Amino acid dipepetide frequency for Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695) (Hybrid yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.206AlaAla: 4.206 ± 0.053
0.722AlaCys: 0.722 ± 0.013
2.925AlaAsp: 2.925 ± 0.029
3.38AlaGlu: 3.38 ± 0.036
2.379AlaPhe: 2.379 ± 0.026
3.188AlaGly: 3.188 ± 0.032
1.186AlaHis: 1.186 ± 0.018
3.486AlaIle: 3.486 ± 0.035
4.039AlaLys: 4.039 ± 0.039
5.417AlaLeu: 5.417 ± 0.042
1.14AlaMet: 1.14 ± 0.017
3.037AlaAsn: 3.037 ± 0.025
2.481AlaPro: 2.481 ± 0.045
2.025AlaGln: 2.025 ± 0.026
2.613AlaArg: 2.613 ± 0.03
5.819AlaSer: 5.819 ± 0.054
3.087AlaThr: 3.087 ± 0.031
3.311AlaVal: 3.311 ± 0.032
0.514AlaTrp: 0.514 ± 0.01
1.809AlaTyr: 1.809 ± 0.02
0.0AlaXaa: 0.0 ± 0.0
Cys
0.608CysAla: 0.608 ± 0.013
0.255CysCys: 0.255 ± 0.008
0.683CysAsp: 0.683 ± 0.014
0.592CysGlu: 0.592 ± 0.013
0.696CysPhe: 0.696 ± 0.012
0.798CysGly: 0.798 ± 0.016
0.297CysHis: 0.297 ± 0.008
0.858CysIle: 0.858 ± 0.015
0.679CysLys: 0.679 ± 0.013
1.287CysLeu: 1.287 ± 0.019
0.25CysMet: 0.25 ± 0.008
0.567CysAsn: 0.567 ± 0.012
0.488CysPro: 0.488 ± 0.012
0.378CysGln: 0.378 ± 0.009
0.492CysArg: 0.492 ± 0.012
1.039CysSer: 1.039 ± 0.02
0.555CysThr: 0.555 ± 0.011
0.729CysVal: 0.729 ± 0.014
0.142CysTrp: 0.142 ± 0.006
0.47CysTyr: 0.47 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
3.248AspAla: 3.248 ± 0.027
0.574AspCys: 0.574 ± 0.014
4.592AspAsp: 4.592 ± 0.048
5.064AspGlu: 5.064 ± 0.043
2.793AspPhe: 2.793 ± 0.024
3.05AspGly: 3.05 ± 0.029
1.151AspHis: 1.151 ± 0.02
4.372AspIle: 4.372 ± 0.034
3.906AspLys: 3.906 ± 0.029
5.728AspLeu: 5.728 ± 0.041
1.215AspMet: 1.215 ± 0.016
3.224AspAsn: 3.224 ± 0.032
2.47AspPro: 2.47 ± 0.025
1.883AspGln: 1.883 ± 0.02
2.311AspArg: 2.311 ± 0.024
5.549AspSer: 5.549 ± 0.047
3.0AspThr: 3.0 ± 0.026
3.593AspVal: 3.593 ± 0.031
0.594AspTrp: 0.594 ± 0.011
2.264AspTyr: 2.264 ± 0.022
0.0AspXaa: 0.0 ± 0.0
Glu
3.755GluAla: 3.755 ± 0.035
0.647GluCys: 0.647 ± 0.012
4.486GluAsp: 4.486 ± 0.039
6.091GluGlu: 6.091 ± 0.058
2.611GluPhe: 2.611 ± 0.029
3.079GluGly: 3.079 ± 0.03
1.371GluHis: 1.371 ± 0.016
4.257GluIle: 4.257 ± 0.031
5.702GluLys: 5.702 ± 0.046
6.158GluLeu: 6.158 ± 0.051
1.28GluMet: 1.28 ± 0.019
4.234GluAsn: 4.234 ± 0.034
2.058GluPro: 2.058 ± 0.025
2.479GluGln: 2.479 ± 0.028
3.028GluArg: 3.028 ± 0.026
5.701GluSer: 5.701 ± 0.044
3.341GluThr: 3.341 ± 0.03
3.653GluVal: 3.653 ± 0.033
0.652GluTrp: 0.652 ± 0.013
2.353GluTyr: 2.353 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
2.398PheAla: 2.398 ± 0.026
0.565PheCys: 0.565 ± 0.012
2.874PheAsp: 2.874 ± 0.029
2.786PheGlu: 2.786 ± 0.028
2.164PhePhe: 2.164 ± 0.03
2.745PheGly: 2.745 ± 0.037
0.989PheHis: 0.989 ± 0.016
2.808PheIle: 2.808 ± 0.033
3.041PheLys: 3.041 ± 0.03
4.175PheLeu: 4.175 ± 0.036
0.929PheMet: 0.929 ± 0.014
2.568PheAsn: 2.568 ± 0.026
1.757PhePro: 1.757 ± 0.02
1.582PheGln: 1.582 ± 0.021
1.793PheArg: 1.793 ± 0.022
4.037PheSer: 4.037 ± 0.033
2.264PheThr: 2.264 ± 0.025
2.617PheVal: 2.617 ± 0.027
0.523PheTrp: 0.523 ± 0.011
1.584PheTyr: 1.584 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
3.259GlyAla: 3.259 ± 0.033
0.701GlyCys: 0.701 ± 0.014
3.015GlyAsp: 3.015 ± 0.027
3.027GlyGlu: 3.027 ± 0.024
2.587GlyPhe: 2.587 ± 0.028
3.601GlyGly: 3.601 ± 0.042
1.191GlyHis: 1.191 ± 0.019
3.557GlyIle: 3.557 ± 0.029
3.775GlyLys: 3.775 ± 0.032
4.854GlyLeu: 4.854 ± 0.041
1.016GlyMet: 1.016 ± 0.016
2.919GlyAsn: 2.919 ± 0.03
1.837GlyPro: 1.837 ± 0.022
1.719GlyGln: 1.719 ± 0.022
2.434GlyArg: 2.434 ± 0.031
5.476GlySer: 5.476 ± 0.073
2.917GlyThr: 2.917 ± 0.029
3.327GlyVal: 3.327 ± 0.044
0.578GlyTrp: 0.578 ± 0.012
2.021GlyTyr: 2.021 ± 0.022
0.0GlyXaa: 0.0 ± 0.0
His
1.118HisAla: 1.118 ± 0.016
0.293HisCys: 0.293 ± 0.008
1.252HisAsp: 1.252 ± 0.016
1.438HisGlu: 1.438 ± 0.019
1.016HisPhe: 1.016 ± 0.015
1.216HisGly: 1.216 ± 0.017
0.65HisHis: 0.65 ± 0.015
1.452HisIle: 1.452 ± 0.018
1.452HisLys: 1.452 ± 0.021
2.104HisLeu: 2.104 ± 0.023
0.455HisMet: 0.455 ± 0.01
1.21HisAsn: 1.21 ± 0.016
1.122HisPro: 1.122 ± 0.015
0.827HisGln: 0.827 ± 0.016
1.006HisArg: 1.006 ± 0.016
2.06HisSer: 2.06 ± 0.027
1.043HisThr: 1.043 ± 0.015
1.179HisVal: 1.179 ± 0.016
0.21HisTrp: 0.21 ± 0.006
0.814HisTyr: 0.814 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
3.534IleAla: 3.534 ± 0.031
0.832IleCys: 0.832 ± 0.014
4.193IleAsp: 4.193 ± 0.035
4.192IleGlu: 4.192 ± 0.036
2.802IlePhe: 2.802 ± 0.029
3.227IleGly: 3.227 ± 0.034
1.391IleHis: 1.391 ± 0.017
4.082IleIle: 4.082 ± 0.036
4.386IleLys: 4.386 ± 0.034
6.073IleLeu: 6.073 ± 0.049
1.237IleMet: 1.237 ± 0.018
3.674IleAsn: 3.674 ± 0.033
3.076IlePro: 3.076 ± 0.029
2.18IleGln: 2.18 ± 0.026
2.883IleArg: 2.883 ± 0.026
6.001IleSer: 6.001 ± 0.038
3.288IleThr: 3.288 ± 0.027
3.563IleVal: 3.563 ± 0.034
0.656IleTrp: 0.656 ± 0.014
2.225IleTyr: 2.225 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
3.959LysAla: 3.959 ± 0.031
0.762LysCys: 0.762 ± 0.016
4.329LysAsp: 4.329 ± 0.033
5.436LysGlu: 5.436 ± 0.041
2.973LysPhe: 2.973 ± 0.028
3.303LysGly: 3.303 ± 0.032
1.673LysHis: 1.673 ± 0.02
4.46LysIle: 4.46 ± 0.036
6.323LysLys: 6.323 ± 0.054
6.906LysLeu: 6.906 ± 0.047
1.323LysMet: 1.323 ± 0.019
4.2LysAsn: 4.2 ± 0.034
2.946LysPro: 2.946 ± 0.029
2.738LysGln: 2.738 ± 0.026
3.727LysArg: 3.727 ± 0.035
6.373LysSer: 6.373 ± 0.048
3.75LysThr: 3.75 ± 0.033
4.178LysVal: 4.178 ± 0.034
0.739LysTrp: 0.739 ± 0.013
2.803LysTyr: 2.803 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
5.475LeuAla: 5.475 ± 0.041
1.246LeuCys: 1.246 ± 0.018
5.427LeuAsp: 5.427 ± 0.035
5.825LeuGlu: 5.825 ± 0.043
4.028LeuPhe: 4.028 ± 0.04
4.807LeuGly: 4.807 ± 0.039
2.083LeuHis: 2.083 ± 0.023
5.783LeuIle: 5.783 ± 0.044
7.023LeuLys: 7.023 ± 0.049
8.682LeuLeu: 8.682 ± 0.063
1.856LeuMet: 1.856 ± 0.02
5.45LeuAsn: 5.45 ± 0.036
4.179LeuPro: 4.179 ± 0.031
3.577LeuGln: 3.577 ± 0.029
4.499LeuArg: 4.499 ± 0.04
9.081LeuSer: 9.081 ± 0.05
4.778LeuThr: 4.778 ± 0.035
5.464LeuVal: 5.464 ± 0.04
0.862LeuTrp: 0.862 ± 0.014
3.086LeuTyr: 3.086 ± 0.026
0.0LeuXaa: 0.0 ± 0.0
Met
1.258MetAla: 1.258 ± 0.019
0.259MetCys: 0.259 ± 0.008
1.103MetAsp: 1.103 ± 0.017
1.146MetGlu: 1.146 ± 0.017
0.771MetPhe: 0.771 ± 0.013
1.173MetGly: 1.173 ± 0.017
0.388MetHis: 0.388 ± 0.009
1.203MetIle: 1.203 ± 0.019
1.474MetLys: 1.474 ± 0.018
1.694MetLeu: 1.694 ± 0.022
0.46MetMet: 0.46 ± 0.014
1.231MetAsn: 1.231 ± 0.019
0.782MetPro: 0.782 ± 0.015
0.618MetGln: 0.618 ± 0.014
0.845MetArg: 0.845 ± 0.014
2.151MetSer: 2.151 ± 0.023
1.049MetThr: 1.049 ± 0.016
1.108MetVal: 1.108 ± 0.017
0.168MetTrp: 0.168 ± 0.007
0.615MetTyr: 0.615 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.091AsnAla: 3.091 ± 0.027
0.599AsnCys: 0.599 ± 0.012
3.796AsnAsp: 3.796 ± 0.032
4.216AsnGlu: 4.216 ± 0.034
2.559AsnPhe: 2.559 ± 0.021
3.179AsnGly: 3.179 ± 0.033
1.218AsnHis: 1.218 ± 0.017
3.851AsnIle: 3.851 ± 0.03
3.856AsnLys: 3.856 ± 0.033
5.077AsnLeu: 5.077 ± 0.039
1.183AsnMet: 1.183 ± 0.018
3.556AsnAsn: 3.556 ± 0.04
2.414AsnPro: 2.414 ± 0.025
2.034AsnGln: 2.034 ± 0.026
2.327AsnArg: 2.327 ± 0.026
5.583AsnSer: 5.583 ± 0.042
3.107AsnThr: 3.107 ± 0.03
3.131AsnVal: 3.131 ± 0.027
0.592AsnTrp: 0.592 ± 0.011
2.193AsnTyr: 2.193 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
2.359ProAla: 2.359 ± 0.034
0.38ProCys: 0.38 ± 0.01
2.38ProAsp: 2.38 ± 0.024
3.037ProGlu: 3.037 ± 0.028
1.88ProPhe: 1.88 ± 0.02
2.13ProGly: 2.13 ± 0.024
0.916ProHis: 0.916 ± 0.014
2.473ProIle: 2.473 ± 0.027
2.887ProLys: 2.887 ± 0.028
3.758ProLeu: 3.758 ± 0.036
0.726ProMet: 0.726 ± 0.014
2.264ProAsn: 2.264 ± 0.025
2.375ProPro: 2.375 ± 0.046
1.755ProGln: 1.755 ± 0.025
1.833ProArg: 1.833 ± 0.026
4.704ProSer: 4.704 ± 0.067
2.313ProThr: 2.313 ± 0.029
2.648ProVal: 2.648 ± 0.028
0.384ProTrp: 0.384 ± 0.01
1.469ProTyr: 1.469 ± 0.017
0.0ProXaa: 0.0 ± 0.0
Gln
2.11GlnAla: 2.11 ± 0.028
0.379GlnCys: 0.379 ± 0.009
1.98GlnAsp: 1.98 ± 0.022
2.588GlnGlu: 2.588 ± 0.027
1.498GlnPhe: 1.498 ± 0.02
1.817GlnGly: 1.817 ± 0.023
0.866GlnHis: 0.866 ± 0.015
2.254GlnIle: 2.254 ± 0.025
2.721GlnLys: 2.721 ± 0.025
3.399GlnLeu: 3.399 ± 0.03
0.727GlnMet: 0.727 ± 0.014
2.191GlnAsn: 2.191 ± 0.024
1.497GlnPro: 1.497 ± 0.025
2.044GlnGln: 2.044 ± 0.05
1.787GlnArg: 1.787 ± 0.019
3.11GlnSer: 3.11 ± 0.034
1.787GlnThr: 1.787 ± 0.018
2.011GlnVal: 2.011 ± 0.021
0.344GlnTrp: 0.344 ± 0.009
1.299GlnTyr: 1.299 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
2.479ArgAla: 2.479 ± 0.029
0.546ArgCys: 0.546 ± 0.011
2.544ArgAsp: 2.544 ± 0.025
2.907ArgGlu: 2.907 ± 0.026
2.003ArgPhe: 2.003 ± 0.022
2.246ArgGly: 2.246 ± 0.028
1.053ArgHis: 1.053 ± 0.016
2.892ArgIle: 2.892 ± 0.026
3.792ArgLys: 3.792 ± 0.037
4.27ArgLeu: 4.27 ± 0.036
0.878ArgMet: 0.878 ± 0.014
2.704ArgAsn: 2.704 ± 0.027
1.829ArgPro: 1.829 ± 0.023
1.751ArgGln: 1.751 ± 0.019
2.928ArgArg: 2.928 ± 0.032
4.159ArgSer: 4.159 ± 0.036
2.202ArgThr: 2.202 ± 0.023
2.411ArgVal: 2.411 ± 0.024
0.473ArgTrp: 0.473 ± 0.009
1.667ArgTyr: 1.667 ± 0.021
0.0ArgXaa: 0.0 ± 0.0
Ser
5.162SerAla: 5.162 ± 0.053
0.998SerCys: 0.998 ± 0.015
5.709SerAsp: 5.709 ± 0.044
5.752SerGlu: 5.752 ± 0.04
4.226SerPhe: 4.226 ± 0.031
5.427SerGly: 5.427 ± 0.087
2.108SerHis: 2.108 ± 0.027
5.909SerIle: 5.909 ± 0.041
7.116SerLys: 7.116 ± 0.052
8.816SerLeu: 8.816 ± 0.053
1.862SerMet: 1.862 ± 0.022
5.843SerAsn: 5.843 ± 0.052
4.162SerPro: 4.162 ± 0.049
3.571SerGln: 3.571 ± 0.035
4.376SerArg: 4.376 ± 0.037
12.132SerSer: 12.132 ± 0.183
5.439SerThr: 5.439 ± 0.042
5.21SerVal: 5.21 ± 0.037
0.897SerTrp: 0.897 ± 0.016
3.144SerTyr: 3.144 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
2.989ThrAla: 2.989 ± 0.034
0.631ThrCys: 0.631 ± 0.011
2.848ThrAsp: 2.848 ± 0.027
3.086ThrGlu: 3.086 ± 0.027
2.269ThrPhe: 2.269 ± 0.024
3.133ThrGly: 3.133 ± 0.033
1.112ThrHis: 1.112 ± 0.018
3.32ThrIle: 3.32 ± 0.034
3.644ThrLys: 3.644 ± 0.033
4.795ThrLeu: 4.795 ± 0.031
0.945ThrMet: 0.945 ± 0.016
2.9ThrAsn: 2.9 ± 0.026
2.718ThrPro: 2.718 ± 0.03
1.737ThrGln: 1.737 ± 0.02
2.278ThrArg: 2.278 ± 0.024
5.382ThrSer: 5.382 ± 0.051
2.881ThrThr: 2.881 ± 0.034
2.992ThrVal: 2.992 ± 0.03
0.516ThrTrp: 0.516 ± 0.011
1.776ThrTyr: 1.776 ± 0.02
0.0ThrXaa: 0.0 ± 0.0
Val
3.41ValAla: 3.41 ± 0.033
0.754ValCys: 0.754 ± 0.015
3.516ValAsp: 3.516 ± 0.029
3.547ValGlu: 3.547 ± 0.03
2.66ValPhe: 2.66 ± 0.025
3.098ValGly: 3.098 ± 0.031
1.219ValHis: 1.219 ± 0.017
3.591ValIle: 3.591 ± 0.03
3.983ValLys: 3.983 ± 0.031
5.54ValLeu: 5.54 ± 0.038
1.075ValMet: 1.075 ± 0.016
3.115ValAsn: 3.115 ± 0.027
2.777ValPro: 2.777 ± 0.03
1.873ValGln: 1.873 ± 0.021
2.491ValArg: 2.491 ± 0.025
5.545ValSer: 5.545 ± 0.042
2.995ValThr: 2.995 ± 0.029
3.596ValVal: 3.596 ± 0.037
0.578ValTrp: 0.578 ± 0.013
1.922ValTyr: 1.922 ± 0.024
0.0ValXaa: 0.0 ± 0.0
Trp
0.531TrpAla: 0.531 ± 0.011
0.218TrpCys: 0.218 ± 0.007
0.607TrpAsp: 0.607 ± 0.015
0.533TrpGlu: 0.533 ± 0.012
0.525TrpPhe: 0.525 ± 0.012
0.532TrpGly: 0.532 ± 0.011
0.211TrpHis: 0.211 ± 0.007
0.655TrpIle: 0.655 ± 0.014
0.784TrpLys: 0.784 ± 0.014
0.955TrpLeu: 0.955 ± 0.016
0.199TrpMet: 0.199 ± 0.006
0.607TrpAsn: 0.607 ± 0.013
0.314TrpPro: 0.314 ± 0.01
0.323TrpGln: 0.323 ± 0.008
0.53TrpArg: 0.53 ± 0.01
0.86TrpSer: 0.86 ± 0.015
0.486TrpThr: 0.486 ± 0.012
0.567TrpVal: 0.567 ± 0.012
0.162TrpTrp: 0.162 ± 0.005
0.386TrpTyr: 0.386 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.815TyrAla: 1.815 ± 0.023
0.503TyrCys: 0.503 ± 0.011
2.321TyrAsp: 2.321 ± 0.022
2.292TyrGlu: 2.292 ± 0.024
1.754TyrPhe: 1.754 ± 0.022
2.062TyrGly: 2.062 ± 0.027
0.844TyrHis: 0.844 ± 0.014
2.233TyrIle: 2.233 ± 0.025
2.316TyrLys: 2.316 ± 0.024
3.522TyrLeu: 3.522 ± 0.029
0.738TyrMet: 0.738 ± 0.014
2.07TyrAsn: 2.07 ± 0.024
1.393TyrPro: 1.393 ± 0.017
1.312TyrGln: 1.312 ± 0.018
1.55TyrArg: 1.55 ± 0.019
3.097TyrSer: 3.097 ± 0.03
1.672TyrThr: 1.672 ± 0.022
1.999TyrVal: 1.999 ± 0.022
0.403TyrTrp: 0.403 ± 0.011
1.477TyrTyr: 1.477 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8851 proteins (4358694 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski