.622HisVal: 1.622 ± 0.022	0.303HisTrp: 0.303 ± 0.01	0.949HisTyr: 0.949 ± 0.019	0.002HisXaa: 0.002 ± 0.001
Ile	3.419IleAla: 3.419 ± 0.039	1.109IleCys: 1.109 ± 0.022	3.06IleAsp: 3.06 ± 0.032	3.399IleGlu: 3.399 ± 0.04	2.052IlePhe: 2.052 ± 0.03	2.588IleGly: 2.588 ± 0.034	1.214IleHis: 1.214 ± 0.019	3.068IleIle: 3.068 ± 0.037	3.524IleLys: 3.524 ± 0.04	4.684IleLeu: 4.684 ± 0.05	1.202IleMet: 1.202 ± 0.022	2.6IleAsn: 2.6 ± 0.029	2.653IlePro: 2.653 ± 0.034	1.973IleGln: 1.973 ± 0.027	2.533IleArg: 2.533 ± 0.031	3.932IleSer: 3.932 ± 0.04	3.222IleThr: 3.222 ± 0.042	3.479IleVal: 3.479 ± 0.034	0.522IleTrp: 0.522 ± 0.014	1.716IleTyr: 1.716 ± 0.025	0.001IleXaa: 0.001 ± 0.0
Lys	3.659LysAla: 3.659 ± 0.039	1.209LysCys: 1.209 ± 0.023	3.566LysAsp: 3.566 ± 0.046	4.721LysGlu: 4.721 ± 0.065	2.035LysPhe: 2.035 ± 0.024	2.637LysGly: 2.637 ± 0.046	1.597LysHis: 1.597 ± 0.028	3.6LysIle: 3.6 ± 0.037	5.434LysLys: 5.434 ± 0.08	5.568LysLeu: 5.568 ± 0.054	1.562LysMet: 1.562 ± 0.023	3.152LysAsn: 3.152 ± 0.036	3.514LysPro: 3.514 ± 0.061	2.521LysGln: 2.521 ± 0.031	3.66LysArg: 3.66 ± 0.037	4.48LysSer: 4.48 ± 0.06	3.751LysThr: 3.751 ± 0.049	3.752LysVal: 3.752 ± 0.04	0.632LysTrp: 0.632 ± 0.015	2.235LysTyr: 2.235 ± 0.031	0.002LysXaa: 0.002 ± 0.001
Leu	6.757LeuAla: 6.757 ± 0.066	1.914LeuCys: 1.914 ± 0.026	4.802LeuAsp: 4.802 ± 0.046	5.707LeuGlu: 5.707 ± 0.07	3.142LeuPhe: 3.142 ± 0.033	4.457LeuGly: 4.457 ± 0.04	2.374LeuHis: 2.374 ± 0.029	4.175LeuIle: 4.175 ± 0.044	5.784LeuLys: 5.784 ± 0.047	8.861LeuLeu: 8.861 ± 0.086	2.035LeuMet: 2.035 ± 0.027	4.051LeuAsn: 4.051 ± 0.039	4.94LeuPro: 4.94 ± 0.046	4.063LeuGln: 4.063 ± 0.045	5.473LeuArg: 5.473 ± 0.047	6.737LeuSer: 6.737 ± 0.049	5.019LeuThr: 5.019 ± 0.042	5.522LeuVal: 5.522 ± 0.049	0.943LeuTrp: 0.943 ± 0.02	2.689LeuTyr: 2.689 ± 0.029	0.005LeuXaa: 0.005 ± 0.001
Met	1.701MetAla: 1.701 ± 0.025	0.46MetCys: 0.46 ± 0.012	1.261MetAsp: 1.261 ± 0.019	1.522MetGlu: 1.522 ± 0.019	0.956MetPhe: 0.956 ± 0.019	1.145MetGly: 1.145 ± 0.024	0.522MetHis: 0.522 ± 0.011	1.062MetIle: 1.062 ± 0.02	1.546MetLys: 1.546 ± 0.022	2.116MetLeu: 2.116 ± 0.026	0.661MetMet: 0.661 ± 0.015	1.034MetAsn: 1.034 ± 0.021	1.143MetPro: 1.143 ± 0.022	0.918MetGln: 0.918 ± 0.019	1.283MetArg: 1.283 ± 0.021	1.877MetSer: 1.877 ± 0.027	1.3MetThr: 1.3 ± 0.018	1.332MetVal: 1.332 ± 0.021	0.268MetTrp: 0.268 ± 0.009	0.785MetTyr: 0.785 ± 0.015	0.001MetXaa: 0.001 ± 0.0
Asn	2.789AsnAla: 2.789 ± 0.036	0.862AsnCys: 0.862 ± 0.019	2.555AsnAsp: 2.555 ± 0.033	3.012AsnGlu: 3.012 ± 0.03	1.797AsnPhe: 1.797 ± 0.026	2.644AsnGly: 2.644 ± 0.045	0.933AsnHis: 0.933 ± 0.018	3.102AsnIle: 3.102 ± 0.031	3.201AsnLys: 3.201 ± 0.033	4.0AsnLeu: 4.0 ± 0.046	1.23AsnMet: 1.23 ± 0.021	2.854AsnAsn: 2.854 ± 0.048	2.139AsnPro: 2.139 ± 0.026	1.717AsnGln: 1.717 ± 0.033	2.151AsnArg: 2.151 ± 0.026	3.383AsnSer: 3.383 ± 0.038	2.775AsnThr: 2.775 ± 0.035	3.198AsnVal: 3.198 ± 0.034	0.476AsnTrp: 0.476 ± 0.012	1.68AsnTyr: 1.68 ± 0.027	0.001AsnXaa: 0.001 ± 0.001
Pro	4.556ProAla: 4.556 ± 0.056	0.842ProCys: 0.842 ± 0.024	3.023ProAsp: 3.023 ± 0.039	3.782ProGlu: 3.782 ± 0.046	1.621ProPhe: 1.621 ± 0.026	3.078ProGly: 3.078 ± 0.081	1.441ProHis: 1.441 ± 0.025	2.454ProIle: 2.454 ± 0.033	3.247ProLys: 3.247 ± 0.054	4.412ProLeu: 4.412 ± 0.04	1.021ProMet: 1.021 ± 0.022	2.224ProAsn: 2.224 ± 0.029	5.073ProPro: 5.073 ± 0.085	2.255ProGln: 2.255 ± 0.034	3.075ProArg: 3.075 ± 0.045	4.266ProSer: 4.266 ± 0.056	3.346ProThr: 3.346 ± 0.045	3.777ProVal: 3.777 ± 0.051	0.509ProTrp: 0.509 ± 0.013	1.602ProTyr: 1.602 ± 0.028	0.004ProXaa: 0.004 ± 0.001
Gln	2.591GlnAla: 2.591 ± 0.032	0.793GlnCys: 0.793 ± 0.02	1.852GlnAsp: 1.852 ± 0.027	2.541GlnGlu: 2.541 ± 0.039	1.355GlnPhe: 1.355 ± 0.024	1.853GlnGly: 1.853 ± 0.043	1.097GlnHis: 1.097 ± 0.019	2.01GlnIle: 2.01 ± 0.028	2.405GlnLys: 2.405 ± 0.029	3.675GlnLeu: 3.675 ± 0.043	0.968GlnMet: 0.968 ± 0.019	2.006GlnAsn: 2.006 ± 0.032	2.225GlnPro: 2.225 ± 0.038	2.309GlnGln: 2.309 ± 0.073	2.351GlnArg: 2.351 ± 0.031	2.607GlnSer: 2.607 ± 0.037	2.115GlnThr: 2.115 ± 0.034	2.235GlnVal: 2.235 ± 0.028	0.446GlnTrp: 0.446 ± 0.012	1.358GlnTyr: 1.358 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.418ArgAla: 4.418 ± 0.05	1.241ArgCys: 1.241 ± 0.038	3.125ArgAsp: 3.125 ± 0.038	3.514ArgGlu: 3.514 ± 0.048	1.841ArgPhe: 1.841 ± 0.024	3.167ArgGly: 3.167 ± 0.042	1.718ArgHis: 1.718 ± 0.024	2.668ArgIle: 2.668 ± 0.028	3.59ArgLys: 3.59 ± 0.041	5.195ArgLeu: 5.195 ± 0.047	1.238ArgMet: 1.238 ± 0.023	2.525ArgAsn: 2.525 ± 0.035	3.134ArgPro: 3.134 ± 0.049	2.237ArgGln: 2.237 ± 0.028	4.912ArgArg: 4.912 ± 0.061	4.249ArgSer: 4.249 ± 0.058	2.902ArgThr: 2.902 ± 0.03	3.411ArgVal: 3.411 ± 0.029	0.716ArgTrp: 0.716 ± 0.014	1.755ArgTyr: 1.755 ± 0.023	0.006ArgXaa: 0.006 ± 0.001
Ser	5.236SerAla: 5.236 ± 0.046	1.436SerCys: 1.436 ± 0.027	4.399SerAsp: 4.399 ± 0.049	4.836SerGlu: 4.836 ± 0.05	2.564SerPhe: 2.564 ± 0.031	4.552SerGly: 4.552 ± 0.055	1.723SerHis: 1.723 ± 0.027	3.7SerIle: 3.7 ± 0.033	4.48SerLys: 4.48 ± 0.052	6.419SerLeu: 6.419 ± 0.051	1.598SerMet: 1.598 ± 0.02	3.425SerAsn: 3.425 ± 0.046	4.586SerPro: 4.586 ± 0.077	2.802SerGln: 2.802 ± 0.043	4.148SerArg: 4.148 ± 0.054	7.241SerSer: 7.241 ± 0.099	4.665SerThr: 4.665 ± 0.054	4.761SerVal: 4.761 ± 0.038	0.803SerTrp: 0.803 ± 0.017	2.283SerTyr: 2.283 ± 0.032	0.005SerXaa: 0.005 ± 0.001
Thr	4.208ThrAla: 4.208 ± 0.044	1.18ThrCys: 1.18 ± 0.026	3.179ThrAsp: 3.179 ± 0.039	3.853ThrGlu: 3.853 ± 0.066	2.103ThrPhe: 2.103 ± 0.026	3.09ThrGly: 3.09 ± 0.046	1.371ThrHis: 1.371 ± 0.021	3.06ThrIle: 3.06 ± 0.035	3.418ThrLys: 3.418 ± 0.037	5.084ThrLeu: 5.084 ± 0.05	1.307ThrMet: 1.307 ± 0.022	2.672ThrAsn: 2.672 ± 0.036	3.75ThrPro: 3.75 ± 0.04	2.142ThrGln: 2.142 ± 0.032	2.842ThrArg: 2.842 ± 0.037	4.706ThrSer: 4.706 ± 0.052	4.171ThrThr: 4.171 ± 0.098	3.983ThrVal: 3.983 ± 0.035	0.661ThrTrp: 0.661 ± 0.016	1.81ThrTyr: 1.81 ± 0.024	0.002ThrXaa: 0.002 ± 0.001
Val	4.746ValAla: 4.746 ± 0.042	1.499ValCys: 1.499 ± 0.032	3.511ValAsp: 3.511 ± 0.036	4.063ValGlu: 4.063 ± 0.045	2.442ValPhe: 2.442 ± 0.034	3.186ValGly: 3.186 ± 0.038	1.588ValHis: 1.588 ± 0.028	3.381ValIle: 3.381 ± 0.04	3.999ValLys: 3.999 ± 0.048	5.993ValLeu: 5.993 ± 0.05	1.427ValMet: 1.427 ± 0.021	2.877ValAsn: 2.877 ± 0.032	3.586ValPro: 3.586 ± 0.042	2.489ValGln: 2.489 ± 0.028	3.529ValArg: 3.529 ± 0.036	4.768ValSer: 4.768 ± 0.04	4.244ValThr: 4.244 ± 0.051	4.564ValVal: 4.564 ± 0.042	0.762ValTrp: 0.762 ± 0.017	2.035ValTyr: 2.035 ± 0.027	0.005ValXaa: 0.005 ± 0.001
Trp	0.72TrpAla: 0.72 ± 0.016	0.249TrpCys: 0.249 ± 0.01	0.603TrpAsp: 0.603 ± 0.015	0.62TrpGlu: 0.62 ± 0.015	0.438TrpPhe: 0.438 ± 0.012	0.642TrpGly: 0.642 ± 0.014	0.265TrpHis: 0.265 ± 0.009	0.549TrpIle: 0.549 ± 0.015	0.678TrpLys: 0.678 ± 0.019	1.156TrpLeu: 1.156 ± 0.024	0.29TrpMet: 0.29 ± 0.008	0.511TrpAsn: 0.511 ± 0.014	0.474TrpPro: 0.474 ± 0.013	0.44TrpGln: 0.44 ± 0.013	0.862TrpArg: 0.862 ± 0.022	0.843TrpSer: 0.843 ± 0.017	0.622TrpThr: 0.622 ± 0.014	0.647TrpVal: 0.647 ± 0.016	0.22TrpTrp: 0.22 ± 0.009	0.376TrpTyr: 0.376 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.97TyrAla: 1.97 ± 0.029	0.736TyrCys: 0.736 ± 0.019	1.852TyrAsp: 1.852 ± 0.026	1.987TyrGlu: 1.987 ± 0.026	1.394TyrPhe: 1.394 ± 0.023	1.987TyrGly: 1.987 ± 0.034	0.856TyrHis: 0.856 ± 0.019	1.745TyrIle: 1.745 ± 0.028	1.93TyrLys: 1.93 ± 0.024	2.852TyrLeu: 2.852 ± 0.033	0.796TyrMet: 0.796 ± 0.017	1.657TyrAsn: 1.657 ± 0.023	1.506TyrPro: 1.506 ± 0.029	1.22TyrGln: 1.22 ± 0.023	1.815TyrArg: 1.815 ± 0.023	2.449TyrSer: 2.449 ± 0.031	1.884TyrThr: 1.884 ± 0.028	2.049TyrVal: 2.049 ± 0.024	0.417TyrTrp: 0.417 ± 0.016	1.321TyrTyr: 1.321 ± 0.025	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.011XaaAla: 0.011 ± 0.002	0.002XaaCys: 0.002 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.004XaaGly: 0.004 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.002XaaIle: 0.002 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.005XaaLeu: 0.005 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.006XaaArg: 0.006 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.002XaaThr: 0.002 ± 0.001	0.004XaaVal: 0.004 ± 0.001	0.002XaaTrp: 0.002 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.585XaaXaa: 0.585 ± 0.093

Statistics based on 8765 proteins (3708793 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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