Amino acid dipepetide frequency for Stella humosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.211AlaAla: 23.211 ± 0.225	1.174AlaCys: 1.174 ± 0.026	8.392AlaAsp: 8.392 ± 0.097	7.62AlaGlu: 7.62 ± 0.075	4.6AlaPhe: 4.6 ± 0.053	14.194AlaGly: 14.194 ± 0.114	2.299AlaHis: 2.299 ± 0.042	7.09AlaIle: 7.09 ± 0.075	2.822AlaLys: 2.822 ± 0.049	14.156AlaLeu: 14.156 ± 0.13	4.12AlaMet: 4.12 ± 0.054	2.516AlaAsn: 2.516 ± 0.04	6.41AlaPro: 6.41 ± 0.068	3.584AlaGln: 3.584 ± 0.053	10.76AlaArg: 10.76 ± 0.099	5.47AlaSer: 5.47 ± 0.056	6.765AlaThr: 6.765 ± 0.056	10.703AlaVal: 10.703 ± 0.095	1.874AlaTrp: 1.874 ± 0.034	2.581AlaTyr: 2.581 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.921CysAla: 0.921 ± 0.025	0.104CysCys: 0.104 ± 0.008	0.502CysAsp: 0.502 ± 0.018	0.356CysGlu: 0.356 ± 0.013	0.297CysPhe: 0.297 ± 0.014	0.955CysGly: 0.955 ± 0.024	0.243CysHis: 0.243 ± 0.011	0.381CysIle: 0.381 ± 0.013	0.127CysLys: 0.127 ± 0.009	0.795CysLeu: 0.795 ± 0.022	0.143CysMet: 0.143 ± 0.009	0.179CysAsn: 0.179 ± 0.01	0.441CysPro: 0.441 ± 0.016	0.219CysGln: 0.219 ± 0.011	0.748CysArg: 0.748 ± 0.02	0.347CysSer: 0.347 ± 0.013	0.37CysThr: 0.37 ± 0.016	0.558CysVal: 0.558 ± 0.018	0.123CysTrp: 0.123 ± 0.007	0.184CysTyr: 0.184 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.291AspAla: 7.291 ± 0.088	0.454AspCys: 0.454 ± 0.015	3.295AspAsp: 3.295 ± 0.078	3.13AspGlu: 3.13 ± 0.043	2.057AspPhe: 2.057 ± 0.044	6.429AspGly: 6.429 ± 0.116	1.28AspHis: 1.28 ± 0.028	2.664AspIle: 2.664 ± 0.037	1.052AspLys: 1.052 ± 0.026	6.17AspLeu: 6.17 ± 0.07	1.22AspMet: 1.22 ± 0.026	0.956AspAsn: 0.956 ± 0.025	4.026AspPro: 4.026 ± 0.05	1.695AspGln: 1.695 ± 0.029	5.717AspArg: 5.717 ± 0.058	1.995AspSer: 1.995 ± 0.051	2.612AspThr: 2.612 ± 0.078	3.973AspVal: 3.973 ± 0.051	1.014AspTrp: 1.014 ± 0.024	1.278AspTyr: 1.278 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.439GluAla: 7.439 ± 0.076	0.316GluCys: 0.316 ± 0.012	2.316GluAsp: 2.316 ± 0.042	2.481GluGlu: 2.481 ± 0.044	1.461GluPhe: 1.461 ± 0.029	4.222GluGly: 4.222 ± 0.056	0.945GluHis: 0.945 ± 0.024	2.749GluIle: 2.749 ± 0.045	1.405GluLys: 1.405 ± 0.034	4.774GluLeu: 4.774 ± 0.058	1.429GluMet: 1.429 ± 0.027	1.05GluAsn: 1.05 ± 0.023	2.729GluPro: 2.729 ± 0.042	1.672GluGln: 1.672 ± 0.035	5.037GluArg: 5.037 ± 0.064	1.839GluSer: 1.839 ± 0.033	2.842GluThr: 2.842 ± 0.042	3.589GluVal: 3.589 ± 0.043	0.752GluTrp: 0.752 ± 0.023	0.861GluTyr: 0.861 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.8PheAla: 4.8 ± 0.053	0.355PheCys: 0.355 ± 0.012	2.511PheAsp: 2.511 ± 0.041	1.759PheGlu: 1.759 ± 0.031	1.283PhePhe: 1.283 ± 0.032	3.758PheGly: 3.758 ± 0.054	0.802PheHis: 0.802 ± 0.02	1.356PheIle: 1.356 ± 0.03	0.681PheLys: 0.681 ± 0.021	3.475PheLeu: 3.475 ± 0.048	0.693PheMet: 0.693 ± 0.022	0.835PheAsn: 0.835 ± 0.024	1.741PhePro: 1.741 ± 0.028	1.056PheGln: 1.056 ± 0.022	2.41PheArg: 2.41 ± 0.035	1.704PheSer: 1.704 ± 0.033	1.811PheThr: 1.811 ± 0.036	2.949PheVal: 2.949 ± 0.042	0.538PheTrp: 0.538 ± 0.019	0.81PheTyr: 0.81 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.56GlyAla: 10.56 ± 0.087	0.889GlyCys: 0.889 ± 0.024	5.248GlyAsp: 5.248 ± 0.117	4.551GlyGlu: 4.551 ± 0.053	3.701GlyPhe: 3.701 ± 0.048	9.146GlyGly: 9.146 ± 0.158	2.036GlyHis: 2.036 ± 0.037	4.91GlyIle: 4.91 ± 0.052	2.294GlyLys: 2.294 ± 0.04	10.019GlyLeu: 10.019 ± 0.095	2.627GlyMet: 2.627 ± 0.036	2.366GlyAsn: 2.366 ± 0.095	4.538GlyPro: 4.538 ± 0.045	3.277GlyGln: 3.277 ± 0.047	8.402GlyArg: 8.402 ± 0.071	4.576GlySer: 4.576 ± 0.064	5.008GlyThr: 5.008 ± 0.062	6.684GlyVal: 6.684 ± 0.061	1.715GlyTrp: 1.715 ± 0.035	2.347GlyTyr: 2.347 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.616HisAla: 2.616 ± 0.043	0.214HisCys: 0.214 ± 0.011	1.186HisAsp: 1.186 ± 0.026	0.899HisGlu: 0.899 ± 0.02	0.831HisPhe: 0.831 ± 0.021	2.168HisGly: 2.168 ± 0.037	0.573HisHis: 0.573 ± 0.023	0.799HisIle: 0.799 ± 0.018	0.333HisLys: 0.333 ± 0.012	2.118HisLeu: 2.118 ± 0.038	0.437HisMet: 0.437 ± 0.018	0.418HisAsn: 0.418 ± 0.015	1.548HisPro: 1.548 ± 0.034	0.535HisGln: 0.535 ± 0.017	1.679HisArg: 1.679 ± 0.031	0.772HisSer: 0.772 ± 0.02	0.729HisThr: 0.729 ± 0.021	1.525HisVal: 1.525 ± 0.028	0.357HisTrp: 0.357 ± 0.013	0.504HisTyr: 0.504 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.131IleAla: 7.131 ± 0.066	0.435IleCys: 0.435 ± 0.016	3.495IleAsp: 3.495 ± 0.043	2.948IleGlu: 2.948 ± 0.047	1.529IlePhe: 1.529 ± 0.032	4.929IleGly: 4.929 ± 0.056	0.947IleHis: 0.947 ± 0.026	1.786IleIle: 1.786 ± 0.038	0.913IleLys: 0.913 ± 0.027	4.608IleLeu: 4.608 ± 0.055	0.822IleMet: 0.822 ± 0.022	1.076IleAsn: 1.076 ± 0.027	2.233IlePro: 2.233 ± 0.039	1.165IleGln: 1.165 ± 0.026	3.232IleArg: 3.232 ± 0.048	1.974IleSer: 1.974 ± 0.042	2.142IleThr: 2.142 ± 0.038	4.296IleVal: 4.296 ± 0.051	0.514IleTrp: 0.514 ± 0.015	1.003IleTyr: 1.003 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.985LysAla: 2.985 ± 0.05	0.109LysCys: 0.109 ± 0.008	1.104LysAsp: 1.104 ± 0.028	1.041LysGlu: 1.041 ± 0.031	0.628LysPhe: 0.628 ± 0.019	2.013LysGly: 2.013 ± 0.039	0.381LysHis: 0.381 ± 0.014	1.032LysIle: 1.032 ± 0.028	0.757LysLys: 0.757 ± 0.027	2.215LysLeu: 2.215 ± 0.037	0.553LysMet: 0.553 ± 0.019	0.496LysAsn: 0.496 ± 0.019	1.53LysPro: 1.53 ± 0.035	0.569LysGln: 0.569 ± 0.02	1.625LysArg: 1.625 ± 0.035	1.076LysSer: 1.076 ± 0.029	1.208LysThr: 1.208 ± 0.029	1.895LysVal: 1.895 ± 0.038	0.269LysTrp: 0.269 ± 0.012	0.45LysTyr: 0.45 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	16.901LeuAla: 16.901 ± 0.152	0.803LeuCys: 0.803 ± 0.02	6.326LeuAsp: 6.326 ± 0.073	4.84LeuGlu: 4.84 ± 0.051	3.657LeuPhe: 3.657 ± 0.055	9.268LeuGly: 9.268 ± 0.089	1.998LeuHis: 1.998 ± 0.038	3.919LeuIle: 3.919 ± 0.054	2.395LeuLys: 2.395 ± 0.04	10.631LeuLeu: 10.631 ± 0.106	2.192LeuMet: 2.192 ± 0.042	1.942LeuAsn: 1.942 ± 0.03	6.401LeuPro: 6.401 ± 0.065	2.376LeuGln: 2.376 ± 0.04	7.483LeuArg: 7.483 ± 0.07	5.362LeuSer: 5.362 ± 0.06	4.974LeuThr: 4.974 ± 0.046	8.697LeuVal: 8.697 ± 0.07	1.286LeuTrp: 1.286 ± 0.028	1.962LeuTyr: 1.962 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.8MetAla: 3.8 ± 0.052	0.145MetCys: 0.145 ± 0.01	1.131MetAsp: 1.131 ± 0.025	1.045MetGlu: 1.045 ± 0.027	0.652MetPhe: 0.652 ± 0.021	1.935MetGly: 1.935 ± 0.035	0.379MetHis: 0.379 ± 0.016	1.193MetIle: 1.193 ± 0.031	0.702MetLys: 0.702 ± 0.022	2.595MetLeu: 2.595 ± 0.04	0.605MetMet: 0.605 ± 0.023	0.582MetAsn: 0.582 ± 0.019	1.595MetPro: 1.595 ± 0.033	0.726MetGln: 0.726 ± 0.021	1.892MetArg: 1.892 ± 0.027	1.297MetSer: 1.297 ± 0.03	1.927MetThr: 1.927 ± 0.039	1.923MetVal: 1.923 ± 0.029	0.224MetTrp: 0.224 ± 0.012	0.309MetTyr: 0.309 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.51AsnAla: 2.51 ± 0.039	0.203AsnCys: 0.203 ± 0.011	1.397AsnAsp: 1.397 ± 0.062	0.789AsnGlu: 0.789 ± 0.023	0.763AsnPhe: 0.763 ± 0.022	2.093AsnGly: 2.093 ± 0.054	0.417AsnHis: 0.417 ± 0.016	0.943AsnIle: 0.943 ± 0.027	0.464AsnLys: 0.464 ± 0.018	2.254AsnLeu: 2.254 ± 0.034	0.466AsnMet: 0.466 ± 0.016	0.535AsnAsn: 0.535 ± 0.018	1.67AsnPro: 1.67 ± 0.025	0.57AsnGln: 0.57 ± 0.019	1.556AsnArg: 1.556 ± 0.028	0.883AsnSer: 0.883 ± 0.03	0.913AsnThr: 0.913 ± 0.025	1.551AsnVal: 1.551 ± 0.031	0.346AsnTrp: 0.346 ± 0.013	0.516AsnTyr: 0.516 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.791ProAla: 8.791 ± 0.092	0.321ProCys: 0.321 ± 0.013	4.026ProAsp: 4.026 ± 0.05	3.321ProGlu: 3.321 ± 0.041	2.049ProPhe: 2.049 ± 0.031	5.715ProGly: 5.715 ± 0.051	1.177ProHis: 1.177 ± 0.03	2.538ProIle: 2.538 ± 0.042	1.199ProLys: 1.199 ± 0.031	5.232ProLeu: 5.232 ± 0.063	1.362ProMet: 1.362 ± 0.031	1.155ProAsn: 1.155 ± 0.026	3.749ProPro: 3.749 ± 0.072	1.46ProGln: 1.46 ± 0.026	3.51ProArg: 3.51 ± 0.046	2.569ProSer: 2.569 ± 0.033	2.855ProThr: 2.855 ± 0.041	4.671ProVal: 4.671 ± 0.051	0.919ProTrp: 0.919 ± 0.023	1.21ProTyr: 1.21 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.276GlnAla: 4.276 ± 0.054	0.172GlnCys: 0.172 ± 0.01	1.324GlnAsp: 1.324 ± 0.027	1.212GlnGlu: 1.212 ± 0.028	0.961GlnPhe: 0.961 ± 0.026	2.354GlnGly: 2.354 ± 0.039	0.554GlnHis: 0.554 ± 0.017	1.39GlnIle: 1.39 ± 0.03	0.698GlnLys: 0.698 ± 0.021	2.521GlnLeu: 2.521 ± 0.034	0.832GlnMet: 0.832 ± 0.023	0.591GlnAsn: 0.591 ± 0.017	1.928GlnPro: 1.928 ± 0.037	1.081GlnGln: 1.081 ± 0.029	2.602GlnArg: 2.602 ± 0.041	1.395GlnSer: 1.395 ± 0.032	1.336GlnThr: 1.336 ± 0.026	2.349GlnVal: 2.349 ± 0.038	0.405GlnTrp: 0.405 ± 0.015	0.53GlnTyr: 0.53 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.467ArgAla: 9.467 ± 0.084	0.596ArgCys: 0.596 ± 0.018	4.356ArgAsp: 4.356 ± 0.049	3.695ArgGlu: 3.695 ± 0.054	3.153ArgPhe: 3.153 ± 0.047	5.721ArgGly: 5.721 ± 0.051	2.094ArgHis: 2.094 ± 0.037	4.272ArgIle: 4.272 ± 0.051	1.582ArgLys: 1.582 ± 0.035	9.665ArgLeu: 9.665 ± 0.09	2.172ArgMet: 2.172 ± 0.035	1.59ArgAsn: 1.59 ± 0.031	5.033ArgPro: 5.033 ± 0.058	2.892ArgGln: 2.892 ± 0.044	7.858ArgArg: 7.858 ± 0.092	3.534ArgSer: 3.534 ± 0.05	3.781ArgThr: 3.781 ± 0.045	5.622ArgVal: 5.622 ± 0.051	1.266ArgTrp: 1.266 ± 0.032	1.702ArgTyr: 1.702 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.525SerAla: 5.525 ± 0.056	0.346SerCys: 0.346 ± 0.014	2.263SerAsp: 2.263 ± 0.051	1.861SerGlu: 1.861 ± 0.033	1.886SerPhe: 1.886 ± 0.034	4.998SerGly: 4.998 ± 0.064	0.904SerHis: 0.904 ± 0.023	2.388SerIle: 2.388 ± 0.036	0.906SerLys: 0.906 ± 0.026	4.608SerLeu: 4.608 ± 0.056	1.092SerMet: 1.092 ± 0.024	0.971SerAsn: 0.971 ± 0.024	2.585SerPro: 2.585 ± 0.035	1.219SerGln: 1.219 ± 0.025	3.23SerArg: 3.23 ± 0.043	2.144SerSer: 2.144 ± 0.041	2.293SerThr: 2.293 ± 0.039	3.477SerVal: 3.477 ± 0.043	0.709SerTrp: 0.709 ± 0.021	1.069SerTyr: 1.069 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.695ThrAla: 6.695 ± 0.059	0.37ThrCys: 0.37 ± 0.018	2.688ThrAsp: 2.688 ± 0.047	2.162ThrGlu: 2.162 ± 0.04	1.782ThrPhe: 1.782 ± 0.034	5.151ThrGly: 5.151 ± 0.054	0.956ThrHis: 0.956 ± 0.023	2.896ThrIle: 2.896 ± 0.05	1.021ThrLys: 1.021 ± 0.027	5.641ThrLeu: 5.641 ± 0.07	1.239ThrMet: 1.239 ± 0.027	1.042ThrAsn: 1.042 ± 0.024	3.164ThrPro: 3.164 ± 0.04	1.209ThrGln: 1.209 ± 0.027	3.305ThrArg: 3.305 ± 0.038	2.149ThrSer: 2.149 ± 0.031	2.725ThrThr: 2.725 ± 0.043	4.603ThrVal: 4.603 ± 0.05	0.668ThrTrp: 0.668 ± 0.02	1.016ThrTyr: 1.016 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	11.553ValAla: 11.553 ± 0.107	0.612ValCys: 0.612 ± 0.019	4.753ValAsp: 4.753 ± 0.061	4.651ValGlu: 4.651 ± 0.057	2.719ValPhe: 2.719 ± 0.044	6.51ValGly: 6.51 ± 0.058	1.483ValHis: 1.483 ± 0.029	3.453ValIle: 3.453 ± 0.053	1.721ValLys: 1.721 ± 0.038	7.999ValLeu: 7.999 ± 0.074	1.855ValMet: 1.855 ± 0.032	1.661ValAsn: 1.661 ± 0.033	4.509ValPro: 4.509 ± 0.057	1.989ValGln: 1.989 ± 0.036	5.691ValArg: 5.691 ± 0.057	3.6ValSer: 3.6 ± 0.043	4.452ValThr: 4.452 ± 0.056	6.913ValVal: 6.913 ± 0.075	0.925ValTrp: 0.925 ± 0.023	1.44ValTyr: 1.44 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.449TrpAla: 1.449 ± 0.029	0.162TrpCys: 0.162 ± 0.01	0.707TrpAsp: 0.707 ± 0.024	0.535TrpGlu: 0.535 ± 0.019	0.518TrpPhe: 0.518 ± 0.018	1.082TrpGly: 1.082 ± 0.025	0.358TrpHis: 0.358 ± 0.016	0.676TrpIle: 0.676 ± 0.018	0.394TrpLys: 0.394 ± 0.015	1.784TrpLeu: 1.784 ± 0.036	0.39TrpMet: 0.39 ± 0.016	0.42TrpAsn: 0.42 ± 0.015	0.864TrpPro: 0.864 ± 0.024	0.627TrpGln: 0.627 ± 0.02	1.405TrpArg: 1.405 ± 0.033	0.803TrpSer: 0.803 ± 0.02	0.804TrpThr: 0.804 ± 0.023	0.954TrpVal: 0.954 ± 0.025	0.244TrpTrp: 0.244 ± 0.013	0.324TrpTyr: 0.324 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.422TyrAla: 2.422 ± 0.034	0.215TyrCys: 0.215 ± 0.01	1.287TyrAsp: 1.287 ± 0.032	1.013TyrGlu: 1.013 ± 0.025	0.799TyrPhe: 0.799 ± 0.025	2.254TyrGly: 2.254 ± 0.049	0.414TyrHis: 0.414 ± 0.013	0.743TyrIle: 0.743 ± 0.022	0.472TyrLys: 0.472 ± 0.018	2.151TyrLeu: 2.151 ± 0.034	0.409TyrMet: 0.409 ± 0.014	0.455TyrAsn: 0.455 ± 0.018	1.135TyrPro: 1.135 ± 0.026	0.59TyrGln: 0.59 ± 0.021	1.908TyrArg: 1.908 ± 0.035	0.983TyrSer: 0.983 ± 0.026	0.936TyrThr: 0.936 ± 0.024	1.558TyrVal: 1.558 ± 0.032	0.352TyrTrp: 0.352 ± 0.013	0.53TyrTyr: 0.53 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5422 proteins (1801500 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---