Amino acid dipepetide frequency for Galerina marginata (strain CBS 339.88)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.448AlaAla: 7.448 ± 0.044	1.079AlaCys: 1.079 ± 0.012	3.728AlaAsp: 3.728 ± 0.021	4.171AlaGlu: 4.171 ± 0.029	3.397AlaPhe: 3.397 ± 0.023	5.109AlaGly: 5.109 ± 0.031	1.861AlaHis: 1.861 ± 0.017	4.272AlaIle: 4.272 ± 0.029	3.557AlaLys: 3.557 ± 0.025	7.924AlaLeu: 7.924 ± 0.04	1.689AlaMet: 1.689 ± 0.015	2.902AlaAsn: 2.902 ± 0.023	4.693AlaPro: 4.693 ± 0.035	3.026AlaGln: 3.026 ± 0.021	4.5AlaArg: 4.5 ± 0.027	7.243AlaSer: 7.243 ± 0.034	4.932AlaThr: 4.932 ± 0.028	5.004AlaVal: 5.004 ± 0.025	1.06AlaTrp: 1.06 ± 0.013	2.094AlaTyr: 2.094 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	0.963CysAla: 0.963 ± 0.01	0.316CysCys: 0.316 ± 0.007	0.652CysAsp: 0.652 ± 0.011	0.597CysGlu: 0.597 ± 0.009	0.617CysPhe: 0.617 ± 0.009	0.953CysGly: 0.953 ± 0.013	0.408CysHis: 0.408 ± 0.007	0.789CysIle: 0.789 ± 0.011	0.557CysLys: 0.557 ± 0.009	1.435CysLeu: 1.435 ± 0.015	0.283CysMet: 0.283 ± 0.005	0.472CysAsn: 0.472 ± 0.008	0.862CysPro: 0.862 ± 0.012	0.499CysGln: 0.499 ± 0.008	0.872CysArg: 0.872 ± 0.011	1.16CysSer: 1.16 ± 0.014	0.77CysThr: 0.77 ± 0.011	0.788CysVal: 0.788 ± 0.011	0.231CysTrp: 0.231 ± 0.006	0.361CysTyr: 0.361 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	4.229AspAla: 4.229 ± 0.023	0.63AspCys: 0.63 ± 0.008	4.029AspAsp: 4.029 ± 0.032	3.966AspGlu: 3.966 ± 0.031	2.253AspPhe: 2.253 ± 0.017	3.748AspGly: 3.748 ± 0.025	1.276AspHis: 1.276 ± 0.013	3.352AspIle: 3.352 ± 0.018	2.135AspLys: 2.135 ± 0.02	5.152AspLeu: 5.152 ± 0.03	1.111AspMet: 1.111 ± 0.012	1.873AspAsn: 1.873 ± 0.016	3.276AspPro: 3.276 ± 0.019	1.669AspGln: 1.669 ± 0.013	2.734AspArg: 2.734 ± 0.021	4.1AspSer: 4.1 ± 0.027	2.794AspThr: 2.794 ± 0.022	3.542AspVal: 3.542 ± 0.021	0.861AspTrp: 0.861 ± 0.012	1.426AspTyr: 1.426 ± 0.013	0.0AspXaa: 0.0 ± 0.0
Glu	4.493GluAla: 4.493 ± 0.032	0.671GluCys: 0.671 ± 0.009	3.847GluAsp: 3.847 ± 0.029	4.808GluGlu: 4.808 ± 0.043	1.966GluPhe: 1.966 ± 0.017	3.362GluGly: 3.362 ± 0.027	1.354GluHis: 1.354 ± 0.014	2.992GluIle: 2.992 ± 0.021	3.122GluLys: 3.122 ± 0.028	5.013GluLeu: 5.013 ± 0.028	1.259GluMet: 1.259 ± 0.013	2.093GluAsn: 2.093 ± 0.018	2.569GluPro: 2.569 ± 0.019	1.939GluGln: 1.939 ± 0.016	3.604GluArg: 3.604 ± 0.03	3.793GluSer: 3.793 ± 0.023	3.041GluThr: 3.041 ± 0.022	3.467GluVal: 3.467 ± 0.023	0.836GluTrp: 0.836 ± 0.01	1.477GluTyr: 1.477 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	3.067PheAla: 3.067 ± 0.021	0.659PheCys: 0.659 ± 0.01	2.365PheAsp: 2.365 ± 0.017	2.098PheGlu: 2.098 ± 0.015	1.925PhePhe: 1.925 ± 0.017	2.755PheGly: 2.755 ± 0.022	1.069PheHis: 1.069 ± 0.012	2.177PheIle: 2.177 ± 0.019	1.662PheLys: 1.662 ± 0.013	4.133PheLeu: 4.133 ± 0.028	0.814PheMet: 0.814 ± 0.01	1.649PheAsn: 1.649 ± 0.017	2.359PhePro: 2.359 ± 0.018	1.46PheGln: 1.46 ± 0.015	2.162PheArg: 2.162 ± 0.019	3.726PheSer: 3.726 ± 0.021	2.339PheThr: 2.339 ± 0.018	2.617PheVal: 2.617 ± 0.02	0.642PheTrp: 0.642 ± 0.01	1.184PheTyr: 1.184 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	4.594GlyAla: 4.594 ± 0.033	0.893GlyCys: 0.893 ± 0.012	3.155GlyAsp: 3.155 ± 0.022	3.074GlyGlu: 3.074 ± 0.023	2.604GlyPhe: 2.604 ± 0.019	5.307GlyGly: 5.307 ± 0.051	1.702GlyHis: 1.702 ± 0.017	3.35GlyIle: 3.35 ± 0.024	3.205GlyLys: 3.205 ± 0.025	5.741GlyLeu: 5.741 ± 0.029	1.417GlyMet: 1.417 ± 0.017	2.446GlyAsn: 2.446 ± 0.02	3.303GlyPro: 3.303 ± 0.022	2.286GlyGln: 2.286 ± 0.019	3.838GlyArg: 3.838 ± 0.027	5.557GlySer: 5.557 ± 0.036	3.833GlyThr: 3.833 ± 0.026	4.12GlyVal: 4.12 ± 0.026	1.073GlyTrp: 1.073 ± 0.014	1.815GlyTyr: 1.815 ± 0.016	0.0GlyXaa: 0.0 ± 0.0
His	1.884HisAla: 1.884 ± 0.016	0.398HisCys: 0.398 ± 0.007	1.311HisAsp: 1.311 ± 0.015	1.23HisGlu: 1.23 ± 0.012	1.113HisPhe: 1.113 ± 0.013	1.634HisGly: 1.634 ± 0.016	0.938HisHis: 0.938 ± 0.015	1.474HisIle: 1.474 ± 0.014	0.905HisLys: 0.905 ± 0.012	2.722HisLeu: 2.722 ± 0.02	0.448HisMet: 0.448 ± 0.007	0.924HisAsn: 0.924 ± 0.011	2.027HisPro: 2.027 ± 0.019	1.016HisGln: 1.016 ± 0.014	1.68HisArg: 1.68 ± 0.016	2.182HisSer: 2.182 ± 0.019	1.433HisThr: 1.433 ± 0.016	1.524HisVal: 1.524 ± 0.014	0.37HisTrp: 0.37 ± 0.007	0.679HisTyr: 0.679 ± 0.008	0.0HisXaa: 0.0 ± 0.0
Ile	4.131IleAla: 4.131 ± 0.026	0.798IleCys: 0.798 ± 0.011	2.856IleAsp: 2.856 ± 0.022	2.638IleGlu: 2.638 ± 0.023	2.375IlePhe: 2.375 ± 0.02	3.026IleGly: 3.026 ± 0.018	1.333IleHis: 1.333 ± 0.011	2.771IleIle: 2.771 ± 0.019	2.187IleLys: 2.187 ± 0.015	5.241IleLeu: 5.241 ± 0.031	1.034IleMet: 1.034 ± 0.011	1.862IleAsn: 1.862 ± 0.015	3.517IlePro: 3.517 ± 0.025	2.012IleGln: 2.012 ± 0.017	2.963IleArg: 2.963 ± 0.02	4.597IleSer: 4.597 ± 0.028	3.065IleThr: 3.065 ± 0.022	3.357IleVal: 3.357 ± 0.024	0.822IleTrp: 0.822 ± 0.013	1.479IleTyr: 1.479 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.013LysAla: 4.013 ± 0.03	0.56LysCys: 0.56 ± 0.009	2.493LysAsp: 2.493 ± 0.018	3.068LysGlu: 3.068 ± 0.027	1.642LysPhe: 1.642 ± 0.016	2.717LysGly: 2.717 ± 0.023	1.113LysHis: 1.113 ± 0.012	2.269LysIle: 2.269 ± 0.018	3.066LysLys: 3.066 ± 0.032	4.14LysLeu: 4.14 ± 0.025	0.94LysMet: 0.94 ± 0.011	1.724LysAsn: 1.724 ± 0.015	2.567LysPro: 2.567 ± 0.022	1.545LysGln: 1.545 ± 0.017	3.175LysArg: 3.175 ± 0.024	3.488LysSer: 3.488 ± 0.024	2.649LysThr: 2.649 ± 0.018	2.707LysVal: 2.707 ± 0.021	0.684LysTrp: 0.684 ± 0.009	1.295LysTyr: 1.295 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	7.882LeuAla: 7.882 ± 0.034	1.381LeuCys: 1.381 ± 0.014	5.331LeuAsp: 5.331 ± 0.029	5.663LeuGlu: 5.663 ± 0.034	3.788LeuPhe: 3.788 ± 0.025	5.669LeuGly: 5.669 ± 0.031	2.637LeuHis: 2.637 ± 0.021	4.31LeuIle: 4.31 ± 0.027	4.434LeuLys: 4.434 ± 0.027	9.225LeuLeu: 9.225 ± 0.046	1.724LeuMet: 1.724 ± 0.015	3.529LeuAsn: 3.529 ± 0.023	6.497LeuPro: 6.497 ± 0.035	3.905LeuGln: 3.905 ± 0.028	6.01LeuArg: 6.01 ± 0.032	8.578LeuSer: 8.578 ± 0.047	5.495LeuThr: 5.495 ± 0.028	5.83LeuVal: 5.83 ± 0.027	1.317LeuTrp: 1.317 ± 0.015	2.485LeuTyr: 2.485 ± 0.016	0.0LeuXaa: 0.0 ± 0.0
Met	1.773MetAla: 1.773 ± 0.015	0.24MetCys: 0.24 ± 0.005	1.224MetAsp: 1.224 ± 0.013	1.165MetGlu: 1.165 ± 0.013	0.769MetPhe: 0.769 ± 0.01	1.267MetGly: 1.267 ± 0.016	0.487MetHis: 0.487 ± 0.008	0.919MetIle: 0.919 ± 0.011	0.974MetLys: 0.974 ± 0.011	1.782MetLeu: 1.782 ± 0.014	0.467MetMet: 0.467 ± 0.009	0.782MetAsn: 0.782 ± 0.011	1.274MetPro: 1.274 ± 0.013	0.772MetGln: 0.772 ± 0.01	1.191MetArg: 1.191 ± 0.012	1.853MetSer: 1.853 ± 0.014	1.255MetThr: 1.255 ± 0.014	1.168MetVal: 1.168 ± 0.012	0.266MetTrp: 0.266 ± 0.005	0.495MetTyr: 0.495 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	3.081AsnAla: 3.081 ± 0.022	0.491AsnCys: 0.491 ± 0.008	1.999AsnAsp: 1.999 ± 0.014	1.858AsnGlu: 1.858 ± 0.015	1.553AsnPhe: 1.553 ± 0.014	2.667AsnGly: 2.667 ± 0.024	0.99AsnHis: 0.99 ± 0.01	2.197AsnIle: 2.197 ± 0.018	1.456AsnLys: 1.456 ± 0.015	3.773AsnLeu: 3.773 ± 0.027	0.763AsnMet: 0.763 ± 0.01	1.55AsnAsn: 1.55 ± 0.016	2.664AsnPro: 2.664 ± 0.02	1.291AsnGln: 1.291 ± 0.014	1.924AsnArg: 1.924 ± 0.018	3.112AsnSer: 3.112 ± 0.024	2.316AsnThr: 2.316 ± 0.018	2.408AsnVal: 2.408 ± 0.018	0.538AsnTrp: 0.538 ± 0.009	0.971AsnTyr: 0.971 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	5.175ProAla: 5.175 ± 0.037	0.625ProCys: 0.625 ± 0.01	3.135ProAsp: 3.135 ± 0.018	3.355ProGlu: 3.355 ± 0.024	2.393ProPhe: 2.393 ± 0.018	3.719ProGly: 3.719 ± 0.029	1.655ProHis: 1.655 ± 0.017	2.968ProIle: 2.968 ± 0.021	2.608ProLys: 2.608 ± 0.021	5.508ProLeu: 5.508 ± 0.028	1.083ProMet: 1.083 ± 0.013	2.474ProAsn: 2.474 ± 0.019	6.334ProPro: 6.334 ± 0.058	2.443ProGln: 2.443 ± 0.022	3.57ProArg: 3.57 ± 0.023	7.156ProSer: 7.156 ± 0.047	4.598ProThr: 4.598 ± 0.029	3.741ProVal: 3.741 ± 0.025	0.726ProTrp: 0.726 ± 0.01	1.537ProTyr: 1.537 ± 0.016	0.0ProXaa: 0.0 ± 0.0
Gln	3.164GlnAla: 3.164 ± 0.022	0.508GlnCys: 0.508 ± 0.009	1.891GlnAsp: 1.891 ± 0.016	2.151GlnGlu: 2.151 ± 0.016	1.398GlnPhe: 1.398 ± 0.013	2.107GlnGly: 2.107 ± 0.021	1.082GlnHis: 1.082 ± 0.013	1.899GlnIle: 1.899 ± 0.015	1.767GlnLys: 1.767 ± 0.016	3.412GlnLeu: 3.412 ± 0.022	0.776GlnMet: 0.776 ± 0.01	1.481GlnAsn: 1.481 ± 0.014	2.452GlnPro: 2.452 ± 0.026	1.951GlnGln: 1.951 ± 0.04	2.344GlnArg: 2.344 ± 0.016	2.953GlnSer: 2.953 ± 0.021	2.319GlnThr: 2.319 ± 0.02	2.183GlnVal: 2.183 ± 0.018	0.531GlnTrp: 0.531 ± 0.008	1.025GlnTyr: 1.025 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	4.313ArgAla: 4.313 ± 0.023	0.886ArgCys: 0.886 ± 0.012	2.971ArgAsp: 2.971 ± 0.023	3.407ArgGlu: 3.407 ± 0.03	2.319ArgPhe: 2.319 ± 0.02	3.391ArgGly: 3.391 ± 0.023	1.655ArgHis: 1.655 ± 0.014	3.068ArgIle: 3.068 ± 0.021	3.22ArgLys: 3.22 ± 0.025	5.855ArgLeu: 5.855 ± 0.034	1.291ArgMet: 1.291 ± 0.013	2.241ArgAsn: 2.241 ± 0.018	3.592ArgPro: 3.592 ± 0.026	2.367ArgGln: 2.367 ± 0.018	5.019ArgArg: 5.019 ± 0.03	5.071ArgSer: 5.071 ± 0.033	3.466ArgThr: 3.466 ± 0.022	3.488ArgVal: 3.488 ± 0.025	0.96ArgTrp: 0.96 ± 0.013	1.599ArgTyr: 1.599 ± 0.014	0.0ArgXaa: 0.0 ± 0.0
Ser	6.701SerAla: 6.701 ± 0.035	1.078SerCys: 1.078 ± 0.013	4.254SerAsp: 4.254 ± 0.028	3.907SerGlu: 3.907 ± 0.027	3.669SerPhe: 3.669 ± 0.024	5.556SerGly: 5.556 ± 0.033	2.17SerHis: 2.17 ± 0.018	4.44SerIle: 4.44 ± 0.022	3.718SerLys: 3.718 ± 0.023	8.564SerLeu: 8.564 ± 0.041	1.748SerMet: 1.748 ± 0.016	3.345SerAsn: 3.345 ± 0.028	6.199SerPro: 6.199 ± 0.046	3.25SerGln: 3.25 ± 0.021	5.292SerArg: 5.292 ± 0.032	10.42SerSer: 10.42 ± 0.07	6.362SerThr: 6.362 ± 0.038	5.063SerVal: 5.063 ± 0.031	1.18SerTrp: 1.18 ± 0.013	2.148SerTyr: 2.148 ± 0.016	0.0SerXaa: 0.0 ± 0.0
Thr	4.889ThrAla: 4.889 ± 0.03	0.825ThrCys: 0.825 ± 0.011	2.777ThrAsp: 2.777 ± 0.019	2.753ThrGlu: 2.753 ± 0.02	2.635ThrPhe: 2.635 ± 0.019	3.827ThrGly: 3.827 ± 0.024	1.508ThrHis: 1.508 ± 0.013	3.298ThrIle: 3.298 ± 0.02	2.533ThrLys: 2.533 ± 0.019	5.91ThrLeu: 5.91 ± 0.03	1.172ThrMet: 1.172 ± 0.011	2.212ThrAsn: 2.212 ± 0.015	4.618ThrPro: 4.618 ± 0.032	2.062ThrGln: 2.062 ± 0.016	3.403ThrArg: 3.403 ± 0.022	5.988ThrSer: 5.988 ± 0.037	4.496ThrThr: 4.496 ± 0.031	3.775ThrVal: 3.775 ± 0.023	0.863ThrTrp: 0.863 ± 0.01	1.605ThrTyr: 1.605 ± 0.014	0.0ThrXaa: 0.0 ± 0.0
Val	4.869ValAla: 4.869 ± 0.027	0.922ValCys: 0.922 ± 0.011	3.733ValAsp: 3.733 ± 0.024	3.661ValGlu: 3.661 ± 0.026	2.56ValPhe: 2.56 ± 0.019	3.877ValGly: 3.877 ± 0.027	1.568ValHis: 1.568 ± 0.015	3.229ValIle: 3.229 ± 0.022	2.859ValLys: 2.859 ± 0.022	6.073ValLeu: 6.073 ± 0.029	1.229ValMet: 1.229 ± 0.012	2.319ValAsn: 2.319 ± 0.017	3.773ValPro: 3.773 ± 0.024	2.377ValGln: 2.377 ± 0.017	3.288ValArg: 3.288 ± 0.021	4.777ValSer: 4.777 ± 0.025	3.444ValThr: 3.444 ± 0.025	4.493ValVal: 4.493 ± 0.03	0.919ValTrp: 0.919 ± 0.012	1.698ValTyr: 1.698 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.047TrpAla: 1.047 ± 0.012	0.223TrpCys: 0.223 ± 0.005	0.871TrpAsp: 0.871 ± 0.011	0.794TrpGlu: 0.794 ± 0.01	0.612TrpPhe: 0.612 ± 0.009	0.865TrpGly: 0.865 ± 0.013	0.331TrpHis: 0.331 ± 0.007	0.831TrpIle: 0.831 ± 0.011	0.863TrpLys: 0.863 ± 0.011	1.332TrpLeu: 1.332 ± 0.015	0.341TrpMet: 0.341 ± 0.007	0.662TrpAsn: 0.662 ± 0.009	0.62TrpPro: 0.62 ± 0.008	0.486TrpGln: 0.486 ± 0.007	1.012TrpArg: 1.012 ± 0.013	1.133TrpSer: 1.133 ± 0.012	0.956TrpThr: 0.956 ± 0.012	0.877TrpVal: 0.877 ± 0.013	0.288TrpTrp: 0.288 ± 0.007	0.405TrpTyr: 0.405 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.972TyrAla: 1.972 ± 0.016	0.402TyrCys: 0.402 ± 0.008	1.536TyrAsp: 1.536 ± 0.013	1.343TyrGlu: 1.343 ± 0.012	1.27TyrPhe: 1.27 ± 0.014	1.757TyrGly: 1.757 ± 0.016	0.756TyrHis: 0.756 ± 0.011	1.461TyrIle: 1.461 ± 0.016	1.03TyrLys: 1.03 ± 0.011	2.751TyrLeu: 2.751 ± 0.018	0.535TyrMet: 0.535 ± 0.008	1.06TyrAsn: 1.06 ± 0.012	1.606TyrPro: 1.606 ± 0.017	1.04TyrGln: 1.04 ± 0.011	1.598TyrArg: 1.598 ± 0.013	2.177TyrSer: 2.177 ± 0.017	1.584TyrThr: 1.584 ± 0.015	1.516TyrVal: 1.516 ± 0.015	0.381TyrTrp: 0.381 ± 0.007	0.874TyrTyr: 0.874 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 21357 proteins (8193245 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---