Amino acid dipepetide frequency for Coxiella endosymbiont of Amblyomma americanum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.588AlaAla: 4.588 ± 0.191
1.077AlaCys: 1.077 ± 0.077
2.412AlaAsp: 2.412 ± 0.121
2.889AlaGlu: 2.889 ± 0.145
3.018AlaPhe: 3.018 ± 0.122
3.747AlaGly: 3.747 ± 0.155
1.447AlaHis: 1.447 ± 0.077
6.944AlaIle: 6.944 ± 0.227
4.341AlaLys: 4.341 ± 0.175
7.685AlaLeu: 7.685 ± 0.203
1.778AlaMet: 1.778 ± 0.1
2.603AlaAsn: 2.603 ± 0.112
1.672AlaPro: 1.672 ± 0.096
2.317AlaGln: 2.317 ± 0.139
3.528AlaArg: 3.528 ± 0.14
3.64AlaSer: 3.64 ± 0.181
3.085AlaThr: 3.085 ± 0.128
4.695AlaVal: 4.695 ± 0.18
0.656AlaTrp: 0.656 ± 0.059
2.272AlaTyr: 2.272 ± 0.11
0.0AlaXaa: 0.0 ± 0.0
Cys
0.791CysAla: 0.791 ± 0.079
0.252CysCys: 0.252 ± 0.044
0.628CysAsp: 0.628 ± 0.064
0.634CysGlu: 0.634 ± 0.073
0.712CysPhe: 0.712 ± 0.054
1.116CysGly: 1.116 ± 0.079
0.398CysHis: 0.398 ± 0.05
1.155CysIle: 1.155 ± 0.072
0.707CysLys: 0.707 ± 0.055
1.436CysLeu: 1.436 ± 0.087
0.303CysMet: 0.303 ± 0.043
0.752CysAsn: 0.752 ± 0.073
0.6CysPro: 0.6 ± 0.056
0.572CysGln: 0.572 ± 0.057
0.729CysArg: 0.729 ± 0.059
0.886CysSer: 0.886 ± 0.069
0.746CysThr: 0.746 ± 0.064
0.948CysVal: 0.948 ± 0.075
0.129CysTrp: 0.129 ± 0.023
0.606CysTyr: 0.606 ± 0.051
0.0CysXaa: 0.0 ± 0.0
Asp
2.676AspAla: 2.676 ± 0.152
0.69AspCys: 0.69 ± 0.062
1.593AspAsp: 1.593 ± 0.103
2.182AspGlu: 2.182 ± 0.104
2.294AspPhe: 2.294 ± 0.115
2.305AspGly: 2.305 ± 0.125
0.993AspHis: 0.993 ± 0.072
4.577AspIle: 4.577 ± 0.172
2.401AspLys: 2.401 ± 0.111
4.779AspLeu: 4.779 ± 0.173
0.903AspMet: 0.903 ± 0.069
1.974AspAsn: 1.974 ± 0.108
1.862AspPro: 1.862 ± 0.096
1.363AspGln: 1.363 ± 0.08
2.664AspArg: 2.664 ± 0.126
2.389AspSer: 2.389 ± 0.128
2.059AspThr: 2.059 ± 0.113
3.13AspVal: 3.13 ± 0.142
0.46AspTrp: 0.46 ± 0.056
1.739AspTyr: 1.739 ± 0.102
0.0AspXaa: 0.0 ± 0.0
Glu
3.579GluAla: 3.579 ± 0.162
0.595GluCys: 0.595 ± 0.054
2.098GluAsp: 2.098 ± 0.116
3.556GluGlu: 3.556 ± 0.191
1.969GluPhe: 1.969 ± 0.106
3.023GluGly: 3.023 ± 0.151
1.133GluHis: 1.133 ± 0.071
5.486GluIle: 5.486 ± 0.171
5.604GluLys: 5.604 ± 0.187
5.278GluLeu: 5.278 ± 0.159
1.374GluMet: 1.374 ± 0.091
2.782GluAsn: 2.782 ± 0.134
1.369GluPro: 1.369 ± 0.099
1.902GluGln: 1.902 ± 0.102
3.242GluArg: 3.242 ± 0.133
2.743GluSer: 2.743 ± 0.132
2.737GluThr: 2.737 ± 0.128
3.612GluVal: 3.612 ± 0.183
0.443GluTrp: 0.443 ± 0.053
1.47GluTyr: 1.47 ± 0.09
0.0GluXaa: 0.0 ± 0.0
Phe
2.204PheAla: 2.204 ± 0.105
0.746PheCys: 0.746 ± 0.065
2.025PheAsp: 2.025 ± 0.121
1.801PheGlu: 1.801 ± 0.108
2.49PhePhe: 2.49 ± 0.146
2.984PheGly: 2.984 ± 0.151
1.234PheHis: 1.234 ± 0.084
3.82PheIle: 3.82 ± 0.161
2.479PheLys: 2.479 ± 0.127
4.958PheLeu: 4.958 ± 0.224
0.892PheMet: 0.892 ± 0.062
2.064PheAsn: 2.064 ± 0.113
2.042PhePro: 2.042 ± 0.097
1.649PheGln: 1.649 ± 0.1
1.958PheArg: 1.958 ± 0.088
4.027PheSer: 4.027 ± 0.171
2.35PheThr: 2.35 ± 0.112
2.294PheVal: 2.294 ± 0.13
0.415PheTrp: 0.415 ± 0.056
1.935PheTyr: 1.935 ± 0.096
0.0PheXaa: 0.0 ± 0.0
Gly
4.039GlyAla: 4.039 ± 0.166
0.931GlyCys: 0.931 ± 0.074
2.827GlyAsp: 2.827 ± 0.155
3.259GlyGlu: 3.259 ± 0.161
3.057GlyPhe: 3.057 ± 0.145
4.364GlyGly: 4.364 ± 0.16
1.475GlyHis: 1.475 ± 0.095
6.209GlyIle: 6.209 ± 0.208
4.644GlyLys: 4.644 ± 0.169
6.097GlyLeu: 6.097 ± 0.224
1.688GlyMet: 1.688 ± 0.093
2.558GlyAsn: 2.558 ± 0.112
1.84GlyPro: 1.84 ± 0.102
1.834GlyGln: 1.834 ± 0.112
3.399GlyArg: 3.399 ± 0.135
3.556GlySer: 3.556 ± 0.145
3.293GlyThr: 3.293 ± 0.146
4.504GlyVal: 4.504 ± 0.175
0.746GlyTrp: 0.746 ± 0.069
2.35GlyTyr: 2.35 ± 0.133
0.0GlyXaa: 0.0 ± 0.0
His
1.688HisAla: 1.688 ± 0.095
0.421HisCys: 0.421 ± 0.052
0.886HisAsp: 0.886 ± 0.081
0.993HisGlu: 0.993 ± 0.086
1.071HisPhe: 1.071 ± 0.078
1.559HisGly: 1.559 ± 0.092
0.724HisHis: 0.724 ± 0.061
2.019HisIle: 2.019 ± 0.096
1.251HisLys: 1.251 ± 0.093
2.294HisLeu: 2.294 ± 0.106
0.567HisMet: 0.567 ± 0.064
1.105HisAsn: 1.105 ± 0.067
1.352HisPro: 1.352 ± 0.109
1.088HisGln: 1.088 ± 0.076
1.475HisArg: 1.475 ± 0.093
1.402HisSer: 1.402 ± 0.078
1.144HisThr: 1.144 ± 0.091
1.307HisVal: 1.307 ± 0.078
0.381HisTrp: 0.381 ± 0.047
1.071HisTyr: 1.071 ± 0.074
0.0HisXaa: 0.0 ± 0.0
Ile
7.023IleAla: 7.023 ± 0.246
1.24IleCys: 1.24 ± 0.097
4.762IleAsp: 4.762 ± 0.164
5.076IleGlu: 5.076 ± 0.187
3.848IlePhe: 3.848 ± 0.189
6.411IleGly: 6.411 ± 0.202
2.047IleHis: 2.047 ± 0.108
7.847IleIle: 7.847 ± 0.265
6.17IleLys: 6.17 ± 0.216
8.515IleLeu: 8.515 ± 0.286
1.873IleMet: 1.873 ± 0.09
4.953IleAsn: 4.953 ± 0.166
3.747IlePro: 3.747 ± 0.133
3.091IleGln: 3.091 ± 0.132
4.846IleArg: 4.846 ± 0.173
6.394IleSer: 6.394 ± 0.226
5.648IleThr: 5.648 ± 0.217
5.951IleVal: 5.951 ± 0.184
0.763IleTrp: 0.763 ± 0.063
2.575IleTyr: 2.575 ± 0.144
0.0IleXaa: 0.0 ± 0.0
Lys
4.274LysAla: 4.274 ± 0.165
0.785LysCys: 0.785 ± 0.072
2.95LysAsp: 2.95 ± 0.138
5.009LysGlu: 5.009 ± 0.19
2.019LysPhe: 2.019 ± 0.105
3.741LysGly: 3.741 ± 0.137
1.346LysHis: 1.346 ± 0.091
7.017LysIle: 7.017 ± 0.225
7.516LysLys: 7.516 ± 0.222
6.181LysLeu: 6.181 ± 0.198
1.66LysMet: 1.66 ± 0.082
4.672LysAsn: 4.672 ± 0.197
1.93LysPro: 1.93 ± 0.1
2.547LysGln: 2.547 ± 0.135
4.224LysArg: 4.224 ± 0.186
4.123LysSer: 4.123 ± 0.161
4.1LysThr: 4.1 ± 0.155
4.128LysVal: 4.128 ± 0.156
0.623LysTrp: 0.623 ± 0.055
2.143LysTyr: 2.143 ± 0.108
0.0LysXaa: 0.0 ± 0.0
Leu
6.473LeuAla: 6.473 ± 0.2
1.329LeuCys: 1.329 ± 0.092
4.347LeuAsp: 4.347 ± 0.177
5.946LeuGlu: 5.946 ± 0.197
4.414LeuPhe: 4.414 ± 0.199
6.462LeuGly: 6.462 ± 0.201
2.468LeuHis: 2.468 ± 0.116
9.036LeuIle: 9.036 ± 0.289
7.348LeuLys: 7.348 ± 0.203
10.977LeuLeu: 10.977 ± 0.329
2.395LeuMet: 2.395 ± 0.135
4.527LeuAsn: 4.527 ± 0.154
4.336LeuPro: 4.336 ± 0.154
4.201LeuGln: 4.201 ± 0.138
5.772LeuArg: 5.772 ± 0.172
7.915LeuSer: 7.915 ± 0.234
5.486LeuThr: 5.486 ± 0.185
6.215LeuVal: 6.215 ± 0.207
1.021LeuTrp: 1.021 ± 0.084
3.231LeuTyr: 3.231 ± 0.125
0.0LeuXaa: 0.0 ± 0.0
Met
1.677MetAla: 1.677 ± 0.102
0.208MetCys: 0.208 ± 0.034
1.066MetAsp: 1.066 ± 0.087
1.329MetGlu: 1.329 ± 0.087
0.662MetPhe: 0.662 ± 0.053
1.61MetGly: 1.61 ± 0.097
0.673MetHis: 0.673 ± 0.057
2.182MetIle: 2.182 ± 0.105
1.829MetLys: 1.829 ± 0.093
2.081MetLeu: 2.081 ± 0.109
0.656MetMet: 0.656 ± 0.068
0.976MetAsn: 0.976 ± 0.073
0.92MetPro: 0.92 ± 0.074
1.004MetGln: 1.004 ± 0.077
1.391MetArg: 1.391 ± 0.088
1.548MetSer: 1.548 ± 0.105
1.268MetThr: 1.268 ± 0.08
1.419MetVal: 1.419 ± 0.094
0.151MetTrp: 0.151 ± 0.033
0.561MetTyr: 0.561 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
3.012AsnAla: 3.012 ± 0.13
0.696AsnCys: 0.696 ± 0.063
1.851AsnAsp: 1.851 ± 0.102
2.395AsnGlu: 2.395 ± 0.116
2.502AsnPhe: 2.502 ± 0.141
2.44AsnGly: 2.44 ± 0.117
1.223AsnHis: 1.223 ± 0.083
4.504AsnIle: 4.504 ± 0.191
3.136AsnLys: 3.136 ± 0.151
4.852AsnLeu: 4.852 ± 0.195
0.976AsnMet: 0.976 ± 0.082
2.614AsnAsn: 2.614 ± 0.132
2.148AsnPro: 2.148 ± 0.103
2.221AsnGln: 2.221 ± 0.119
2.692AsnArg: 2.692 ± 0.108
2.625AsnSer: 2.625 ± 0.126
2.676AsnThr: 2.676 ± 0.133
3.063AsnVal: 3.063 ± 0.139
0.538AsnTrp: 0.538 ± 0.063
1.829AsnTyr: 1.829 ± 0.097
0.0AsnXaa: 0.0 ± 0.0
Pro
1.733ProAla: 1.733 ± 0.101
0.454ProCys: 0.454 ± 0.048
1.576ProAsp: 1.576 ± 0.108
2.21ProGlu: 2.21 ± 0.111
1.733ProPhe: 1.733 ± 0.097
2.294ProGly: 2.294 ± 0.116
0.886ProHis: 0.886 ± 0.087
3.663ProIle: 3.663 ± 0.167
2.631ProLys: 2.631 ± 0.115
3.882ProLeu: 3.882 ± 0.154
0.735ProMet: 0.735 ± 0.077
2.031ProAsn: 2.031 ± 0.095
1.015ProPro: 1.015 ± 0.073
1.189ProGln: 1.189 ± 0.085
1.543ProArg: 1.543 ± 0.088
2.232ProSer: 2.232 ± 0.124
2.002ProThr: 2.002 ± 0.101
2.771ProVal: 2.771 ± 0.144
0.438ProTrp: 0.438 ± 0.046
1.442ProTyr: 1.442 ± 0.094
0.0ProXaa: 0.0 ± 0.0
Gln
2.451GlnAla: 2.451 ± 0.122
0.466GlnCys: 0.466 ± 0.052
1.313GlnAsp: 1.313 ± 0.097
2.16GlnGlu: 2.16 ± 0.121
1.565GlnPhe: 1.565 ± 0.1
1.986GlnGly: 1.986 ± 0.095
0.819GlnHis: 0.819 ± 0.07
3.141GlnIle: 3.141 ± 0.141
3.152GlnLys: 3.152 ± 0.132
4.588GlnLeu: 4.588 ± 0.17
0.942GlnMet: 0.942 ± 0.07
1.509GlnAsn: 1.509 ± 0.086
1.2GlnPro: 1.2 ± 0.08
1.486GlnGln: 1.486 ± 0.097
2.137GlnArg: 2.137 ± 0.101
2.378GlnSer: 2.378 ± 0.112
1.621GlnThr: 1.621 ± 0.102
2.328GlnVal: 2.328 ± 0.113
0.583GlnTrp: 0.583 ± 0.056
1.397GlnTyr: 1.397 ± 0.089
0.0GlnXaa: 0.0 ± 0.0
Arg
3.343ArgAla: 3.343 ± 0.135
0.74ArgCys: 0.74 ± 0.056
2.406ArgAsp: 2.406 ± 0.124
3.27ArgGlu: 3.27 ± 0.146
2.664ArgPhe: 2.664 ± 0.128
3.023ArgGly: 3.023 ± 0.14
1.453ArgHis: 1.453 ± 0.077
4.723ArgIle: 4.723 ± 0.169
3.966ArgLys: 3.966 ± 0.198
6.047ArgLeu: 6.047 ± 0.191
1.318ArgMet: 1.318 ± 0.086
2.547ArgAsn: 2.547 ± 0.127
1.705ArgPro: 1.705 ± 0.099
2.137ArgGln: 2.137 ± 0.119
3.197ArgArg: 3.197 ± 0.185
3.248ArgSer: 3.248 ± 0.13
2.406ArgThr: 2.406 ± 0.098
3.41ArgVal: 3.41 ± 0.124
0.684ArgTrp: 0.684 ± 0.064
2.322ArgTyr: 2.322 ± 0.12
0.0ArgXaa: 0.0 ± 0.0
Ser
4.123SerAla: 4.123 ± 0.174
0.926SerCys: 0.926 ± 0.067
2.715SerAsp: 2.715 ± 0.117
3.164SerGlu: 3.164 ± 0.13
2.754SerPhe: 2.754 ± 0.138
5.104SerGly: 5.104 ± 0.175
1.447SerHis: 1.447 ± 0.088
5.469SerIle: 5.469 ± 0.194
3.713SerLys: 3.713 ± 0.16
6.737SerLeu: 6.737 ± 0.194
1.402SerMet: 1.402 ± 0.079
3.023SerAsn: 3.023 ± 0.131
2.115SerPro: 2.115 ± 0.123
2.367SerGln: 2.367 ± 0.113
3.259SerArg: 3.259 ± 0.144
4.285SerSer: 4.285 ± 0.215
3.287SerThr: 3.287 ± 0.14
4.689SerVal: 4.689 ± 0.176
0.634SerTrp: 0.634 ± 0.058
2.221SerTyr: 2.221 ± 0.118
0.0SerXaa: 0.0 ± 0.0
Thr
3.831ThrAla: 3.831 ± 0.134
0.718ThrCys: 0.718 ± 0.067
2.401ThrAsp: 2.401 ± 0.127
2.67ThrGlu: 2.67 ± 0.123
2.339ThrPhe: 2.339 ± 0.12
3.646ThrGly: 3.646 ± 0.152
1.122ThrHis: 1.122 ± 0.08
4.622ThrIle: 4.622 ± 0.178
3.057ThrLys: 3.057 ± 0.123
5.8ThrLeu: 5.8 ± 0.191
1.2ThrMet: 1.2 ± 0.091
2.3ThrAsn: 2.3 ± 0.108
2.081ThrPro: 2.081 ± 0.13
2.047ThrGln: 2.047 ± 0.101
2.462ThrArg: 2.462 ± 0.125
2.995ThrSer: 2.995 ± 0.122
3.242ThrThr: 3.242 ± 0.122
3.982ThrVal: 3.982 ± 0.162
0.438ThrTrp: 0.438 ± 0.047
1.615ThrTyr: 1.615 ± 0.101
0.0ThrXaa: 0.0 ± 0.0
Val
4.375ValAla: 4.375 ± 0.179
0.959ValCys: 0.959 ± 0.077
3.27ValAsp: 3.27 ± 0.141
3.466ValGlu: 3.466 ± 0.163
2.883ValPhe: 2.883 ± 0.135
4.14ValGly: 4.14 ± 0.18
1.565ValHis: 1.565 ± 0.098
6.495ValIle: 6.495 ± 0.19
4.055ValLys: 4.055 ± 0.161
6.686ValLeu: 6.686 ± 0.234
1.739ValMet: 1.739 ± 0.083
2.956ValAsn: 2.956 ± 0.137
2.765ValPro: 2.765 ± 0.141
1.902ValGln: 1.902 ± 0.099
3.343ValArg: 3.343 ± 0.156
4.353ValSer: 4.353 ± 0.156
3.455ValThr: 3.455 ± 0.161
4.975ValVal: 4.975 ± 0.191
0.583ValTrp: 0.583 ± 0.063
1.879ValTyr: 1.879 ± 0.101
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.06
0.157TrpCys: 0.157 ± 0.029
0.415TrpAsp: 0.415 ± 0.048
0.46TrpGlu: 0.46 ± 0.052
0.466TrpPhe: 0.466 ± 0.054
0.494TrpGly: 0.494 ± 0.051
0.314TrpHis: 0.314 ± 0.038
1.2TrpIle: 1.2 ± 0.092
0.853TrpLys: 0.853 ± 0.086
1.234TrpLeu: 1.234 ± 0.105
0.241TrpMet: 0.241 ± 0.037
0.466TrpAsn: 0.466 ± 0.053
0.348TrpPro: 0.348 ± 0.051
0.499TrpGln: 0.499 ± 0.056
0.538TrpArg: 0.538 ± 0.054
0.544TrpSer: 0.544 ± 0.062
0.398TrpThr: 0.398 ± 0.045
0.533TrpVal: 0.533 ± 0.051
0.107TrpTrp: 0.107 ± 0.025
0.409TrpTyr: 0.409 ± 0.056
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.986TyrAla: 1.986 ± 0.125
0.712TyrCys: 0.712 ± 0.07
1.492TyrAsp: 1.492 ± 0.106
1.526TyrGlu: 1.526 ± 0.104
1.907TyrPhe: 1.907 ± 0.105
2.221TyrGly: 2.221 ± 0.117
1.032TyrHis: 1.032 ± 0.073
2.67TyrIle: 2.67 ± 0.139
2.137TyrLys: 2.137 ± 0.113
3.797TyrLeu: 3.797 ± 0.138
0.561TyrMet: 0.561 ± 0.064
1.582TyrAsn: 1.582 ± 0.089
1.414TyrPro: 1.414 ± 0.088
1.806TyrGln: 1.806 ± 0.096
2.21TyrArg: 2.21 ± 0.133
2.148TyrSer: 2.148 ± 0.1
1.565TyrThr: 1.565 ± 0.096
1.89TyrVal: 1.89 ± 0.114
0.409TyrTrp: 0.409 ± 0.048
1.357TyrTyr: 1.357 ± 0.091
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 536 proteins (178281 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski