Amino acid dipepetide frequency for Sulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.077AlaAla: 4.077 ± 0.094
0.953AlaCys: 0.953 ± 0.052
2.929AlaAsp: 2.929 ± 0.072
3.571AlaGlu: 3.571 ± 0.07
4.003AlaPhe: 4.003 ± 0.083
4.275AlaGly: 4.275 ± 0.1
2.014AlaHis: 2.014 ± 0.058
6.359AlaIle: 6.359 ± 0.104
6.227AlaLys: 6.227 ± 0.111
10.328AlaLeu: 10.328 ± 0.145
2.463AlaMet: 2.463 ± 0.056
3.235AlaAsn: 3.235 ± 0.077
2.278AlaPro: 2.278 ± 0.063
3.05AlaGln: 3.05 ± 0.07
2.583AlaArg: 2.583 ± 0.062
4.93AlaSer: 4.93 ± 0.094
4.007AlaThr: 4.007 ± 0.08
3.849AlaVal: 3.849 ± 0.074
0.59AlaTrp: 0.59 ± 0.031
3.202AlaTyr: 3.202 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.887CysAla: 0.887 ± 0.044
0.138CysCys: 0.138 ± 0.015
0.741CysAsp: 0.741 ± 0.03
0.905CysGlu: 0.905 ± 0.04
0.419CysPhe: 0.419 ± 0.024
0.852CysGly: 0.852 ± 0.04
0.342CysHis: 0.342 ± 0.028
0.661CysIle: 0.661 ± 0.034
0.822CysLys: 0.822 ± 0.033
0.852CysLeu: 0.852 ± 0.034
0.279CysMet: 0.279 ± 0.023
0.432CysAsn: 0.432 ± 0.029
0.44CysPro: 0.44 ± 0.027
0.308CysGln: 0.308 ± 0.021
0.298CysArg: 0.298 ± 0.025
0.638CysSer: 0.638 ± 0.03
0.48CysThr: 0.48 ± 0.024
0.798CysVal: 0.798 ± 0.04
0.058CysTrp: 0.058 ± 0.01
0.352CysTyr: 0.352 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.463AspAla: 4.463 ± 0.076
0.407AspCys: 0.407 ± 0.022
2.48AspAsp: 2.48 ± 0.084
4.502AspGlu: 4.502 ± 0.089
2.903AspPhe: 2.903 ± 0.071
3.178AspGly: 3.178 ± 0.108
0.729AspHis: 0.729 ± 0.029
4.214AspIle: 4.214 ± 0.083
3.634AspLys: 3.634 ± 0.079
4.388AspLeu: 4.388 ± 0.071
1.305AspMet: 1.305 ± 0.046
1.876AspAsn: 1.876 ± 0.064
1.444AspPro: 1.444 ± 0.049
0.956AspGln: 0.956 ± 0.039
1.593AspArg: 1.593 ± 0.054
2.423AspSer: 2.423 ± 0.07
2.973AspThr: 2.973 ± 0.142
3.865AspVal: 3.865 ± 0.085
0.35AspTrp: 0.35 ± 0.023
1.769AspTyr: 1.769 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
6.369GluAla: 6.369 ± 0.123
0.675GluCys: 0.675 ± 0.035
3.235GluAsp: 3.235 ± 0.064
6.108GluGlu: 6.108 ± 0.107
2.685GluPhe: 2.685 ± 0.066
4.544GluGly: 4.544 ± 0.112
1.87GluHis: 1.87 ± 0.065
5.653GluIle: 5.653 ± 0.099
6.789GluLys: 6.789 ± 0.11
6.769GluLeu: 6.769 ± 0.109
2.034GluMet: 2.034 ± 0.068
3.912GluAsn: 3.912 ± 0.082
1.775GluPro: 1.775 ± 0.049
2.422GluGln: 2.422 ± 0.066
3.301GluArg: 3.301 ± 0.066
4.278GluSer: 4.278 ± 0.079
3.439GluThr: 3.439 ± 0.076
4.651GluVal: 4.651 ± 0.088
0.553GluTrp: 0.553 ± 0.031
2.316GluTyr: 2.316 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.712PheAla: 3.712 ± 0.075
0.664PheCys: 0.664 ± 0.034
2.895PheAsp: 2.895 ± 0.067
3.786PheGlu: 3.786 ± 0.082
2.987PhePhe: 2.987 ± 0.08
3.53PheGly: 3.53 ± 0.082
0.95PheHis: 0.95 ± 0.035
3.846PheIle: 3.846 ± 0.086
3.185PheLys: 3.185 ± 0.063
5.312PheLeu: 5.312 ± 0.106
1.353PheMet: 1.353 ± 0.046
2.148PheAsn: 2.148 ± 0.059
1.345PhePro: 1.345 ± 0.044
1.315PheGln: 1.315 ± 0.049
1.427PheArg: 1.427 ± 0.047
3.821PheSer: 3.821 ± 0.078
2.433PheThr: 2.433 ± 0.066
3.261PheVal: 3.261 ± 0.082
0.494PheTrp: 0.494 ± 0.029
2.003PheTyr: 2.003 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
4.549GlyAla: 4.549 ± 0.088
0.843GlyCys: 0.843 ± 0.04
3.121GlyAsp: 3.121 ± 0.116
4.125GlyGlu: 4.125 ± 0.087
3.541GlyPhe: 3.541 ± 0.076
4.266GlyGly: 4.266 ± 0.126
1.246GlyHis: 1.246 ± 0.042
5.227GlyIle: 5.227 ± 0.089
4.533GlyLys: 4.533 ± 0.077
5.826GlyLeu: 5.826 ± 0.102
2.016GlyMet: 2.016 ± 0.057
2.393GlyAsn: 2.393 ± 0.142
0.873GlyPro: 0.873 ± 0.038
1.38GlyGln: 1.38 ± 0.043
2.202GlyArg: 2.202 ± 0.054
3.835GlySer: 3.835 ± 0.09
3.131GlyThr: 3.131 ± 0.086
5.168GlyVal: 5.168 ± 0.103
0.6GlyTrp: 0.6 ± 0.033
2.862GlyTyr: 2.862 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.744HisAla: 1.744 ± 0.045
0.275HisCys: 0.275 ± 0.021
1.104HisAsp: 1.104 ± 0.04
1.648HisGlu: 1.648 ± 0.048
1.434HisPhe: 1.434 ± 0.044
1.325HisGly: 1.325 ± 0.04
0.765HisHis: 0.765 ± 0.035
1.645HisIle: 1.645 ± 0.046
1.385HisLys: 1.385 ± 0.047
2.375HisLeu: 2.375 ± 0.066
0.564HisMet: 0.564 ± 0.03
0.943HisAsn: 0.943 ± 0.038
1.058HisPro: 1.058 ± 0.033
0.899HisGln: 0.899 ± 0.036
0.717HisArg: 0.717 ± 0.032
1.362HisSer: 1.362 ± 0.04
1.342HisThr: 1.342 ± 0.043
2.036HisVal: 2.036 ± 0.061
0.165HisTrp: 0.165 ± 0.017
1.009HisTyr: 1.009 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.916IleAla: 6.916 ± 0.103
0.782IleCys: 0.782 ± 0.038
4.474IleAsp: 4.474 ± 0.09
6.311IleGlu: 6.311 ± 0.11
3.504IlePhe: 3.504 ± 0.086
4.999IleGly: 4.999 ± 0.085
1.617IleHis: 1.617 ± 0.044
5.143IleIle: 5.143 ± 0.099
5.39IleLys: 5.39 ± 0.095
7.343IleLeu: 7.343 ± 0.115
1.652IleMet: 1.652 ± 0.05
3.35IleAsn: 3.35 ± 0.07
2.721IlePro: 2.721 ± 0.059
2.402IleGln: 2.402 ± 0.062
2.617IleArg: 2.617 ± 0.06
5.106IleSer: 5.106 ± 0.104
3.9IleThr: 3.9 ± 0.08
5.362IleVal: 5.362 ± 0.094
0.513IleTrp: 0.513 ± 0.031
2.439IleTyr: 2.439 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
6.138LysAla: 6.138 ± 0.11
0.537LysCys: 0.537 ± 0.027
3.546LysAsp: 3.546 ± 0.083
8.351LysGlu: 8.351 ± 0.141
2.229LysPhe: 2.229 ± 0.06
4.219LysGly: 4.219 ± 0.082
1.576LysHis: 1.576 ± 0.05
5.959LysIle: 5.959 ± 0.101
6.271LysLys: 6.271 ± 0.122
6.513LysLeu: 6.513 ± 0.11
2.246LysMet: 2.246 ± 0.055
4.141LysAsn: 4.141 ± 0.081
2.405LysPro: 2.405 ± 0.076
2.298LysGln: 2.298 ± 0.066
3.558LysArg: 3.558 ± 0.078
4.571LysSer: 4.571 ± 0.091
4.155LysThr: 4.155 ± 0.083
4.603LysVal: 4.603 ± 0.087
0.479LysTrp: 0.479 ± 0.029
2.231LysTyr: 2.231 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
7.316LeuAla: 7.316 ± 0.119
1.244LeuCys: 1.244 ± 0.045
5.074LeuAsp: 5.074 ± 0.094
7.645LeuGlu: 7.645 ± 0.123
6.098LeuPhe: 6.098 ± 0.135
6.492LeuGly: 6.492 ± 0.114
3.004LeuHis: 3.004 ± 0.067
6.786LeuIle: 6.786 ± 0.116
8.255LeuLys: 8.255 ± 0.109
10.986LeuLeu: 10.986 ± 0.169
2.737LeuMet: 2.737 ± 0.066
4.527LeuAsn: 4.527 ± 0.086
3.727LeuPro: 3.727 ± 0.08
3.37LeuGln: 3.37 ± 0.071
3.709LeuArg: 3.709 ± 0.084
8.627LeuSer: 8.627 ± 0.116
4.519LeuThr: 4.519 ± 0.072
5.835LeuVal: 5.835 ± 0.103
0.809LeuTrp: 0.809 ± 0.035
3.623LeuTyr: 3.623 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
2.107MetAla: 2.107 ± 0.055
0.246MetCys: 0.246 ± 0.019
1.36MetAsp: 1.36 ± 0.047
1.739MetGlu: 1.739 ± 0.057
1.07MetPhe: 1.07 ± 0.044
1.829MetGly: 1.829 ± 0.055
0.695MetHis: 0.695 ± 0.037
2.246MetIle: 2.246 ± 0.058
2.217MetLys: 2.217 ± 0.055
2.795MetLeu: 2.795 ± 0.073
0.954MetMet: 0.954 ± 0.041
1.346MetAsn: 1.346 ± 0.039
1.053MetPro: 1.053 ± 0.039
1.207MetGln: 1.207 ± 0.041
1.189MetArg: 1.189 ± 0.037
1.859MetSer: 1.859 ± 0.053
1.034MetThr: 1.034 ± 0.042
1.873MetVal: 1.873 ± 0.061
0.185MetTrp: 0.185 ± 0.018
0.755MetTyr: 0.755 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.917AsnAla: 3.917 ± 0.085
0.338AsnCys: 0.338 ± 0.022
2.637AsnAsp: 2.637 ± 0.123
3.416AsnGlu: 3.416 ± 0.068
1.98AsnPhe: 1.98 ± 0.048
2.657AsnGly: 2.657 ± 0.079
1.029AsnHis: 1.029 ± 0.04
3.637AsnIle: 3.637 ± 0.078
2.556AsnLys: 2.556 ± 0.067
4.197AsnLeu: 4.197 ± 0.073
0.983AsnMet: 0.983 ± 0.037
1.846AsnAsn: 1.846 ± 0.065
2.09AsnPro: 2.09 ± 0.059
1.472AsnGln: 1.472 ± 0.046
1.732AsnArg: 1.732 ± 0.05
2.5AsnSer: 2.5 ± 0.067
2.399AsnThr: 2.399 ± 0.073
2.926AsnVal: 2.926 ± 0.067
0.251AsnTrp: 0.251 ± 0.019
1.748AsnTyr: 1.748 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
1.667ProAla: 1.667 ± 0.052
0.308ProCys: 0.308 ± 0.022
1.358ProAsp: 1.358 ± 0.045
2.123ProGlu: 2.123 ± 0.056
2.037ProPhe: 2.037 ± 0.062
1.108ProGly: 1.108 ± 0.048
0.954ProHis: 0.954 ± 0.04
2.497ProIle: 2.497 ± 0.066
2.637ProLys: 2.637 ± 0.061
4.067ProLeu: 4.067 ± 0.084
0.87ProMet: 0.87 ± 0.035
1.479ProAsn: 1.479 ± 0.044
0.845ProPro: 0.845 ± 0.043
1.041ProGln: 1.041 ± 0.038
1.007ProArg: 1.007 ± 0.042
2.365ProSer: 2.365 ± 0.056
1.919ProThr: 1.919 ± 0.055
1.917ProVal: 1.917 ± 0.064
0.298ProTrp: 0.298 ± 0.023
1.397ProTyr: 1.397 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.187GlnAla: 2.187 ± 0.068
0.305GlnCys: 0.305 ± 0.021
1.192GlnAsp: 1.192 ± 0.041
2.553GlnGlu: 2.553 ± 0.071
1.266GlnPhe: 1.266 ± 0.044
1.915GlnGly: 1.915 ± 0.051
0.702GlnHis: 0.702 ± 0.03
2.255GlnIle: 2.255 ± 0.065
3.618GlnLys: 3.618 ± 0.087
2.388GlnLeu: 2.388 ± 0.075
0.984GlnMet: 0.984 ± 0.04
1.936GlnAsn: 1.936 ± 0.054
0.856GlnPro: 0.856 ± 0.034
0.947GlnGln: 0.947 ± 0.033
1.282GlnArg: 1.282 ± 0.042
2.331GlnSer: 2.331 ± 0.073
2.256GlnThr: 2.256 ± 0.066
1.467GlnVal: 1.467 ± 0.047
0.291GlnTrp: 0.291 ± 0.019
0.984GlnTyr: 0.984 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.556ArgAla: 2.556 ± 0.071
0.34ArgCys: 0.34 ± 0.022
1.833ArgAsp: 1.833 ± 0.058
2.707ArgGlu: 2.707 ± 0.076
2.225ArgPhe: 2.225 ± 0.067
2.04ArgGly: 2.04 ± 0.057
0.868ArgHis: 0.868 ± 0.037
2.933ArgIle: 2.933 ± 0.071
2.343ArgLys: 2.343 ± 0.067
3.926ArgLeu: 3.926 ± 0.084
1.07ArgMet: 1.07 ± 0.037
1.509ArgAsn: 1.509 ± 0.048
0.953ArgPro: 0.953 ± 0.041
1.053ArgGln: 1.053 ± 0.044
1.312ArgArg: 1.312 ± 0.05
2.123ArgSer: 2.123 ± 0.059
1.652ArgThr: 1.652 ± 0.058
2.554ArgVal: 2.554 ± 0.069
0.318ArgTrp: 0.318 ± 0.023
1.87ArgTyr: 1.87 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
4.611SerAla: 4.611 ± 0.076
0.63SerCys: 0.63 ± 0.03
3.211SerAsp: 3.211 ± 0.102
3.829SerGlu: 3.829 ± 0.085
3.946SerPhe: 3.946 ± 0.079
4.289SerGly: 4.289 ± 0.105
1.638SerHis: 1.638 ± 0.045
5.187SerIle: 5.187 ± 0.088
4.597SerLys: 4.597 ± 0.084
7.698SerLeu: 7.698 ± 0.116
1.805SerMet: 1.805 ± 0.051
2.661SerAsn: 2.661 ± 0.071
1.875SerPro: 1.875 ± 0.052
1.997SerGln: 1.997 ± 0.059
2.172SerArg: 2.172 ± 0.06
4.662SerSer: 4.662 ± 0.103
3.358SerThr: 3.358 ± 0.067
4.278SerVal: 4.278 ± 0.091
0.533SerTrp: 0.533 ± 0.029
2.578SerTyr: 2.578 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.157ThrAla: 3.157 ± 0.077
0.727ThrCys: 0.727 ± 0.033
1.962ThrAsp: 1.962 ± 0.065
2.084ThrGlu: 2.084 ± 0.053
2.781ThrPhe: 2.781 ± 0.068
2.882ThrGly: 2.882 ± 0.081
1.467ThrHis: 1.467 ± 0.049
4.331ThrIle: 4.331 ± 0.098
3.845ThrLys: 3.845 ± 0.076
7.197ThrLeu: 7.197 ± 0.129
1.266ThrMet: 1.266 ± 0.041
2.144ThrAsn: 2.144 ± 0.067
2.688ThrPro: 2.688 ± 0.059
2.117ThrGln: 2.117 ± 0.057
1.537ThrArg: 1.537 ± 0.047
3.251ThrSer: 3.251 ± 0.091
3.046ThrThr: 3.046 ± 0.105
2.558ThrVal: 2.558 ± 0.061
0.403ThrTrp: 0.403 ± 0.029
2.084ThrTyr: 2.084 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
5.067ValAla: 5.067 ± 0.108
0.853ValCys: 0.853 ± 0.042
3.603ValAsp: 3.603 ± 0.084
4.643ValGlu: 4.643 ± 0.083
2.826ValPhe: 2.826 ± 0.079
4.301ValGly: 4.301 ± 0.09
1.235ValHis: 1.235 ± 0.045
4.989ValIle: 4.989 ± 0.086
4.63ValLys: 4.63 ± 0.099
6.688ValLeu: 6.688 ± 0.093
1.943ValMet: 1.943 ± 0.047
2.587ValAsn: 2.587 ± 0.064
1.977ValPro: 1.977 ± 0.05
1.88ValGln: 1.88 ± 0.051
2.256ValArg: 2.256 ± 0.057
4.399ValSer: 4.399 ± 0.094
3.041ValThr: 3.041 ± 0.071
4.863ValVal: 4.863 ± 0.097
0.534ValTrp: 0.534 ± 0.035
2.255ValTyr: 2.255 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.51TrpAla: 0.51 ± 0.03
0.074TrpCys: 0.074 ± 0.01
0.403TrpAsp: 0.403 ± 0.024
0.496TrpGlu: 0.496 ± 0.029
0.457TrpPhe: 0.457 ± 0.028
0.513TrpGly: 0.513 ± 0.029
0.211TrpHis: 0.211 ± 0.017
0.65TrpIle: 0.65 ± 0.029
0.47TrpLys: 0.47 ± 0.027
0.905TrpLeu: 0.905 ± 0.041
0.336TrpMet: 0.336 ± 0.024
0.321TrpAsn: 0.321 ± 0.019
0.131TrpPro: 0.131 ± 0.015
0.312TrpGln: 0.312 ± 0.022
0.295TrpArg: 0.295 ± 0.02
0.479TrpSer: 0.479 ± 0.028
0.259TrpThr: 0.259 ± 0.019
0.574TrpVal: 0.574 ± 0.03
0.09TrpTrp: 0.09 ± 0.013
0.36TrpTyr: 0.36 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.973TyrAla: 2.973 ± 0.065
0.362TyrCys: 0.362 ± 0.021
2.295TyrAsp: 2.295 ± 0.065
2.838TyrGlu: 2.838 ± 0.059
2.074TyrPhe: 2.074 ± 0.059
2.526TyrGly: 2.526 ± 0.082
0.88TyrHis: 0.88 ± 0.035
2.325TyrIle: 2.325 ± 0.064
2.624TyrLys: 2.624 ± 0.065
3.832TyrLeu: 3.832 ± 0.074
0.897TyrMet: 0.897 ± 0.035
1.523TyrAsn: 1.523 ± 0.047
1.36TyrPro: 1.36 ± 0.036
1.291TyrGln: 1.291 ± 0.047
1.396TyrArg: 1.396 ± 0.045
1.997TyrSer: 1.997 ± 0.05
2.181TyrThr: 2.181 ± 0.059
2.133TyrVal: 2.133 ± 0.058
0.332TyrTrp: 0.332 ± 0.02
1.396TyrTyr: 1.396 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2243 proteins (701989 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski