Amino acid dipepetide frequency for Treponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.192AlaAla: 10.192 ± 0.154	0.852AlaCys: 0.852 ± 0.03	4.681AlaAsp: 4.681 ± 0.071	6.161AlaGlu: 6.161 ± 0.091	3.64AlaPhe: 3.64 ± 0.063	7.863AlaGly: 7.863 ± 0.096	1.161AlaHis: 1.161 ± 0.031	5.336AlaIle: 5.336 ± 0.077	4.247AlaLys: 4.247 ± 0.077	10.065AlaLeu: 10.065 ± 0.122	2.015AlaMet: 2.015 ± 0.05	2.72AlaAsn: 2.72 ± 0.064	3.38AlaPro: 3.38 ± 0.069	2.619AlaGln: 2.619 ± 0.052	4.192AlaArg: 4.192 ± 0.077	4.865AlaSer: 4.865 ± 0.064	3.359AlaThr: 3.359 ± 0.094	6.34AlaVal: 6.34 ± 0.077	0.917AlaTrp: 0.917 ± 0.024	2.661AlaTyr: 2.661 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.823CysAla: 0.823 ± 0.029	0.156CysCys: 0.156 ± 0.012	0.478CysAsp: 0.478 ± 0.022	0.458CysGlu: 0.458 ± 0.021	0.476CysPhe: 0.476 ± 0.021	1.018CysGly: 1.018 ± 0.036	0.198CysHis: 0.198 ± 0.014	0.789CysIle: 0.789 ± 0.025	0.442CysLys: 0.442 ± 0.02	0.955CysLeu: 0.955 ± 0.03	0.204CysMet: 0.204 ± 0.014	0.366CysAsn: 0.366 ± 0.021	0.497CysPro: 0.497 ± 0.026	0.227CysGln: 0.227 ± 0.016	0.601CysArg: 0.601 ± 0.023	0.633CysSer: 0.633 ± 0.026	0.512CysThr: 0.512 ± 0.026	0.632CysVal: 0.632 ± 0.023	0.105CysTrp: 0.105 ± 0.009	0.323CysTyr: 0.323 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.285AspAla: 4.285 ± 0.062	0.532AspCys: 0.532 ± 0.021	2.833AspAsp: 2.833 ± 0.068	3.542AspGlu: 3.542 ± 0.061	2.715AspPhe: 2.715 ± 0.053	4.194AspGly: 4.194 ± 0.087	0.853AspHis: 0.853 ± 0.032	4.367AspIle: 4.367 ± 0.067	2.826AspLys: 2.826 ± 0.059	5.289AspLeu: 5.289 ± 0.084	1.313AspMet: 1.313 ± 0.039	1.888AspAsn: 1.888 ± 0.052	2.865AspPro: 2.865 ± 0.057	1.483AspGln: 1.483 ± 0.036	3.111AspArg: 3.111 ± 0.058	3.192AspSer: 3.192 ± 0.058	3.189AspThr: 3.189 ± 0.079	3.016AspVal: 3.016 ± 0.054	0.69AspTrp: 0.69 ± 0.027	2.153AspTyr: 2.153 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.186GluAla: 6.186 ± 0.086	0.447GluCys: 0.447 ± 0.017	3.249GluAsp: 3.249 ± 0.058	4.575GluGlu: 4.575 ± 0.086	2.396GluPhe: 2.396 ± 0.05	4.515GluGly: 4.515 ± 0.067	0.956GluHis: 0.956 ± 0.029	4.855GluIle: 4.855 ± 0.074	5.007GluLys: 5.007 ± 0.087	6.644GluLeu: 6.644 ± 0.099	1.51GluMet: 1.51 ± 0.038	3.029GluAsn: 3.029 ± 0.06	2.17GluPro: 2.17 ± 0.046	2.283GluGln: 2.283 ± 0.05	3.491GluArg: 3.491 ± 0.067	3.343GluSer: 3.343 ± 0.058	3.933GluThr: 3.933 ± 0.055	3.268GluVal: 3.268 ± 0.064	0.693GluTrp: 0.693 ± 0.023	2.403GluTyr: 2.403 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.397PheAla: 3.397 ± 0.061	0.583PheCys: 0.583 ± 0.023	2.613PheAsp: 2.613 ± 0.055	2.46PheGlu: 2.46 ± 0.049	2.398PhePhe: 2.398 ± 0.058	3.073PheGly: 3.073 ± 0.059	0.723PheHis: 0.723 ± 0.026	3.399PheIle: 3.399 ± 0.065	2.026PheLys: 2.026 ± 0.042	4.406PheLeu: 4.406 ± 0.084	0.993PheMet: 0.993 ± 0.029	1.887PheAsn: 1.887 ± 0.045	2.095PhePro: 2.095 ± 0.039	1.184PheGln: 1.184 ± 0.029	2.273PheArg: 2.273 ± 0.047	3.76PheSer: 3.76 ± 0.057	3.051PheThr: 3.051 ± 0.074	2.614PheVal: 2.614 ± 0.055	0.435PheTrp: 0.435 ± 0.021	1.599PheTyr: 1.599 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	6.732GlyAla: 6.732 ± 0.087	0.906GlyCys: 0.906 ± 0.034	4.303GlyAsp: 4.303 ± 0.073	5.09GlyGlu: 5.09 ± 0.074	3.686GlyPhe: 3.686 ± 0.059	6.737GlyGly: 6.737 ± 0.194	1.114GlyHis: 1.114 ± 0.037	6.31GlyIle: 6.31 ± 0.087	5.146GlyLys: 5.146 ± 0.08	7.234GlyLeu: 7.234 ± 0.093	2.015GlyMet: 2.015 ± 0.049	3.347GlyAsn: 3.347 ± 0.083	2.424GlyPro: 2.424 ± 0.045	2.083GlyGln: 2.083 ± 0.044	3.909GlyArg: 3.909 ± 0.07	5.076GlySer: 5.076 ± 0.09	4.922GlyThr: 4.922 ± 0.129	5.197GlyVal: 5.197 ± 0.085	0.848GlyTrp: 0.848 ± 0.029	2.643GlyTyr: 2.643 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.103HisAla: 1.103 ± 0.037	0.241HisCys: 0.241 ± 0.015	0.75HisAsp: 0.75 ± 0.024	0.906HisGlu: 0.906 ± 0.027	0.746HisPhe: 0.746 ± 0.025	1.232HisGly: 1.232 ± 0.037	0.339HisHis: 0.339 ± 0.019	1.241HisIle: 1.241 ± 0.033	0.635HisLys: 0.635 ± 0.026	1.425HisLeu: 1.425 ± 0.038	0.295HisMet: 0.295 ± 0.016	0.625HisAsn: 0.625 ± 0.025	1.013HisPro: 1.013 ± 0.028	0.473HisGln: 0.473 ± 0.02	0.932HisArg: 0.932 ± 0.03	0.97HisSer: 0.97 ± 0.03	0.835HisThr: 0.835 ± 0.027	0.764HisVal: 0.764 ± 0.025	0.197HisTrp: 0.197 ± 0.011	0.608HisTyr: 0.608 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.229IleAla: 6.229 ± 0.084	0.78IleCys: 0.78 ± 0.029	3.845IleAsp: 3.845 ± 0.059	4.251IleGlu: 4.251 ± 0.069	3.165IlePhe: 3.165 ± 0.066	4.903IleGly: 4.903 ± 0.074	1.19IleHis: 1.19 ± 0.032	5.477IleIle: 5.477 ± 0.106	3.912IleLys: 3.912 ± 0.07	7.206IleLeu: 7.206 ± 0.103	1.472IleMet: 1.472 ± 0.042	3.207IleAsn: 3.207 ± 0.059	3.983IlePro: 3.983 ± 0.056	2.206IleGln: 2.206 ± 0.04	4.16IleArg: 4.16 ± 0.06	5.162IleSer: 5.162 ± 0.08	4.448IleThr: 4.448 ± 0.087	4.053IleVal: 4.053 ± 0.068	0.56IleTrp: 0.56 ± 0.024	2.201IleTyr: 2.201 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.776LysAla: 4.776 ± 0.081	0.409LysCys: 0.409 ± 0.021	3.2LysAsp: 3.2 ± 0.058	3.902LysGlu: 3.902 ± 0.071	1.703LysPhe: 1.703 ± 0.039	3.676LysGly: 3.676 ± 0.07	0.77LysHis: 0.77 ± 0.027	4.121LysIle: 4.121 ± 0.07	4.213LysLys: 4.213 ± 0.08	4.945LysLeu: 4.945 ± 0.06	1.241LysMet: 1.241 ± 0.037	2.918LysAsn: 2.918 ± 0.056	2.393LysPro: 2.393 ± 0.048	1.724LysGln: 1.724 ± 0.042	2.886LysArg: 2.886 ± 0.055	3.054LysSer: 3.054 ± 0.053	3.669LysThr: 3.669 ± 0.068	3.118LysVal: 3.118 ± 0.054	0.515LysTrp: 0.515 ± 0.023	1.969LysTyr: 1.969 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	8.463LeuAla: 8.463 ± 0.105	1.093LeuCys: 1.093 ± 0.037	5.504LeuAsp: 5.504 ± 0.073	6.577LeuGlu: 6.577 ± 0.09	4.666LeuPhe: 4.666 ± 0.081	7.782LeuGly: 7.782 ± 0.106	1.454LeuHis: 1.454 ± 0.039	6.411LeuIle: 6.411 ± 0.094	5.55LeuLys: 5.55 ± 0.079	9.402LeuLeu: 9.402 ± 0.129	2.134LeuMet: 2.134 ± 0.053	3.784LeuAsn: 3.784 ± 0.056	4.779LeuPro: 4.779 ± 0.066	2.677LeuGln: 2.677 ± 0.056	5.245LeuArg: 5.245 ± 0.079	7.555LeuSer: 7.555 ± 0.097	5.224LeuThr: 5.224 ± 0.074	6.048LeuVal: 6.048 ± 0.085	0.927LeuTrp: 0.927 ± 0.029	3.124LeuTyr: 3.124 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.248MetAla: 2.248 ± 0.051	0.141MetCys: 0.141 ± 0.011	1.477MetAsp: 1.477 ± 0.035	1.668MetGlu: 1.668 ± 0.037	0.697MetPhe: 0.697 ± 0.024	1.919MetGly: 1.919 ± 0.052	0.283MetHis: 0.283 ± 0.018	1.564MetIle: 1.564 ± 0.043	1.496MetLys: 1.496 ± 0.038	1.837MetLeu: 1.837 ± 0.047	0.51MetMet: 0.51 ± 0.021	1.128MetAsn: 1.128 ± 0.033	1.052MetPro: 1.052 ± 0.03	0.644MetGln: 0.644 ± 0.022	1.082MetArg: 1.082 ± 0.037	1.304MetSer: 1.304 ± 0.037	1.256MetThr: 1.256 ± 0.034	1.617MetVal: 1.617 ± 0.044	0.108MetTrp: 0.108 ± 0.009	0.516MetTyr: 0.516 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.23AsnAla: 3.23 ± 0.055	0.371AsnCys: 0.371 ± 0.019	1.933AsnAsp: 1.933 ± 0.047	2.235AsnGlu: 2.235 ± 0.048	1.772AsnPhe: 1.772 ± 0.043	3.127AsnGly: 3.127 ± 0.082	0.688AsnHis: 0.688 ± 0.025	3.356AsnIle: 3.356 ± 0.068	2.09AsnLys: 2.09 ± 0.053	3.767AsnLeu: 3.767 ± 0.061	0.972AsnMet: 0.972 ± 0.029	1.962AsnAsn: 1.962 ± 0.068	2.508AsnPro: 2.508 ± 0.053	1.279AsnGln: 1.279 ± 0.033	2.29AsnArg: 2.29 ± 0.053	2.575AsnSer: 2.575 ± 0.06	2.513AsnThr: 2.513 ± 0.075	2.148AsnVal: 2.148 ± 0.043	0.493AsnTrp: 0.493 ± 0.028	1.606AsnTyr: 1.606 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	4.088ProAla: 4.088 ± 0.079	0.397ProCys: 0.397 ± 0.019	2.811ProAsp: 2.811 ± 0.052	3.753ProGlu: 3.753 ± 0.062	1.98ProPhe: 1.98 ± 0.044	4.249ProGly: 4.249 ± 0.057	0.704ProHis: 0.704 ± 0.026	2.534ProIle: 2.534 ± 0.051	1.828ProLys: 1.828 ± 0.039	4.333ProLeu: 4.333 ± 0.057	0.934ProMet: 0.934 ± 0.03	1.466ProAsn: 1.466 ± 0.043	2.159ProPro: 2.159 ± 0.072	1.423ProGln: 1.423 ± 0.037	2.014ProArg: 2.014 ± 0.043	2.688ProSer: 2.688 ± 0.052	1.865ProThr: 1.865 ± 0.06	3.675ProVal: 3.675 ± 0.063	0.592ProTrp: 0.592 ± 0.022	1.568ProTyr: 1.568 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.746GlnAla: 2.746 ± 0.056	0.225GlnCys: 0.225 ± 0.012	1.694GlnAsp: 1.694 ± 0.044	2.19GlnGlu: 2.19 ± 0.052	1.231GlnPhe: 1.231 ± 0.03	2.664GlnGly: 2.664 ± 0.048	0.43GlnHis: 0.43 ± 0.022	2.011GlnIle: 2.011 ± 0.048	1.842GlnLys: 1.842 ± 0.043	2.363GlnLeu: 2.363 ± 0.048	0.697GlnMet: 0.697 ± 0.024	1.385GlnAsn: 1.385 ± 0.037	0.936GlnPro: 0.936 ± 0.027	0.959GlnGln: 0.959 ± 0.031	1.595GlnArg: 1.595 ± 0.037	1.663GlnSer: 1.663 ± 0.041	1.497GlnThr: 1.497 ± 0.041	1.929GlnVal: 1.929 ± 0.041	0.361GlnTrp: 0.361 ± 0.018	1.208GlnTyr: 1.208 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.941ArgAla: 3.941 ± 0.073	0.499ArgCys: 0.499 ± 0.022	3.115ArgAsp: 3.115 ± 0.057	4.17ArgGlu: 4.17 ± 0.078	2.551ArgPhe: 2.551 ± 0.046	3.593ArgGly: 3.593 ± 0.062	0.822ArgHis: 0.822 ± 0.024	4.365ArgIle: 4.365 ± 0.06	2.945ArgLys: 2.945 ± 0.052	5.215ArgLeu: 5.215 ± 0.093	1.203ArgMet: 1.203 ± 0.033	2.284ArgAsn: 2.284 ± 0.048	1.928ArgPro: 1.928 ± 0.044	1.708ArgGln: 1.708 ± 0.047	3.129ArgArg: 3.129 ± 0.064	3.027ArgSer: 3.027 ± 0.053	2.411ArgThr: 2.411 ± 0.039	3.294ArgVal: 3.294 ± 0.057	0.562ArgTrp: 0.562 ± 0.023	2.01ArgTyr: 2.01 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.611SerAla: 5.611 ± 0.076	0.675SerCys: 0.675 ± 0.025	3.065SerAsp: 3.065 ± 0.058	3.207SerGlu: 3.207 ± 0.052	3.439SerPhe: 3.439 ± 0.058	6.438SerGly: 6.438 ± 0.106	0.937SerHis: 0.937 ± 0.028	4.434SerIle: 4.434 ± 0.068	2.731SerLys: 2.731 ± 0.055	6.664SerLeu: 6.664 ± 0.096	1.418SerMet: 1.418 ± 0.038	2.193SerAsn: 2.193 ± 0.056	3.226SerPro: 3.226 ± 0.058	1.771SerGln: 1.771 ± 0.04	3.478SerArg: 3.478 ± 0.065	4.149SerSer: 4.149 ± 0.09	2.86SerThr: 2.86 ± 0.076	4.11SerVal: 4.11 ± 0.066	0.814SerTrp: 0.814 ± 0.026	2.234SerTyr: 2.234 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.265ThrAla: 5.265 ± 0.108	0.404ThrCys: 0.404 ± 0.021	2.805ThrAsp: 2.805 ± 0.068	3.385ThrGlu: 3.385 ± 0.057	2.117ThrPhe: 2.117 ± 0.055	5.44ThrGly: 5.44 ± 0.093	0.84ThrHis: 0.84 ± 0.032	4.257ThrIle: 4.257 ± 0.095	2.363ThrLys: 2.363 ± 0.048	5.884ThrLeu: 5.884 ± 0.081	1.208ThrMet: 1.208 ± 0.041	2.051ThrAsn: 2.051 ± 0.065	2.741ThrPro: 2.741 ± 0.071	1.426ThrGln: 1.426 ± 0.043	2.527ThrArg: 2.527 ± 0.047	2.683ThrSer: 2.683 ± 0.078	2.81ThrThr: 2.81 ± 0.104	4.576ThrVal: 4.576 ± 0.103	0.574ThrTrp: 0.574 ± 0.031	1.535ThrTyr: 1.535 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.473ValAla: 4.473 ± 0.079	0.688ValCys: 0.688 ± 0.025	3.329ValAsp: 3.329 ± 0.064	3.779ValGlu: 3.779 ± 0.069	3.34ValPhe: 3.34 ± 0.062	3.901ValGly: 3.901 ± 0.085	1.019ValHis: 1.019 ± 0.025	4.564ValIle: 4.564 ± 0.065	3.49ValLys: 3.49 ± 0.058	6.465ValLeu: 6.465 ± 0.089	1.521ValMet: 1.521 ± 0.041	2.589ValAsn: 2.589 ± 0.052	2.924ValPro: 2.924 ± 0.043	1.936ValGln: 1.936 ± 0.043	3.187ValArg: 3.187 ± 0.051	4.983ValSer: 4.983 ± 0.076	3.72ValThr: 3.72 ± 0.095	4.055ValVal: 4.055 ± 0.065	0.653ValTrp: 0.653 ± 0.026	2.36ValTyr: 2.36 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.884TrpAla: 0.884 ± 0.029	0.093TrpCys: 0.093 ± 0.01	0.706TrpAsp: 0.706 ± 0.028	0.781TrpGlu: 0.781 ± 0.028	0.496TrpPhe: 0.496 ± 0.019	0.788TrpGly: 0.788 ± 0.028	0.191TrpHis: 0.191 ± 0.014	0.727TrpIle: 0.727 ± 0.025	0.65TrpLys: 0.65 ± 0.023	0.956TrpLeu: 0.956 ± 0.033	0.232TrpMet: 0.232 ± 0.014	0.499TrpAsn: 0.499 ± 0.022	0.353TrpPro: 0.353 ± 0.018	0.381TrpGln: 0.381 ± 0.018	0.528TrpArg: 0.528 ± 0.024	0.566TrpSer: 0.566 ± 0.027	0.582TrpThr: 0.582 ± 0.03	0.651TrpVal: 0.651 ± 0.024	0.128TrpTrp: 0.128 ± 0.011	0.432TrpTyr: 0.432 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.595TyrAla: 2.595 ± 0.054	0.4TyrCys: 0.4 ± 0.021	1.943TyrAsp: 1.943 ± 0.047	1.864TyrGlu: 1.864 ± 0.037	1.755TyrPhe: 1.755 ± 0.044	2.61TyrGly: 2.61 ± 0.05	0.657TyrHis: 0.657 ± 0.024	2.291TyrIle: 2.291 ± 0.044	1.765TyrLys: 1.765 ± 0.041	3.343TyrLeu: 3.343 ± 0.061	0.659TyrMet: 0.659 ± 0.024	1.583TyrAsn: 1.583 ± 0.04	1.636TyrPro: 1.636 ± 0.038	1.14TyrGln: 1.14 ± 0.031	2.144TyrArg: 2.144 ± 0.049	2.21TyrSer: 2.21 ± 0.047	2.234TyrThr: 2.234 ± 0.061	1.871TyrVal: 1.871 ± 0.044	0.453TyrTrp: 0.453 ± 0.022	1.507TyrTyr: 1.507 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3512 proteins (1208744 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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