Amino acid dipepetide frequency for Vibrio furnissii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.819AlaAla: 8.819 ± 0.101
1.021AlaCys: 1.021 ± 0.026
4.82AlaAsp: 4.82 ± 0.061
5.557AlaGlu: 5.557 ± 0.07
3.667AlaPhe: 3.667 ± 0.052
6.224AlaGly: 6.224 ± 0.079
2.043AlaHis: 2.043 ± 0.043
6.026AlaIle: 6.026 ± 0.063
4.805AlaLys: 4.805 ± 0.07
11.223AlaLeu: 11.223 ± 0.115
3.185AlaMet: 3.185 ± 0.049
3.539AlaAsn: 3.539 ± 0.053
3.293AlaPro: 3.293 ± 0.054
4.861AlaGln: 4.861 ± 0.067
4.25AlaArg: 4.25 ± 0.06
5.581AlaSer: 5.581 ± 0.07
4.885AlaThr: 4.885 ± 0.058
6.344AlaVal: 6.344 ± 0.068
1.134AlaTrp: 1.134 ± 0.029
2.468AlaTyr: 2.468 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.886CysAla: 0.886 ± 0.027
0.152CysCys: 0.152 ± 0.011
0.657CysAsp: 0.657 ± 0.021
0.617CysGlu: 0.617 ± 0.026
0.454CysPhe: 0.454 ± 0.019
0.97CysGly: 0.97 ± 0.032
0.362CysHis: 0.362 ± 0.017
0.548CysIle: 0.548 ± 0.02
0.385CysLys: 0.385 ± 0.017
0.998CysLeu: 0.998 ± 0.03
0.234CysMet: 0.234 ± 0.011
0.337CysAsn: 0.337 ± 0.015
0.451CysPro: 0.451 ± 0.018
0.527CysGln: 0.527 ± 0.02
0.511CysArg: 0.511 ± 0.018
0.656CysSer: 0.656 ± 0.022
0.473CysThr: 0.473 ± 0.017
0.736CysVal: 0.736 ± 0.025
0.139CysTrp: 0.139 ± 0.01
0.307CysTyr: 0.307 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.25AspAla: 5.25 ± 0.069
0.545AspCys: 0.545 ± 0.022
3.289AspAsp: 3.289 ± 0.061
3.873AspGlu: 3.873 ± 0.064
2.301AspPhe: 2.301 ± 0.04
3.766AspGly: 3.766 ± 0.06
1.253AspHis: 1.253 ± 0.032
3.711AspIle: 3.711 ± 0.052
2.801AspLys: 2.801 ± 0.054
5.162AspLeu: 5.162 ± 0.063
1.432AspMet: 1.432 ± 0.033
2.149AspAsn: 2.149 ± 0.038
1.995AspPro: 1.995 ± 0.046
2.11AspGln: 2.11 ± 0.038
2.373AspArg: 2.373 ± 0.041
3.015AspSer: 3.015 ± 0.049
2.79AspThr: 2.79 ± 0.047
4.28AspVal: 4.28 ± 0.057
0.873AspTrp: 0.873 ± 0.027
2.025AspTyr: 2.025 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
5.38GluAla: 5.38 ± 0.065
0.524GluCys: 0.524 ± 0.023
2.423GluAsp: 2.423 ± 0.046
3.357GluGlu: 3.357 ± 0.068
2.339GluPhe: 2.339 ± 0.044
3.237GluGly: 3.237 ± 0.054
1.844GluHis: 1.844 ± 0.037
3.338GluIle: 3.338 ± 0.057
3.256GluLys: 3.256 ± 0.056
6.8GluLeu: 6.8 ± 0.076
1.726GluMet: 1.726 ± 0.038
2.233GluAsn: 2.233 ± 0.045
2.078GluPro: 2.078 ± 0.049
3.903GluGln: 3.903 ± 0.064
3.688GluArg: 3.688 ± 0.052
3.364GluSer: 3.364 ± 0.051
3.077GluThr: 3.077 ± 0.045
4.065GluVal: 4.065 ± 0.056
0.8GluTrp: 0.8 ± 0.026
1.584GluTyr: 1.584 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.902PheAla: 3.902 ± 0.065
0.495PheCys: 0.495 ± 0.019
2.7PheAsp: 2.7 ± 0.046
2.401PheGlu: 2.401 ± 0.044
1.679PhePhe: 1.679 ± 0.036
3.276PheGly: 3.276 ± 0.056
0.963PheHis: 0.963 ± 0.026
2.525PheIle: 2.525 ± 0.043
1.72PheLys: 1.72 ± 0.034
3.416PheLeu: 3.416 ± 0.055
1.005PheMet: 1.005 ± 0.029
1.85PheAsn: 1.85 ± 0.038
1.463PhePro: 1.463 ± 0.034
1.359PheGln: 1.359 ± 0.027
1.561PheArg: 1.561 ± 0.034
3.066PheSer: 3.066 ± 0.043
2.32PheThr: 2.32 ± 0.043
2.919PheVal: 2.919 ± 0.047
0.53PheTrp: 0.53 ± 0.021
1.258PheTyr: 1.258 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
5.455GlyAla: 5.455 ± 0.086
0.889GlyCys: 0.889 ± 0.027
3.667GlyAsp: 3.667 ± 0.059
4.31GlyGlu: 4.31 ± 0.06
3.272GlyPhe: 3.272 ± 0.052
4.732GlyGly: 4.732 ± 0.078
1.67GlyHis: 1.67 ± 0.038
4.596GlyIle: 4.596 ± 0.063
3.567GlyLys: 3.567 ± 0.056
7.149GlyLeu: 7.149 ± 0.082
2.112GlyMet: 2.112 ± 0.042
2.371GlyAsn: 2.371 ± 0.047
1.664GlyPro: 1.664 ± 0.036
2.998GlyGln: 2.998 ± 0.043
3.233GlyArg: 3.233 ± 0.055
3.93GlySer: 3.93 ± 0.063
3.379GlyThr: 3.379 ± 0.049
5.442GlyVal: 5.442 ± 0.066
1.004GlyTrp: 1.004 ± 0.027
2.558GlyTyr: 2.558 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.144HisAla: 2.144 ± 0.047
0.341HisCys: 0.341 ± 0.018
1.417HisAsp: 1.417 ± 0.034
1.255HisGlu: 1.255 ± 0.031
1.163HisPhe: 1.163 ± 0.03
1.735HisGly: 1.735 ± 0.037
0.918HisHis: 0.918 ± 0.03
1.525HisIle: 1.525 ± 0.029
0.97HisLys: 0.97 ± 0.027
2.518HisLeu: 2.518 ± 0.041
0.608HisMet: 0.608 ± 0.02
0.93HisAsn: 0.93 ± 0.026
1.324HisPro: 1.324 ± 0.032
1.48HisGln: 1.48 ± 0.034
1.261HisArg: 1.261 ± 0.028
1.467HisSer: 1.467 ± 0.037
1.241HisThr: 1.241 ± 0.028
1.574HisVal: 1.574 ± 0.029
0.453HisTrp: 0.453 ± 0.019
0.933HisTyr: 0.933 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.542IleAla: 6.542 ± 0.061
0.655IleCys: 0.655 ± 0.02
4.021IleAsp: 4.021 ± 0.054
4.275IleGlu: 4.275 ± 0.05
2.096IlePhe: 2.096 ± 0.048
4.592IleGly: 4.592 ± 0.069
1.368IleHis: 1.368 ± 0.03
3.161IleIle: 3.161 ± 0.053
2.699IleLys: 2.699 ± 0.045
5.015IleLeu: 5.015 ± 0.065
1.218IleMet: 1.218 ± 0.031
2.576IleAsn: 2.576 ± 0.045
2.528IlePro: 2.528 ± 0.041
2.388IleGln: 2.388 ± 0.039
2.852IleArg: 2.852 ± 0.047
4.01IleSer: 4.01 ± 0.059
3.359IleThr: 3.359 ± 0.046
4.164IleVal: 4.164 ± 0.054
0.614IleTrp: 0.614 ± 0.021
1.582IleTyr: 1.582 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.78LysAla: 4.78 ± 0.065
0.272LysCys: 0.272 ± 0.014
2.353LysAsp: 2.353 ± 0.042
2.804LysGlu: 2.804 ± 0.048
1.366LysPhe: 1.366 ± 0.029
3.025LysGly: 3.025 ± 0.054
1.161LysHis: 1.161 ± 0.025
2.451LysIle: 2.451 ± 0.045
2.419LysLys: 2.419 ± 0.05
4.865LysLeu: 4.865 ± 0.074
1.32LysMet: 1.32 ± 0.028
1.758LysAsn: 1.758 ± 0.036
2.185LysPro: 2.185 ± 0.044
2.666LysGln: 2.666 ± 0.052
2.672LysArg: 2.672 ± 0.045
2.748LysSer: 2.748 ± 0.044
2.603LysThr: 2.603 ± 0.05
3.447LysVal: 3.447 ± 0.049
0.484LysTrp: 0.484 ± 0.021
1.236LysTyr: 1.236 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
10.87LeuAla: 10.87 ± 0.108
1.179LeuCys: 1.179 ± 0.026
5.983LeuAsp: 5.983 ± 0.072
5.803LeuGlu: 5.803 ± 0.078
4.275LeuPhe: 4.275 ± 0.059
7.123LeuGly: 7.123 ± 0.081
2.353LeuHis: 2.353 ± 0.044
6.014LeuIle: 6.014 ± 0.074
5.001LeuLys: 5.001 ± 0.06
10.951LeuLeu: 10.951 ± 0.124
3.056LeuMet: 3.056 ± 0.043
4.694LeuAsn: 4.694 ± 0.063
4.876LeuPro: 4.876 ± 0.068
3.89LeuGln: 3.89 ± 0.061
4.728LeuArg: 4.728 ± 0.068
7.96LeuSer: 7.96 ± 0.087
6.292LeuThr: 6.292 ± 0.064
7.356LeuVal: 7.356 ± 0.084
1.147LeuTrp: 1.147 ± 0.036
2.702LeuTyr: 2.702 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.941MetAla: 2.941 ± 0.048
0.229MetCys: 0.229 ± 0.013
1.349MetAsp: 1.349 ± 0.029
1.302MetGlu: 1.302 ± 0.031
0.991MetPhe: 0.991 ± 0.033
1.894MetGly: 1.894 ± 0.039
0.525MetHis: 0.525 ± 0.019
1.545MetIle: 1.545 ± 0.034
1.478MetLys: 1.478 ± 0.031
2.941MetLeu: 2.941 ± 0.045
0.925MetMet: 0.925 ± 0.026
1.17MetAsn: 1.17 ± 0.03
1.296MetPro: 1.296 ± 0.034
1.292MetGln: 1.292 ± 0.029
1.337MetArg: 1.337 ± 0.032
2.032MetSer: 2.032 ± 0.041
1.812MetThr: 1.812 ± 0.032
2.0MetVal: 2.0 ± 0.035
0.257MetTrp: 0.257 ± 0.014
0.535MetTyr: 0.535 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.573AsnAla: 3.573 ± 0.051
0.369AsnCys: 0.369 ± 0.016
2.225AsnAsp: 2.225 ± 0.043
2.154AsnGlu: 2.154 ± 0.042
1.392AsnPhe: 1.392 ± 0.03
2.704AsnGly: 2.704 ± 0.049
1.025AsnHis: 1.025 ± 0.026
2.438AsnIle: 2.438 ± 0.045
1.742AsnLys: 1.742 ± 0.037
3.715AsnLeu: 3.715 ± 0.052
0.941AsnMet: 0.941 ± 0.027
1.568AsnAsn: 1.568 ± 0.035
2.024AsnPro: 2.024 ± 0.039
2.172AsnGln: 2.172 ± 0.039
2.022AsnArg: 2.022 ± 0.035
2.128AsnSer: 2.128 ± 0.041
2.036AsnThr: 2.036 ± 0.038
2.733AsnVal: 2.733 ± 0.049
0.506AsnTrp: 0.506 ± 0.019
1.254AsnTyr: 1.254 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
3.471ProAla: 3.471 ± 0.053
0.354ProCys: 0.354 ± 0.016
2.355ProAsp: 2.355 ± 0.039
2.902ProGlu: 2.902 ± 0.054
1.727ProPhe: 1.727 ± 0.034
2.326ProGly: 2.326 ± 0.046
1.057ProHis: 1.057 ± 0.027
2.333ProIle: 2.333 ± 0.043
1.862ProLys: 1.862 ± 0.038
4.337ProLeu: 4.337 ± 0.055
1.186ProMet: 1.186 ± 0.031
1.655ProAsn: 1.655 ± 0.036
1.189ProPro: 1.189 ± 0.029
1.997ProGln: 1.997 ± 0.042
1.499ProArg: 1.499 ± 0.035
2.492ProSer: 2.492 ± 0.047
2.263ProThr: 2.263 ± 0.044
3.164ProVal: 3.164 ± 0.052
0.542ProTrp: 0.542 ± 0.019
1.346ProTyr: 1.346 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.961GlnAla: 4.961 ± 0.061
0.448GlnCys: 0.448 ± 0.018
2.184GlnAsp: 2.184 ± 0.048
2.389GlnGlu: 2.389 ± 0.041
1.894GlnPhe: 1.894 ± 0.038
3.275GlnGly: 3.275 ± 0.049
1.586GlnHis: 1.586 ± 0.041
2.551GlnIle: 2.551 ± 0.044
1.88GlnLys: 1.88 ± 0.036
5.44GlnLeu: 5.44 ± 0.074
1.264GlnMet: 1.264 ± 0.027
1.522GlnAsn: 1.522 ± 0.03
2.077GlnPro: 2.077 ± 0.041
3.276GlnGln: 3.276 ± 0.064
2.875GlnArg: 2.875 ± 0.052
2.941GlnSer: 2.941 ± 0.049
2.541GlnThr: 2.541 ± 0.049
3.392GlnVal: 3.392 ± 0.048
0.758GlnTrp: 0.758 ± 0.023
1.457GlnTyr: 1.457 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.931ArgAla: 3.931 ± 0.054
0.52ArgCys: 0.52 ± 0.019
2.808ArgAsp: 2.808 ± 0.039
3.144ArgGlu: 3.144 ± 0.051
2.325ArgPhe: 2.325 ± 0.046
2.797ArgGly: 2.797 ± 0.046
1.423ArgHis: 1.423 ± 0.033
3.156ArgIle: 3.156 ± 0.051
2.268ArgLys: 2.268 ± 0.044
5.357ArgLeu: 5.357 ± 0.075
1.34ArgMet: 1.34 ± 0.03
1.832ArgAsn: 1.832 ± 0.037
1.63ArgPro: 1.63 ± 0.034
2.467ArgGln: 2.467 ± 0.044
2.606ArgArg: 2.606 ± 0.052
2.748ArgSer: 2.748 ± 0.049
2.335ArgThr: 2.335 ± 0.037
3.492ArgVal: 3.492 ± 0.052
0.728ArgTrp: 0.728 ± 0.023
1.892ArgTyr: 1.892 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
5.718SerAla: 5.718 ± 0.07
0.543SerCys: 0.543 ± 0.02
3.621SerAsp: 3.621 ± 0.057
3.639SerGlu: 3.639 ± 0.048
2.65SerPhe: 2.65 ± 0.047
4.778SerGly: 4.778 ± 0.053
1.614SerHis: 1.614 ± 0.033
3.694SerIle: 3.694 ± 0.052
2.665SerLys: 2.665 ± 0.049
6.834SerLeu: 6.834 ± 0.068
1.742SerMet: 1.742 ± 0.033
2.367SerAsn: 2.367 ± 0.044
2.461SerPro: 2.461 ± 0.047
3.047SerGln: 3.047 ± 0.047
3.011SerArg: 3.011 ± 0.05
3.968SerSer: 3.968 ± 0.066
3.182SerThr: 3.182 ± 0.044
4.669SerVal: 4.669 ± 0.059
0.773SerTrp: 0.773 ± 0.023
1.825SerTyr: 1.825 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
4.716ThrAla: 4.716 ± 0.06
0.506ThrCys: 0.506 ± 0.022
2.738ThrAsp: 2.738 ± 0.045
2.851ThrGlu: 2.851 ± 0.047
2.121ThrPhe: 2.121 ± 0.039
3.899ThrGly: 3.899 ± 0.051
1.414ThrHis: 1.414 ± 0.034
3.217ThrIle: 3.217 ± 0.054
2.014ThrLys: 2.014 ± 0.038
6.923ThrLeu: 6.923 ± 0.07
1.244ThrMet: 1.244 ± 0.027
1.829ThrAsn: 1.829 ± 0.033
2.863ThrPro: 2.863 ± 0.047
2.827ThrGln: 2.827 ± 0.045
2.484ThrArg: 2.484 ± 0.037
3.24ThrSer: 3.24 ± 0.052
2.887ThrThr: 2.887 ± 0.052
3.887ThrVal: 3.887 ± 0.052
0.585ThrTrp: 0.585 ± 0.02
1.474ThrTyr: 1.474 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
7.023ValAla: 7.023 ± 0.075
0.813ValCys: 0.813 ± 0.025
4.153ValAsp: 4.153 ± 0.051
4.409ValGlu: 4.409 ± 0.056
2.757ValPhe: 2.757 ± 0.047
4.829ValGly: 4.829 ± 0.062
1.393ValHis: 1.393 ± 0.036
4.699ValIle: 4.699 ± 0.059
3.433ValLys: 3.433 ± 0.055
7.354ValLeu: 7.354 ± 0.078
2.271ValMet: 2.271 ± 0.038
2.858ValAsn: 2.858 ± 0.047
2.798ValPro: 2.798 ± 0.046
2.48ValGln: 2.48 ± 0.04
3.294ValArg: 3.294 ± 0.057
4.973ValSer: 4.973 ± 0.062
4.268ValThr: 4.268 ± 0.054
5.81ValVal: 5.81 ± 0.076
0.848ValTrp: 0.848 ± 0.025
1.925ValTyr: 1.925 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.924TrpAla: 0.924 ± 0.027
0.18TrpCys: 0.18 ± 0.012
0.591TrpAsp: 0.591 ± 0.022
0.534TrpGlu: 0.534 ± 0.019
0.614TrpPhe: 0.614 ± 0.02
0.777TrpGly: 0.777 ± 0.024
0.409TrpHis: 0.409 ± 0.017
0.703TrpIle: 0.703 ± 0.022
0.501TrpLys: 0.501 ± 0.019
1.86TrpLeu: 1.86 ± 0.041
0.416TrpMet: 0.416 ± 0.021
0.448TrpAsn: 0.448 ± 0.017
0.496TrpPro: 0.496 ± 0.019
0.976TrpGln: 0.976 ± 0.028
0.693TrpArg: 0.693 ± 0.025
0.678TrpSer: 0.678 ± 0.023
0.501TrpThr: 0.501 ± 0.019
0.952TrpVal: 0.952 ± 0.029
0.213TrpTrp: 0.213 ± 0.013
0.381TrpTyr: 0.381 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.456TyrAla: 2.456 ± 0.04
0.366TyrCys: 0.366 ± 0.015
1.638TyrAsp: 1.638 ± 0.034
1.438TyrGlu: 1.438 ± 0.04
1.327TyrPhe: 1.327 ± 0.03
2.036TyrGly: 2.036 ± 0.045
0.876TyrHis: 0.876 ± 0.026
1.485TyrIle: 1.485 ± 0.034
1.151TyrLys: 1.151 ± 0.032
3.397TyrLeu: 3.397 ± 0.05
0.621TyrMet: 0.621 ± 0.019
1.036TyrAsn: 1.036 ± 0.028
1.368TyrPro: 1.368 ± 0.033
1.995TyrGln: 1.995 ± 0.042
1.846TyrArg: 1.846 ± 0.036
1.805TyrSer: 1.805 ± 0.035
1.477TyrThr: 1.477 ± 0.034
1.962TyrVal: 1.962 ± 0.038
0.461TyrTrp: 0.461 ± 0.019
0.97TyrTyr: 0.97 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4417 proteins (1435389 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski