Amino acid dipepetide frequency for Vibrio phage K04M1_VK04M1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.398AlaAla: 6.398 ± 2.5
0.492AlaCys: 0.492 ± 0.395
2.461AlaAsp: 2.461 ± 1.226
3.445AlaGlu: 3.445 ± 1.175
0.984AlaPhe: 0.984 ± 0.745
3.445AlaGly: 3.445 ± 0.729
1.969AlaHis: 1.969 ± 0.91
4.429AlaIle: 4.429 ± 1.489
7.382AlaLys: 7.382 ± 1.892
8.366AlaLeu: 8.366 ± 2.389
3.445AlaMet: 3.445 ± 1.701
2.461AlaAsn: 2.461 ± 1.118
2.461AlaPro: 2.461 ± 1.447
1.476AlaGln: 1.476 ± 0.89
2.953AlaArg: 2.953 ± 1.305
4.429AlaSer: 4.429 ± 1.191
1.969AlaThr: 1.969 ± 1.178
6.398AlaVal: 6.398 ± 2.206
1.476AlaTrp: 1.476 ± 0.761
4.921AlaTyr: 4.921 ± 1.327
0.0AlaXaa: 0.0 ± 0.0
Cys
2.461CysAla: 2.461 ± 1.059
0.0CysCys: 0.0 ± 0.0
0.984CysAsp: 0.984 ± 0.639
1.969CysGlu: 1.969 ± 1.152
1.476CysPhe: 1.476 ± 0.923
2.461CysGly: 2.461 ± 0.472
1.476CysHis: 1.476 ± 0.651
0.492CysIle: 0.492 ± 0.395
0.984CysLys: 0.984 ± 0.529
0.984CysLeu: 0.984 ± 0.755
0.492CysMet: 0.492 ± 0.395
0.492CysAsn: 0.492 ± 0.565
0.492CysPro: 0.492 ± 0.395
0.492CysGln: 0.492 ± 0.395
0.492CysArg: 0.492 ± 0.473
0.492CysSer: 0.492 ± 0.637
1.969CysThr: 1.969 ± 1.098
0.492CysVal: 0.492 ± 0.475
0.0CysTrp: 0.0 ± 0.0
0.984CysTyr: 0.984 ± 0.529
0.0CysXaa: 0.0 ± 0.0
Asp
1.969AspAla: 1.969 ± 0.685
1.969AspCys: 1.969 ± 1.352
5.906AspAsp: 5.906 ± 2.258
2.953AspGlu: 2.953 ± 0.785
2.461AspPhe: 2.461 ± 0.958
8.858AspGly: 8.858 ± 1.875
0.984AspHis: 0.984 ± 0.666
5.906AspIle: 5.906 ± 1.52
1.969AspLys: 1.969 ± 1.159
6.89AspLeu: 6.89 ± 1.18
2.461AspMet: 2.461 ± 0.736
1.969AspAsn: 1.969 ± 1.245
4.921AspPro: 4.921 ± 2.141
0.984AspGln: 0.984 ± 0.849
0.984AspArg: 0.984 ± 0.608
2.461AspSer: 2.461 ± 1.347
5.906AspThr: 5.906 ± 2.749
4.921AspVal: 4.921 ± 1.599
2.461AspTrp: 2.461 ± 0.736
2.953AspTyr: 2.953 ± 0.852
0.0AspXaa: 0.0 ± 0.0
Glu
4.429GluAla: 4.429 ± 1.617
0.492GluCys: 0.492 ± 0.61
4.429GluAsp: 4.429 ± 1.233
2.461GluGlu: 2.461 ± 0.886
0.984GluPhe: 0.984 ± 0.529
2.953GluGly: 2.953 ± 1.44
0.492GluHis: 0.492 ± 0.61
2.953GluIle: 2.953 ± 1.332
3.937GluLys: 3.937 ± 1.722
3.937GluLeu: 3.937 ± 1.509
0.984GluMet: 0.984 ± 0.709
3.445GluAsn: 3.445 ± 1.826
1.476GluPro: 1.476 ± 0.752
4.429GluGln: 4.429 ± 1.071
1.969GluArg: 1.969 ± 0.581
3.445GluSer: 3.445 ± 1.407
1.969GluThr: 1.969 ± 1.116
2.953GluVal: 2.953 ± 1.164
1.476GluTrp: 1.476 ± 0.88
2.953GluTyr: 2.953 ± 0.918
0.0GluXaa: 0.0 ± 0.0
Phe
3.445PheAla: 3.445 ± 1.807
0.492PheCys: 0.492 ± 0.473
4.429PheAsp: 4.429 ± 1.129
2.461PheGlu: 2.461 ± 0.861
2.461PhePhe: 2.461 ± 1.059
4.429PheGly: 4.429 ± 1.599
0.984PheHis: 0.984 ± 0.634
0.984PheIle: 0.984 ± 0.79
1.476PheLys: 1.476 ± 0.788
1.969PheLeu: 1.969 ± 0.984
0.0PheMet: 0.0 ± 0.0
2.461PheAsn: 2.461 ± 0.971
1.969PhePro: 1.969 ± 0.896
1.969PheGln: 1.969 ± 0.992
0.984PheArg: 0.984 ± 0.684
3.445PheSer: 3.445 ± 1.592
3.937PheThr: 3.937 ± 1.304
3.445PheVal: 3.445 ± 0.852
1.476PheTrp: 1.476 ± 0.604
3.445PheTyr: 3.445 ± 1.604
0.0PheXaa: 0.0 ± 0.0
Gly
3.937GlyAla: 3.937 ± 1.586
2.461GlyCys: 2.461 ± 0.472
4.429GlyAsp: 4.429 ± 2.075
3.937GlyGlu: 3.937 ± 1.013
4.921GlyPhe: 4.921 ± 1.461
5.413GlyGly: 5.413 ± 1.314
0.492GlyHis: 0.492 ± 0.395
4.429GlyIle: 4.429 ± 1.444
5.413GlyLys: 5.413 ± 1.595
7.382GlyLeu: 7.382 ± 1.438
2.461GlyMet: 2.461 ± 1.393
1.476GlyAsn: 1.476 ± 0.805
1.969GlyPro: 1.969 ± 0.788
2.953GlyGln: 2.953 ± 1.159
3.445GlyArg: 3.445 ± 1.662
5.906GlySer: 5.906 ± 1.655
4.429GlyThr: 4.429 ± 1.328
4.429GlyVal: 4.429 ± 1.459
0.0GlyTrp: 0.0 ± 0.0
3.445GlyTyr: 3.445 ± 1.563
0.0GlyXaa: 0.0 ± 0.0
His
0.492HisAla: 0.492 ± 0.508
0.984HisCys: 0.984 ± 0.947
1.969HisAsp: 1.969 ± 0.942
1.476HisGlu: 1.476 ± 1.42
1.476HisPhe: 1.476 ± 0.808
0.492HisGly: 0.492 ± 0.395
0.492HisHis: 0.492 ± 0.565
3.445HisIle: 3.445 ± 1.06
0.492HisLys: 0.492 ± 0.473
1.969HisLeu: 1.969 ± 1.535
0.984HisMet: 0.984 ± 0.49
0.492HisAsn: 0.492 ± 0.395
0.492HisPro: 0.492 ± 0.508
0.492HisGln: 0.492 ± 0.543
0.984HisArg: 0.984 ± 0.949
0.984HisSer: 0.984 ± 0.683
0.984HisThr: 0.984 ± 0.684
0.492HisVal: 0.492 ± 0.473
0.492HisTrp: 0.492 ± 0.473
1.476HisTyr: 1.476 ± 0.651
0.0HisXaa: 0.0 ± 0.0
Ile
5.906IleAla: 5.906 ± 2.345
0.984IleCys: 0.984 ± 0.529
4.921IleAsp: 4.921 ± 0.86
4.921IleGlu: 4.921 ± 1.058
1.969IlePhe: 1.969 ± 0.812
3.937IleGly: 3.937 ± 1.115
1.969IleHis: 1.969 ± 0.698
2.953IleIle: 2.953 ± 1.104
4.921IleLys: 4.921 ± 1.886
4.429IleLeu: 4.429 ± 1.342
1.476IleMet: 1.476 ± 0.599
2.461IleAsn: 2.461 ± 1.207
2.953IlePro: 2.953 ± 1.304
0.984IleGln: 0.984 ± 0.79
2.461IleArg: 2.461 ± 1.052
3.937IleSer: 3.937 ± 1.65
4.429IleThr: 4.429 ± 1.618
1.969IleVal: 1.969 ± 1.075
0.492IleTrp: 0.492 ± 0.475
3.445IleTyr: 3.445 ± 1.168
0.0IleXaa: 0.0 ± 0.0
Lys
6.398LysAla: 6.398 ± 0.884
0.984LysCys: 0.984 ± 0.709
4.429LysAsp: 4.429 ± 1.063
0.984LysGlu: 0.984 ± 0.634
3.937LysPhe: 3.937 ± 1.663
2.461LysGly: 2.461 ± 0.923
2.953LysHis: 2.953 ± 1.097
3.937LysIle: 3.937 ± 1.073
6.89LysLys: 6.89 ± 1.888
3.937LysLeu: 3.937 ± 1.683
0.984LysMet: 0.984 ± 0.79
2.461LysAsn: 2.461 ± 1.161
1.969LysPro: 1.969 ± 1.116
2.461LysGln: 2.461 ± 1.054
3.445LysArg: 3.445 ± 1.243
5.413LysSer: 5.413 ± 0.8
1.969LysThr: 1.969 ± 0.517
3.937LysVal: 3.937 ± 1.838
0.492LysTrp: 0.492 ± 0.473
0.984LysTyr: 0.984 ± 0.683
0.0LysXaa: 0.0 ± 0.0
Leu
6.398LeuAla: 6.398 ± 1.673
1.969LeuCys: 1.969 ± 0.886
3.937LeuAsp: 3.937 ± 1.307
5.413LeuGlu: 5.413 ± 1.326
2.461LeuPhe: 2.461 ± 1.641
7.382LeuGly: 7.382 ± 1.77
1.969LeuHis: 1.969 ± 1.397
5.413LeuIle: 5.413 ± 1.703
4.921LeuLys: 4.921 ± 0.891
8.858LeuLeu: 8.858 ± 3.193
1.969LeuMet: 1.969 ± 1.503
5.413LeuAsn: 5.413 ± 1.389
3.445LeuPro: 3.445 ± 1.329
1.969LeuGln: 1.969 ± 0.592
4.921LeuArg: 4.921 ± 1.47
8.366LeuSer: 8.366 ± 2.798
4.921LeuThr: 4.921 ± 2.25
7.382LeuVal: 7.382 ± 2.114
0.492LeuTrp: 0.492 ± 0.508
1.476LeuTyr: 1.476 ± 0.94
0.0LeuXaa: 0.0 ± 0.0
Met
2.953MetAla: 2.953 ± 2.205
0.0MetCys: 0.0 ± 0.0
1.969MetAsp: 1.969 ± 0.883
0.0MetGlu: 0.0 ± 0.0
0.984MetPhe: 0.984 ± 0.709
0.984MetGly: 0.984 ± 0.908
0.0MetHis: 0.0 ± 0.0
1.476MetIle: 1.476 ± 1.021
1.969MetLys: 1.969 ± 1.313
2.953MetLeu: 2.953 ± 1.934
0.0MetMet: 0.0 ± 0.0
1.969MetAsn: 1.969 ± 1.58
0.984MetPro: 0.984 ± 0.787
0.984MetGln: 0.984 ± 0.684
1.476MetArg: 1.476 ± 0.651
1.476MetSer: 1.476 ± 1.001
1.969MetThr: 1.969 ± 1.027
1.969MetVal: 1.969 ± 0.984
0.492MetTrp: 0.492 ± 0.508
0.984MetTyr: 0.984 ± 0.802
0.0MetXaa: 0.0 ± 0.0
Asn
4.429AsnAla: 4.429 ± 1.982
0.0AsnCys: 0.0 ± 0.0
2.461AsnAsp: 2.461 ± 1.05
2.953AsnGlu: 2.953 ± 1.489
0.984AsnPhe: 0.984 ± 0.79
2.461AsnGly: 2.461 ± 0.879
0.492AsnHis: 0.492 ± 0.395
3.445AsnIle: 3.445 ± 1.566
4.921AsnLys: 4.921 ± 1.147
1.476AsnLeu: 1.476 ± 0.949
1.476AsnMet: 1.476 ± 0.94
0.984AsnAsn: 0.984 ± 0.612
3.445AsnPro: 3.445 ± 1.454
2.461AsnGln: 2.461 ± 1.194
0.492AsnArg: 0.492 ± 0.565
2.953AsnSer: 2.953 ± 1.345
5.906AsnThr: 5.906 ± 2.713
2.461AsnVal: 2.461 ± 1.396
0.0AsnTrp: 0.0 ± 0.0
0.984AsnTyr: 0.984 ± 0.612
0.0AsnXaa: 0.0 ± 0.0
Pro
1.969ProAla: 1.969 ± 0.962
0.0ProCys: 0.0 ± 0.0
7.382ProAsp: 7.382 ± 2.868
2.461ProGlu: 2.461 ± 0.911
3.937ProPhe: 3.937 ± 1.481
0.984ProGly: 0.984 ± 0.787
0.492ProHis: 0.492 ± 0.508
1.969ProIle: 1.969 ± 0.672
0.492ProLys: 0.492 ± 0.473
2.953ProLeu: 2.953 ± 1.792
0.0ProMet: 0.0 ± 0.0
0.492ProAsn: 0.492 ± 0.637
2.461ProPro: 2.461 ± 0.817
1.476ProGln: 1.476 ± 0.815
1.476ProArg: 1.476 ± 0.897
3.445ProSer: 3.445 ± 1.483
2.953ProThr: 2.953 ± 1.291
5.413ProVal: 5.413 ± 1.739
0.0ProTrp: 0.0 ± 0.0
1.476ProTyr: 1.476 ± 1.185
0.0ProXaa: 0.0 ± 0.0
Gln
2.953GlnAla: 2.953 ± 1.153
0.984GlnCys: 0.984 ± 0.6
0.984GlnAsp: 0.984 ± 0.608
1.476GlnGlu: 1.476 ± 0.892
2.461GlnPhe: 2.461 ± 0.66
1.969GlnGly: 1.969 ± 0.893
0.0GlnHis: 0.0 ± 0.0
4.429GlnIle: 4.429 ± 0.867
0.984GlnLys: 0.984 ± 0.529
4.429GlnLeu: 4.429 ± 1.746
0.492GlnMet: 0.492 ± 0.395
2.461GlnAsn: 2.461 ± 1.181
1.476GlnPro: 1.476 ± 1.021
1.476GlnGln: 1.476 ± 0.752
0.984GlnArg: 0.984 ± 0.558
2.461GlnSer: 2.461 ± 0.67
1.476GlnThr: 1.476 ± 0.709
1.476GlnVal: 1.476 ± 0.475
1.476GlnTrp: 1.476 ± 0.874
2.461GlnTyr: 2.461 ± 1.265
0.0GlnXaa: 0.0 ± 0.0
Arg
1.969ArgAla: 1.969 ± 0.915
1.969ArgCys: 1.969 ± 1.098
2.461ArgAsp: 2.461 ± 1.448
2.461ArgGlu: 2.461 ± 1.381
1.476ArgPhe: 1.476 ± 0.615
3.445ArgGly: 3.445 ± 1.157
1.476ArgHis: 1.476 ± 0.92
3.445ArgIle: 3.445 ± 1.173
2.461ArgLys: 2.461 ± 1.425
4.921ArgLeu: 4.921 ± 2.195
0.492ArgMet: 0.492 ± 0.68
1.476ArgAsn: 1.476 ± 0.59
2.953ArgPro: 2.953 ± 1.195
0.492ArgGln: 0.492 ± 0.473
3.445ArgArg: 3.445 ± 1.691
0.984ArgSer: 0.984 ± 0.634
2.953ArgThr: 2.953 ± 1.306
0.984ArgVal: 0.984 ± 0.558
0.492ArgTrp: 0.492 ± 0.475
0.984ArgTyr: 0.984 ± 0.639
0.0ArgXaa: 0.0 ± 0.0
Ser
2.461SerAla: 2.461 ± 1.326
1.476SerCys: 1.476 ± 0.913
3.445SerAsp: 3.445 ± 1.265
4.429SerGlu: 4.429 ± 1.552
2.953SerPhe: 2.953 ± 1.357
6.89SerGly: 6.89 ± 1.637
1.476SerHis: 1.476 ± 0.83
5.906SerIle: 5.906 ± 1.646
0.492SerLys: 0.492 ± 0.508
8.366SerLeu: 8.366 ± 3.139
2.953SerMet: 2.953 ± 0.958
2.461SerAsn: 2.461 ± 1.645
0.984SerPro: 0.984 ± 0.684
3.445SerGln: 3.445 ± 1.143
2.953SerArg: 2.953 ± 1.118
2.461SerSer: 2.461 ± 0.866
4.921SerThr: 4.921 ± 1.339
3.445SerVal: 3.445 ± 1.463
0.0SerTrp: 0.0 ± 0.0
1.969SerTyr: 1.969 ± 0.951
0.0SerXaa: 0.0 ± 0.0
Thr
4.429ThrAla: 4.429 ± 1.288
2.461ThrCys: 2.461 ± 1.468
2.953ThrAsp: 2.953 ± 1.472
3.445ThrGlu: 3.445 ± 1.737
1.969ThrPhe: 1.969 ± 0.812
6.89ThrGly: 6.89 ± 2.644
0.984ThrHis: 0.984 ± 0.634
1.969ThrIle: 1.969 ± 0.871
4.429ThrLys: 4.429 ± 1.676
4.921ThrLeu: 4.921 ± 1.488
0.984ThrMet: 0.984 ± 0.697
3.937ThrAsn: 3.937 ± 1.244
2.461ThrPro: 2.461 ± 1.142
1.969ThrGln: 1.969 ± 0.874
1.969ThrArg: 1.969 ± 0.932
4.921ThrSer: 4.921 ± 1.469
1.476ThrThr: 1.476 ± 0.709
5.413ThrVal: 5.413 ± 1.668
1.476ThrTrp: 1.476 ± 0.707
2.461ThrTyr: 2.461 ± 0.911
0.0ThrXaa: 0.0 ± 0.0
Val
3.445ValAla: 3.445 ± 2.183
1.969ValCys: 1.969 ± 1.054
5.413ValAsp: 5.413 ± 1.535
1.969ValGlu: 1.969 ± 0.842
6.89ValPhe: 6.89 ± 1.423
3.937ValGly: 3.937 ± 1.173
1.969ValHis: 1.969 ± 1.116
2.461ValIle: 2.461 ± 1.387
1.969ValLys: 1.969 ± 1.355
5.906ValLeu: 5.906 ± 1.154
2.461ValMet: 2.461 ± 1.387
5.906ValAsn: 5.906 ± 1.957
2.953ValPro: 2.953 ± 1.168
2.953ValGln: 2.953 ± 1.127
2.461ValArg: 2.461 ± 0.885
1.969ValSer: 1.969 ± 1.057
4.429ValThr: 4.429 ± 0.811
3.445ValVal: 3.445 ± 1.813
0.492ValTrp: 0.492 ± 0.473
1.476ValTyr: 1.476 ± 0.88
0.0ValXaa: 0.0 ± 0.0
Trp
0.984TrpAla: 0.984 ± 0.702
0.0TrpCys: 0.0 ± 0.0
0.492TrpAsp: 0.492 ± 0.543
0.984TrpGlu: 0.984 ± 0.608
0.492TrpPhe: 0.492 ± 0.475
0.492TrpGly: 0.492 ± 0.395
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.492TrpLys: 0.492 ± 0.475
1.969TrpLeu: 1.969 ± 0.728
0.492TrpMet: 0.492 ± 0.473
0.984TrpAsn: 0.984 ± 0.699
0.984TrpPro: 0.984 ± 0.949
0.0TrpGln: 0.0 ± 0.0
1.476TrpArg: 1.476 ± 0.92
0.984TrpSer: 0.984 ± 0.634
0.492TrpThr: 0.492 ± 0.395
1.476TrpVal: 1.476 ± 0.828
0.492TrpTrp: 0.492 ± 0.475
0.984TrpTyr: 0.984 ± 0.558
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.429TyrAla: 4.429 ± 1.644
0.0TyrCys: 0.0 ± 0.0
4.429TyrAsp: 4.429 ± 1.354
1.969TyrGlu: 1.969 ± 1.098
0.984TyrPhe: 0.984 ± 0.49
3.445TyrGly: 3.445 ± 1.405
0.492TyrHis: 0.492 ± 0.475
1.476TyrIle: 1.476 ± 0.965
4.429TyrLys: 4.429 ± 1.034
2.461TyrLeu: 2.461 ± 0.964
0.492TyrMet: 0.492 ± 0.588
0.984TyrAsn: 0.984 ± 0.947
0.984TyrPro: 0.984 ± 0.79
3.445TyrGln: 3.445 ± 1.566
1.969TyrArg: 1.969 ± 1.116
2.953TyrSer: 2.953 ± 1.09
2.461TyrThr: 2.461 ± 0.995
1.969TyrVal: 1.969 ± 0.84
0.492TyrTrp: 0.492 ± 0.473
0.492TyrTyr: 0.492 ± 0.395
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (2033 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski