Amino acid dipepetide frequency for Mycolicibacterium llatzerense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.035AlaAla: 20.035 ± 0.184	0.94AlaCys: 0.94 ± 0.026	8.572AlaAsp: 8.572 ± 0.075	7.529AlaGlu: 7.529 ± 0.077	3.501AlaPhe: 3.501 ± 0.048	11.732AlaGly: 11.732 ± 0.098	2.597AlaHis: 2.597 ± 0.044	5.425AlaIle: 5.425 ± 0.064	3.353AlaLys: 3.353 ± 0.058	12.8AlaLeu: 12.8 ± 0.111	2.992AlaMet: 2.992 ± 0.046	2.754AlaAsn: 2.754 ± 0.043	6.303AlaPro: 6.303 ± 0.078	4.132AlaGln: 4.132 ± 0.047	7.903AlaArg: 7.903 ± 0.08	5.78AlaSer: 5.78 ± 0.063	7.306AlaThr: 7.306 ± 0.069	11.77AlaVal: 11.77 ± 0.101	1.626AlaTrp: 1.626 ± 0.03	2.416AlaTyr: 2.416 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.086CysAla: 1.086 ± 0.025	0.102CysCys: 0.102 ± 0.009	0.545CysAsp: 0.545 ± 0.019	0.394CysGlu: 0.394 ± 0.016	0.223CysPhe: 0.223 ± 0.013	0.943CysGly: 0.943 ± 0.03	0.19CysHis: 0.19 ± 0.011	0.279CysIle: 0.279 ± 0.013	0.139CysLys: 0.139 ± 0.011	0.682CysLeu: 0.682 ± 0.018	0.138CysMet: 0.138 ± 0.009	0.163CysAsn: 0.163 ± 0.009	0.533CysPro: 0.533 ± 0.018	0.236CysGln: 0.236 ± 0.013	0.565CysArg: 0.565 ± 0.018	0.478CysSer: 0.478 ± 0.018	0.511CysThr: 0.511 ± 0.017	0.641CysVal: 0.641 ± 0.019	0.132CysTrp: 0.132 ± 0.01	0.182CysTyr: 0.182 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.8AspAla: 7.8 ± 0.075	0.472AspCys: 0.472 ± 0.019	4.257AspAsp: 4.257 ± 0.059	4.017AspGlu: 4.017 ± 0.058	1.793AspPhe: 1.793 ± 0.033	5.939AspGly: 5.939 ± 0.067	1.474AspHis: 1.474 ± 0.032	2.812AspIle: 2.812 ± 0.042	1.449AspLys: 1.449 ± 0.031	6.004AspLeu: 6.004 ± 0.065	1.088AspMet: 1.088 ± 0.027	1.38AspAsn: 1.38 ± 0.032	4.183AspPro: 4.183 ± 0.053	1.932AspGln: 1.932 ± 0.033	4.374AspArg: 4.374 ± 0.052	2.848AspSer: 2.848 ± 0.038	3.171AspThr: 3.171 ± 0.046	5.29AspVal: 5.29 ± 0.057	1.025AspTrp: 1.025 ± 0.026	1.46AspTyr: 1.46 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	5.882GluAla: 5.882 ± 0.07	0.371GluCys: 0.371 ± 0.015	2.299GluAsp: 2.299 ± 0.044	2.275GluGlu: 2.275 ± 0.049	1.947GluPhe: 1.947 ± 0.032	3.156GluGly: 3.156 ± 0.051	1.545GluHis: 1.545 ± 0.034	2.574GluIle: 2.574 ± 0.041	1.385GluLys: 1.385 ± 0.032	6.69GluLeu: 6.69 ± 0.077	1.078GluMet: 1.078 ± 0.025	1.151GluAsn: 1.151 ± 0.028	2.857GluPro: 2.857 ± 0.042	2.256GluGln: 2.256 ± 0.039	4.124GluArg: 4.124 ± 0.056	2.683GluSer: 2.683 ± 0.037	2.625GluThr: 2.625 ± 0.041	4.205GluVal: 4.205 ± 0.056	0.741GluTrp: 0.741 ± 0.022	1.159GluTyr: 1.159 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.016PheAla: 4.016 ± 0.051	0.316PheCys: 0.316 ± 0.014	2.479PheAsp: 2.479 ± 0.037	1.587PheGlu: 1.587 ± 0.029	1.025PhePhe: 1.025 ± 0.029	3.615PheGly: 3.615 ± 0.047	0.668PheHis: 0.668 ± 0.022	1.188PheIle: 1.188 ± 0.03	0.606PheLys: 0.606 ± 0.021	2.554PheLeu: 2.554 ± 0.041	0.546PheMet: 0.546 ± 0.018	0.848PheAsn: 0.848 ± 0.024	1.454PhePro: 1.454 ± 0.026	0.75PheGln: 0.75 ± 0.022	1.722PheArg: 1.722 ± 0.03	1.768PheSer: 1.768 ± 0.031	2.176PheThr: 2.176 ± 0.038	2.616PheVal: 2.616 ± 0.04	0.47PheTrp: 0.47 ± 0.02	0.741PheTyr: 0.741 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.147GlyAla: 10.147 ± 0.082	0.811GlyCys: 0.811 ± 0.026	4.899GlyAsp: 4.899 ± 0.061	4.188GlyGlu: 4.188 ± 0.057	3.161GlyPhe: 3.161 ± 0.047	7.805GlyGly: 7.805 ± 0.121	2.063GlyHis: 2.063 ± 0.035	4.302GlyIle: 4.302 ± 0.053	2.519GlyLys: 2.519 ± 0.047	8.594GlyLeu: 8.594 ± 0.084	2.14GlyMet: 2.14 ± 0.043	2.043GlyAsn: 2.043 ± 0.055	4.524GlyPro: 4.524 ± 0.057	2.942GlyGln: 2.942 ± 0.05	5.963GlyArg: 5.963 ± 0.059	5.166GlySer: 5.166 ± 0.066	5.444GlyThr: 5.444 ± 0.058	7.383GlyVal: 7.383 ± 0.069	1.67GlyTrp: 1.67 ± 0.032	2.441GlyTyr: 2.441 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.466HisAla: 2.466 ± 0.034	0.237HisCys: 0.237 ± 0.013	1.449HisAsp: 1.449 ± 0.028	1.091HisGlu: 1.091 ± 0.027	0.724HisPhe: 0.724 ± 0.021	2.101HisGly: 2.101 ± 0.036	0.749HisHis: 0.749 ± 0.024	0.92HisIle: 0.92 ± 0.019	0.405HisLys: 0.405 ± 0.016	2.254HisLeu: 2.254 ± 0.041	0.395HisMet: 0.395 ± 0.015	0.519HisAsn: 0.519 ± 0.015	1.625HisPro: 1.625 ± 0.033	0.735HisGln: 0.735 ± 0.02	1.792HisArg: 1.792 ± 0.038	1.141HisSer: 1.141 ± 0.026	1.283HisThr: 1.283 ± 0.028	1.781HisVal: 1.781 ± 0.032	0.409HisTrp: 0.409 ± 0.017	0.561HisTyr: 0.561 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.565IleAla: 6.565 ± 0.056	0.409IleCys: 0.409 ± 0.018	3.436IleAsp: 3.436 ± 0.046	2.665IleGlu: 2.665 ± 0.041	1.108IlePhe: 1.108 ± 0.03	4.614IleGly: 4.614 ± 0.057	0.834IleHis: 0.834 ± 0.023	1.634IleIle: 1.634 ± 0.034	1.063IleLys: 1.063 ± 0.03	3.125IleLeu: 3.125 ± 0.043	0.648IleMet: 0.648 ± 0.022	1.245IleAsn: 1.245 ± 0.029	2.369IlePro: 2.369 ± 0.039	1.022IleGln: 1.022 ± 0.021	2.657IleArg: 2.657 ± 0.037	2.409IleSer: 2.409 ± 0.04	2.903IleThr: 2.903 ± 0.049	3.824IleVal: 3.824 ± 0.053	0.491IleTrp: 0.491 ± 0.018	0.874IleTyr: 0.874 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	3.022LysAla: 3.022 ± 0.054	0.136LysCys: 0.136 ± 0.009	1.284LysAsp: 1.284 ± 0.034	0.996LysGlu: 0.996 ± 0.03	0.746LysPhe: 0.746 ± 0.019	1.716LysGly: 1.716 ± 0.037	0.543LysHis: 0.543 ± 0.019	1.122LysIle: 1.122 ± 0.03	0.75LysLys: 0.75 ± 0.027	2.546LysLeu: 2.546 ± 0.043	0.561LysMet: 0.561 ± 0.019	0.592LysAsn: 0.592 ± 0.021	1.592LysPro: 1.592 ± 0.035	0.798LysGln: 0.798 ± 0.023	1.649LysArg: 1.649 ± 0.039	1.397LysSer: 1.397 ± 0.033	1.477LysThr: 1.477 ± 0.032	2.124LysVal: 2.124 ± 0.038	0.363LysTrp: 0.363 ± 0.015	0.566LysTyr: 0.566 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.886LeuAla: 13.886 ± 0.104	0.814LeuCys: 0.814 ± 0.023	6.507LeuAsp: 6.507 ± 0.071	4.334LeuGlu: 4.334 ± 0.059	2.7LeuPhe: 2.7 ± 0.043	8.763LeuGly: 8.763 ± 0.078	2.11LeuHis: 2.11 ± 0.04	4.224LeuIle: 4.224 ± 0.055	2.076LeuLys: 2.076 ± 0.04	9.541LeuLeu: 9.541 ± 0.097	1.84LeuMet: 1.84 ± 0.035	2.235LeuAsn: 2.235 ± 0.035	5.923LeuPro: 5.923 ± 0.064	2.734LeuGln: 2.734 ± 0.04	7.155LeuArg: 7.155 ± 0.081	5.713LeuSer: 5.713 ± 0.054	6.602LeuThr: 6.602 ± 0.07	8.293LeuVal: 8.293 ± 0.077	1.248LeuTrp: 1.248 ± 0.029	1.671LeuTyr: 1.671 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	2.694MetAla: 2.694 ± 0.048	0.214MetCys: 0.214 ± 0.012	0.939MetAsp: 0.939 ± 0.024	0.732MetGlu: 0.732 ± 0.022	0.706MetPhe: 0.706 ± 0.02	1.53MetGly: 1.53 ± 0.032	0.452MetHis: 0.452 ± 0.015	0.947MetIle: 0.947 ± 0.028	0.532MetLys: 0.532 ± 0.021	2.095MetLeu: 2.095 ± 0.039	0.44MetMet: 0.44 ± 0.017	0.535MetAsn: 0.535 ± 0.016	1.255MetPro: 1.255 ± 0.025	0.591MetGln: 0.591 ± 0.018	1.474MetArg: 1.474 ± 0.031	1.684MetSer: 1.684 ± 0.034	1.93MetThr: 1.93 ± 0.03	1.696MetVal: 1.696 ± 0.031	0.27MetTrp: 0.27 ± 0.012	0.369MetTyr: 0.369 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.782AsnAla: 2.782 ± 0.041	0.22AsnCys: 0.22 ± 0.01	1.278AsnAsp: 1.278 ± 0.025	1.033AsnGlu: 1.033 ± 0.023	0.732AsnPhe: 0.732 ± 0.024	2.164AsnGly: 2.164 ± 0.056	0.533AsnHis: 0.533 ± 0.019	1.079AsnIle: 1.079 ± 0.026	0.553AsnLys: 0.553 ± 0.02	2.219AsnLeu: 2.219 ± 0.035	0.498AsnMet: 0.498 ± 0.016	0.649AsnAsn: 0.649 ± 0.022	1.885AsnPro: 1.885 ± 0.041	0.734AsnGln: 0.734 ± 0.023	1.604AsnArg: 1.604 ± 0.03	1.255AsnSer: 1.255 ± 0.025	1.402AsnThr: 1.402 ± 0.026	1.94AsnVal: 1.94 ± 0.034	0.398AsnTrp: 0.398 ± 0.015	0.614AsnTyr: 0.614 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.335ProAla: 7.335 ± 0.082	0.303ProCys: 0.303 ± 0.014	4.305ProAsp: 4.305 ± 0.05	3.611ProGlu: 3.611 ± 0.053	1.669ProPhe: 1.669 ± 0.032	5.473ProGly: 5.473 ± 0.06	1.244ProHis: 1.244 ± 0.028	2.23ProIle: 2.23 ± 0.04	1.436ProLys: 1.436 ± 0.03	4.896ProLeu: 4.896 ± 0.061	1.246ProMet: 1.246 ± 0.03	1.395ProAsn: 1.395 ± 0.031	3.109ProPro: 3.109 ± 0.063	1.824ProGln: 1.824 ± 0.035	3.089ProArg: 3.089 ± 0.048	2.96ProSer: 2.96 ± 0.036	3.463ProThr: 3.463 ± 0.054	5.128ProVal: 5.128 ± 0.065	0.832ProTrp: 0.832 ± 0.024	1.226ProTyr: 1.226 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.787GlnAla: 3.787 ± 0.052	0.223GlnCys: 0.223 ± 0.011	1.357GlnAsp: 1.357 ± 0.031	1.122GlnGlu: 1.122 ± 0.03	1.115GlnPhe: 1.115 ± 0.026	2.013GlnGly: 2.013 ± 0.035	0.837GlnHis: 0.837 ± 0.025	1.608GlnIle: 1.608 ± 0.03	0.675GlnLys: 0.675 ± 0.021	3.788GlnLeu: 3.788 ± 0.053	0.753GlnMet: 0.753 ± 0.022	0.677GlnAsn: 0.677 ± 0.023	1.898GlnPro: 1.898 ± 0.04	1.397GlnGln: 1.397 ± 0.029	2.669GlnArg: 2.669 ± 0.043	1.634GlnSer: 1.634 ± 0.035	1.725GlnThr: 1.725 ± 0.032	2.677GlnVal: 2.677 ± 0.037	0.625GlnTrp: 0.625 ± 0.02	0.732GlnTyr: 0.732 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.547ArgAla: 7.547 ± 0.073	0.546ArgCys: 0.546 ± 0.018	4.079ArgAsp: 4.079 ± 0.057	3.613ArgGlu: 3.613 ± 0.053	2.306ArgPhe: 2.306 ± 0.035	4.937ArgGly: 4.937 ± 0.059	1.696ArgHis: 1.696 ± 0.032	3.379ArgIle: 3.379 ± 0.045	1.666ArgLys: 1.666 ± 0.033	7.038ArgLeu: 7.038 ± 0.081	1.74ArgMet: 1.74 ± 0.035	1.7ArgAsn: 1.7 ± 0.035	3.717ArgPro: 3.717 ± 0.049	2.34ArgGln: 2.34 ± 0.037	5.858ArgArg: 5.858 ± 0.076	3.757ArgSer: 3.757 ± 0.053	4.17ArgThr: 4.17 ± 0.049	5.259ArgVal: 5.259 ± 0.056	1.298ArgTrp: 1.298 ± 0.031	1.872ArgTyr: 1.872 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.942SerAla: 6.942 ± 0.065	0.432SerCys: 0.432 ± 0.015	3.257SerAsp: 3.257 ± 0.043	2.518SerGlu: 2.518 ± 0.038	1.705SerPhe: 1.705 ± 0.029	5.664SerGly: 5.664 ± 0.067	1.121SerHis: 1.121 ± 0.028	2.228SerIle: 2.228 ± 0.037	1.301SerLys: 1.301 ± 0.035	4.767SerLeu: 4.767 ± 0.053	1.352SerMet: 1.352 ± 0.028	1.224SerAsn: 1.224 ± 0.03	2.894SerPro: 2.894 ± 0.038	1.541SerGln: 1.541 ± 0.032	3.54SerArg: 3.54 ± 0.046	3.174SerSer: 3.174 ± 0.051	3.46SerThr: 3.46 ± 0.049	4.609SerVal: 4.609 ± 0.051	0.954SerTrp: 0.954 ± 0.027	1.261SerTyr: 1.261 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.098ThrAla: 8.098 ± 0.069	0.433ThrCys: 0.433 ± 0.016	3.924ThrAsp: 3.924 ± 0.047	3.253ThrGlu: 3.253 ± 0.042	1.955ThrPhe: 1.955 ± 0.034	5.926ThrGly: 5.926 ± 0.063	1.206ThrHis: 1.206 ± 0.029	2.595ThrIle: 2.595 ± 0.044	1.457ThrLys: 1.457 ± 0.031	5.654ThrLeu: 5.654 ± 0.06	1.271ThrMet: 1.271 ± 0.029	1.369ThrAsn: 1.369 ± 0.028	3.795ThrPro: 3.795 ± 0.051	1.579ThrGln: 1.579 ± 0.032	3.563ThrArg: 3.563 ± 0.05	3.197ThrSer: 3.197 ± 0.05	4.037ThrThr: 4.037 ± 0.057	6.0ThrVal: 6.0 ± 0.068	0.867ThrTrp: 0.867 ± 0.026	1.352ThrTyr: 1.352 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.374ValAla: 11.374 ± 0.104	0.785ValCys: 0.785 ± 0.022	5.68ValAsp: 5.68 ± 0.067	4.339ValGlu: 4.339 ± 0.06	2.618ValPhe: 2.618 ± 0.041	6.978ValGly: 6.978 ± 0.07	1.865ValHis: 1.865 ± 0.033	4.002ValIle: 4.002 ± 0.047	1.851ValLys: 1.851 ± 0.042	8.926ValLeu: 8.926 ± 0.073	1.671ValMet: 1.671 ± 0.033	2.136ValAsn: 2.136 ± 0.04	4.751ValPro: 4.751 ± 0.065	2.294ValGln: 2.294 ± 0.04	5.707ValArg: 5.707 ± 0.067	4.812ValSer: 4.812 ± 0.06	5.668ValThr: 5.668 ± 0.068	8.419ValVal: 8.419 ± 0.09	1.055ValTrp: 1.055 ± 0.028	1.576ValTyr: 1.576 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.573TrpAla: 1.573 ± 0.034	0.157TrpCys: 0.157 ± 0.009	0.807TrpAsp: 0.807 ± 0.025	0.629TrpGlu: 0.629 ± 0.021	0.577TrpPhe: 0.577 ± 0.019	1.047TrpGly: 1.047 ± 0.024	0.426TrpHis: 0.426 ± 0.015	0.675TrpIle: 0.675 ± 0.02	0.339TrpLys: 0.339 ± 0.015	1.712TrpLeu: 1.712 ± 0.036	0.357TrpMet: 0.357 ± 0.015	0.449TrpAsn: 0.449 ± 0.015	0.823TrpPro: 0.823 ± 0.022	0.721TrpGln: 0.721 ± 0.022	1.21TrpArg: 1.21 ± 0.028	0.925TrpSer: 0.925 ± 0.025	0.934TrpThr: 0.934 ± 0.025	1.146TrpVal: 1.146 ± 0.028	0.346TrpTrp: 0.346 ± 0.016	0.347TrpTyr: 0.347 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.429TyrAla: 2.429 ± 0.03	0.24TyrCys: 0.24 ± 0.012	1.413TyrAsp: 1.413 ± 0.028	1.075TyrGlu: 1.075 ± 0.026	0.834TyrPhe: 0.834 ± 0.02	2.09TyrGly: 2.09 ± 0.04	0.484TyrHis: 0.484 ± 0.016	0.672TyrIle: 0.672 ± 0.019	0.422TyrLys: 0.422 ± 0.017	2.484TyrLeu: 2.484 ± 0.041	0.329TyrMet: 0.329 ± 0.013	0.512TyrAsn: 0.512 ± 0.018	1.285TyrPro: 1.285 ± 0.029	0.756TyrGln: 0.756 ± 0.022	1.898TyrArg: 1.898 ± 0.034	1.166TyrSer: 1.166 ± 0.033	1.245TyrThr: 1.245 ± 0.03	1.708TyrVal: 1.708 ± 0.033	0.379TyrTrp: 0.379 ± 0.016	0.511TyrTyr: 0.511 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5405 proteins (1698364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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