Amino acid dipepetide frequency for Tenacibaculum holothuriorum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.587AlaAla: 3.587 ± 0.081	0.493AlaCys: 0.493 ± 0.025	2.993AlaAsp: 2.993 ± 0.105	3.653AlaGlu: 3.653 ± 0.071	3.097AlaPhe: 3.097 ± 0.068	3.844AlaGly: 3.844 ± 0.087	1.019AlaHis: 1.019 ± 0.035	5.265AlaIle: 5.265 ± 0.078	5.156AlaLys: 5.156 ± 0.084	5.685AlaLeu: 5.685 ± 0.096	1.348AlaMet: 1.348 ± 0.046	3.5AlaAsn: 3.5 ± 0.064	1.781AlaPro: 1.781 ± 0.047	2.329AlaGln: 2.329 ± 0.049	1.914AlaArg: 1.914 ± 0.049	3.991AlaSer: 3.991 ± 0.082	3.698AlaThr: 3.698 ± 0.073	3.789AlaVal: 3.789 ± 0.076	0.536AlaTrp: 0.536 ± 0.025	2.266AlaTyr: 2.266 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.393CysAla: 0.393 ± 0.022	0.082CysCys: 0.082 ± 0.01	0.379CysAsp: 0.379 ± 0.021	0.408CysGlu: 0.408 ± 0.021	0.377CysPhe: 0.377 ± 0.02	0.578CysGly: 0.578 ± 0.027	0.168CysHis: 0.168 ± 0.014	0.515CysIle: 0.515 ± 0.024	0.525CysLys: 0.525 ± 0.025	0.54CysLeu: 0.54 ± 0.021	0.131CysMet: 0.131 ± 0.012	0.442CysAsn: 0.442 ± 0.023	0.281CysPro: 0.281 ± 0.024	0.174CysGln: 0.174 ± 0.014	0.175CysArg: 0.175 ± 0.015	0.552CysSer: 0.552 ± 0.027	0.387CysThr: 0.387 ± 0.026	0.402CysVal: 0.402 ± 0.02	0.047CysTrp: 0.047 ± 0.007	0.277CysTyr: 0.277 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.382AspAla: 3.382 ± 0.067	0.374AspCys: 0.374 ± 0.021	2.64AspAsp: 2.64 ± 0.059	3.616AspGlu: 3.616 ± 0.066	3.529AspPhe: 3.529 ± 0.066	3.387AspGly: 3.387 ± 0.116	0.689AspHis: 0.689 ± 0.028	4.303AspIle: 4.303 ± 0.07	4.539AspLys: 4.539 ± 0.082	4.853AspLeu: 4.853 ± 0.078	0.94AspMet: 0.94 ± 0.03	3.202AspAsn: 3.202 ± 0.064	1.274AspPro: 1.274 ± 0.039	1.159AspGln: 1.159 ± 0.034	1.732AspArg: 1.732 ± 0.045	2.913AspSer: 2.913 ± 0.069	2.668AspThr: 2.668 ± 0.066	3.593AspVal: 3.593 ± 0.065	0.672AspTrp: 0.672 ± 0.028	2.659AspTyr: 2.659 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	4.235GluAla: 4.235 ± 0.076	0.318GluCys: 0.318 ± 0.019	3.387GluAsp: 3.387 ± 0.063	5.433GluGlu: 5.433 ± 0.113	3.11GluPhe: 3.11 ± 0.055	3.642GluGly: 3.642 ± 0.067	1.164GluHis: 1.164 ± 0.039	5.556GluIle: 5.556 ± 0.077	6.519GluLys: 6.519 ± 0.102	6.594GluLeu: 6.594 ± 0.093	1.472GluMet: 1.472 ± 0.038	5.002GluAsn: 5.002 ± 0.073	1.396GluPro: 1.396 ± 0.04	2.298GluGln: 2.298 ± 0.054	2.406GluArg: 2.406 ± 0.059	2.999GluSer: 2.999 ± 0.061	3.656GluThr: 3.656 ± 0.064	4.695GluVal: 4.695 ± 0.071	0.579GluTrp: 0.579 ± 0.03	2.507GluTyr: 2.507 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	2.777PheAla: 2.777 ± 0.054	0.404PheCys: 0.404 ± 0.02	3.106PheAsp: 3.106 ± 0.063	3.349PheGlu: 3.349 ± 0.059	2.941PhePhe: 2.941 ± 0.072	3.638PheGly: 3.638 ± 0.068	0.818PheHis: 0.818 ± 0.022	4.147PheIle: 4.147 ± 0.073	4.321PheLys: 4.321 ± 0.08	5.071PheLeu: 5.071 ± 0.104	1.02PheMet: 1.02 ± 0.035	3.637PheAsn: 3.637 ± 0.064	1.615PhePro: 1.615 ± 0.036	1.518PheGln: 1.518 ± 0.04	1.564PheArg: 1.564 ± 0.043	4.246PheSer: 4.246 ± 0.086	3.199PheThr: 3.199 ± 0.059	3.183PheVal: 3.183 ± 0.06	0.613PheTrp: 0.613 ± 0.025	2.273PheTyr: 2.273 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.046GlyAla: 4.046 ± 0.133	0.492GlyCys: 0.492 ± 0.028	3.085GlyAsp: 3.085 ± 0.068	3.512GlyGlu: 3.512 ± 0.067	3.638GlyPhe: 3.638 ± 0.073	4.392GlyGly: 4.392 ± 0.1	0.989GlyHis: 0.989 ± 0.033	5.198GlyIle: 5.198 ± 0.084	5.388GlyLys: 5.388 ± 0.093	5.34GlyLeu: 5.34 ± 0.089	1.481GlyMet: 1.481 ± 0.04	3.821GlyAsn: 3.821 ± 0.083	1.119GlyPro: 1.119 ± 0.037	1.615GlyGln: 1.615 ± 0.048	2.053GlyArg: 2.053 ± 0.047	3.657GlySer: 3.657 ± 0.077	3.946GlyThr: 3.946 ± 0.099	4.392GlyVal: 4.392 ± 0.076	0.677GlyTrp: 0.677 ± 0.026	2.693GlyTyr: 2.693 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.865HisAla: 0.865 ± 0.029	0.173HisCys: 0.173 ± 0.013	0.769HisAsp: 0.769 ± 0.029	0.963HisGlu: 0.963 ± 0.034	1.131HisPhe: 1.131 ± 0.035	0.902HisGly: 0.902 ± 0.035	0.488HisHis: 0.488 ± 0.025	1.461HisIle: 1.461 ± 0.042	1.405HisLys: 1.405 ± 0.043	1.662HisLeu: 1.662 ± 0.045	0.297HisMet: 0.297 ± 0.018	1.024HisAsn: 1.024 ± 0.031	0.846HisPro: 0.846 ± 0.029	0.728HisGln: 0.728 ± 0.03	0.64HisArg: 0.64 ± 0.025	1.047HisSer: 1.047 ± 0.035	0.991HisThr: 0.991 ± 0.032	0.886HisVal: 0.886 ± 0.033	0.216HisTrp: 0.216 ± 0.014	0.758HisTyr: 0.758 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.417IleAla: 5.417 ± 0.086	0.585IleCys: 0.585 ± 0.028	4.858IleAsp: 4.858 ± 0.089	5.742IleGlu: 5.742 ± 0.078	3.693IlePhe: 3.693 ± 0.08	4.969IleGly: 4.969 ± 0.083	1.377IleHis: 1.377 ± 0.042	6.286IleIle: 6.286 ± 0.104	6.622IleLys: 6.622 ± 0.091	6.846IleLeu: 6.846 ± 0.096	1.274IleMet: 1.274 ± 0.038	5.274IleAsn: 5.274 ± 0.092	3.253IlePro: 3.253 ± 0.057	2.839IleGln: 2.839 ± 0.057	2.455IleArg: 2.455 ± 0.047	5.67IleSer: 5.67 ± 0.088	5.135IleThr: 5.135 ± 0.086	4.875IleVal: 4.875 ± 0.089	0.623IleTrp: 0.623 ± 0.026	2.844IleTyr: 2.844 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	5.123LysAla: 5.123 ± 0.083	0.354LysCys: 0.354 ± 0.021	4.743LysAsp: 4.743 ± 0.075	7.785LysGlu: 7.785 ± 0.127	3.272LysPhe: 3.272 ± 0.066	5.033LysGly: 5.033 ± 0.081	1.615LysHis: 1.615 ± 0.045	6.769LysIle: 6.769 ± 0.098	8.767LysLys: 8.767 ± 0.145	7.45LysLeu: 7.45 ± 0.097	2.046LysMet: 2.046 ± 0.049	6.227LysAsn: 6.227 ± 0.094	2.462LysPro: 2.462 ± 0.054	3.09LysGln: 3.09 ± 0.063	3.224LysArg: 3.224 ± 0.06	4.917LysSer: 4.917 ± 0.079	5.169LysThr: 5.169 ± 0.085	5.491LysVal: 5.491 ± 0.076	0.839LysTrp: 0.839 ± 0.031	3.386LysTyr: 3.386 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	5.675LeuAla: 5.675 ± 0.097	0.575LeuCys: 0.575 ± 0.025	4.802LeuAsp: 4.802 ± 0.071	5.968LeuGlu: 5.968 ± 0.088	5.069LeuPhe: 5.069 ± 0.088	5.755LeuGly: 5.755 ± 0.09	1.635LeuHis: 1.635 ± 0.043	7.137LeuIle: 7.137 ± 0.098	8.076LeuLys: 8.076 ± 0.117	8.773LeuLeu: 8.773 ± 0.121	1.87LeuMet: 1.87 ± 0.047	5.923LeuAsn: 5.923 ± 0.081	3.362LeuPro: 3.362 ± 0.065	3.508LeuGln: 3.508 ± 0.075	3.005LeuArg: 3.005 ± 0.056	6.473LeuSer: 6.473 ± 0.091	5.236LeuThr: 5.236 ± 0.091	5.415LeuVal: 5.415 ± 0.082	0.736LeuTrp: 0.736 ± 0.03	3.111LeuTyr: 3.111 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	1.335MetAla: 1.335 ± 0.044	0.142MetCys: 0.142 ± 0.013	0.916MetAsp: 0.916 ± 0.032	1.159MetGlu: 1.159 ± 0.041	0.894MetPhe: 0.894 ± 0.035	1.175MetGly: 1.175 ± 0.041	0.38MetHis: 0.38 ± 0.02	1.462MetIle: 1.462 ± 0.044	2.178MetLys: 2.178 ± 0.054	1.898MetLeu: 1.898 ± 0.045	0.582MetMet: 0.582 ± 0.026	1.335MetAsn: 1.335 ± 0.037	0.744MetPro: 0.744 ± 0.025	0.778MetGln: 0.778 ± 0.033	0.817MetArg: 0.817 ± 0.028	1.325MetSer: 1.325 ± 0.038	1.034MetThr: 1.034 ± 0.034	1.222MetVal: 1.222 ± 0.035	0.163MetTrp: 0.163 ± 0.013	0.737MetTyr: 0.737 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.807AsnAla: 3.807 ± 0.074	0.473AsnCys: 0.473 ± 0.025	3.428AsnAsp: 3.428 ± 0.068	3.941AsnGlu: 3.941 ± 0.074	3.376AsnPhe: 3.376 ± 0.07	4.14AsnGly: 4.14 ± 0.09	1.168AsnHis: 1.168 ± 0.035	5.314AsnIle: 5.314 ± 0.091	5.483AsnLys: 5.483 ± 0.09	5.601AsnLeu: 5.601 ± 0.092	1.222AsnMet: 1.222 ± 0.034	4.879AsnAsn: 4.879 ± 0.123	2.802AsnPro: 2.802 ± 0.064	2.408AsnGln: 2.408 ± 0.051	2.161AsnArg: 2.161 ± 0.053	4.449AsnSer: 4.449 ± 0.085	4.218AsnThr: 4.218 ± 0.07	3.741AsnVal: 3.741 ± 0.072	0.791AsnTrp: 0.791 ± 0.029	3.12AsnTyr: 3.12 ± 0.068	0.0AsnXaa: 0.0 ± 0.0
Pro	1.721ProAla: 1.721 ± 0.05	0.191ProCys: 0.191 ± 0.016	1.614ProAsp: 1.614 ± 0.045	2.398ProGlu: 2.398 ± 0.048	1.816ProPhe: 1.816 ± 0.044	1.517ProGly: 1.517 ± 0.051	0.594ProHis: 0.594 ± 0.026	2.701ProIle: 2.701 ± 0.057	2.856ProLys: 2.856 ± 0.064	2.713ProLeu: 2.713 ± 0.057	0.666ProMet: 0.666 ± 0.028	2.455ProAsn: 2.455 ± 0.064	0.703ProPro: 0.703 ± 0.032	1.074ProGln: 1.074 ± 0.036	0.846ProArg: 0.846 ± 0.032	1.989ProSer: 1.989 ± 0.045	2.106ProThr: 2.106 ± 0.045	2.104ProVal: 2.104 ± 0.047	0.32ProTrp: 0.32 ± 0.02	1.268ProTyr: 1.268 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.818GlnAla: 1.818 ± 0.046	0.159GlnCys: 0.159 ± 0.013	1.46GlnAsp: 1.46 ± 0.036	2.438GlnGlu: 2.438 ± 0.053	1.805GlnPhe: 1.805 ± 0.048	1.637GlnGly: 1.637 ± 0.037	0.599GlnHis: 0.599 ± 0.024	2.648GlnIle: 2.648 ± 0.054	3.305GlnLys: 3.305 ± 0.067	3.638GlnLeu: 3.638 ± 0.079	0.759GlnMet: 0.759 ± 0.031	2.269GlnAsn: 2.269 ± 0.054	1.068GlnPro: 1.068 ± 0.035	1.719GlnGln: 1.719 ± 0.051	1.207GlnArg: 1.207 ± 0.032	1.794GlnSer: 1.794 ± 0.044	1.875GlnThr: 1.875 ± 0.044	1.905GlnVal: 1.905 ± 0.049	0.324GlnTrp: 0.324 ± 0.02	1.375GlnTyr: 1.375 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	1.965ArgAla: 1.965 ± 0.052	0.166ArgCys: 0.166 ± 0.012	1.575ArgAsp: 1.575 ± 0.045	2.182ArgGlu: 2.182 ± 0.048	1.889ArgPhe: 1.889 ± 0.051	1.937ArgGly: 1.937 ± 0.055	0.551ArgHis: 0.551 ± 0.022	2.795ArgIle: 2.795 ± 0.055	3.134ArgLys: 3.134 ± 0.065	3.143ArgLeu: 3.143 ± 0.057	0.808ArgMet: 0.808 ± 0.026	2.15ArgAsn: 2.15 ± 0.048	0.943ArgPro: 0.943 ± 0.032	0.986ArgGln: 0.986 ± 0.032	1.229ArgArg: 1.229 ± 0.046	1.696ArgSer: 1.696 ± 0.039	1.803ArgThr: 1.803 ± 0.047	2.129ArgVal: 2.129 ± 0.048	0.357ArgTrp: 0.357 ± 0.021	1.405ArgTyr: 1.405 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.315SerAla: 3.315 ± 0.069	0.611SerCys: 0.611 ± 0.028	3.198SerAsp: 3.198 ± 0.065	3.977SerGlu: 3.977 ± 0.072	4.172SerPhe: 4.172 ± 0.085	4.14SerGly: 4.14 ± 0.09	0.947SerHis: 0.947 ± 0.033	5.515SerIle: 5.515 ± 0.082	5.384SerLys: 5.384 ± 0.076	6.136SerLeu: 6.136 ± 0.092	1.229SerMet: 1.229 ± 0.037	4.055SerAsn: 4.055 ± 0.089	1.9SerPro: 1.9 ± 0.045	1.913SerGln: 1.913 ± 0.051	1.873SerArg: 1.873 ± 0.045	4.368SerSer: 4.368 ± 0.084	3.518SerThr: 3.518 ± 0.068	4.002SerVal: 4.002 ± 0.063	0.709SerTrp: 0.709 ± 0.03	2.855SerTyr: 2.855 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.483ThrAla: 3.483 ± 0.084	0.378ThrCys: 0.378 ± 0.02	3.073ThrAsp: 3.073 ± 0.064	3.551ThrGlu: 3.551 ± 0.065	3.029ThrPhe: 3.029 ± 0.059	3.785ThrGly: 3.785 ± 0.088	1.105ThrHis: 1.105 ± 0.031	5.269ThrIle: 5.269 ± 0.081	4.651ThrLys: 4.651 ± 0.071	5.309ThrLeu: 5.309 ± 0.084	0.912ThrMet: 0.912 ± 0.037	3.906ThrAsn: 3.906 ± 0.081	2.507ThrPro: 2.507 ± 0.05	1.962ThrGln: 1.962 ± 0.044	1.697ThrArg: 1.697 ± 0.039	4.053ThrSer: 4.053 ± 0.075	3.72ThrThr: 3.72 ± 0.087	3.909ThrVal: 3.909 ± 0.083	0.523ThrTrp: 0.523 ± 0.026	2.339ThrTyr: 2.339 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.152ValAla: 4.152 ± 0.088	0.489ValCys: 0.489 ± 0.023	3.488ValAsp: 3.488 ± 0.063	4.063ValGlu: 4.063 ± 0.071	3.535ValPhe: 3.535 ± 0.061	3.889ValGly: 3.889 ± 0.08	1.005ValHis: 1.005 ± 0.035	4.779ValIle: 4.779 ± 0.07	4.888ValLys: 4.888 ± 0.083	6.09ValLeu: 6.09 ± 0.079	1.281ValMet: 1.281 ± 0.042	3.908ValAsn: 3.908 ± 0.064	2.019ValPro: 2.019 ± 0.036	1.792ValGln: 1.792 ± 0.043	1.96ValArg: 1.96 ± 0.054	4.527ValSer: 4.527 ± 0.077	3.75ValThr: 3.75 ± 0.085	4.384ValVal: 4.384 ± 0.078	0.596ValTrp: 0.596 ± 0.025	2.354ValTyr: 2.354 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.561TrpAla: 0.561 ± 0.021	0.078TrpCys: 0.078 ± 0.009	0.502TrpAsp: 0.502 ± 0.022	0.601TrpGlu: 0.601 ± 0.025	0.621TrpPhe: 0.621 ± 0.028	0.617TrpGly: 0.617 ± 0.028	0.202TrpHis: 0.202 ± 0.015	0.689TrpIle: 0.689 ± 0.028	0.936TrpLys: 0.936 ± 0.034	0.991TrpLeu: 0.991 ± 0.045	0.267TrpMet: 0.267 ± 0.016	0.74TrpAsn: 0.74 ± 0.031	0.151TrpPro: 0.151 ± 0.014	0.335TrpGln: 0.335 ± 0.02	0.38TrpArg: 0.38 ± 0.02	0.567TrpSer: 0.567 ± 0.026	0.505TrpThr: 0.505 ± 0.025	0.593TrpVal: 0.593 ± 0.027	0.148TrpTrp: 0.148 ± 0.012	0.434TrpTyr: 0.434 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.289TyrAla: 2.289 ± 0.059	0.296TyrCys: 0.296 ± 0.017	2.108TyrAsp: 2.108 ± 0.048	2.229TyrGlu: 2.229 ± 0.052	2.445TyrPhe: 2.445 ± 0.06	2.558TyrGly: 2.558 ± 0.046	0.74TyrHis: 0.74 ± 0.029	2.827TyrIle: 2.827 ± 0.059	3.629TyrLys: 3.629 ± 0.066	3.774TyrLeu: 3.774 ± 0.074	0.669TyrMet: 0.669 ± 0.026	2.773TyrAsn: 2.773 ± 0.067	1.425TyrPro: 1.425 ± 0.038	1.577TyrGln: 1.577 ± 0.058	1.505TyrArg: 1.505 ± 0.044	2.581TyrSer: 2.581 ± 0.051	2.547TyrThr: 2.547 ± 0.059	2.241TyrVal: 2.241 ± 0.052	0.447TyrTrp: 0.447 ± 0.023	1.806TyrTyr: 1.806 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2802 proteins (936333 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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