Amino acid dipepetide frequency for Vibrio variabilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.518AlaAla: 7.518 ± 0.085	0.912AlaCys: 0.912 ± 0.028	4.341AlaAsp: 4.341 ± 0.054	5.312AlaGlu: 5.312 ± 0.066	3.453AlaPhe: 3.453 ± 0.048	5.808AlaGly: 5.808 ± 0.082	1.631AlaHis: 1.631 ± 0.033	5.98AlaIle: 5.98 ± 0.064	4.898AlaLys: 4.898 ± 0.064	9.626AlaLeu: 9.626 ± 0.078	2.979AlaMet: 2.979 ± 0.047	3.65AlaAsn: 3.65 ± 0.051	2.87AlaPro: 2.87 ± 0.043	3.488AlaGln: 3.488 ± 0.05	3.599AlaArg: 3.599 ± 0.051	5.605AlaSer: 5.605 ± 0.061	4.813AlaThr: 4.813 ± 0.056	5.858AlaVal: 5.858 ± 0.052	0.954AlaTrp: 0.954 ± 0.024	2.363AlaTyr: 2.363 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.776CysAla: 0.776 ± 0.025	0.179CysCys: 0.179 ± 0.012	0.609CysAsp: 0.609 ± 0.019	0.616CysGlu: 0.616 ± 0.019	0.446CysPhe: 0.446 ± 0.017	0.893CysGly: 0.893 ± 0.024	0.354CysHis: 0.354 ± 0.016	0.584CysIle: 0.584 ± 0.021	0.442CysLys: 0.442 ± 0.017	1.005CysLeu: 1.005 ± 0.024	0.319CysMet: 0.319 ± 0.013	0.361CysAsn: 0.361 ± 0.016	0.432CysPro: 0.432 ± 0.016	0.439CysGln: 0.439 ± 0.015	0.501CysArg: 0.501 ± 0.02	0.765CysSer: 0.765 ± 0.021	0.5CysThr: 0.5 ± 0.019	0.711CysVal: 0.711 ± 0.025	0.158CysTrp: 0.158 ± 0.009	0.354CysTyr: 0.354 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.555AspAla: 4.555 ± 0.055	0.512AspCys: 0.512 ± 0.017	3.153AspAsp: 3.153 ± 0.063	3.883AspGlu: 3.883 ± 0.053	2.443AspPhe: 2.443 ± 0.045	4.023AspGly: 4.023 ± 0.067	1.136AspHis: 1.136 ± 0.034	3.949AspIle: 3.949 ± 0.054	3.218AspLys: 3.218 ± 0.048	5.09AspLeu: 5.09 ± 0.072	1.488AspMet: 1.488 ± 0.031	2.481AspAsn: 2.481 ± 0.045	1.994AspPro: 1.994 ± 0.044	1.845AspGln: 1.845 ± 0.034	2.246AspArg: 2.246 ± 0.034	3.521AspSer: 3.521 ± 0.046	2.894AspThr: 2.894 ± 0.049	4.222AspVal: 4.222 ± 0.062	0.876AspTrp: 0.876 ± 0.023	2.146AspTyr: 2.146 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.383GluAla: 5.383 ± 0.064	0.513GluCys: 0.513 ± 0.02	2.99GluAsp: 2.99 ± 0.052	3.977GluGlu: 3.977 ± 0.063	2.57GluPhe: 2.57 ± 0.043	3.765GluGly: 3.765 ± 0.061	1.605GluHis: 1.605 ± 0.036	3.626GluIle: 3.626 ± 0.046	3.564GluLys: 3.564 ± 0.05	7.127GluLeu: 7.127 ± 0.073	1.751GluMet: 1.751 ± 0.035	2.62GluAsn: 2.62 ± 0.044	2.149GluPro: 2.149 ± 0.038	3.886GluGln: 3.886 ± 0.056	3.51GluArg: 3.51 ± 0.045	4.122GluSer: 4.122 ± 0.058	3.288GluThr: 3.288 ± 0.045	4.557GluVal: 4.557 ± 0.058	0.837GluTrp: 0.837 ± 0.021	1.797GluTyr: 1.797 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.619PheAla: 3.619 ± 0.055	0.482PheCys: 0.482 ± 0.017	2.873PheAsp: 2.873 ± 0.044	2.708PheGlu: 2.708 ± 0.048	1.653PhePhe: 1.653 ± 0.038	3.486PheGly: 3.486 ± 0.049	0.843PheHis: 0.843 ± 0.024	2.591PheIle: 2.591 ± 0.041	1.894PheLys: 1.894 ± 0.036	3.418PheLeu: 3.418 ± 0.05	1.134PheMet: 1.134 ± 0.03	1.982PheAsn: 1.982 ± 0.039	1.395PhePro: 1.395 ± 0.028	1.271PheGln: 1.271 ± 0.026	1.478PheArg: 1.478 ± 0.032	3.168PheSer: 3.168 ± 0.046	2.415PheThr: 2.415 ± 0.043	3.061PheVal: 3.061 ± 0.046	0.543PheTrp: 0.543 ± 0.019	1.28PheTyr: 1.28 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	5.517GlyAla: 5.517 ± 0.067	0.903GlyCys: 0.903 ± 0.027	3.841GlyAsp: 3.841 ± 0.064	4.51GlyGlu: 4.51 ± 0.063	3.286GlyPhe: 3.286 ± 0.052	4.962GlyGly: 4.962 ± 0.075	1.549GlyHis: 1.549 ± 0.036	4.644GlyIle: 4.644 ± 0.06	3.887GlyLys: 3.887 ± 0.049	6.761GlyLeu: 6.761 ± 0.07	2.183GlyMet: 2.183 ± 0.042	2.648GlyAsn: 2.648 ± 0.052	1.614GlyPro: 1.614 ± 0.031	2.791GlyGln: 2.791 ± 0.04	3.001GlyArg: 3.001 ± 0.04	4.242GlySer: 4.242 ± 0.055	3.647GlyThr: 3.647 ± 0.058	5.369GlyVal: 5.369 ± 0.063	0.999GlyTrp: 0.999 ± 0.025	2.611GlyTyr: 2.611 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.628HisAla: 1.628 ± 0.033	0.325HisCys: 0.325 ± 0.014	1.148HisAsp: 1.148 ± 0.034	1.147HisGlu: 1.147 ± 0.023	1.031HisPhe: 1.031 ± 0.026	1.542HisGly: 1.542 ± 0.036	0.713HisHis: 0.713 ± 0.024	1.373HisIle: 1.373 ± 0.032	1.009HisLys: 1.009 ± 0.023	2.223HisLeu: 2.223 ± 0.043	0.553HisMet: 0.553 ± 0.019	0.824HisAsn: 0.824 ± 0.021	1.048HisPro: 1.048 ± 0.026	1.117HisGln: 1.117 ± 0.026	1.087HisArg: 1.087 ± 0.025	1.456HisSer: 1.456 ± 0.031	1.086HisThr: 1.086 ± 0.032	1.345HisVal: 1.345 ± 0.031	0.374HisTrp: 0.374 ± 0.017	0.882HisTyr: 0.882 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.404IleAla: 6.404 ± 0.069	0.653IleCys: 0.653 ± 0.018	4.124IleAsp: 4.124 ± 0.054	4.806IleGlu: 4.806 ± 0.067	2.086IlePhe: 2.086 ± 0.037	4.722IleGly: 4.722 ± 0.058	1.189IleHis: 1.189 ± 0.029	3.374IleIle: 3.374 ± 0.057	3.024IleLys: 3.024 ± 0.04	4.973IleLeu: 4.973 ± 0.061	1.395IleMet: 1.395 ± 0.03	2.792IleAsn: 2.792 ± 0.046	2.633IlePro: 2.633 ± 0.043	2.19IleGln: 2.19 ± 0.039	2.698IleArg: 2.698 ± 0.047	4.296IleSer: 4.296 ± 0.057	3.68IleThr: 3.68 ± 0.053	4.291IleVal: 4.291 ± 0.064	0.655IleTrp: 0.655 ± 0.023	1.669IleTyr: 1.669 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.824LysAla: 4.824 ± 0.06	0.36LysCys: 0.36 ± 0.014	2.687LysAsp: 2.687 ± 0.042	3.265LysGlu: 3.265 ± 0.046	1.532LysPhe: 1.532 ± 0.028	3.341LysGly: 3.341 ± 0.048	1.307LysHis: 1.307 ± 0.032	2.545LysIle: 2.545 ± 0.046	2.774LysLys: 2.774 ± 0.053	5.276LysLeu: 5.276 ± 0.055	1.521LysMet: 1.521 ± 0.033	1.879LysAsn: 1.879 ± 0.036	2.448LysPro: 2.448 ± 0.04	2.892LysGln: 2.892 ± 0.047	2.89LysArg: 2.89 ± 0.046	3.262LysSer: 3.262 ± 0.044	2.871LysThr: 2.871 ± 0.048	3.881LysVal: 3.881 ± 0.048	0.628LysTrp: 0.628 ± 0.02	1.392LysTyr: 1.392 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	9.391LeuAla: 9.391 ± 0.077	1.117LeuCys: 1.117 ± 0.025	5.78LeuAsp: 5.78 ± 0.071	6.332LeuGlu: 6.332 ± 0.068	4.179LeuPhe: 4.179 ± 0.066	6.954LeuGly: 6.954 ± 0.079	1.883LeuHis: 1.883 ± 0.033	5.904LeuIle: 5.904 ± 0.064	5.151LeuLys: 5.151 ± 0.06	9.72LeuLeu: 9.72 ± 0.098	2.962LeuMet: 2.962 ± 0.044	4.432LeuAsn: 4.432 ± 0.053	4.584LeuPro: 4.584 ± 0.054	3.282LeuGln: 3.282 ± 0.047	4.258LeuArg: 4.258 ± 0.047	8.089LeuSer: 8.089 ± 0.082	6.114LeuThr: 6.114 ± 0.062	7.326LeuVal: 7.326 ± 0.069	1.058LeuTrp: 1.058 ± 0.027	2.559LeuTyr: 2.559 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.765MetAla: 2.765 ± 0.052	0.247MetCys: 0.247 ± 0.013	1.401MetAsp: 1.401 ± 0.028	1.416MetGlu: 1.416 ± 0.027	1.086MetPhe: 1.086 ± 0.027	1.966MetGly: 1.966 ± 0.036	0.549MetHis: 0.549 ± 0.018	1.655MetIle: 1.655 ± 0.033	1.649MetLys: 1.649 ± 0.029	3.035MetLeu: 3.035 ± 0.042	0.949MetMet: 0.949 ± 0.024	1.267MetAsn: 1.267 ± 0.029	1.352MetPro: 1.352 ± 0.029	1.154MetGln: 1.154 ± 0.028	1.314MetArg: 1.314 ± 0.03	2.328MetSer: 2.328 ± 0.041	1.91MetThr: 1.91 ± 0.031	2.169MetVal: 2.169 ± 0.043	0.3MetTrp: 0.3 ± 0.013	0.64MetTyr: 0.64 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.402AsnAla: 3.402 ± 0.05	0.391AsnCys: 0.391 ± 0.016	2.467AsnAsp: 2.467 ± 0.045	2.519AsnGlu: 2.519 ± 0.042	1.554AsnPhe: 1.554 ± 0.03	3.059AsnGly: 3.059 ± 0.058	1.008AsnHis: 1.008 ± 0.025	2.587AsnIle: 2.587 ± 0.041	2.138AsnLys: 2.138 ± 0.039	3.878AsnLeu: 3.878 ± 0.052	1.055AsnMet: 1.055 ± 0.027	1.836AsnAsn: 1.836 ± 0.041	2.014AsnPro: 2.014 ± 0.04	2.126AsnGln: 2.126 ± 0.04	1.909AsnArg: 1.909 ± 0.037	2.541AsnSer: 2.541 ± 0.04	2.249AsnThr: 2.249 ± 0.044	2.814AsnVal: 2.814 ± 0.047	0.606AsnTrp: 0.606 ± 0.018	1.363AsnTyr: 1.363 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.88ProAla: 2.88 ± 0.041	0.344ProCys: 0.344 ± 0.016	2.201ProAsp: 2.201 ± 0.04	3.206ProGlu: 3.206 ± 0.047	1.699ProPhe: 1.699 ± 0.036	2.047ProGly: 2.047 ± 0.037	0.82ProHis: 0.82 ± 0.022	2.54ProIle: 2.54 ± 0.04	1.976ProLys: 1.976 ± 0.035	3.942ProLeu: 3.942 ± 0.05	1.178ProMet: 1.178 ± 0.026	1.774ProAsn: 1.774 ± 0.039	1.084ProPro: 1.084 ± 0.027	1.48ProGln: 1.48 ± 0.036	1.315ProArg: 1.315 ± 0.027	2.694ProSer: 2.694 ± 0.043	2.401ProThr: 2.401 ± 0.041	2.995ProVal: 2.995 ± 0.045	0.494ProTrp: 0.494 ± 0.018	1.276ProTyr: 1.276 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.92GlnAla: 3.92 ± 0.049	0.405GlnCys: 0.405 ± 0.017	2.057GlnAsp: 2.057 ± 0.034	2.479GlnGlu: 2.479 ± 0.043	1.723GlnPhe: 1.723 ± 0.035	2.871GlnGly: 2.871 ± 0.046	1.098GlnHis: 1.098 ± 0.029	2.441GlnIle: 2.441 ± 0.036	2.0GlnLys: 2.0 ± 0.038	4.598GlnLeu: 4.598 ± 0.061	1.224GlnMet: 1.224 ± 0.024	1.506GlnAsn: 1.506 ± 0.034	1.625GlnPro: 1.625 ± 0.032	2.479GlnGln: 2.479 ± 0.049	2.213GlnArg: 2.213 ± 0.043	2.955GlnSer: 2.955 ± 0.045	2.306GlnThr: 2.306 ± 0.041	3.068GlnVal: 3.068 ± 0.045	0.64GlnTrp: 0.64 ± 0.024	1.398GlnTyr: 1.398 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.404ArgAla: 3.404 ± 0.049	0.534ArgCys: 0.534 ± 0.019	2.469ArgAsp: 2.469 ± 0.04	2.938ArgGlu: 2.938 ± 0.041	2.259ArgPhe: 2.259 ± 0.041	2.58ArgGly: 2.58 ± 0.04	1.075ArgHis: 1.075 ± 0.024	2.84ArgIle: 2.84 ± 0.041	2.274ArgLys: 2.274 ± 0.037	4.853ArgLeu: 4.853 ± 0.058	1.466ArgMet: 1.466 ± 0.032	1.822ArgAsn: 1.822 ± 0.036	1.528ArgPro: 1.528 ± 0.033	2.08ArgGln: 2.08 ± 0.037	2.347ArgArg: 2.347 ± 0.042	2.796ArgSer: 2.796 ± 0.043	2.223ArgThr: 2.223 ± 0.042	3.276ArgVal: 3.276 ± 0.045	0.654ArgTrp: 0.654 ± 0.021	1.747ArgTyr: 1.747 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.446SerAla: 5.446 ± 0.059	0.662SerCys: 0.662 ± 0.021	3.816SerAsp: 3.816 ± 0.045	4.278SerGlu: 4.278 ± 0.051	2.952SerPhe: 2.952 ± 0.043	4.966SerGly: 4.966 ± 0.062	1.508SerHis: 1.508 ± 0.036	4.424SerIle: 4.424 ± 0.056	3.458SerLys: 3.458 ± 0.049	7.316SerLeu: 7.316 ± 0.078	2.154SerMet: 2.154 ± 0.038	2.835SerAsn: 2.835 ± 0.049	2.424SerPro: 2.424 ± 0.038	3.004SerGln: 3.004 ± 0.05	2.979SerArg: 2.979 ± 0.046	4.847SerSer: 4.847 ± 0.073	3.72SerThr: 3.72 ± 0.047	5.015SerVal: 5.015 ± 0.059	0.904SerTrp: 0.904 ± 0.024	2.127SerTyr: 2.127 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.515ThrAla: 4.515 ± 0.055	0.513ThrCys: 0.513 ± 0.021	2.988ThrAsp: 2.988 ± 0.052	3.217ThrGlu: 3.217 ± 0.044	2.275ThrPhe: 2.275 ± 0.045	4.087ThrGly: 4.087 ± 0.053	1.232ThrHis: 1.232 ± 0.026	3.659ThrIle: 3.659 ± 0.052	2.624ThrLys: 2.624 ± 0.036	6.432ThrLeu: 6.432 ± 0.07	1.493ThrMet: 1.493 ± 0.027	2.178ThrAsn: 2.178 ± 0.04	2.671ThrPro: 2.671 ± 0.039	2.424ThrGln: 2.424 ± 0.045	2.345ThrArg: 2.345 ± 0.038	3.755ThrSer: 3.755 ± 0.054	3.222ThrThr: 3.222 ± 0.047	4.073ThrVal: 4.073 ± 0.062	0.687ThrTrp: 0.687 ± 0.02	1.603ThrTyr: 1.603 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.582ValAla: 6.582 ± 0.074	0.815ValCys: 0.815 ± 0.024	4.323ValAsp: 4.323 ± 0.064	4.878ValGlu: 4.878 ± 0.062	3.014ValPhe: 3.014 ± 0.047	4.914ValGly: 4.914 ± 0.059	1.257ValHis: 1.257 ± 0.028	4.675ValIle: 4.675 ± 0.053	3.698ValLys: 3.698 ± 0.051	6.914ValLeu: 6.914 ± 0.065	2.176ValMet: 2.176 ± 0.039	2.951ValAsn: 2.951 ± 0.045	2.723ValPro: 2.723 ± 0.04	2.343ValGln: 2.343 ± 0.039	3.007ValArg: 3.007 ± 0.05	5.378ValSer: 5.378 ± 0.059	4.435ValThr: 4.435 ± 0.068	5.706ValVal: 5.706 ± 0.07	0.833ValTrp: 0.833 ± 0.025	1.943ValTyr: 1.943 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.835TrpAla: 0.835 ± 0.025	0.181TrpCys: 0.181 ± 0.011	0.635TrpAsp: 0.635 ± 0.02	0.557TrpGlu: 0.557 ± 0.019	0.631TrpPhe: 0.631 ± 0.02	0.807TrpGly: 0.807 ± 0.026	0.369TrpHis: 0.369 ± 0.012	0.69TrpIle: 0.69 ± 0.022	0.583TrpLys: 0.583 ± 0.018	1.678TrpLeu: 1.678 ± 0.033	0.458TrpMet: 0.458 ± 0.017	0.529TrpAsn: 0.529 ± 0.019	0.445TrpPro: 0.445 ± 0.017	0.811TrpGln: 0.811 ± 0.023	0.703TrpArg: 0.703 ± 0.022	0.882TrpSer: 0.882 ± 0.022	0.595TrpThr: 0.595 ± 0.021	0.886TrpVal: 0.886 ± 0.025	0.217TrpTrp: 0.217 ± 0.013	0.426TrpTyr: 0.426 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.295TyrAla: 2.295 ± 0.04	0.397TyrCys: 0.397 ± 0.017	1.774TyrAsp: 1.774 ± 0.035	1.593TyrGlu: 1.593 ± 0.031	1.423TyrPhe: 1.423 ± 0.029	2.173TyrGly: 2.173 ± 0.041	0.784TyrHis: 0.784 ± 0.021	1.572TyrIle: 1.572 ± 0.031	1.314TyrLys: 1.314 ± 0.029	3.211TyrLeu: 3.211 ± 0.041	0.713TyrMet: 0.713 ± 0.022	1.149TyrAsn: 1.149 ± 0.029	1.312TyrPro: 1.312 ± 0.029	1.903TyrGln: 1.903 ± 0.039	1.767TyrArg: 1.767 ± 0.037	2.133TyrSer: 2.133 ± 0.044	1.619TyrThr: 1.619 ± 0.036	1.941TyrVal: 1.941 ± 0.038	0.501TyrTrp: 0.501 ± 0.019	1.041TyrTyr: 1.041 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7941 proteins (1574166 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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