Amino acid dipepetide frequency for Quezon virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.697AlaAla: 2.697 ± 0.869
2.157AlaCys: 2.157 ± 0.65
3.506AlaAsp: 3.506 ± 1.143
2.967AlaGlu: 2.967 ± 1.589
1.888AlaPhe: 1.888 ± 0.081
3.776AlaGly: 3.776 ± 0.785
1.618AlaHis: 1.618 ± 0.286
2.157AlaIle: 2.157 ± 0.383
4.585AlaLys: 4.585 ± 1.295
6.742AlaLeu: 6.742 ± 1.002
1.348AlaMet: 1.348 ± 0.759
0.27AlaAsn: 0.27 ± 0.152
1.888AlaPro: 1.888 ± 0.554
2.427AlaGln: 2.427 ± 0.723
1.618AlaArg: 1.618 ± 0.71
4.315AlaSer: 4.315 ± 0.484
2.967AlaThr: 2.967 ± 0.52
3.236AlaVal: 3.236 ± 0.507
0.539AlaTrp: 0.539 ± 0.304
2.427AlaTyr: 2.427 ± 0.314
0.0AlaXaa: 0.0 ± 0.0
Cys
1.348CysAla: 1.348 ± 0.581
0.539CysCys: 0.539 ± 0.538
0.539CysAsp: 0.539 ± 0.538
0.539CysGlu: 0.539 ± 0.153
2.157CysPhe: 2.157 ± 0.969
1.079CysGly: 1.079 ± 0.463
0.27CysHis: 0.27 ± 0.269
0.539CysIle: 0.539 ± 0.153
2.157CysLys: 2.157 ± 1.059
2.157CysLeu: 2.157 ± 0.969
0.539CysMet: 0.539 ± 0.538
1.618CysAsn: 1.618 ± 0.822
2.697CysPro: 2.697 ± 2.0
1.079CysGln: 1.079 ± 0.849
0.27CysArg: 0.27 ± 0.269
3.776CysSer: 3.776 ± 2.176
1.348CysThr: 1.348 ± 0.254
1.888CysVal: 1.888 ± 0.395
0.0CysTrp: 0.0 ± 0.0
1.618CysTyr: 1.618 ± 0.822
0.0CysXaa: 0.0 ± 0.0
Asp
4.315AspAla: 4.315 ± 0.525
1.079AspCys: 1.079 ± 0.306
3.776AspAsp: 3.776 ± 1.424
4.585AspGlu: 4.585 ± 1.274
1.888AspPhe: 1.888 ± 0.709
2.427AspGly: 2.427 ± 0.64
1.348AspHis: 1.348 ± 0.695
4.315AspIle: 4.315 ± 0.968
2.157AspLys: 2.157 ± 0.597
7.821AspLeu: 7.821 ± 1.774
2.157AspMet: 2.157 ± 0.879
3.506AspAsn: 3.506 ± 1.973
1.888AspPro: 1.888 ± 0.395
3.236AspGln: 3.236 ± 0.173
2.697AspArg: 2.697 ± 0.462
1.888AspSer: 1.888 ± 0.081
2.697AspThr: 2.697 ± 0.998
2.427AspVal: 2.427 ± 1.366
1.618AspTrp: 1.618 ± 0.71
2.157AspTyr: 2.157 ± 0.504
0.0AspXaa: 0.0 ± 0.0
Glu
2.967GluAla: 2.967 ± 0.222
1.079GluCys: 1.079 ± 0.306
4.854GluAsp: 4.854 ± 1.051
4.045GluGlu: 4.045 ± 1.363
2.967GluPhe: 2.967 ± 0.926
2.697GluGly: 2.697 ± 0.08
1.888GluHis: 1.888 ± 0.081
4.315GluIle: 4.315 ± 0.612
6.203GluLys: 6.203 ± 0.785
6.472GluLeu: 6.472 ± 0.516
1.079GluMet: 1.079 ± 0.465
1.888GluAsn: 1.888 ± 0.798
2.697GluPro: 2.697 ± 0.921
1.618GluGln: 1.618 ± 0.71
5.124GluArg: 5.124 ± 0.381
3.236GluSer: 3.236 ± 0.173
2.697GluThr: 2.697 ± 0.45
2.967GluVal: 2.967 ± 0.63
0.809GluTrp: 0.809 ± 0.143
1.079GluTyr: 1.079 ± 0.306
0.0GluXaa: 0.0 ± 0.0
Phe
2.427PheAla: 2.427 ± 0.417
1.348PheCys: 1.348 ± 0.946
1.348PheAsp: 1.348 ± 0.759
3.236PheGlu: 3.236 ± 0.647
3.236PhePhe: 3.236 ± 1.166
1.348PheGly: 1.348 ± 0.254
1.348PheHis: 1.348 ± 0.315
3.776PheIle: 3.776 ± 0.653
5.394PheLys: 5.394 ± 1.206
3.236PheLeu: 3.236 ± 0.572
1.348PheMet: 1.348 ± 0.581
3.236PheAsn: 3.236 ± 0.631
0.809PhePro: 0.809 ± 0.455
2.427PheGln: 2.427 ± 0.429
1.888PheArg: 1.888 ± 0.381
4.854PheSer: 4.854 ± 0.195
3.506PheThr: 3.506 ± 0.774
1.079PheVal: 1.079 ± 0.607
0.27PheTrp: 0.27 ± 0.152
0.809PheTyr: 0.809 ± 0.376
0.0PheXaa: 0.0 ± 0.0
Gly
2.697GlyAla: 2.697 ± 1.182
1.348GlyCys: 1.348 ± 0.225
2.427GlyAsp: 2.427 ± 0.915
2.157GlyGlu: 2.157 ± 0.504
2.967GlyPhe: 2.967 ± 0.636
1.618GlyGly: 1.618 ± 0.173
1.888GlyHis: 1.888 ± 0.709
3.776GlyIle: 3.776 ± 1.444
3.776GlyLys: 3.776 ± 0.332
5.124GlyLeu: 5.124 ± 1.592
2.157GlyMet: 2.157 ± 0.504
2.967GlyAsn: 2.967 ± 1.189
1.079GlyPro: 1.079 ± 0.678
1.888GlyGln: 1.888 ± 0.798
0.809GlyArg: 0.809 ± 0.74
5.124GlySer: 5.124 ± 0.567
3.776GlyThr: 3.776 ± 0.785
4.585GlyVal: 4.585 ± 0.526
1.079GlyTrp: 1.079 ± 0.678
2.697GlyTyr: 2.697 ± 0.367
0.0GlyXaa: 0.0 ± 0.0
His
1.079HisAla: 1.079 ± 0.465
1.079HisCys: 1.079 ± 0.678
1.888HisAsp: 1.888 ± 0.381
1.888HisGlu: 1.888 ± 0.395
1.348HisPhe: 1.348 ± 0.315
2.427HisGly: 2.427 ± 1.233
0.539HisHis: 0.539 ± 0.304
1.079HisIle: 1.079 ± 0.252
1.079HisLys: 1.079 ± 0.306
3.506HisLeu: 3.506 ± 0.826
0.539HisMet: 0.539 ± 0.304
0.809HisAsn: 0.809 ± 0.143
1.079HisPro: 1.079 ± 0.252
0.539HisGln: 0.539 ± 0.153
0.809HisArg: 0.809 ± 0.143
1.618HisSer: 1.618 ± 0.286
1.348HisThr: 1.348 ± 0.559
0.539HisVal: 0.539 ± 0.153
0.539HisTrp: 0.539 ± 0.153
0.809HisTyr: 0.809 ± 0.455
0.0HisXaa: 0.0 ± 0.0
Ile
3.236IleAla: 3.236 ± 0.631
1.888IleCys: 1.888 ± 1.483
3.776IleAsp: 3.776 ± 0.634
5.663IleGlu: 5.663 ± 1.479
2.967IlePhe: 2.967 ± 0.636
3.506IleGly: 3.506 ± 0.774
0.539IleHis: 0.539 ± 0.153
4.854IleIle: 4.854 ± 1.83
5.663IleLys: 5.663 ± 0.244
7.012IleLeu: 7.012 ± 0.789
1.618IleMet: 1.618 ± 0.543
2.427IleAsn: 2.427 ± 1.233
5.394IlePro: 5.394 ± 0.858
2.697IleGln: 2.697 ± 0.462
1.618IleArg: 1.618 ± 0.173
6.472IleSer: 6.472 ± 0.347
6.742IleThr: 6.742 ± 0.987
4.045IleVal: 4.045 ± 0.241
0.27IleTrp: 0.27 ± 0.269
2.427IleTyr: 2.427 ± 0.429
0.0IleXaa: 0.0 ± 0.0
Lys
5.663LysAla: 5.663 ± 0.244
0.809LysCys: 0.809 ± 0.143
3.506LysAsp: 3.506 ± 0.774
5.663LysGlu: 5.663 ± 0.673
3.506LysPhe: 3.506 ± 0.656
3.506LysGly: 3.506 ± 0.663
2.967LysHis: 2.967 ± 0.222
7.282LysIle: 7.282 ± 0.833
5.124LysLys: 5.124 ± 0.371
6.203LysLeu: 6.203 ± 1.464
2.697LysMet: 2.697 ± 0.629
3.236LysAsn: 3.236 ± 1.073
1.888LysPro: 1.888 ± 0.833
3.776LysGln: 3.776 ± 0.332
1.888LysArg: 1.888 ± 0.943
5.933LysSer: 5.933 ± 0.595
4.045LysThr: 4.045 ± 0.826
4.585LysVal: 4.585 ± 0.483
1.079LysTrp: 1.079 ± 0.219
1.348LysTyr: 1.348 ± 0.254
0.0LysXaa: 0.0 ± 0.0
Leu
4.585LeuAla: 4.585 ± 1.301
0.539LeuCys: 0.539 ± 0.153
6.203LeuAsp: 6.203 ± 0.785
5.124LeuGlu: 5.124 ± 0.381
3.506LeuPhe: 3.506 ± 1.973
5.394LeuGly: 5.394 ± 0.16
1.618LeuHis: 1.618 ± 0.286
8.63LeuIle: 8.63 ± 1.687
5.394LeuLys: 5.394 ± 0.44
9.439LeuLeu: 9.439 ± 1.296
2.967LeuMet: 2.967 ± 0.504
3.236LeuAsn: 3.236 ± 0.763
2.967LeuPro: 2.967 ± 0.243
2.427LeuGln: 2.427 ± 0.723
5.933LeuArg: 5.933 ± 1.497
8.091LeuSer: 8.091 ± 0.586
4.315LeuThr: 4.315 ± 1.503
8.9LeuVal: 8.9 ± 1.473
0.809LeuTrp: 0.809 ± 0.143
5.124LeuTyr: 5.124 ± 1.328
0.0LeuXaa: 0.0 ± 0.0
Met
1.079MetAla: 1.079 ± 0.849
0.539MetCys: 0.539 ± 0.153
2.157MetAsp: 2.157 ± 0.579
1.618MetGlu: 1.618 ± 0.286
1.618MetPhe: 1.618 ± 0.71
1.079MetGly: 1.079 ± 0.671
0.0MetHis: 0.0 ± 0.0
2.157MetIle: 2.157 ± 0.242
2.697MetLys: 2.697 ± 0.08
1.079MetLeu: 1.079 ± 1.084
1.079MetMet: 1.079 ± 0.647
2.427MetAsn: 2.427 ± 0.429
0.539MetPro: 0.539 ± 0.538
0.539MetGln: 0.539 ± 0.304
1.348MetArg: 1.348 ± 0.225
2.427MetSer: 2.427 ± 0.506
1.888MetThr: 1.888 ± 0.441
1.348MetVal: 1.348 ± 0.581
0.27MetTrp: 0.27 ± 0.152
1.348MetTyr: 1.348 ± 0.391
0.0MetXaa: 0.0 ± 0.0
Asn
1.888AsnAla: 1.888 ± 0.554
1.888AsnCys: 1.888 ± 0.709
1.888AsnAsp: 1.888 ± 0.505
1.348AsnGlu: 1.348 ± 0.581
1.618AsnPhe: 1.618 ± 0.537
0.809AsnGly: 0.809 ± 0.143
1.079AsnHis: 1.079 ± 0.252
4.315AsnIle: 4.315 ± 1.225
3.236AsnLys: 3.236 ± 1.166
4.315AsnLeu: 4.315 ± 0.344
1.079AsnMet: 1.079 ± 0.306
1.348AsnAsn: 1.348 ± 0.759
1.618AsnPro: 1.618 ± 0.286
2.427AsnGln: 2.427 ± 0.68
1.888AsnArg: 1.888 ± 0.392
1.888AsnSer: 1.888 ± 1.062
3.236AsnThr: 3.236 ± 0.905
2.157AsnVal: 2.157 ± 0.65
0.809AsnTrp: 0.809 ± 0.143
0.809AsnTyr: 0.809 ± 0.455
0.0AsnXaa: 0.0 ± 0.0
Pro
1.618ProAla: 1.618 ± 0.173
1.079ProCys: 1.079 ± 0.463
2.427ProAsp: 2.427 ± 0.887
3.506ProGlu: 3.506 ± 0.914
1.348ProPhe: 1.348 ± 0.254
3.776ProGly: 3.776 ± 1.043
1.618ProHis: 1.618 ± 0.946
2.427ProIle: 2.427 ± 1.366
1.618ProLys: 1.618 ± 0.316
2.967ProLeu: 2.967 ± 1.011
0.539ProMet: 0.539 ± 0.153
1.348ProAsn: 1.348 ± 0.391
1.348ProPro: 1.348 ± 0.695
1.079ProGln: 1.079 ± 0.463
0.809ProArg: 0.809 ± 0.455
3.236ProSer: 3.236 ± 0.763
2.157ProThr: 2.157 ± 0.597
2.157ProVal: 2.157 ± 0.242
0.539ProTrp: 0.539 ± 0.425
1.079ProTyr: 1.079 ± 0.306
0.0ProXaa: 0.0 ± 0.0
Gln
3.506GlnAla: 3.506 ± 1.316
0.809GlnCys: 0.809 ± 0.411
1.618GlnAsp: 1.618 ± 0.603
1.618GlnGlu: 1.618 ± 0.537
1.079GlnPhe: 1.079 ± 0.219
2.157GlnGly: 2.157 ± 0.383
1.348GlnHis: 1.348 ± 0.254
2.967GlnIle: 2.967 ± 0.612
3.776GlnLys: 3.776 ± 0.163
2.427GlnLeu: 2.427 ± 0.417
0.809GlnMet: 0.809 ± 0.143
2.157GlnAsn: 2.157 ± 0.612
0.809GlnPro: 0.809 ± 0.302
0.809GlnGln: 0.809 ± 0.376
2.157GlnArg: 2.157 ± 0.879
4.315GlnSer: 4.315 ± 0.963
1.348GlnThr: 1.348 ± 0.225
2.157GlnVal: 2.157 ± 0.612
1.079GlnTrp: 1.079 ± 0.252
0.539GlnTyr: 0.539 ± 0.304
0.0GlnXaa: 0.0 ± 0.0
Arg
1.888ArgAla: 1.888 ± 0.392
1.348ArgCys: 1.348 ± 0.315
1.348ArgAsp: 1.348 ± 0.759
2.427ArgGlu: 2.427 ± 1.042
3.776ArgPhe: 3.776 ± 0.332
2.967ArgGly: 2.967 ± 0.297
1.618ArgHis: 1.618 ± 0.911
1.888ArgIle: 1.888 ± 0.943
3.236ArgLys: 3.236 ± 0.771
4.315ArgLeu: 4.315 ± 0.612
1.079ArgMet: 1.079 ± 0.465
0.809ArgAsn: 0.809 ± 0.376
1.079ArgPro: 1.079 ± 0.607
1.348ArgGln: 1.348 ± 0.579
1.348ArgArg: 1.348 ± 0.225
1.618ArgSer: 1.618 ± 0.753
2.427ArgThr: 2.427 ± 0.723
1.888ArgVal: 1.888 ± 0.381
0.539ArgTrp: 0.539 ± 0.304
2.967ArgTyr: 2.967 ± 0.484
0.0ArgXaa: 0.0 ± 0.0
Ser
2.427SerAla: 2.427 ± 0.417
2.427SerCys: 2.427 ± 1.623
4.854SerAsp: 4.854 ± 0.44
2.697SerGlu: 2.697 ± 0.08
4.045SerPhe: 4.045 ± 0.675
5.933SerGly: 5.933 ± 0.682
1.348SerHis: 1.348 ± 0.559
5.124SerIle: 5.124 ± 0.704
6.203SerLys: 6.203 ± 0.976
8.36SerLeu: 8.36 ± 0.957
1.079SerMet: 1.079 ± 0.655
3.236SerAsn: 3.236 ± 0.302
3.506SerPro: 3.506 ± 0.223
1.618SerGln: 1.618 ± 0.543
2.967SerArg: 2.967 ± 0.926
6.203SerSer: 6.203 ± 1.53
5.933SerThr: 5.933 ± 1.384
8.091SerVal: 8.091 ± 0.673
1.348SerTrp: 1.348 ± 0.695
3.236SerTyr: 3.236 ± 0.173
0.0SerXaa: 0.0 ± 0.0
Thr
4.045ThrAla: 4.045 ± 0.516
2.427ThrCys: 2.427 ± 2.021
4.045ThrAsp: 4.045 ± 1.072
4.315ThrGlu: 4.315 ± 0.875
2.427ThrPhe: 2.427 ± 0.429
4.315ThrGly: 4.315 ± 1.581
1.079ThrHis: 1.079 ± 0.306
4.854ThrIle: 4.854 ± 1.42
3.506ThrLys: 3.506 ± 1.174
4.854ThrLeu: 4.854 ± 0.858
1.618ThrMet: 1.618 ± 0.286
1.348ThrAsn: 1.348 ± 0.315
2.157ThrPro: 2.157 ± 0.172
1.079ThrGln: 1.079 ± 0.219
1.618ThrArg: 1.618 ± 0.316
4.854ThrSer: 4.854 ± 1.084
2.967ThrThr: 2.967 ± 0.243
5.394ThrVal: 5.394 ± 0.16
0.539ThrTrp: 0.539 ± 0.153
1.079ThrTyr: 1.079 ± 0.252
0.0ThrXaa: 0.0 ± 0.0
Val
3.236ValAla: 3.236 ± 0.507
1.888ValCys: 1.888 ± 0.734
4.585ValAsp: 4.585 ± 0.758
3.776ValGlu: 3.776 ± 0.761
2.427ValPhe: 2.427 ± 0.506
1.618ValGly: 1.618 ± 0.875
1.079ValHis: 1.079 ± 0.607
5.124ValIle: 5.124 ± 1.078
4.854ValLys: 4.854 ± 0.947
4.045ValLeu: 4.045 ± 0.88
1.888ValMet: 1.888 ± 0.441
2.697ValAsn: 2.697 ± 0.363
1.348ValPro: 1.348 ± 0.946
3.506ValGln: 3.506 ± 0.523
3.506ValArg: 3.506 ± 0.914
5.933ValSer: 5.933 ± 0.751
3.776ValThr: 3.776 ± 1.072
3.236ValVal: 3.236 ± 0.756
1.618ValTrp: 1.618 ± 0.459
2.967ValTyr: 2.967 ± 1.286
0.0ValXaa: 0.0 ± 0.0
Trp
1.618TrpAla: 1.618 ± 0.286
0.27TrpCys: 0.27 ± 0.269
0.27TrpAsp: 0.27 ± 0.152
1.348TrpGlu: 1.348 ± 0.695
1.079TrpPhe: 1.079 ± 0.252
1.079TrpGly: 1.079 ± 0.219
0.27TrpHis: 0.27 ± 0.152
0.539TrpIle: 0.539 ± 0.336
0.809TrpLys: 0.809 ± 0.143
1.618TrpLeu: 1.618 ± 0.286
0.539TrpMet: 0.539 ± 0.538
0.27TrpAsn: 0.27 ± 0.152
0.539TrpPro: 0.539 ± 0.304
0.809TrpGln: 0.809 ± 0.411
0.27TrpArg: 0.27 ± 0.152
1.618TrpSer: 1.618 ± 0.286
0.27TrpThr: 0.27 ± 0.269
0.809TrpVal: 0.809 ± 0.376
0.27TrpTrp: 0.27 ± 0.269
0.27TrpTyr: 0.27 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.809TyrAla: 0.809 ± 0.455
1.618TyrCys: 1.618 ± 0.822
2.967TyrAsp: 2.967 ± 1.425
2.157TyrGlu: 2.157 ± 0.612
1.079TyrPhe: 1.079 ± 0.465
2.427TyrGly: 2.427 ± 0.506
1.079TyrHis: 1.079 ± 0.607
2.697TyrIle: 2.697 ± 0.781
3.236TyrLys: 3.236 ± 0.507
3.506TyrLeu: 3.506 ± 0.752
0.809TyrMet: 0.809 ± 0.259
0.809TyrAsn: 0.809 ± 0.455
1.348TyrPro: 1.348 ± 0.225
2.157TyrGln: 2.157 ± 0.242
1.348TyrArg: 1.348 ± 0.391
3.236TyrSer: 3.236 ± 0.647
1.079TyrThr: 1.079 ± 0.678
1.618TyrVal: 1.618 ± 0.753
0.539TyrTrp: 0.539 ± 0.304
1.618TyrTyr: 1.618 ± 0.286
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (3709 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski