Amino acid dipepetide frequency for Actinoalloteichus hoggarensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.422AlaAla: 22.422 ± 0.221	1.061AlaCys: 1.061 ± 0.025	9.218AlaAsp: 9.218 ± 0.089	10.36AlaGlu: 10.36 ± 0.095	3.219AlaPhe: 3.219 ± 0.047	13.634AlaGly: 13.634 ± 0.115	2.45AlaHis: 2.45 ± 0.039	3.461AlaIle: 3.461 ± 0.05	1.695AlaLys: 1.695 ± 0.044	13.5AlaLeu: 13.5 ± 0.122	2.45AlaMet: 2.45 ± 0.039	1.746AlaAsn: 1.746 ± 0.031	6.544AlaPro: 6.544 ± 0.075	3.146AlaGln: 3.146 ± 0.047	10.648AlaArg: 10.648 ± 0.097	6.111AlaSer: 6.111 ± 0.064	6.896AlaThr: 6.896 ± 0.064	12.934AlaVal: 12.934 ± 0.106	1.765AlaTrp: 1.765 ± 0.032	2.003AlaTyr: 2.003 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.962CysAla: 0.962 ± 0.026	0.097CysCys: 0.097 ± 0.007	0.473CysAsp: 0.473 ± 0.017	0.371CysGlu: 0.371 ± 0.014	0.206CysPhe: 0.206 ± 0.011	0.922CysGly: 0.922 ± 0.024	0.215CysHis: 0.215 ± 0.01	0.141CysIle: 0.141 ± 0.008	0.067CysLys: 0.067 ± 0.007	0.753CysLeu: 0.753 ± 0.022	0.099CysMet: 0.099 ± 0.007	0.102CysAsn: 0.102 ± 0.008	0.492CysPro: 0.492 ± 0.02	0.15CysGln: 0.15 ± 0.01	0.699CysArg: 0.699 ± 0.024	0.464CysSer: 0.464 ± 0.016	0.458CysThr: 0.458 ± 0.016	0.648CysVal: 0.648 ± 0.018	0.133CysTrp: 0.133 ± 0.009	0.153CysTyr: 0.153 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.861AspAla: 7.861 ± 0.079	0.405AspCys: 0.405 ± 0.017	4.207AspAsp: 4.207 ± 0.056	4.429AspGlu: 4.429 ± 0.051	1.643AspPhe: 1.643 ± 0.029	6.707AspGly: 6.707 ± 0.074	1.622AspHis: 1.622 ± 0.034	1.622AspIle: 1.622 ± 0.038	0.637AspLys: 0.637 ± 0.024	6.52AspLeu: 6.52 ± 0.061	0.766AspMet: 0.766 ± 0.02	0.725AspAsn: 0.725 ± 0.022	4.739AspPro: 4.739 ± 0.063	1.734AspGln: 1.734 ± 0.036	5.853AspArg: 5.853 ± 0.062	2.949AspSer: 2.949 ± 0.043	3.041AspThr: 3.041 ± 0.046	5.79AspVal: 5.79 ± 0.054	1.091AspTrp: 1.091 ± 0.028	1.241AspTyr: 1.241 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.019GluAla: 7.019 ± 0.065	0.355GluCys: 0.355 ± 0.015	3.031GluAsp: 3.031 ± 0.045	3.329GluGlu: 3.329 ± 0.052	1.73GluPhe: 1.73 ± 0.031	3.915GluGly: 3.915 ± 0.053	1.674GluHis: 1.674 ± 0.032	2.558GluIle: 2.558 ± 0.039	0.916GluLys: 0.916 ± 0.024	7.245GluLeu: 7.245 ± 0.075	0.906GluMet: 0.906 ± 0.022	1.05GluAsn: 1.05 ± 0.023	3.898GluPro: 3.898 ± 0.054	2.471GluGln: 2.471 ± 0.045	5.422GluArg: 5.422 ± 0.059	3.212GluSer: 3.212 ± 0.044	3.178GluThr: 3.178 ± 0.047	4.989GluVal: 4.989 ± 0.058	0.76GluTrp: 0.76 ± 0.024	1.027GluTyr: 1.027 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.673PheAla: 3.673 ± 0.048	0.229PheCys: 0.229 ± 0.011	2.194PheAsp: 2.194 ± 0.038	1.36PheGlu: 1.36 ± 0.03	0.793PhePhe: 0.793 ± 0.026	3.086PheGly: 3.086 ± 0.043	0.668PheHis: 0.668 ± 0.02	0.689PheIle: 0.689 ± 0.022	0.259PheLys: 0.259 ± 0.013	2.622PheLeu: 2.622 ± 0.045	0.344PheMet: 0.344 ± 0.015	0.428PheAsn: 0.428 ± 0.019	1.269PhePro: 1.269 ± 0.029	0.66PheGln: 0.66 ± 0.017	1.863PheArg: 1.863 ± 0.036	1.494PheSer: 1.494 ± 0.031	1.69PheThr: 1.69 ± 0.035	2.335PheVal: 2.335 ± 0.046	0.394PheTrp: 0.394 ± 0.015	0.553PheTyr: 0.553 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.621GlyAla: 10.621 ± 0.086	0.806GlyCys: 0.806 ± 0.024	5.383GlyAsp: 5.383 ± 0.075	5.364GlyGlu: 5.364 ± 0.058	2.797GlyPhe: 2.797 ± 0.043	9.044GlyGly: 9.044 ± 0.137	2.147GlyHis: 2.147 ± 0.035	3.429GlyIle: 3.429 ± 0.047	1.28GlyLys: 1.28 ± 0.032	9.779GlyLeu: 9.779 ± 0.095	2.133GlyMet: 2.133 ± 0.039	1.42GlyAsn: 1.42 ± 0.035	5.398GlyPro: 5.398 ± 0.076	2.335GlyGln: 2.335 ± 0.041	8.91GlyArg: 8.91 ± 0.089	5.484GlySer: 5.484 ± 0.057	5.687GlyThr: 5.687 ± 0.065	8.355GlyVal: 8.355 ± 0.087	1.607GlyTrp: 1.607 ± 0.035	1.976GlyTyr: 1.976 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.724HisAla: 2.724 ± 0.042	0.211HisCys: 0.211 ± 0.01	1.437HisAsp: 1.437 ± 0.03	1.219HisGlu: 1.219 ± 0.025	0.552HisPhe: 0.552 ± 0.018	2.454HisGly: 2.454 ± 0.043	0.637HisHis: 0.637 ± 0.024	0.497HisIle: 0.497 ± 0.016	0.199HisLys: 0.199 ± 0.012	2.19HisLeu: 2.19 ± 0.034	0.212HisMet: 0.212 ± 0.011	0.299HisAsn: 0.299 ± 0.013	1.771HisPro: 1.771 ± 0.037	0.613HisGln: 0.613 ± 0.021	2.361HisArg: 2.361 ± 0.042	1.038HisSer: 1.038 ± 0.025	1.14HisThr: 1.14 ± 0.028	1.707HisVal: 1.707 ± 0.034	0.34HisTrp: 0.34 ± 0.015	0.412HisTyr: 0.412 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.059IleAla: 5.059 ± 0.068	0.253IleCys: 0.253 ± 0.013	2.569IleAsp: 2.569 ± 0.037	2.239IleGlu: 2.239 ± 0.036	0.653IlePhe: 0.653 ± 0.021	3.767IleGly: 3.767 ± 0.058	0.519IleHis: 0.519 ± 0.02	0.925IleIle: 0.925 ± 0.026	0.494IleLys: 0.494 ± 0.016	2.541IleLeu: 2.541 ± 0.049	0.422IleMet: 0.422 ± 0.019	0.633IleAsn: 0.633 ± 0.021	1.809IlePro: 1.809 ± 0.035	0.647IleGln: 0.647 ± 0.022	2.491IleArg: 2.491 ± 0.045	1.848IleSer: 1.848 ± 0.034	2.39IleThr: 2.39 ± 0.038	2.973IleVal: 2.973 ± 0.043	0.367IleTrp: 0.367 ± 0.014	0.447IleTyr: 0.447 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.69LysAla: 1.69 ± 0.038	0.066LysCys: 0.066 ± 0.007	0.665LysAsp: 0.665 ± 0.024	0.649LysGlu: 0.649 ± 0.021	0.24LysPhe: 0.24 ± 0.013	0.972LysGly: 0.972 ± 0.028	0.259LysHis: 0.259 ± 0.014	0.604LysIle: 0.604 ± 0.019	0.363LysLys: 0.363 ± 0.017	1.083LysLeu: 1.083 ± 0.028	0.216LysMet: 0.216 ± 0.01	0.301LysAsn: 0.301 ± 0.013	0.784LysPro: 0.784 ± 0.025	0.382LysGln: 0.382 ± 0.018	0.909LysArg: 0.909 ± 0.028	0.783LysSer: 0.783 ± 0.024	0.902LysThr: 0.902 ± 0.022	1.135LysVal: 1.135 ± 0.029	0.141LysTrp: 0.141 ± 0.008	0.219LysTyr: 0.219 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.356LeuAla: 15.356 ± 0.131	0.78LeuCys: 0.78 ± 0.017	6.983LeuAsp: 6.983 ± 0.07	4.11LeuGlu: 4.11 ± 0.057	2.749LeuPhe: 2.749 ± 0.048	9.676LeuGly: 9.676 ± 0.092	2.278LeuHis: 2.278 ± 0.04	3.977LeuIle: 3.977 ± 0.056	0.977LeuLys: 0.977 ± 0.024	11.904LeuLeu: 11.904 ± 0.127	1.373LeuMet: 1.373 ± 0.033	1.43LeuAsn: 1.43 ± 0.033	6.583LeuPro: 6.583 ± 0.068	1.73LeuGln: 1.73 ± 0.035	9.81LeuArg: 9.81 ± 0.083	5.551LeuSer: 5.551 ± 0.058	6.593LeuThr: 6.593 ± 0.067	9.454LeuVal: 9.454 ± 0.08	1.259LeuTrp: 1.259 ± 0.026	1.546LeuTyr: 1.546 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.029MetAla: 2.029 ± 0.035	0.101MetCys: 0.101 ± 0.007	0.736MetAsp: 0.736 ± 0.022	0.645MetGlu: 0.645 ± 0.019	0.484MetPhe: 0.484 ± 0.018	1.144MetGly: 1.144 ± 0.026	0.296MetHis: 0.296 ± 0.012	0.736MetIle: 0.736 ± 0.023	0.24MetLys: 0.24 ± 0.012	1.854MetLeu: 1.854 ± 0.037	0.282MetMet: 0.282 ± 0.015	0.407MetAsn: 0.407 ± 0.016	1.123MetPro: 1.123 ± 0.028	0.387MetGln: 0.387 ± 0.016	1.473MetArg: 1.473 ± 0.027	1.35MetSer: 1.35 ± 0.026	1.627MetThr: 1.627 ± 0.03	1.369MetVal: 1.369 ± 0.029	0.16MetTrp: 0.16 ± 0.01	0.244MetTyr: 0.244 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	1.869AsnAla: 1.869 ± 0.033	0.139AsnCys: 0.139 ± 0.01	0.814AsnAsp: 0.814 ± 0.026	0.782AsnGlu: 0.782 ± 0.021	0.38AsnPhe: 0.38 ± 0.015	1.627AsnGly: 1.627 ± 0.032	0.353AsnHis: 0.353 ± 0.016	0.583AsnIle: 0.583 ± 0.02	0.238AsnLys: 0.238 ± 0.012	1.594AsnLeu: 1.594 ± 0.034	0.246AsnMet: 0.246 ± 0.012	0.327AsnAsn: 0.327 ± 0.015	1.261AsnPro: 1.261 ± 0.033	0.464AsnGln: 0.464 ± 0.019	1.304AsnArg: 1.304 ± 0.028	0.858AsnSer: 0.858 ± 0.025	0.922AsnThr: 0.922 ± 0.028	1.182AsnVal: 1.182 ± 0.026	0.269AsnTrp: 0.269 ± 0.014	0.324AsnTyr: 0.324 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.909ProAla: 8.909 ± 0.095	0.381ProCys: 0.381 ± 0.017	4.825ProAsp: 4.825 ± 0.062	4.389ProGlu: 4.389 ± 0.059	1.486ProPhe: 1.486 ± 0.031	6.403ProGly: 6.403 ± 0.088	1.181ProHis: 1.181 ± 0.028	1.664ProIle: 1.664 ± 0.032	0.793ProLys: 0.793 ± 0.024	4.972ProLeu: 4.972 ± 0.056	1.06ProMet: 1.06 ± 0.022	0.932ProAsn: 0.932 ± 0.026	4.188ProPro: 4.188 ± 0.075	1.455ProGln: 1.455 ± 0.035	4.571ProArg: 4.571 ± 0.061	3.571ProSer: 3.571 ± 0.055	3.755ProThr: 3.755 ± 0.056	5.405ProVal: 5.405 ± 0.062	0.936ProTrp: 0.936 ± 0.025	0.982ProTyr: 0.982 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.826GlnAla: 3.826 ± 0.052	0.149GlnCys: 0.149 ± 0.012	1.347GlnAsp: 1.347 ± 0.029	1.315GlnGlu: 1.315 ± 0.031	0.578GlnPhe: 0.578 ± 0.021	1.993GlnGly: 1.993 ± 0.033	0.533GlnHis: 0.533 ± 0.02	0.949GlnIle: 0.949 ± 0.023	0.318GlnLys: 0.318 ± 0.014	2.578GlnLeu: 2.578 ± 0.041	0.353GlnMet: 0.353 ± 0.015	0.45GlnAsn: 0.45 ± 0.016	1.563GlnPro: 1.563 ± 0.039	1.053GlnGln: 1.053 ± 0.043	2.355GlnArg: 2.355 ± 0.039	1.167GlnSer: 1.167 ± 0.028	1.393GlnThr: 1.393 ± 0.031	2.237GlnVal: 2.237 ± 0.036	0.408GlnTrp: 0.408 ± 0.015	0.439GlnTyr: 0.439 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.21ArgAla: 10.21 ± 0.079	0.726ArgCys: 0.726 ± 0.023	4.83ArgAsp: 4.83 ± 0.056	4.675ArgGlu: 4.675 ± 0.06	2.586ArgPhe: 2.586 ± 0.04	6.416ArgGly: 6.416 ± 0.064	2.384ArgHis: 2.384 ± 0.047	3.352ArgIle: 3.352 ± 0.039	1.156ArgLys: 1.156 ± 0.031	10.167ArgLeu: 10.167 ± 0.102	1.909ArgMet: 1.909 ± 0.038	1.315ArgAsn: 1.315 ± 0.031	5.929ArgPro: 5.929 ± 0.069	2.455ArgGln: 2.455 ± 0.04	10.509ArgArg: 10.509 ± 0.118	5.126ArgSer: 5.126 ± 0.06	5.123ArgThr: 5.123 ± 0.059	6.583ArgVal: 6.583 ± 0.062	1.512ArgTrp: 1.512 ± 0.034	1.707ArgTyr: 1.707 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	7.471SerAla: 7.471 ± 0.074	0.422SerCys: 0.422 ± 0.017	3.046SerAsp: 3.046 ± 0.041	2.731SerGlu: 2.731 ± 0.042	1.491SerPhe: 1.491 ± 0.033	5.952SerGly: 5.952 ± 0.065	0.969SerHis: 0.969 ± 0.023	1.771SerIle: 1.771 ± 0.03	0.622SerLys: 0.622 ± 0.021	4.988SerLeu: 4.988 ± 0.054	1.152SerMet: 1.152 ± 0.027	0.86SerAsn: 0.86 ± 0.02	3.618SerPro: 3.618 ± 0.059	1.15SerGln: 1.15 ± 0.024	4.491SerArg: 4.491 ± 0.054	3.315SerSer: 3.315 ± 0.047	3.569SerThr: 3.569 ± 0.051	4.822SerVal: 4.822 ± 0.064	1.033SerTrp: 1.033 ± 0.024	0.957SerTyr: 0.957 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.633ThrAla: 8.633 ± 0.085	0.383ThrCys: 0.383 ± 0.015	3.538ThrAsp: 3.538 ± 0.046	3.595ThrGlu: 3.595 ± 0.049	1.408ThrPhe: 1.408 ± 0.031	6.365ThrGly: 6.365 ± 0.067	1.066ThrHis: 1.066 ± 0.025	1.919ThrIle: 1.919 ± 0.035	0.751ThrLys: 0.751 ± 0.02	5.605ThrLeu: 5.605 ± 0.069	1.077ThrMet: 1.077 ± 0.026	0.947ThrAsn: 0.947 ± 0.023	3.997ThrPro: 3.997 ± 0.05	1.16ThrGln: 1.16 ± 0.024	4.415ThrArg: 4.415 ± 0.048	3.395ThrSer: 3.395 ± 0.046	4.009ThrThr: 4.009 ± 0.059	5.8ThrVal: 5.8 ± 0.063	0.79ThrTrp: 0.79 ± 0.023	0.89ThrTyr: 0.89 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.266ValAla: 11.266 ± 0.088	0.717ValCys: 0.717 ± 0.02	6.369ValAsp: 6.369 ± 0.065	5.488ValGlu: 5.488 ± 0.055	2.576ValPhe: 2.576 ± 0.037	7.198ValGly: 7.198 ± 0.067	1.972ValHis: 1.972 ± 0.035	3.226ValIle: 3.226 ± 0.046	0.971ValLys: 0.971 ± 0.028	10.361ValLeu: 10.361 ± 0.093	1.228ValMet: 1.228 ± 0.028	1.505ValAsn: 1.505 ± 0.029	5.1ValPro: 5.1 ± 0.058	1.835ValGln: 1.835 ± 0.033	7.383ValArg: 7.383 ± 0.066	4.775ValSer: 4.775 ± 0.053	5.495ValThr: 5.495 ± 0.065	8.793ValVal: 8.793 ± 0.079	1.087ValTrp: 1.087 ± 0.024	1.467ValTyr: 1.467 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.62TrpAla: 1.62 ± 0.035	0.156TrpCys: 0.156 ± 0.01	0.771TrpAsp: 0.771 ± 0.021	0.694TrpGlu: 0.694 ± 0.02	0.504TrpPhe: 0.504 ± 0.018	0.972TrpGly: 0.972 ± 0.022	0.362TrpHis: 0.362 ± 0.013	0.575TrpIle: 0.575 ± 0.016	0.181TrpLys: 0.181 ± 0.011	1.797TrpLeu: 1.797 ± 0.033	0.303TrpMet: 0.303 ± 0.013	0.354TrpAsn: 0.354 ± 0.015	0.808TrpPro: 0.808 ± 0.024	0.592TrpGln: 0.592 ± 0.018	1.444TrpArg: 1.444 ± 0.033	1.005TrpSer: 1.005 ± 0.025	0.962TrpThr: 0.962 ± 0.023	0.987TrpVal: 0.987 ± 0.023	0.386TrpTrp: 0.386 ± 0.014	0.28TrpTyr: 0.28 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.044TyrAla: 2.044 ± 0.035	0.169TyrCys: 0.169 ± 0.01	1.145TyrAsp: 1.145 ± 0.03	0.941TyrGlu: 0.941 ± 0.025	0.527TyrPhe: 0.527 ± 0.017	1.708TyrGly: 1.708 ± 0.032	0.427TyrHis: 0.427 ± 0.014	0.366TyrIle: 0.366 ± 0.017	0.206TyrLys: 0.206 ± 0.011	2.066TyrLeu: 2.066 ± 0.038	0.156TyrMet: 0.156 ± 0.009	0.304TyrAsn: 0.304 ± 0.016	0.984TyrPro: 0.984 ± 0.028	0.588TyrGln: 0.588 ± 0.02	1.762TyrArg: 1.762 ± 0.03	0.934TyrSer: 0.934 ± 0.022	0.915TyrThr: 0.915 ± 0.027	1.312TyrVal: 1.312 ± 0.027	0.313TyrTrp: 0.313 ± 0.012	0.393TyrTyr: 0.393 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5520 proteins (1798018 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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