Amino acid dipepetide frequency for Pararhodospirillum photometricum DSM 122

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.254AlaAla: 16.254 ± 0.199	1.424AlaCys: 1.424 ± 0.042	6.453AlaAsp: 6.453 ± 0.081	7.244AlaGlu: 7.244 ± 0.09	4.14AlaPhe: 4.14 ± 0.061	10.772AlaGly: 10.772 ± 0.107	2.545AlaHis: 2.545 ± 0.063	4.295AlaIle: 4.295 ± 0.07	2.673AlaLys: 2.673 ± 0.058	17.343AlaLeu: 17.343 ± 0.196	2.909AlaMet: 2.909 ± 0.06	2.248AlaAsn: 2.248 ± 0.055	6.67AlaPro: 6.67 ± 0.11	5.025AlaGln: 5.025 ± 0.113	11.002AlaArg: 11.002 ± 0.131	6.128AlaSer: 6.128 ± 0.088	6.276AlaThr: 6.276 ± 0.113	9.735AlaVal: 9.735 ± 0.097	1.776AlaTrp: 1.776 ± 0.041	2.239AlaTyr: 2.239 ± 0.048	0.013AlaXaa: 0.013 ± 0.003
Cys	1.097CysAla: 1.097 ± 0.039	0.158CysCys: 0.158 ± 0.013	0.546CysAsp: 0.546 ± 0.019	0.398CysGlu: 0.398 ± 0.021	0.328CysPhe: 0.328 ± 0.02	0.947CysGly: 0.947 ± 0.031	0.283CysHis: 0.283 ± 0.016	0.274CysIle: 0.274 ± 0.016	0.186CysLys: 0.186 ± 0.015	1.165CysLeu: 1.165 ± 0.035	0.151CysMet: 0.151 ± 0.011	0.165CysAsn: 0.165 ± 0.013	0.747CysPro: 0.747 ± 0.034	0.306CysGln: 0.306 ± 0.016	0.813CysArg: 0.813 ± 0.03	0.484CysSer: 0.484 ± 0.023	0.456CysThr: 0.456 ± 0.021	0.717CysVal: 0.717 ± 0.027	0.164CysTrp: 0.164 ± 0.014	0.214CysTyr: 0.214 ± 0.013	0.002CysXaa: 0.002 ± 0.001
Asp	6.48AspAla: 6.48 ± 0.078	0.381AspCys: 0.381 ± 0.019	3.065AspAsp: 3.065 ± 0.07	2.972AspGlu: 2.972 ± 0.057	1.708AspPhe: 1.708 ± 0.041	4.766AspGly: 4.766 ± 0.093	1.288AspHis: 1.288 ± 0.036	2.442AspIle: 2.442 ± 0.05	1.31AspLys: 1.31 ± 0.038	6.901AspLeu: 6.901 ± 0.093	1.096AspMet: 1.096 ± 0.032	1.04AspAsn: 1.04 ± 0.033	4.374AspPro: 4.374 ± 0.076	1.828AspGln: 1.828 ± 0.041	4.045AspArg: 4.045 ± 0.072	2.113AspSer: 2.113 ± 0.058	3.005AspThr: 3.005 ± 0.084	3.931AspVal: 3.931 ± 0.059	0.789AspTrp: 0.789 ± 0.027	1.036AspTyr: 1.036 ± 0.036	0.006AspXaa: 0.006 ± 0.002
Glu	8.897GluAla: 8.897 ± 0.114	0.341GluCys: 0.341 ± 0.02	2.964GluAsp: 2.964 ± 0.059	3.336GluGlu: 3.336 ± 0.071	1.283GluPhe: 1.283 ± 0.039	5.02GluGly: 5.02 ± 0.076	1.086GluHis: 1.086 ± 0.032	2.908GluIle: 2.908 ± 0.053	1.628GluLys: 1.628 ± 0.048	3.751GluLeu: 3.751 ± 0.057	1.266GluMet: 1.266 ± 0.038	1.222GluAsn: 1.222 ± 0.036	2.465GluPro: 2.465 ± 0.052	1.82GluGln: 1.82 ± 0.038	5.615GluArg: 5.615 ± 0.084	2.48GluSer: 2.48 ± 0.048	3.905GluThr: 3.905 ± 0.061	4.173GluVal: 4.173 ± 0.057	0.488GluTrp: 0.488 ± 0.022	0.761GluTyr: 0.761 ± 0.029	0.008GluXaa: 0.008 ± 0.003
Phe	3.607PheAla: 3.607 ± 0.065	0.441PheCys: 0.441 ± 0.02	2.069PheAsp: 2.069 ± 0.048	1.684PheGlu: 1.684 ± 0.043	1.286PhePhe: 1.286 ± 0.041	2.808PheGly: 2.808 ± 0.057	0.707PheHis: 0.707 ± 0.027	1.208PheIle: 1.208 ± 0.039	0.834PheLys: 0.834 ± 0.032	3.695PheLeu: 3.695 ± 0.072	0.674PheMet: 0.674 ± 0.027	0.778PheAsn: 0.778 ± 0.028	1.655PhePro: 1.655 ± 0.038	1.049PheGln: 1.049 ± 0.03	2.124PheArg: 2.124 ± 0.047	1.928PheSer: 1.928 ± 0.043	1.844PheThr: 1.844 ± 0.044	2.469PheVal: 2.469 ± 0.049	0.495PheTrp: 0.495 ± 0.023	0.725PheTyr: 0.725 ± 0.028	0.006PheXaa: 0.006 ± 0.002
Gly	9.845GlyAla: 9.845 ± 0.126	1.006GlyCys: 1.006 ± 0.034	4.301GlyAsp: 4.301 ± 0.074	4.767GlyGlu: 4.767 ± 0.074	3.184GlyPhe: 3.184 ± 0.057	7.85GlyGly: 7.85 ± 0.118	1.981GlyHis: 1.981 ± 0.053	3.608GlyIle: 3.608 ± 0.061	2.579GlyLys: 2.579 ± 0.054	10.614GlyLeu: 10.614 ± 0.115	2.09GlyMet: 2.09 ± 0.045	1.615GlyAsn: 1.615 ± 0.049	4.678GlyPro: 4.678 ± 0.077	3.285GlyGln: 3.285 ± 0.056	7.647GlyArg: 7.647 ± 0.099	4.491GlySer: 4.491 ± 0.089	4.913GlyThr: 4.913 ± 0.105	7.092GlyVal: 7.092 ± 0.101	1.357GlyTrp: 1.357 ± 0.036	1.803GlyTyr: 1.803 ± 0.039	0.018GlyXaa: 0.018 ± 0.004
His	2.522HisAla: 2.522 ± 0.048	0.231HisCys: 0.231 ± 0.016	1.351HisAsp: 1.351 ± 0.036	1.037HisGlu: 1.037 ± 0.03	0.74HisPhe: 0.74 ± 0.028	2.098HisGly: 2.098 ± 0.055	0.685HisHis: 0.685 ± 0.031	0.675HisIle: 0.675 ± 0.025	0.444HisLys: 0.444 ± 0.021	2.338HisLeu: 2.338 ± 0.059	0.383HisMet: 0.383 ± 0.021	0.413HisAsn: 0.413 ± 0.02	1.692HisPro: 1.692 ± 0.035	0.694HisGln: 0.694 ± 0.029	1.713HisArg: 1.713 ± 0.043	0.784HisSer: 0.784 ± 0.027	1.009HisThr: 1.009 ± 0.032	1.545HisVal: 1.545 ± 0.04	0.283HisTrp: 0.283 ± 0.017	0.459HisTyr: 0.459 ± 0.022	0.001HisXaa: 0.001 ± 0.001
Ile	5.185IleAla: 5.185 ± 0.071	0.328IleCys: 0.328 ± 0.021	2.695IleAsp: 2.695 ± 0.047	2.616IleGlu: 2.616 ± 0.056	1.117IlePhe: 1.117 ± 0.029	3.728IleGly: 3.728 ± 0.065	0.845IleHis: 0.845 ± 0.031	1.522IleIle: 1.522 ± 0.041	1.152IleLys: 1.152 ± 0.04	4.091IleLeu: 4.091 ± 0.064	0.775IleMet: 0.775 ± 0.029	1.2IleAsn: 1.2 ± 0.036	2.022IlePro: 2.022 ± 0.038	1.172IleGln: 1.172 ± 0.036	2.63IleArg: 2.63 ± 0.051	2.184IleSer: 2.184 ± 0.053	2.433IleThr: 2.433 ± 0.062	2.978IleVal: 2.978 ± 0.054	0.356IleTrp: 0.356 ± 0.016	0.705IleTyr: 0.705 ± 0.028	0.004IleXaa: 0.004 ± 0.002
Lys	3.502LysAla: 3.502 ± 0.07	0.111LysCys: 0.111 ± 0.01	1.329LysAsp: 1.329 ± 0.038	1.394LysGlu: 1.394 ± 0.04	0.532LysPhe: 0.532 ± 0.026	2.523LysGly: 2.523 ± 0.052	0.404LysHis: 0.404 ± 0.02	1.246LysIle: 1.246 ± 0.033	0.906LysLys: 0.906 ± 0.037	1.928LysLeu: 1.928 ± 0.045	0.576LysMet: 0.576 ± 0.026	0.653LysAsn: 0.653 ± 0.028	1.561LysPro: 1.561 ± 0.043	0.624LysGln: 0.624 ± 0.029	1.897LysArg: 1.897 ± 0.045	1.279LysSer: 1.279 ± 0.034	1.809LysThr: 1.809 ± 0.048	2.13LysVal: 2.13 ± 0.047	0.2LysTrp: 0.2 ± 0.014	0.427LysTyr: 0.427 ± 0.022	0.005LysXaa: 0.005 ± 0.002
Leu	16.039LeuAla: 16.039 ± 0.162	1.062LeuCys: 1.062 ± 0.035	6.787LeuAsp: 6.787 ± 0.092	6.452LeuGlu: 6.452 ± 0.089	3.606LeuPhe: 3.606 ± 0.061	10.339LeuGly: 10.339 ± 0.115	2.116LeuHis: 2.116 ± 0.045	4.571LeuIle: 4.571 ± 0.065	2.97LeuLys: 2.97 ± 0.057	10.608LeuLeu: 10.608 ± 0.128	2.412LeuMet: 2.412 ± 0.047	2.306LeuAsn: 2.306 ± 0.044	6.753LeuPro: 6.753 ± 0.087	2.638LeuGln: 2.638 ± 0.053	8.245LeuArg: 8.245 ± 0.112	7.08LeuSer: 7.08 ± 0.138	6.713LeuThr: 6.713 ± 0.163	8.594LeuVal: 8.594 ± 0.101	1.28LeuTrp: 1.28 ± 0.041	1.941LeuTyr: 1.941 ± 0.046	0.006LeuXaa: 0.006 ± 0.002
Met	3.051MetAla: 3.051 ± 0.058	0.142MetCys: 0.142 ± 0.011	1.133MetAsp: 1.133 ± 0.034	1.061MetGlu: 1.061 ± 0.031	0.525MetPhe: 0.525 ± 0.022	1.944MetGly: 1.944 ± 0.043	0.359MetHis: 0.359 ± 0.02	1.102MetIle: 1.102 ± 0.034	0.663MetLys: 0.663 ± 0.028	1.933MetLeu: 1.933 ± 0.047	0.624MetMet: 0.624 ± 0.029	0.536MetAsn: 0.536 ± 0.022	1.405MetPro: 1.405 ± 0.04	0.516MetGln: 0.516 ± 0.023	1.592MetArg: 1.592 ± 0.034	1.446MetSer: 1.446 ± 0.035	1.802MetThr: 1.802 ± 0.041	1.792MetVal: 1.792 ± 0.046	0.167MetTrp: 0.167 ± 0.011	0.232MetTyr: 0.232 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	2.706AsnAla: 2.706 ± 0.058	0.187AsnCys: 0.187 ± 0.014	1.2AsnAsp: 1.2 ± 0.04	1.02AsnGlu: 1.02 ± 0.034	0.605AsnPhe: 0.605 ± 0.026	1.806AsnGly: 1.806 ± 0.052	0.444AsnHis: 0.444 ± 0.023	0.943AsnIle: 0.943 ± 0.033	0.613AsnLys: 0.613 ± 0.024	1.893AsnLeu: 1.893 ± 0.046	0.42AsnMet: 0.42 ± 0.023	0.517AsnAsn: 0.517 ± 0.027	1.487AsnPro: 1.487 ± 0.04	0.65AsnGln: 0.65 ± 0.024	1.621AsnArg: 1.621 ± 0.044	0.85AsnSer: 0.85 ± 0.031	1.284AsnThr: 1.284 ± 0.042	1.507AsnVal: 1.507 ± 0.042	0.243AsnTrp: 0.243 ± 0.014	0.402AsnTyr: 0.402 ± 0.021	0.001AsnXaa: 0.001 ± 0.001
Pro	7.24ProAla: 7.24 ± 0.113	0.64ProCys: 0.64 ± 0.026	3.754ProAsp: 3.754 ± 0.064	4.079ProGlu: 4.079 ± 0.063	1.952ProPhe: 1.952 ± 0.042	5.786ProGly: 5.786 ± 0.085	1.188ProHis: 1.188 ± 0.037	1.7ProIle: 1.7 ± 0.044	1.274ProLys: 1.274 ± 0.039	6.522ProLeu: 6.522 ± 0.095	1.339ProMet: 1.339 ± 0.039	1.003ProAsn: 1.003 ± 0.028	4.5ProPro: 4.5 ± 0.088	1.77ProGln: 1.77 ± 0.037	4.297ProArg: 4.297 ± 0.078	3.507ProSer: 3.507 ± 0.058	2.967ProThr: 2.967 ± 0.064	4.83ProVal: 4.83 ± 0.08	1.093ProTrp: 1.093 ± 0.037	1.011ProTyr: 1.011 ± 0.034	0.008ProXaa: 0.008 ± 0.003
Gln	5.238GlnAla: 5.238 ± 0.079	0.198GlnCys: 0.198 ± 0.013	1.687GlnAsp: 1.687 ± 0.043	1.729GlnGlu: 1.729 ± 0.038	0.731GlnPhe: 0.731 ± 0.029	3.362GlnGly: 3.362 ± 0.055	0.572GlnHis: 0.572 ± 0.022	1.558GlnIle: 1.558 ± 0.071	0.862GlnLys: 0.862 ± 0.029	2.079GlnLeu: 2.079 ± 0.055	0.688GlnMet: 0.688 ± 0.03	0.681GlnAsn: 0.681 ± 0.026	1.731GlnPro: 1.731 ± 0.038	1.006GlnGln: 1.006 ± 0.038	2.77GlnArg: 2.77 ± 0.054	1.541GlnSer: 1.541 ± 0.039	2.037GlnThr: 2.037 ± 0.047	2.794GlnVal: 2.794 ± 0.108	0.363GlnTrp: 0.363 ± 0.017	0.452GlnTyr: 0.452 ± 0.02	0.003GlnXaa: 0.003 ± 0.001
Arg	9.872ArgAla: 9.872 ± 0.115	0.685ArgCys: 0.685 ± 0.028	4.421ArgAsp: 4.421 ± 0.08	4.499ArgGlu: 4.499 ± 0.071	2.773ArgPhe: 2.773 ± 0.05	5.708ArgGly: 5.708 ± 0.08	2.141ArgHis: 2.141 ± 0.05	3.044ArgIle: 3.044 ± 0.055	1.971ArgLys: 1.971 ± 0.044	10.66ArgLeu: 10.66 ± 0.147	1.618ArgMet: 1.618 ± 0.043	1.355ArgAsn: 1.355 ± 0.032	5.119ArgPro: 5.119 ± 0.087	2.887ArgGln: 2.887 ± 0.056	7.587ArgArg: 7.587 ± 0.116	3.684ArgSer: 3.684 ± 0.058	3.78ArgThr: 3.78 ± 0.058	6.1ArgVal: 6.1 ± 0.087	1.118ArgTrp: 1.118 ± 0.033	1.446ArgTyr: 1.446 ± 0.035	0.011ArgXaa: 0.011 ± 0.003
Ser	5.965SerAla: 5.965 ± 0.114	0.539SerCys: 0.539 ± 0.025	2.522SerAsp: 2.522 ± 0.063	2.39SerGlu: 2.39 ± 0.054	1.941SerPhe: 1.941 ± 0.04	5.078SerGly: 5.078 ± 0.1	1.093SerHis: 1.093 ± 0.032	1.875SerIle: 1.875 ± 0.045	1.149SerLys: 1.149 ± 0.038	6.56SerLeu: 6.56 ± 0.077	1.25SerMet: 1.25 ± 0.031	0.963SerAsn: 0.963 ± 0.034	3.543SerPro: 3.543 ± 0.062	1.715SerGln: 1.715 ± 0.042	3.896SerArg: 3.896 ± 0.063	2.973SerSer: 2.973 ± 0.088	2.565SerThr: 2.565 ± 0.086	4.262SerVal: 4.262 ± 0.07	0.732SerTrp: 0.732 ± 0.02	0.975SerTyr: 0.975 ± 0.034	0.004SerXaa: 0.004 ± 0.002
Thr	6.419ThrAla: 6.419 ± 0.138	0.498ThrCys: 0.498 ± 0.023	2.712ThrAsp: 2.712 ± 0.066	2.661ThrGlu: 2.661 ± 0.049	1.85ThrPhe: 1.85 ± 0.047	5.054ThrGly: 5.054 ± 0.081	1.068ThrHis: 1.068 ± 0.032	2.122ThrIle: 2.122 ± 0.062	1.199ThrLys: 1.199 ± 0.037	7.911ThrLeu: 7.911 ± 0.161	1.091ThrMet: 1.091 ± 0.03	1.207ThrAsn: 1.207 ± 0.036	4.117ThrPro: 4.117 ± 0.094	1.845ThrGln: 1.845 ± 0.074	3.984ThrArg: 3.984 ± 0.057	2.797ThrSer: 2.797 ± 0.087	3.382ThrThr: 3.382 ± 0.123	4.703ThrVal: 4.703 ± 0.098	0.794ThrTrp: 0.794 ± 0.029	1.072ThrTyr: 1.072 ± 0.038	0.004ThrXaa: 0.004 ± 0.002
Val	9.86ValAla: 9.86 ± 0.113	0.856ValCys: 0.856 ± 0.031	3.821ValAsp: 3.821 ± 0.066	4.536ValGlu: 4.536 ± 0.077	2.782ValPhe: 2.782 ± 0.048	6.307ValGly: 6.307 ± 0.091	1.515ValHis: 1.515 ± 0.034	3.466ValIle: 3.466 ± 0.056	1.822ValLys: 1.822 ± 0.042	9.049ValLeu: 9.049 ± 0.106	1.965ValMet: 1.965 ± 0.047	1.724ValAsn: 1.724 ± 0.044	4.224ValPro: 4.224 ± 0.072	2.116ValGln: 2.116 ± 0.042	6.071ValArg: 6.071 ± 0.09	4.58ValSer: 4.58 ± 0.07	4.467ValThr: 4.467 ± 0.093	7.261ValVal: 7.261 ± 0.106	1.052ValTrp: 1.052 ± 0.032	1.344ValTyr: 1.344 ± 0.037	0.006ValXaa: 0.006 ± 0.002
Trp	1.355TrpAla: 1.355 ± 0.038	0.164TrpCys: 0.164 ± 0.013	0.63TrpAsp: 0.63 ± 0.027	0.623TrpGlu: 0.623 ± 0.023	0.39TrpPhe: 0.39 ± 0.017	1.161TrpGly: 1.161 ± 0.034	0.297TrpHis: 0.297 ± 0.016	0.567TrpIle: 0.567 ± 0.024	0.324TrpLys: 0.324 ± 0.018	1.547TrpLeu: 1.547 ± 0.038	0.332TrpMet: 0.332 ± 0.018	0.292TrpAsn: 0.292 ± 0.019	0.836TrpPro: 0.836 ± 0.034	0.47TrpGln: 0.47 ± 0.022	1.302TrpArg: 1.302 ± 0.038	0.784TrpSer: 0.784 ± 0.027	0.773TrpThr: 0.773 ± 0.028	0.921TrpVal: 0.921 ± 0.026	0.219TrpTrp: 0.219 ± 0.015	0.235TrpTyr: 0.235 ± 0.015	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.018TyrAla: 2.018 ± 0.053	0.206TyrCys: 0.206 ± 0.014	1.129TyrAsp: 1.129 ± 0.033	0.911TyrGlu: 0.911 ± 0.027	0.607TyrPhe: 0.607 ± 0.023	1.652TyrGly: 1.652 ± 0.044	0.474TyrHis: 0.474 ± 0.021	0.606TyrIle: 0.606 ± 0.025	0.468TyrLys: 0.468 ± 0.023	1.925TyrLeu: 1.925 ± 0.047	0.362TyrMet: 0.362 ± 0.021	0.477TyrAsn: 0.477 ± 0.024	0.87TyrPro: 0.87 ± 0.029	0.67TyrGln: 0.67 ± 0.027	1.622TyrArg: 1.622 ± 0.038	0.875TyrSer: 0.875 ± 0.026	1.064TyrThr: 1.064 ± 0.038	1.284TyrVal: 1.284 ± 0.037	0.254TyrTrp: 0.254 ± 0.017	0.477TyrTyr: 0.477 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.01XaaAla: 0.01 ± 0.003	0.001XaaCys: 0.001 ± 0.001	0.005XaaAsp: 0.005 ± 0.002	0.01XaaGlu: 0.01 ± 0.003	0.005XaaPhe: 0.005 ± 0.002	0.015XaaGly: 0.015 ± 0.004	0.005XaaHis: 0.005 ± 0.002	0.003XaaIle: 0.003 ± 0.001	0.007XaaLys: 0.007 ± 0.003	0.009XaaLeu: 0.009 ± 0.003	0.0XaaMet: 0.0 ± 0.0	0.002XaaAsn: 0.002 ± 0.001	0.013XaaPro: 0.013 ± 0.003	0.001XaaGln: 0.001 ± 0.001	0.007XaaArg: 0.007 ± 0.002	0.005XaaSer: 0.005 ± 0.002	0.006XaaThr: 0.006 ± 0.003	0.003XaaVal: 0.003 ± 0.002	0.001XaaTrp: 0.001 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 3275 proteins (1089982 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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