Amino acid dipepetide frequency for Pectobacterium phage DU_PP_IV

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.552AlaAla: 6.552 ± 0.559
0.897AlaCys: 0.897 ± 0.144
4.23AlaAsp: 4.23 ± 0.324
4.851AlaGlu: 4.851 ± 0.31
2.667AlaPhe: 2.667 ± 0.25
6.069AlaGly: 6.069 ± 0.476
1.494AlaHis: 1.494 ± 0.179
3.931AlaIle: 3.931 ± 0.282
4.621AlaLys: 4.621 ± 0.428
6.276AlaLeu: 6.276 ± 0.432
2.207AlaMet: 2.207 ± 0.217
3.173AlaAsn: 3.173 ± 0.237
2.322AlaPro: 2.322 ± 0.26
2.644AlaGln: 2.644 ± 0.28
3.885AlaArg: 3.885 ± 0.358
3.563AlaSer: 3.563 ± 0.312
3.977AlaThr: 3.977 ± 0.436
5.035AlaVal: 5.035 ± 0.414
1.241AlaTrp: 1.241 ± 0.181
2.92AlaTyr: 2.92 ± 0.268
0.0AlaXaa: 0.0 ± 0.0
Cys
0.966CysAla: 0.966 ± 0.164
0.299CysCys: 0.299 ± 0.082
0.966CysAsp: 0.966 ± 0.153
1.058CysGlu: 1.058 ± 0.168
0.759CysPhe: 0.759 ± 0.133
1.448CysGly: 1.448 ± 0.215
0.322CysHis: 0.322 ± 0.081
0.368CysIle: 0.368 ± 0.091
1.058CysLys: 1.058 ± 0.208
0.805CysLeu: 0.805 ± 0.163
0.368CysMet: 0.368 ± 0.091
0.598CysAsn: 0.598 ± 0.117
0.782CysPro: 0.782 ± 0.173
0.414CysGln: 0.414 ± 0.123
0.713CysArg: 0.713 ± 0.135
0.667CysSer: 0.667 ± 0.143
0.437CysThr: 0.437 ± 0.118
0.736CysVal: 0.736 ± 0.148
0.184CysTrp: 0.184 ± 0.061
0.667CysTyr: 0.667 ± 0.107
0.0CysXaa: 0.0 ± 0.0
Asp
4.483AspAla: 4.483 ± 0.367
0.736AspCys: 0.736 ± 0.116
3.609AspAsp: 3.609 ± 0.315
4.138AspGlu: 4.138 ± 0.333
3.196AspPhe: 3.196 ± 0.258
5.357AspGly: 5.357 ± 0.415
1.655AspHis: 1.655 ± 0.199
3.908AspIle: 3.908 ± 0.33
4.207AspLys: 4.207 ± 0.327
6.529AspLeu: 6.529 ± 0.417
2.046AspMet: 2.046 ± 0.202
3.058AspAsn: 3.058 ± 0.239
3.265AspPro: 3.265 ± 0.257
2.506AspGln: 2.506 ± 0.286
3.173AspArg: 3.173 ± 0.319
3.173AspSer: 3.173 ± 0.322
2.621AspThr: 2.621 ± 0.321
4.161AspVal: 4.161 ± 0.329
1.264AspTrp: 1.264 ± 0.165
2.414AspTyr: 2.414 ± 0.281
0.0AspXaa: 0.0 ± 0.0
Glu
4.943GluAla: 4.943 ± 0.364
0.667GluCys: 0.667 ± 0.147
4.759GluAsp: 4.759 ± 0.376
6.276GluGlu: 6.276 ± 0.482
3.104GluPhe: 3.104 ± 0.268
5.334GluGly: 5.334 ± 0.36
1.379GluHis: 1.379 ± 0.217
4.414GluIle: 4.414 ± 0.338
4.828GluLys: 4.828 ± 0.369
5.426GluLeu: 5.426 ± 0.331
2.207GluMet: 2.207 ± 0.224
3.15GluAsn: 3.15 ± 0.268
1.908GluPro: 1.908 ± 0.202
2.138GluGln: 2.138 ± 0.235
3.54GluArg: 3.54 ± 0.333
2.69GluSer: 2.69 ± 0.31
3.816GluThr: 3.816 ± 0.3
5.426GluVal: 5.426 ± 0.425
1.241GluTrp: 1.241 ± 0.159
2.552GluTyr: 2.552 ± 0.244
0.0GluXaa: 0.0 ± 0.0
Phe
2.23PheAla: 2.23 ± 0.225
0.782PheCys: 0.782 ± 0.147
3.012PheAsp: 3.012 ± 0.302
2.851PheGlu: 2.851 ± 0.257
1.793PhePhe: 1.793 ± 0.211
3.632PheGly: 3.632 ± 0.344
0.897PheHis: 0.897 ± 0.174
2.506PheIle: 2.506 ± 0.247
2.736PheLys: 2.736 ± 0.27
3.472PheLeu: 3.472 ± 0.266
1.035PheMet: 1.035 ± 0.157
1.862PheAsn: 1.862 ± 0.21
1.609PhePro: 1.609 ± 0.213
1.494PheGln: 1.494 ± 0.21
1.931PheArg: 1.931 ± 0.176
2.575PheSer: 2.575 ± 0.224
2.368PheThr: 2.368 ± 0.228
3.127PheVal: 3.127 ± 0.287
0.874PheTrp: 0.874 ± 0.151
1.586PheTyr: 1.586 ± 0.25
0.0PheXaa: 0.0 ± 0.0
Gly
5.012GlyAla: 5.012 ± 0.488
1.195GlyCys: 1.195 ± 0.187
5.518GlyAsp: 5.518 ± 0.772
4.69GlyGlu: 4.69 ± 0.281
3.655GlyPhe: 3.655 ± 0.307
5.104GlyGly: 5.104 ± 0.423
1.264GlyHis: 1.264 ± 0.183
4.069GlyIle: 4.069 ± 0.261
6.897GlyLys: 6.897 ± 0.423
5.725GlyLeu: 5.725 ± 0.348
2.414GlyMet: 2.414 ± 0.192
3.403GlyAsn: 3.403 ± 0.345
2.874GlyPro: 2.874 ± 0.693
2.759GlyGln: 2.759 ± 0.247
3.678GlyArg: 3.678 ± 0.265
4.713GlySer: 4.713 ± 0.313
4.782GlyThr: 4.782 ± 0.438
4.966GlyVal: 4.966 ± 0.391
1.701GlyTrp: 1.701 ± 0.221
3.77GlyTyr: 3.77 ± 0.24
0.0GlyXaa: 0.0 ± 0.0
His
0.897HisAla: 0.897 ± 0.141
0.437HisCys: 0.437 ± 0.112
1.104HisAsp: 1.104 ± 0.146
1.356HisGlu: 1.356 ± 0.185
0.874HisPhe: 0.874 ± 0.141
1.356HisGly: 1.356 ± 0.183
0.483HisHis: 0.483 ± 0.101
1.241HisIle: 1.241 ± 0.188
1.172HisLys: 1.172 ± 0.174
1.678HisLeu: 1.678 ± 0.198
0.506HisMet: 0.506 ± 0.126
1.035HisAsn: 1.035 ± 0.165
1.195HisPro: 1.195 ± 0.157
0.575HisGln: 0.575 ± 0.117
1.494HisArg: 1.494 ± 0.198
0.966HisSer: 0.966 ± 0.143
1.127HisThr: 1.127 ± 0.168
1.425HisVal: 1.425 ± 0.208
0.322HisTrp: 0.322 ± 0.078
0.575HisTyr: 0.575 ± 0.112
0.0HisXaa: 0.0 ± 0.0
Ile
3.862IleAla: 3.862 ± 0.307
0.644IleCys: 0.644 ± 0.124
3.908IleAsp: 3.908 ± 0.277
4.345IleGlu: 4.345 ± 0.292
2.092IlePhe: 2.092 ± 0.26
3.77IleGly: 3.77 ± 0.354
1.195IleHis: 1.195 ± 0.146
2.644IleIle: 2.644 ± 0.252
3.334IleLys: 3.334 ± 0.332
4.207IleLeu: 4.207 ± 0.252
1.632IleMet: 1.632 ± 0.177
2.713IleAsn: 2.713 ± 0.242
2.483IlePro: 2.483 ± 0.26
1.655IleGln: 1.655 ± 0.216
3.701IleArg: 3.701 ± 0.291
3.426IleSer: 3.426 ± 0.281
3.357IleThr: 3.357 ± 0.29
3.701IleVal: 3.701 ± 0.285
0.713IleTrp: 0.713 ± 0.142
2.115IleTyr: 2.115 ± 0.216
0.0IleXaa: 0.0 ± 0.0
Lys
5.977LysAla: 5.977 ± 0.477
0.621LysCys: 0.621 ± 0.123
4.552LysAsp: 4.552 ± 0.329
4.667LysGlu: 4.667 ± 0.352
2.92LysPhe: 2.92 ± 0.316
5.839LysGly: 5.839 ± 0.61
1.494LysHis: 1.494 ± 0.224
3.196LysIle: 3.196 ± 0.26
5.058LysLys: 5.058 ± 0.39
4.414LysLeu: 4.414 ± 0.318
2.368LysMet: 2.368 ± 0.21
2.805LysAsn: 2.805 ± 0.246
2.575LysPro: 2.575 ± 0.254
2.414LysGln: 2.414 ± 0.226
3.426LysArg: 3.426 ± 0.288
3.54LysSer: 3.54 ± 0.295
3.311LysThr: 3.311 ± 0.279
5.15LysVal: 5.15 ± 0.297
1.035LysTrp: 1.035 ± 0.15
2.46LysTyr: 2.46 ± 0.213
0.0LysXaa: 0.0 ± 0.0
Leu
6.391LeuAla: 6.391 ± 0.493
1.195LeuCys: 1.195 ± 0.176
5.334LeuAsp: 5.334 ± 0.34
5.725LeuGlu: 5.725 ± 0.38
3.219LeuPhe: 3.219 ± 0.296
5.288LeuGly: 5.288 ± 0.353
1.678LeuHis: 1.678 ± 0.224
4.414LeuIle: 4.414 ± 0.303
4.943LeuLys: 4.943 ± 0.324
5.127LeuLeu: 5.127 ± 0.341
2.391LeuMet: 2.391 ± 0.279
4.23LeuAsn: 4.23 ± 0.294
3.931LeuPro: 3.931 ± 0.312
2.092LeuGln: 2.092 ± 0.186
4.368LeuArg: 4.368 ± 0.306
4.598LeuSer: 4.598 ± 0.251
4.161LeuThr: 4.161 ± 0.275
5.081LeuVal: 5.081 ± 0.388
1.264LeuTrp: 1.264 ± 0.166
3.035LeuTyr: 3.035 ± 0.259
0.0LeuXaa: 0.0 ± 0.0
Met
2.46MetAla: 2.46 ± 0.186
0.345MetCys: 0.345 ± 0.084
1.494MetAsp: 1.494 ± 0.204
1.862MetGlu: 1.862 ± 0.231
1.632MetPhe: 1.632 ± 0.199
1.862MetGly: 1.862 ± 0.212
0.414MetHis: 0.414 ± 0.085
1.954MetIle: 1.954 ± 0.225
2.414MetLys: 2.414 ± 0.255
2.207MetLeu: 2.207 ± 0.223
0.736MetMet: 0.736 ± 0.127
1.264MetAsn: 1.264 ± 0.152
0.897MetPro: 0.897 ± 0.13
0.897MetGln: 0.897 ± 0.129
1.448MetArg: 1.448 ± 0.173
2.207MetSer: 2.207 ± 0.226
1.839MetThr: 1.839 ± 0.238
1.954MetVal: 1.954 ± 0.252
0.207MetTrp: 0.207 ± 0.079
0.828MetTyr: 0.828 ± 0.127
0.0MetXaa: 0.0 ± 0.0
Asn
3.173AsnAla: 3.173 ± 0.26
0.552AsnCys: 0.552 ± 0.117
2.253AsnAsp: 2.253 ± 0.221
2.414AsnGlu: 2.414 ± 0.24
1.609AsnPhe: 1.609 ± 0.222
4.069AsnGly: 4.069 ± 0.306
0.92AsnHis: 0.92 ± 0.14
2.621AsnIle: 2.621 ± 0.262
2.621AsnLys: 2.621 ± 0.246
4.345AsnLeu: 4.345 ± 0.364
1.241AsnMet: 1.241 ± 0.168
2.0AsnAsn: 2.0 ± 0.216
2.023AsnPro: 2.023 ± 0.225
1.54AsnGln: 1.54 ± 0.155
2.713AsnArg: 2.713 ± 0.288
2.322AsnSer: 2.322 ± 0.232
2.759AsnThr: 2.759 ± 0.258
2.759AsnVal: 2.759 ± 0.229
0.598AsnTrp: 0.598 ± 0.107
1.448AsnTyr: 1.448 ± 0.179
0.0AsnXaa: 0.0 ± 0.0
Pro
2.92ProAla: 2.92 ± 0.315
0.483ProCys: 0.483 ± 0.1
2.736ProAsp: 2.736 ± 0.252
3.931ProGlu: 3.931 ± 0.276
1.609ProPhe: 1.609 ± 0.184
3.334ProGly: 3.334 ± 0.287
0.966ProHis: 0.966 ± 0.128
1.609ProIle: 1.609 ± 0.226
2.368ProLys: 2.368 ± 0.251
2.368ProLeu: 2.368 ± 0.234
0.92ProMet: 0.92 ± 0.135
1.379ProAsn: 1.379 ± 0.171
1.356ProPro: 1.356 ± 0.192
1.586ProGln: 1.586 ± 0.312
1.839ProArg: 1.839 ± 0.228
2.023ProSer: 2.023 ± 0.225
2.299ProThr: 2.299 ± 0.183
3.242ProVal: 3.242 ± 0.255
0.782ProTrp: 0.782 ± 0.119
1.517ProTyr: 1.517 ± 0.177
0.0ProXaa: 0.0 ± 0.0
Gln
2.276GlnAla: 2.276 ± 0.203
0.437GlnCys: 0.437 ± 0.106
2.0GlnAsp: 2.0 ± 0.202
2.575GlnGlu: 2.575 ± 0.318
1.172GlnPhe: 1.172 ± 0.18
2.713GlnGly: 2.713 ± 0.504
0.552GlnHis: 0.552 ± 0.112
2.46GlnIle: 2.46 ± 0.218
1.793GlnLys: 1.793 ± 0.187
2.598GlnLeu: 2.598 ± 0.229
1.127GlnMet: 1.127 ± 0.166
1.517GlnAsn: 1.517 ± 0.181
0.92GlnPro: 0.92 ± 0.136
1.333GlnGln: 1.333 ± 0.219
2.069GlnArg: 2.069 ± 0.206
1.517GlnSer: 1.517 ± 0.172
1.678GlnThr: 1.678 ± 0.175
2.989GlnVal: 2.989 ± 0.281
0.828GlnTrp: 0.828 ± 0.14
1.678GlnTyr: 1.678 ± 0.207
0.0GlnXaa: 0.0 ± 0.0
Arg
3.954ArgAla: 3.954 ± 0.314
0.874ArgCys: 0.874 ± 0.141
3.77ArgAsp: 3.77 ± 0.33
4.253ArgGlu: 4.253 ± 0.376
2.0ArgPhe: 2.0 ± 0.18
4.138ArgGly: 4.138 ± 0.293
0.92ArgHis: 0.92 ± 0.139
3.058ArgIle: 3.058 ± 0.31
4.069ArgLys: 4.069 ± 0.311
4.437ArgLeu: 4.437 ± 0.327
1.816ArgMet: 1.816 ± 0.22
2.322ArgAsn: 2.322 ± 0.211
1.678ArgPro: 1.678 ± 0.176
2.138ArgGln: 2.138 ± 0.217
3.219ArgArg: 3.219 ± 0.316
2.989ArgSer: 2.989 ± 0.271
2.529ArgThr: 2.529 ± 0.244
3.793ArgVal: 3.793 ± 0.296
0.736ArgTrp: 0.736 ± 0.131
1.862ArgTyr: 1.862 ± 0.238
0.0ArgXaa: 0.0 ± 0.0
Ser
4.023SerAla: 4.023 ± 0.292
0.759SerCys: 0.759 ± 0.134
3.816SerAsp: 3.816 ± 0.295
3.081SerGlu: 3.081 ± 0.25
2.322SerPhe: 2.322 ± 0.213
4.782SerGly: 4.782 ± 0.343
0.759SerHis: 0.759 ± 0.124
2.483SerIle: 2.483 ± 0.255
3.701SerLys: 3.701 ± 0.288
4.322SerLeu: 4.322 ± 0.342
1.425SerMet: 1.425 ± 0.17
2.115SerAsn: 2.115 ± 0.202
2.299SerPro: 2.299 ± 0.225
1.632SerGln: 1.632 ± 0.176
3.173SerArg: 3.173 ± 0.32
3.173SerSer: 3.173 ± 0.376
3.173SerThr: 3.173 ± 0.291
3.908SerVal: 3.908 ± 0.347
0.966SerTrp: 0.966 ± 0.142
2.23SerTyr: 2.23 ± 0.225
0.0SerXaa: 0.0 ± 0.0
Thr
3.931ThrAla: 3.931 ± 0.333
0.667ThrCys: 0.667 ± 0.137
3.081ThrAsp: 3.081 ± 0.283
3.035ThrGlu: 3.035 ± 0.274
2.506ThrPhe: 2.506 ± 0.26
5.725ThrGly: 5.725 ± 0.755
1.012ThrHis: 1.012 ± 0.135
3.357ThrIle: 3.357 ± 0.288
3.586ThrLys: 3.586 ± 0.257
4.506ThrLeu: 4.506 ± 0.414
1.195ThrMet: 1.195 ± 0.164
2.046ThrAsn: 2.046 ± 0.231
2.69ThrPro: 2.69 ± 0.23
1.724ThrGln: 1.724 ± 0.186
2.897ThrArg: 2.897 ± 0.249
2.483ThrSer: 2.483 ± 0.187
3.54ThrThr: 3.54 ± 0.443
4.437ThrVal: 4.437 ± 0.366
0.828ThrTrp: 0.828 ± 0.138
1.885ThrTyr: 1.885 ± 0.198
0.0ThrXaa: 0.0 ± 0.0
Val
5.081ValAla: 5.081 ± 0.358
0.989ValCys: 0.989 ± 0.164
5.38ValAsp: 5.38 ± 0.421
5.357ValGlu: 5.357 ± 0.38
2.92ValPhe: 2.92 ± 0.285
4.368ValGly: 4.368 ± 0.321
0.966ValHis: 0.966 ± 0.144
4.529ValIle: 4.529 ± 0.366
5.081ValLys: 5.081 ± 0.309
4.805ValLeu: 4.805 ± 0.308
2.046ValMet: 2.046 ± 0.252
3.104ValAsn: 3.104 ± 0.278
2.575ValPro: 2.575 ± 0.228
2.506ValGln: 2.506 ± 0.252
3.862ValArg: 3.862 ± 0.29
4.299ValSer: 4.299 ± 0.316
4.391ValThr: 4.391 ± 0.337
5.104ValVal: 5.104 ± 0.401
1.035ValTrp: 1.035 ± 0.154
2.644ValTyr: 2.644 ± 0.239
0.0ValXaa: 0.0 ± 0.0
Trp
1.218TrpAla: 1.218 ± 0.144
0.253TrpCys: 0.253 ± 0.093
1.127TrpAsp: 1.127 ± 0.173
1.241TrpGlu: 1.241 ± 0.133
0.736TrpPhe: 0.736 ± 0.136
0.897TrpGly: 0.897 ± 0.146
0.253TrpHis: 0.253 ± 0.074
0.874TrpIle: 0.874 ± 0.111
1.104TrpLys: 1.104 ± 0.169
1.333TrpLeu: 1.333 ± 0.172
0.575TrpMet: 0.575 ± 0.101
0.736TrpAsn: 0.736 ± 0.15
0.437TrpPro: 0.437 ± 0.091
0.713TrpGln: 0.713 ± 0.124
0.943TrpArg: 0.943 ± 0.132
0.966TrpSer: 0.966 ± 0.147
1.035TrpThr: 1.035 ± 0.142
0.966TrpVal: 0.966 ± 0.144
0.437TrpTrp: 0.437 ± 0.12
0.874TrpTyr: 0.874 ± 0.155
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.207TyrAla: 2.207 ± 0.194
0.782TyrCys: 0.782 ± 0.13
2.851TyrAsp: 2.851 ± 0.268
2.092TyrGlu: 2.092 ± 0.232
1.586TyrPhe: 1.586 ± 0.196
3.104TyrGly: 3.104 ± 0.25
1.195TyrHis: 1.195 ± 0.16
1.862TyrIle: 1.862 ± 0.209
2.253TyrLys: 2.253 ± 0.226
3.885TyrLeu: 3.885 ± 0.292
0.644TyrMet: 0.644 ± 0.123
1.471TyrAsn: 1.471 ± 0.17
1.448TyrPro: 1.448 ± 0.187
1.471TyrGln: 1.471 ± 0.195
2.483TyrArg: 2.483 ± 0.235
2.253TyrSer: 2.253 ± 0.23
1.931TyrThr: 1.931 ± 0.223
3.081TyrVal: 3.081 ± 0.246
0.46TyrTrp: 0.46 ± 0.097
1.333TyrTyr: 1.333 ± 0.188
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 268 proteins (43498 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski