Amino acid dipepetide frequency for Solirubrum puertoriconensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.2AlaAla: 13.2 ± 0.174
0.811AlaCys: 0.811 ± 0.029
5.566AlaAsp: 5.566 ± 0.068
6.547AlaGlu: 6.547 ± 0.088
3.648AlaPhe: 3.648 ± 0.055
8.133AlaGly: 8.133 ± 0.099
1.88AlaHis: 1.88 ± 0.043
3.896AlaIle: 3.896 ± 0.057
3.713AlaLys: 3.713 ± 0.059
10.681AlaLeu: 10.681 ± 0.112
2.02AlaMet: 2.02 ± 0.041
3.555AlaAsn: 3.555 ± 0.058
5.113AlaPro: 5.113 ± 0.087
5.185AlaGln: 5.185 ± 0.063
5.631AlaArg: 5.631 ± 0.068
5.489AlaSer: 5.489 ± 0.071
6.479AlaThr: 6.479 ± 0.094
7.289AlaVal: 7.289 ± 0.09
1.24AlaTrp: 1.24 ± 0.034
3.2AlaTyr: 3.2 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.619CysAla: 0.619 ± 0.021
0.106CysCys: 0.106 ± 0.009
0.358CysAsp: 0.358 ± 0.019
0.356CysGlu: 0.356 ± 0.018
0.306CysPhe: 0.306 ± 0.016
0.653CysGly: 0.653 ± 0.025
0.214CysHis: 0.214 ± 0.014
0.347CysIle: 0.347 ± 0.015
0.188CysLys: 0.188 ± 0.013
0.776CysLeu: 0.776 ± 0.025
0.125CysMet: 0.125 ± 0.01
0.279CysAsn: 0.279 ± 0.017
0.426CysPro: 0.426 ± 0.026
0.338CysGln: 0.338 ± 0.017
0.45CysArg: 0.45 ± 0.019
0.434CysSer: 0.434 ± 0.016
0.465CysThr: 0.465 ± 0.024
0.503CysVal: 0.503 ± 0.019
0.114CysTrp: 0.114 ± 0.009
0.279CysTyr: 0.279 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
5.092AspAla: 5.092 ± 0.062
0.338AspCys: 0.338 ± 0.017
2.439AspAsp: 2.439 ± 0.054
3.22AspGlu: 3.22 ± 0.055
2.368AspPhe: 2.368 ± 0.044
3.634AspGly: 3.634 ± 0.062
0.792AspHis: 0.792 ± 0.029
2.281AspIle: 2.281 ± 0.049
2.223AspLys: 2.223 ± 0.051
4.764AspLeu: 4.764 ± 0.072
0.95AspMet: 0.95 ± 0.028
1.978AspAsn: 1.978 ± 0.051
2.265AspPro: 2.265 ± 0.043
1.874AspGln: 1.874 ± 0.042
2.475AspArg: 2.475 ± 0.048
2.38AspSer: 2.38 ± 0.049
2.507AspThr: 2.507 ± 0.042
3.622AspVal: 3.622 ± 0.054
0.701AspTrp: 0.701 ± 0.023
2.086AspTyr: 2.086 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
6.056GluAla: 6.056 ± 0.079
0.314GluCys: 0.314 ± 0.015
2.214GluAsp: 2.214 ± 0.04
3.29GluGlu: 3.29 ± 0.059
2.153GluPhe: 2.153 ± 0.045
3.566GluGly: 3.566 ± 0.061
1.419GluHis: 1.419 ± 0.036
2.401GluIle: 2.401 ± 0.051
2.496GluLys: 2.496 ± 0.052
6.768GluLeu: 6.768 ± 0.074
1.184GluMet: 1.184 ± 0.032
1.934GluAsn: 1.934 ± 0.044
2.536GluPro: 2.536 ± 0.045
3.746GluGln: 3.746 ± 0.057
3.878GluArg: 3.878 ± 0.053
2.314GluSer: 2.314 ± 0.041
2.625GluThr: 2.625 ± 0.046
4.449GluVal: 4.449 ± 0.072
0.691GluTrp: 0.691 ± 0.023
1.825GluTyr: 1.825 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.819PheAla: 3.819 ± 0.055
0.353PheCys: 0.353 ± 0.015
2.398PheAsp: 2.398 ± 0.046
2.321PheGlu: 2.321 ± 0.041
1.746PhePhe: 1.746 ± 0.045
3.526PheGly: 3.526 ± 0.056
0.693PheHis: 0.693 ± 0.024
1.66PheIle: 1.66 ± 0.037
1.385PheLys: 1.385 ± 0.037
3.503PheLeu: 3.503 ± 0.063
0.733PheMet: 0.733 ± 0.026
1.634PheAsn: 1.634 ± 0.042
1.607PhePro: 1.607 ± 0.037
1.425PheGln: 1.425 ± 0.034
2.636PheArg: 2.636 ± 0.048
2.571PheSer: 2.571 ± 0.045
2.561PheThr: 2.561 ± 0.047
3.061PheVal: 3.061 ± 0.055
0.526PheTrp: 0.526 ± 0.021
1.492PheTyr: 1.492 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
6.894GlyAla: 6.894 ± 0.091
0.665GlyCys: 0.665 ± 0.027
2.958GlyAsp: 2.958 ± 0.048
3.655GlyGlu: 3.655 ± 0.056
3.253GlyPhe: 3.253 ± 0.056
6.192GlyGly: 6.192 ± 0.113
1.588GlyHis: 1.588 ± 0.039
3.749GlyIle: 3.749 ± 0.051
3.628GlyLys: 3.628 ± 0.068
7.904GlyLeu: 7.904 ± 0.092
1.649GlyMet: 1.649 ± 0.041
3.065GlyAsn: 3.065 ± 0.058
2.807GlyPro: 2.807 ± 0.05
3.979GlyGln: 3.979 ± 0.057
4.848GlyArg: 4.848 ± 0.069
4.776GlySer: 4.776 ± 0.091
5.192GlyThr: 5.192 ± 0.086
5.212GlyVal: 5.212 ± 0.062
1.101GlyTrp: 1.101 ± 0.03
3.07GlyTyr: 3.07 ± 0.048
0.001GlyXaa: 0.001 ± 0.001
His
1.759HisAla: 1.759 ± 0.043
0.196HisCys: 0.196 ± 0.013
1.102HisAsp: 1.102 ± 0.034
1.189HisGlu: 1.189 ± 0.033
1.014HisPhe: 1.014 ± 0.029
1.55HisGly: 1.55 ± 0.037
0.642HisHis: 0.642 ± 0.026
0.93HisIle: 0.93 ± 0.027
0.679HisLys: 0.679 ± 0.025
2.491HisLeu: 2.491 ± 0.049
0.393HisMet: 0.393 ± 0.016
0.783HisAsn: 0.783 ± 0.024
1.289HisPro: 1.289 ± 0.034
0.91HisGln: 0.91 ± 0.025
1.306HisArg: 1.306 ± 0.031
1.002HisSer: 1.002 ± 0.032
1.168HisThr: 1.168 ± 0.035
1.354HisVal: 1.354 ± 0.033
0.269HisTrp: 0.269 ± 0.014
0.864HisTyr: 0.864 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
3.97IleAla: 3.97 ± 0.065
0.386IleCys: 0.386 ± 0.016
2.616IleAsp: 2.616 ± 0.048
2.751IleGlu: 2.751 ± 0.05
1.518IlePhe: 1.518 ± 0.038
3.637IleGly: 3.637 ± 0.058
0.738IleHis: 0.738 ± 0.026
2.21IleIle: 2.21 ± 0.049
1.757IleLys: 1.757 ± 0.045
3.481IleLeu: 3.481 ± 0.064
0.786IleMet: 0.786 ± 0.026
1.889IleAsn: 1.889 ± 0.041
2.055IlePro: 2.055 ± 0.037
1.597IleGln: 1.597 ± 0.037
2.773IleArg: 2.773 ± 0.043
2.821IleSer: 2.821 ± 0.058
2.953IleThr: 2.953 ± 0.059
3.039IleVal: 3.039 ± 0.051
0.497IleTrp: 0.497 ± 0.022
1.367IleTyr: 1.367 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.023LysAla: 4.023 ± 0.064
0.179LysCys: 0.179 ± 0.013
1.852LysAsp: 1.852 ± 0.046
2.242LysGlu: 2.242 ± 0.046
1.267LysPhe: 1.267 ± 0.033
2.698LysGly: 2.698 ± 0.055
0.862LysHis: 0.862 ± 0.029
1.664LysIle: 1.664 ± 0.042
1.95LysLys: 1.95 ± 0.057
4.28LysLeu: 4.28 ± 0.065
0.905LysMet: 0.905 ± 0.029
1.425LysAsn: 1.425 ± 0.036
2.407LysPro: 2.407 ± 0.056
2.123LysGln: 2.123 ± 0.048
2.298LysArg: 2.298 ± 0.041
1.814LysSer: 1.814 ± 0.042
2.16LysThr: 2.16 ± 0.044
2.847LysVal: 2.847 ± 0.057
0.441LysTrp: 0.441 ± 0.018
1.376LysTyr: 1.376 ± 0.033
0.001LysXaa: 0.001 ± 0.001
Leu
10.703LeuAla: 10.703 ± 0.114
0.796LeuCys: 0.796 ± 0.029
5.088LeuAsp: 5.088 ± 0.066
5.389LeuGlu: 5.389 ± 0.068
3.801LeuPhe: 3.801 ± 0.065
8.812LeuGly: 8.812 ± 0.092
2.389LeuHis: 2.389 ± 0.051
4.148LeuIle: 4.148 ± 0.07
3.87LeuLys: 3.87 ± 0.06
13.155LeuLeu: 13.155 ± 0.169
2.147LeuMet: 2.147 ± 0.045
4.134LeuAsn: 4.134 ± 0.066
6.369LeuPro: 6.369 ± 0.08
5.124LeuGln: 5.124 ± 0.062
7.901LeuArg: 7.901 ± 0.097
6.185LeuSer: 6.185 ± 0.068
6.477LeuThr: 6.477 ± 0.084
7.328LeuVal: 7.328 ± 0.093
1.154LeuTrp: 1.154 ± 0.034
3.209LeuTyr: 3.209 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.017MetAla: 2.017 ± 0.043
0.117MetCys: 0.117 ± 0.01
0.761MetAsp: 0.761 ± 0.024
0.992MetGlu: 0.992 ± 0.03
0.636MetPhe: 0.636 ± 0.024
1.323MetGly: 1.323 ± 0.038
0.485MetHis: 0.485 ± 0.019
0.748MetIle: 0.748 ± 0.025
1.037MetLys: 1.037 ± 0.03
2.276MetLeu: 2.276 ± 0.049
0.438MetMet: 0.438 ± 0.019
0.777MetAsn: 0.777 ± 0.024
1.288MetPro: 1.288 ± 0.032
1.079MetGln: 1.079 ± 0.029
1.426MetArg: 1.426 ± 0.033
1.167MetSer: 1.167 ± 0.033
0.943MetThr: 0.943 ± 0.024
1.291MetVal: 1.291 ± 0.035
0.178MetTrp: 0.178 ± 0.012
0.506MetTyr: 0.506 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.574AsnAla: 3.574 ± 0.06
0.297AsnCys: 0.297 ± 0.017
1.843AsnAsp: 1.843 ± 0.044
1.875AsnGlu: 1.875 ± 0.038
1.662AsnPhe: 1.662 ± 0.041
3.178AsnGly: 3.178 ± 0.069
0.674AsnHis: 0.674 ± 0.025
1.857AsnIle: 1.857 ± 0.042
1.477AsnLys: 1.477 ± 0.043
3.997AsnLeu: 3.997 ± 0.052
0.692AsnMet: 0.692 ± 0.024
1.726AsnAsn: 1.726 ± 0.048
2.521AsnPro: 2.521 ± 0.051
1.791AsnGln: 1.791 ± 0.04
2.384AsnArg: 2.384 ± 0.048
2.138AsnSer: 2.138 ± 0.043
2.441AsnThr: 2.441 ± 0.053
2.66AsnVal: 2.66 ± 0.052
0.567AsnTrp: 0.567 ± 0.022
1.551AsnTyr: 1.551 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
6.62ProAla: 6.62 ± 0.1
0.266ProCys: 0.266 ± 0.014
3.155ProAsp: 3.155 ± 0.048
3.719ProGlu: 3.719 ± 0.067
1.831ProPhe: 1.831 ± 0.042
3.874ProGly: 3.874 ± 0.053
0.996ProHis: 0.996 ± 0.031
1.98ProIle: 1.98 ± 0.042
1.831ProLys: 1.831 ± 0.041
4.84ProLeu: 4.84 ± 0.058
0.891ProMet: 0.891 ± 0.027
2.279ProAsn: 2.279 ± 0.044
1.992ProPro: 1.992 ± 0.057
2.252ProGln: 2.252 ± 0.043
2.606ProArg: 2.606 ± 0.049
2.56ProSer: 2.56 ± 0.044
3.322ProThr: 3.322 ± 0.056
4.154ProVal: 4.154 ± 0.057
0.593ProTrp: 0.593 ± 0.022
1.649ProTyr: 1.649 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
5.326GlnAla: 5.326 ± 0.078
0.247GlnCys: 0.247 ± 0.015
1.821GlnAsp: 1.821 ± 0.042
2.616GlnGlu: 2.616 ± 0.049
1.699GlnPhe: 1.699 ± 0.038
2.999GlnGly: 2.999 ± 0.056
1.365GlnHis: 1.365 ± 0.031
1.819GlnIle: 1.819 ± 0.04
1.788GlnLys: 1.788 ± 0.045
6.075GlnLeu: 6.075 ± 0.069
0.958GlnMet: 0.958 ± 0.028
1.747GlnAsn: 1.747 ± 0.043
3.141GlnPro: 3.141 ± 0.058
3.775GlnGln: 3.775 ± 0.075
3.624GlnArg: 3.624 ± 0.059
2.067GlnSer: 2.067 ± 0.042
2.518GlnThr: 2.518 ± 0.047
3.687GlnVal: 3.687 ± 0.051
0.67GlnTrp: 0.67 ± 0.026
1.657GlnTyr: 1.657 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
5.255ArgAla: 5.255 ± 0.083
0.425ArgCys: 0.425 ± 0.018
2.74ArgAsp: 2.74 ± 0.051
3.575ArgGlu: 3.575 ± 0.059
2.794ArgPhe: 2.794 ± 0.046
3.905ArgGly: 3.905 ± 0.064
1.475ArgHis: 1.475 ± 0.035
3.199ArgIle: 3.199 ± 0.05
2.42ArgLys: 2.42 ± 0.046
7.221ArgLeu: 7.221 ± 0.099
1.453ArgMet: 1.453 ± 0.03
2.632ArgAsn: 2.632 ± 0.049
3.1ArgPro: 3.1 ± 0.052
3.625ArgGln: 3.625 ± 0.053
4.715ArgArg: 4.715 ± 0.071
3.079ArgSer: 3.079 ± 0.05
3.833ArgThr: 3.833 ± 0.066
4.659ArgVal: 4.659 ± 0.065
0.963ArgTrp: 0.963 ± 0.032
2.754ArgTyr: 2.754 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
5.512SerAla: 5.512 ± 0.076
0.494SerCys: 0.494 ± 0.021
2.349SerAsp: 2.349 ± 0.043
2.629SerGlu: 2.629 ± 0.048
2.514SerPhe: 2.514 ± 0.045
4.784SerGly: 4.784 ± 0.08
0.963SerHis: 0.963 ± 0.027
2.605SerIle: 2.605 ± 0.05
2.105SerLys: 2.105 ± 0.043
5.5SerLeu: 5.5 ± 0.076
1.098SerMet: 1.098 ± 0.03
2.185SerAsn: 2.185 ± 0.048
2.707SerPro: 2.707 ± 0.048
2.071SerGln: 2.071 ± 0.043
3.104SerArg: 3.104 ± 0.058
3.441SerSer: 3.441 ± 0.061
3.465SerThr: 3.465 ± 0.065
3.995SerVal: 3.995 ± 0.054
0.762SerTrp: 0.762 ± 0.025
2.15SerTyr: 2.15 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
6.466ThrAla: 6.466 ± 0.099
0.362ThrCys: 0.362 ± 0.018
3.144ThrAsp: 3.144 ± 0.045
3.141ThrGlu: 3.141 ± 0.043
2.362ThrPhe: 2.362 ± 0.04
5.09ThrGly: 5.09 ± 0.087
1.143ThrHis: 1.143 ± 0.029
2.639ThrIle: 2.639 ± 0.048
2.031ThrLys: 2.031 ± 0.045
6.389ThrLeu: 6.389 ± 0.076
0.946ThrMet: 0.946 ± 0.026
2.312ThrAsn: 2.312 ± 0.051
3.737ThrPro: 3.737 ± 0.06
2.276ThrGln: 2.276 ± 0.044
3.119ThrArg: 3.119 ± 0.053
3.375ThrSer: 3.375 ± 0.06
3.994ThrThr: 3.994 ± 0.077
4.558ThrVal: 4.558 ± 0.072
0.746ThrTrp: 0.746 ± 0.026
2.135ThrTyr: 2.135 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
8.009ValAla: 8.009 ± 0.091
0.588ValCys: 0.588 ± 0.021
3.124ValAsp: 3.124 ± 0.057
3.898ValGlu: 3.898 ± 0.058
2.849ValPhe: 2.849 ± 0.044
5.174ValGly: 5.174 ± 0.06
1.415ValHis: 1.415 ± 0.034
2.961ValIle: 2.961 ± 0.053
2.613ValLys: 2.613 ± 0.057
8.373ValLeu: 8.373 ± 0.099
1.297ValMet: 1.297 ± 0.03
2.52ValAsn: 2.52 ± 0.043
3.911ValPro: 3.911 ± 0.062
3.672ValGln: 3.672 ± 0.053
5.03ValArg: 5.03 ± 0.08
4.15ValSer: 4.15 ± 0.07
4.129ValThr: 4.129 ± 0.069
6.199ValVal: 6.199 ± 0.087
0.883ValTrp: 0.883 ± 0.03
2.328ValTyr: 2.328 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
1.152TrpAla: 1.152 ± 0.033
0.087TrpCys: 0.087 ± 0.009
0.508TrpAsp: 0.508 ± 0.023
0.632TrpGlu: 0.632 ± 0.023
0.539TrpPhe: 0.539 ± 0.022
0.816TrpGly: 0.816 ± 0.027
0.345TrpHis: 0.345 ± 0.017
0.449TrpIle: 0.449 ± 0.021
0.423TrpLys: 0.423 ± 0.019
1.84TrpLeu: 1.84 ± 0.05
0.27TrpMet: 0.27 ± 0.014
0.475TrpAsn: 0.475 ± 0.021
0.564TrpPro: 0.564 ± 0.021
0.906TrpGln: 0.906 ± 0.025
0.957TrpArg: 0.957 ± 0.031
0.644TrpSer: 0.644 ± 0.028
0.622TrpThr: 0.622 ± 0.025
0.934TrpVal: 0.934 ± 0.032
0.237TrpTrp: 0.237 ± 0.015
0.423TrpTyr: 0.423 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.212TyrAla: 3.212 ± 0.057
0.308TyrCys: 0.308 ± 0.016
1.955TyrAsp: 1.955 ± 0.04
1.823TyrGlu: 1.823 ± 0.04
1.691TyrPhe: 1.691 ± 0.038
2.639TyrGly: 2.639 ± 0.06
0.811TyrHis: 0.811 ± 0.026
1.299TyrIle: 1.299 ± 0.035
1.202TyrLys: 1.202 ± 0.031
3.864TyrLeu: 3.864 ± 0.059
0.547TyrMet: 0.547 ± 0.02
1.571TyrAsn: 1.571 ± 0.037
1.574TyrPro: 1.574 ± 0.037
1.851TyrGln: 1.851 ± 0.041
2.66TyrArg: 2.66 ± 0.045
2.029TyrSer: 2.029 ± 0.041
2.111TyrThr: 2.111 ± 0.044
2.283TyrVal: 2.283 ± 0.046
0.489TyrTrp: 0.489 ± 0.023
1.501TyrTyr: 1.501 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.001
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.001XaaVal: 0.001 ± 0.001
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4037 proteins (1338913 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski