Amino acid dipepetide frequency for Marivita hallyeonensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.494AlaAla: 14.494 ± 0.163	1.155AlaCys: 1.155 ± 0.031	6.912AlaAsp: 6.912 ± 0.087	7.783AlaGlu: 7.783 ± 0.104	4.463AlaPhe: 4.463 ± 0.068	9.119AlaGly: 9.119 ± 0.099	2.351AlaHis: 2.351 ± 0.053	5.959AlaIle: 5.959 ± 0.073	3.955AlaLys: 3.955 ± 0.066	13.257AlaLeu: 13.257 ± 0.139	3.707AlaMet: 3.707 ± 0.058	2.863AlaAsn: 2.863 ± 0.051	5.319AlaPro: 5.319 ± 0.073	4.437AlaGln: 4.437 ± 0.062	7.884AlaArg: 7.884 ± 0.09	5.736AlaSer: 5.736 ± 0.078	6.044AlaThr: 6.044 ± 0.076	8.241AlaVal: 8.241 ± 0.081	1.416AlaTrp: 1.416 ± 0.031	2.639AlaTyr: 2.639 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.153CysAla: 1.153 ± 0.031	0.116CysCys: 0.116 ± 0.011	0.627CysAsp: 0.627 ± 0.024	0.44CysGlu: 0.44 ± 0.019	0.352CysPhe: 0.352 ± 0.018	0.962CysGly: 0.962 ± 0.033	0.294CysHis: 0.294 ± 0.017	0.429CysIle: 0.429 ± 0.018	0.237CysLys: 0.237 ± 0.013	0.892CysLeu: 0.892 ± 0.028	0.161CysMet: 0.161 ± 0.012	0.224CysAsn: 0.224 ± 0.013	0.506CysPro: 0.506 ± 0.022	0.24CysGln: 0.24 ± 0.015	0.488CysArg: 0.488 ± 0.02	0.448CysSer: 0.448 ± 0.021	0.483CysThr: 0.483 ± 0.021	0.693CysVal: 0.693 ± 0.024	0.106CysTrp: 0.106 ± 0.008	0.215CysTyr: 0.215 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.946AspAla: 7.946 ± 0.096	0.513AspCys: 0.513 ± 0.021	3.771AspAsp: 3.771 ± 0.085	3.692AspGlu: 3.692 ± 0.06	2.42AspPhe: 2.42 ± 0.046	5.956AspGly: 5.956 ± 0.089	1.468AspHis: 1.468 ± 0.034	3.281AspIle: 3.281 ± 0.052	1.691AspLys: 1.691 ± 0.041	6.534AspLeu: 6.534 ± 0.072	1.796AspMet: 1.796 ± 0.035	1.372AspAsn: 1.372 ± 0.036	3.761AspPro: 3.761 ± 0.052	2.021AspGln: 2.021 ± 0.04	4.337AspArg: 4.337 ± 0.064	2.191AspSer: 2.191 ± 0.041	3.56AspThr: 3.56 ± 0.063	4.921AspVal: 4.921 ± 0.067	1.227AspTrp: 1.227 ± 0.028	1.524AspTyr: 1.524 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.792GluAla: 7.792 ± 0.093	0.377GluCys: 0.377 ± 0.017	3.931GluAsp: 3.931 ± 0.061	3.595GluGlu: 3.595 ± 0.07	1.903GluPhe: 1.903 ± 0.042	4.524GluGly: 4.524 ± 0.06	1.168GluHis: 1.168 ± 0.032	3.618GluIle: 3.618 ± 0.057	2.154GluLys: 2.154 ± 0.05	5.028GluLeu: 5.028 ± 0.065	1.927GluMet: 1.927 ± 0.038	1.865GluAsn: 1.865 ± 0.039	2.558GluPro: 2.558 ± 0.05	1.893GluGln: 1.893 ± 0.042	4.071GluArg: 4.071 ± 0.063	2.149GluSer: 2.149 ± 0.042	4.229GluThr: 4.229 ± 0.058	4.31GluVal: 4.31 ± 0.056	0.696GluTrp: 0.696 ± 0.024	1.108GluTyr: 1.108 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.578PheAla: 4.578 ± 0.066	0.454PheCys: 0.454 ± 0.018	3.163PheAsp: 3.163 ± 0.057	2.454PheGlu: 2.454 ± 0.051	1.6PhePhe: 1.6 ± 0.042	3.886PheGly: 3.886 ± 0.055	0.771PheHis: 0.771 ± 0.028	1.797PheIle: 1.797 ± 0.042	0.987PheLys: 0.987 ± 0.029	3.625PheLeu: 3.625 ± 0.064	0.886PheMet: 0.886 ± 0.027	1.102PheAsn: 1.102 ± 0.031	1.625PhePro: 1.625 ± 0.036	1.142PheGln: 1.142 ± 0.031	2.138PheArg: 2.138 ± 0.046	2.137PheSer: 2.137 ± 0.044	2.169PheThr: 2.169 ± 0.045	2.876PheVal: 2.876 ± 0.048	0.624PheTrp: 0.624 ± 0.025	0.936PheTyr: 0.936 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.076GlyAla: 9.076 ± 0.093	0.853GlyCys: 0.853 ± 0.029	4.84GlyAsp: 4.84 ± 0.064	4.395GlyGlu: 4.395 ± 0.062	3.818GlyPhe: 3.818 ± 0.059	6.921GlyGly: 6.921 ± 0.087	1.868GlyHis: 1.868 ± 0.043	4.585GlyIle: 4.585 ± 0.066	3.021GlyLys: 3.021 ± 0.055	8.826GlyLeu: 8.826 ± 0.096	2.5GlyMet: 2.5 ± 0.049	2.061GlyAsn: 2.061 ± 0.043	3.607GlyPro: 3.607 ± 0.054	3.141GlyGln: 3.141 ± 0.054	5.093GlyArg: 5.093 ± 0.065	4.307GlySer: 4.307 ± 0.06	4.944GlyThr: 4.944 ± 0.067	6.515GlyVal: 6.515 ± 0.069	1.425GlyTrp: 1.425 ± 0.031	2.259GlyTyr: 2.259 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.335HisAla: 2.335 ± 0.047	0.239HisCys: 0.239 ± 0.014	1.278HisAsp: 1.278 ± 0.038	1.08HisGlu: 1.08 ± 0.032	0.836HisPhe: 0.836 ± 0.023	1.882HisGly: 1.882 ± 0.042	0.576HisHis: 0.576 ± 0.022	1.064HisIle: 1.064 ± 0.026	0.568HisLys: 0.568 ± 0.024	2.172HisLeu: 2.172 ± 0.043	0.567HisMet: 0.567 ± 0.021	0.472HisAsn: 0.472 ± 0.019	1.382HisPro: 1.382 ± 0.039	0.614HisGln: 0.614 ± 0.026	1.333HisArg: 1.333 ± 0.036	0.948HisSer: 0.948 ± 0.024	0.909HisThr: 0.909 ± 0.026	1.675HisVal: 1.675 ± 0.033	0.347HisTrp: 0.347 ± 0.018	0.537HisTyr: 0.537 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.086IleAla: 7.086 ± 0.089	0.576IleCys: 0.576 ± 0.018	3.777IleAsp: 3.777 ± 0.057	3.582IleGlu: 3.582 ± 0.054	1.823IlePhe: 1.823 ± 0.035	5.017IleGly: 5.017 ± 0.071	0.913IleHis: 0.913 ± 0.03	2.322IleIle: 2.322 ± 0.051	1.418IleLys: 1.418 ± 0.037	4.938IleLeu: 4.938 ± 0.08	1.089IleMet: 1.089 ± 0.032	1.464IleAsn: 1.464 ± 0.036	2.42IlePro: 2.42 ± 0.048	1.259IleGln: 1.259 ± 0.034	3.001IleArg: 3.001 ± 0.055	3.067IleSer: 3.067 ± 0.055	3.026IleThr: 3.026 ± 0.051	3.994IleVal: 3.994 ± 0.064	0.76IleTrp: 0.76 ± 0.024	1.164IleTyr: 1.164 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.007LysAla: 4.007 ± 0.067	0.189LysCys: 0.189 ± 0.013	1.983LysAsp: 1.983 ± 0.047	1.652LysGlu: 1.652 ± 0.042	0.911LysPhe: 0.911 ± 0.026	2.699LysGly: 2.699 ± 0.05	0.69LysHis: 0.69 ± 0.023	1.622LysIle: 1.622 ± 0.042	1.223LysLys: 1.223 ± 0.041	2.992LysLeu: 2.992 ± 0.049	0.912LysMet: 0.912 ± 0.028	0.873LysAsn: 0.873 ± 0.027	1.904LysPro: 1.904 ± 0.041	0.904LysGln: 0.904 ± 0.03	2.346LysArg: 2.346 ± 0.048	2.007LysSer: 2.007 ± 0.043	2.154LysThr: 2.154 ± 0.043	2.268LysVal: 2.268 ± 0.046	0.392LysTrp: 0.392 ± 0.016	0.655LysTyr: 0.655 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.838LeuAla: 11.838 ± 0.127	0.993LeuCys: 0.993 ± 0.032	6.1LeuAsp: 6.1 ± 0.079	5.323LeuGlu: 5.323 ± 0.073	3.726LeuPhe: 3.726 ± 0.059	8.176LeuGly: 8.176 ± 0.106	1.856LeuHis: 1.856 ± 0.042	5.373LeuIle: 5.373 ± 0.084	3.302LeuLys: 3.302 ± 0.049	8.678LeuLeu: 8.678 ± 0.117	2.678LeuMet: 2.678 ± 0.055	2.816LeuAsn: 2.816 ± 0.054	5.458LeuPro: 5.458 ± 0.075	2.811LeuGln: 2.811 ± 0.055	6.731LeuArg: 6.731 ± 0.078	6.952LeuSer: 6.952 ± 0.084	6.156LeuThr: 6.156 ± 0.078	6.788LeuVal: 6.788 ± 0.073	1.343LeuTrp: 1.343 ± 0.039	1.954LeuTyr: 1.954 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.359MetAla: 3.359 ± 0.047	0.21MetCys: 0.21 ± 0.014	1.452MetAsp: 1.452 ± 0.033	1.325MetGlu: 1.325 ± 0.034	0.86MetPhe: 0.86 ± 0.027	2.254MetGly: 2.254 ± 0.044	0.487MetHis: 0.487 ± 0.019	1.55MetIle: 1.55 ± 0.039	1.056MetLys: 1.056 ± 0.029	2.559MetLeu: 2.559 ± 0.047	0.782MetMet: 0.782 ± 0.029	0.872MetAsn: 0.872 ± 0.026	1.556MetPro: 1.556 ± 0.037	1.015MetGln: 1.015 ± 0.025	1.945MetArg: 1.945 ± 0.045	1.872MetSer: 1.872 ± 0.045	2.132MetThr: 2.132 ± 0.04	1.919MetVal: 1.919 ± 0.042	0.287MetTrp: 0.287 ± 0.015	0.377MetTyr: 0.377 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.354AsnAla: 3.354 ± 0.057	0.278AsnCys: 0.278 ± 0.014	1.58AsnAsp: 1.58 ± 0.037	1.326AsnGlu: 1.326 ± 0.032	0.97AsnPhe: 0.97 ± 0.028	2.504AsnGly: 2.504 ± 0.044	0.524AsnHis: 0.524 ± 0.021	1.436AsnIle: 1.436 ± 0.032	0.697AsnLys: 0.697 ± 0.024	2.527AsnLeu: 2.527 ± 0.045	0.73AsnMet: 0.73 ± 0.025	0.727AsnAsn: 0.727 ± 0.024	1.915AsnPro: 1.915 ± 0.04	0.764AsnGln: 0.764 ± 0.027	1.748AsnArg: 1.748 ± 0.04	1.234AsnSer: 1.234 ± 0.035	1.459AsnThr: 1.459 ± 0.032	2.033AsnVal: 2.033 ± 0.038	0.447AsnTrp: 0.447 ± 0.017	0.66AsnTyr: 0.66 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.968ProAla: 4.968 ± 0.063	0.355ProCys: 0.355 ± 0.019	4.219ProAsp: 4.219 ± 0.057	4.02ProGlu: 4.02 ± 0.052	2.045ProPhe: 2.045 ± 0.042	4.108ProGly: 4.108 ± 0.063	1.137ProHis: 1.137 ± 0.033	2.385ProIle: 2.385 ± 0.043	1.979ProLys: 1.979 ± 0.048	4.446ProLeu: 4.446 ± 0.069	1.338ProMet: 1.338 ± 0.035	1.489ProAsn: 1.489 ± 0.035	2.169ProPro: 2.169 ± 0.048	1.626ProGln: 1.626 ± 0.041	2.57ProArg: 2.57 ± 0.049	2.72ProSer: 2.72 ± 0.05	2.714ProThr: 2.714 ± 0.045	4.222ProVal: 4.222 ± 0.057	0.709ProTrp: 0.709 ± 0.025	1.135ProTyr: 1.135 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.847GlnAla: 3.847 ± 0.054	0.216GlnCys: 0.216 ± 0.013	1.912GlnAsp: 1.912 ± 0.037	1.602GlnGlu: 1.602 ± 0.031	1.148GlnPhe: 1.148 ± 0.03	2.467GlnGly: 2.467 ± 0.046	0.629GlnHis: 0.629 ± 0.021	2.023GlnIle: 2.023 ± 0.041	1.152GlnLys: 1.152 ± 0.034	2.831GlnLeu: 2.831 ± 0.047	1.062GlnMet: 1.062 ± 0.032	1.03GlnAsn: 1.03 ± 0.03	1.585GlnPro: 1.585 ± 0.037	1.057GlnGln: 1.057 ± 0.037	2.065GlnArg: 2.065 ± 0.04	1.963GlnSer: 1.963 ± 0.039	1.992GlnThr: 1.992 ± 0.048	2.355GlnVal: 2.355 ± 0.044	0.424GlnTrp: 0.424 ± 0.02	0.603GlnTyr: 0.603 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.287ArgAla: 7.287 ± 0.087	0.49ArgCys: 0.49 ± 0.019	4.297ArgAsp: 4.297 ± 0.065	3.597ArgGlu: 3.597 ± 0.06	2.743ArgPhe: 2.743 ± 0.045	4.311ArgGly: 4.311 ± 0.057	1.458ArgHis: 1.458 ± 0.037	3.646ArgIle: 3.646 ± 0.056	2.316ArgLys: 2.316 ± 0.042	6.78ArgLeu: 6.78 ± 0.086	1.897ArgMet: 1.897 ± 0.039	1.772ArgAsn: 1.772 ± 0.038	3.017ArgPro: 3.017 ± 0.05	2.176ArgGln: 2.176 ± 0.043	4.461ArgArg: 4.461 ± 0.07	3.21ArgSer: 3.21 ± 0.057	3.107ArgThr: 3.107 ± 0.053	4.683ArgVal: 4.683 ± 0.073	0.939ArgTrp: 0.939 ± 0.031	1.51ArgTyr: 1.51 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.882SerAla: 5.882 ± 0.073	0.428SerCys: 0.428 ± 0.019	3.716SerAsp: 3.716 ± 0.055	3.225SerGlu: 3.225 ± 0.055	2.326SerPhe: 2.326 ± 0.045	5.332SerGly: 5.332 ± 0.073	1.104SerHis: 1.104 ± 0.032	2.666SerIle: 2.666 ± 0.049	1.685SerLys: 1.685 ± 0.04	5.084SerLeu: 5.084 ± 0.07	1.408SerMet: 1.408 ± 0.033	1.515SerAsn: 1.515 ± 0.036	2.501SerPro: 2.501 ± 0.043	1.636SerGln: 1.636 ± 0.034	3.137SerArg: 3.137 ± 0.054	2.636SerSer: 2.636 ± 0.054	2.672SerThr: 2.672 ± 0.049	4.108SerVal: 4.108 ± 0.059	0.716SerTrp: 0.716 ± 0.024	1.23SerTyr: 1.23 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.236ThrAla: 6.236 ± 0.078	0.544ThrCys: 0.544 ± 0.022	3.567ThrAsp: 3.567 ± 0.053	3.349ThrGlu: 3.349 ± 0.059	2.256ThrPhe: 2.256 ± 0.042	5.359ThrGly: 5.359 ± 0.067	1.238ThrHis: 1.238 ± 0.033	2.894ThrIle: 2.894 ± 0.058	1.672ThrLys: 1.672 ± 0.036	6.303ThrLeu: 6.303 ± 0.073	1.334ThrMet: 1.334 ± 0.034	1.432ThrAsn: 1.432 ± 0.035	3.57ThrPro: 3.57 ± 0.056	1.743ThrGln: 1.743 ± 0.038	3.556ThrArg: 3.556 ± 0.056	2.938ThrSer: 2.938 ± 0.055	3.026ThrThr: 3.026 ± 0.047	4.638ThrVal: 4.638 ± 0.066	0.73ThrTrp: 0.73 ± 0.026	1.32ThrTyr: 1.32 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.624ValAla: 8.624 ± 0.087	0.687ValCys: 0.687 ± 0.024	4.396ValAsp: 4.396 ± 0.064	4.443ValGlu: 4.443 ± 0.069	3.15ValPhe: 3.15 ± 0.051	5.499ValGly: 5.499 ± 0.072	1.415ValHis: 1.415 ± 0.031	4.379ValIle: 4.379 ± 0.059	2.187ValLys: 2.187 ± 0.045	7.645ValLeu: 7.645 ± 0.087	2.187ValMet: 2.187 ± 0.043	1.984ValAsn: 1.984 ± 0.037	3.754ValPro: 3.754 ± 0.054	2.225ValGln: 2.225 ± 0.043	4.249ValArg: 4.249 ± 0.062	4.516ValSer: 4.516 ± 0.066	4.897ValThr: 4.897 ± 0.071	5.636ValVal: 5.636 ± 0.077	1.058ValTrp: 1.058 ± 0.03	1.503ValTyr: 1.503 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.355TrpAla: 1.355 ± 0.034	0.149TrpCys: 0.149 ± 0.01	0.867TrpAsp: 0.867 ± 0.024	0.712TrpGlu: 0.712 ± 0.025	0.616TrpPhe: 0.616 ± 0.023	1.006TrpGly: 1.006 ± 0.03	0.327TrpHis: 0.327 ± 0.018	0.718TrpIle: 0.718 ± 0.027	0.455TrpLys: 0.455 ± 0.017	1.669TrpLeu: 1.669 ± 0.047	0.416TrpMet: 0.416 ± 0.018	0.425TrpAsn: 0.425 ± 0.019	0.701TrpPro: 0.701 ± 0.023	0.565TrpGln: 0.565 ± 0.022	1.061TrpArg: 1.061 ± 0.029	0.833TrpSer: 0.833 ± 0.024	0.852TrpThr: 0.852 ± 0.028	0.992TrpVal: 0.992 ± 0.029	0.23TrpTrp: 0.23 ± 0.015	0.291TrpTyr: 0.291 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.517TyrAla: 2.517 ± 0.041	0.244TyrCys: 0.244 ± 0.014	1.595TyrAsp: 1.595 ± 0.035	1.297TyrGlu: 1.297 ± 0.036	0.983TyrPhe: 0.983 ± 0.032	2.071TyrGly: 2.071 ± 0.042	0.537TyrHis: 0.537 ± 0.02	0.951TyrIle: 0.951 ± 0.027	0.625TyrLys: 0.625 ± 0.024	2.266TyrLeu: 2.266 ± 0.04	0.49TyrMet: 0.49 ± 0.02	0.56TyrAsn: 0.56 ± 0.022	1.048TyrPro: 1.048 ± 0.028	0.695TyrGln: 0.695 ± 0.021	1.483TyrArg: 1.483 ± 0.042	1.142TyrSer: 1.142 ± 0.034	1.181TyrThr: 1.181 ± 0.033	1.569TyrVal: 1.569 ± 0.032	0.366TyrTrp: 0.366 ± 0.02	0.568TyrTyr: 0.568 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4131 proteins (1271774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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