Amino acid dipepetide frequency for Agitococcus lubricus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.052AlaAla: 9.052 ± 0.131
1.08AlaCys: 1.08 ± 0.031
5.317AlaAsp: 5.317 ± 0.081
5.623AlaGlu: 5.623 ± 0.099
3.436AlaPhe: 3.436 ± 0.066
6.455AlaGly: 6.455 ± 0.103
2.169AlaHis: 2.169 ± 0.047
6.336AlaIle: 6.336 ± 0.088
5.256AlaLys: 5.256 ± 0.082
10.83AlaLeu: 10.83 ± 0.141
2.502AlaMet: 2.502 ± 0.057
4.505AlaAsn: 4.505 ± 0.107
3.258AlaPro: 3.258 ± 0.063
5.06AlaGln: 5.06 ± 0.093
4.322AlaArg: 4.322 ± 0.08
5.363AlaSer: 5.363 ± 0.071
4.997AlaThr: 4.997 ± 0.095
6.148AlaVal: 6.148 ± 0.093
1.306AlaTrp: 1.306 ± 0.038
2.78AlaTyr: 2.78 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.801CysAla: 0.801 ± 0.027
0.139CysCys: 0.139 ± 0.012
0.492CysAsp: 0.492 ± 0.02
0.504CysGlu: 0.504 ± 0.024
0.419CysPhe: 0.419 ± 0.018
0.789CysGly: 0.789 ± 0.026
0.337CysHis: 0.337 ± 0.018
0.473CysIle: 0.473 ± 0.022
0.361CysLys: 0.361 ± 0.02
1.195CysLeu: 1.195 ± 0.036
0.191CysMet: 0.191 ± 0.014
0.294CysAsn: 0.294 ± 0.016
0.489CysPro: 0.489 ± 0.023
0.686CysGln: 0.686 ± 0.027
0.497CysArg: 0.497 ± 0.025
0.584CysSer: 0.584 ± 0.026
0.49CysThr: 0.49 ± 0.051
0.67CysVal: 0.67 ± 0.024
0.125CysTrp: 0.125 ± 0.01
0.337CysTyr: 0.337 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.741AspAla: 4.741 ± 0.066
0.549AspCys: 0.549 ± 0.02
2.914AspAsp: 2.914 ± 0.073
3.128AspGlu: 3.128 ± 0.056
2.409AspPhe: 2.409 ± 0.057
3.721AspGly: 3.721 ± 0.099
0.899AspHis: 0.899 ± 0.031
4.0AspIle: 4.0 ± 0.067
2.946AspLys: 2.946 ± 0.063
5.222AspLeu: 5.222 ± 0.075
1.333AspMet: 1.333 ± 0.043
2.543AspAsn: 2.543 ± 0.058
1.857AspPro: 1.857 ± 0.046
1.537AspGln: 1.537 ± 0.04
2.068AspArg: 2.068 ± 0.044
3.096AspSer: 3.096 ± 0.064
3.167AspThr: 3.167 ± 0.148
3.814AspVal: 3.814 ± 0.067
0.909AspTrp: 0.909 ± 0.026
2.176AspTyr: 2.176 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
5.279GluAla: 5.279 ± 0.074
0.43GluCys: 0.43 ± 0.022
2.458GluAsp: 2.458 ± 0.054
2.845GluGlu: 2.845 ± 0.068
2.001GluPhe: 2.001 ± 0.041
3.429GluGly: 3.429 ± 0.063
1.43GluHis: 1.43 ± 0.038
3.169GluIle: 3.169 ± 0.061
3.103GluLys: 3.103 ± 0.074
6.13GluLeu: 6.13 ± 0.076
1.284GluMet: 1.284 ± 0.041
2.206GluAsn: 2.206 ± 0.063
1.884GluPro: 1.884 ± 0.045
3.965GluGln: 3.965 ± 0.076
3.394GluArg: 3.394 ± 0.067
2.735GluSer: 2.735 ± 0.054
2.674GluThr: 2.674 ± 0.051
3.59GluVal: 3.59 ± 0.065
0.776GluTrp: 0.776 ± 0.023
1.517GluTyr: 1.517 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.805PheAla: 3.805 ± 0.073
0.472PheCys: 0.472 ± 0.02
2.457PheAsp: 2.457 ± 0.048
1.95PheGlu: 1.95 ± 0.038
1.553PhePhe: 1.553 ± 0.042
2.762PheGly: 2.762 ± 0.053
0.711PheHis: 0.711 ± 0.029
2.409PheIle: 2.409 ± 0.044
1.817PheLys: 1.817 ± 0.048
3.506PheLeu: 3.506 ± 0.068
0.938PheMet: 0.938 ± 0.031
1.947PheAsn: 1.947 ± 0.049
1.322PhePro: 1.322 ± 0.043
1.259PheGln: 1.259 ± 0.036
1.539PheArg: 1.539 ± 0.039
2.881PheSer: 2.881 ± 0.07
1.977PheThr: 1.977 ± 0.048
2.677PheVal: 2.677 ± 0.058
0.534PheTrp: 0.534 ± 0.026
1.377PheTyr: 1.377 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.542GlyAla: 5.542 ± 0.107
0.779GlyCys: 0.779 ± 0.031
3.429GlyAsp: 3.429 ± 0.076
3.666GlyGlu: 3.666 ± 0.061
3.038GlyPhe: 3.038 ± 0.059
5.123GlyGly: 5.123 ± 0.152
1.63GlyHis: 1.63 ± 0.043
4.246GlyIle: 4.246 ± 0.067
3.579GlyLys: 3.579 ± 0.073
7.317GlyLeu: 7.317 ± 0.096
1.795GlyMet: 1.795 ± 0.041
2.91GlyAsn: 2.91 ± 0.185
0.991GlyPro: 0.991 ± 0.037
3.623GlyGln: 3.623 ± 0.075
3.188GlyArg: 3.188 ± 0.064
3.743GlySer: 3.743 ± 0.092
3.779GlyThr: 3.779 ± 0.132
4.837GlyVal: 4.837 ± 0.077
0.926GlyTrp: 0.926 ± 0.03
2.324GlyTyr: 2.324 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.106HisAla: 2.106 ± 0.047
0.322HisCys: 0.322 ± 0.017
1.225HisAsp: 1.225 ± 0.034
1.201HisGlu: 1.201 ± 0.035
0.979HisPhe: 0.979 ± 0.03
1.572HisGly: 1.572 ± 0.045
0.927HisHis: 0.927 ± 0.034
1.698HisIle: 1.698 ± 0.044
1.067HisLys: 1.067 ± 0.031
2.679HisLeu: 2.679 ± 0.061
0.46HisMet: 0.46 ± 0.02
0.787HisAsn: 0.787 ± 0.027
1.315HisPro: 1.315 ± 0.039
1.377HisGln: 1.377 ± 0.04
1.179HisArg: 1.179 ± 0.038
1.368HisSer: 1.368 ± 0.035
1.247HisThr: 1.247 ± 0.034
1.42HisVal: 1.42 ± 0.042
0.366HisTrp: 0.366 ± 0.018
1.05HisTyr: 1.05 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
6.237IleAla: 6.237 ± 0.085
0.615IleCys: 0.615 ± 0.025
3.944IleAsp: 3.944 ± 0.066
3.853IleGlu: 3.853 ± 0.069
2.051IlePhe: 2.051 ± 0.045
4.292IleGly: 4.292 ± 0.077
1.412IleHis: 1.412 ± 0.034
3.439IleIle: 3.439 ± 0.065
3.26IleLys: 3.26 ± 0.065
5.146IleLeu: 5.146 ± 0.065
1.178IleMet: 1.178 ± 0.033
3.064IleAsn: 3.064 ± 0.066
2.609IlePro: 2.609 ± 0.056
2.497IleGln: 2.497 ± 0.056
3.054IleArg: 3.054 ± 0.054
4.098IleSer: 4.098 ± 0.073
3.459IleThr: 3.459 ± 0.078
3.979IleVal: 3.979 ± 0.069
0.609IleTrp: 0.609 ± 0.025
1.743IleTyr: 1.743 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
4.923LysAla: 4.923 ± 0.082
0.266LysCys: 0.266 ± 0.019
2.55LysAsp: 2.55 ± 0.057
2.742LysGlu: 2.742 ± 0.071
1.383LysPhe: 1.383 ± 0.037
2.867LysGly: 2.867 ± 0.06
1.181LysHis: 1.181 ± 0.031
2.93LysIle: 2.93 ± 0.053
2.743LysLys: 2.743 ± 0.071
4.926LysLeu: 4.926 ± 0.076
1.212LysMet: 1.212 ± 0.039
2.152LysAsn: 2.152 ± 0.056
2.376LysPro: 2.376 ± 0.056
3.018LysGln: 3.018 ± 0.063
2.501LysArg: 2.501 ± 0.052
2.598LysSer: 2.598 ± 0.056
3.171LysThr: 3.171 ± 0.063
3.396LysVal: 3.396 ± 0.057
0.518LysTrp: 0.518 ± 0.023
1.258LysTyr: 1.258 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
12.609LeuAla: 12.609 ± 0.138
1.12LeuCys: 1.12 ± 0.032
5.492LeuAsp: 5.492 ± 0.075
5.659LeuGlu: 5.659 ± 0.084
3.865LeuPhe: 3.865 ± 0.071
7.152LeuGly: 7.152 ± 0.09
2.279LeuHis: 2.279 ± 0.048
5.829LeuIle: 5.829 ± 0.093
5.38LeuLys: 5.38 ± 0.081
11.43LeuLeu: 11.43 ± 0.149
2.6LeuMet: 2.6 ± 0.055
4.655LeuAsn: 4.655 ± 0.093
4.999LeuPro: 4.999 ± 0.082
4.995LeuGln: 4.995 ± 0.094
5.323LeuArg: 5.323 ± 0.073
8.012LeuSer: 8.012 ± 0.1
6.468LeuThr: 6.468 ± 0.099
7.334LeuVal: 7.334 ± 0.085
1.34LeuTrp: 1.34 ± 0.045
2.651LeuTyr: 2.651 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.526MetAla: 2.526 ± 0.048
0.176MetCys: 0.176 ± 0.012
1.044MetAsp: 1.044 ± 0.035
0.905MetGlu: 0.905 ± 0.03
0.652MetPhe: 0.652 ± 0.025
1.724MetGly: 1.724 ± 0.047
0.441MetHis: 0.441 ± 0.023
1.291MetIle: 1.291 ± 0.035
1.024MetLys: 1.024 ± 0.036
2.515MetLeu: 2.515 ± 0.053
0.768MetMet: 0.768 ± 0.025
0.992MetAsn: 0.992 ± 0.029
1.313MetPro: 1.313 ± 0.036
1.162MetGln: 1.162 ± 0.039
1.294MetArg: 1.294 ± 0.04
1.848MetSer: 1.848 ± 0.043
1.785MetThr: 1.785 ± 0.043
1.541MetVal: 1.541 ± 0.042
0.194MetTrp: 0.194 ± 0.015
0.48MetTyr: 0.48 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.787AsnAla: 3.787 ± 0.064
0.352AsnCys: 0.352 ± 0.017
2.435AsnAsp: 2.435 ± 0.098
2.019AsnGlu: 2.019 ± 0.041
1.428AsnPhe: 1.428 ± 0.044
2.995AsnGly: 2.995 ± 0.092
1.045AsnHis: 1.045 ± 0.034
2.63AsnIle: 2.63 ± 0.065
2.003AsnLys: 2.003 ± 0.055
4.196AsnLeu: 4.196 ± 0.095
0.888AsnMet: 0.888 ± 0.03
2.233AsnAsn: 2.233 ± 0.097
2.341AsnPro: 2.341 ± 0.052
2.281AsnGln: 2.281 ± 0.055
1.934AsnArg: 1.934 ± 0.045
2.501AsnSer: 2.501 ± 0.072
2.751AsnThr: 2.751 ± 0.096
2.338AsnVal: 2.338 ± 0.065
0.501AsnTrp: 0.501 ± 0.018
1.446AsnTyr: 1.446 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
3.656ProAla: 3.656 ± 0.072
0.345ProCys: 0.345 ± 0.018
2.429ProAsp: 2.429 ± 0.047
2.874ProGlu: 2.874 ± 0.056
1.638ProPhe: 1.638 ± 0.046
1.004ProGly: 1.004 ± 0.035
1.082ProHis: 1.082 ± 0.033
2.608ProIle: 2.608 ± 0.06
2.046ProLys: 2.046 ± 0.049
4.509ProLeu: 4.509 ± 0.076
1.056ProMet: 1.056 ± 0.032
1.926ProAsn: 1.926 ± 0.043
1.655ProPro: 1.655 ± 0.045
2.03ProGln: 2.03 ± 0.043
1.612ProArg: 1.612 ± 0.045
2.622ProSer: 2.622 ± 0.048
2.53ProThr: 2.53 ± 0.048
3.261ProVal: 3.261 ± 0.071
0.509ProTrp: 0.509 ± 0.023
1.366ProTyr: 1.366 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
5.973GlnAla: 5.973 ± 0.102
0.395GlnCys: 0.395 ± 0.02
2.255GlnAsp: 2.255 ± 0.046
2.599GlnGlu: 2.599 ± 0.054
1.786GlnPhe: 1.786 ± 0.039
3.473GlnGly: 3.473 ± 0.064
1.831GlnHis: 1.831 ± 0.051
2.78GlnIle: 2.78 ± 0.058
2.374GlnLys: 2.374 ± 0.053
6.425GlnLeu: 6.425 ± 0.119
1.05GlnMet: 1.05 ± 0.03
1.527GlnAsn: 1.527 ± 0.042
2.078GlnPro: 2.078 ± 0.044
5.232GlnGln: 5.232 ± 0.143
3.268GlnArg: 3.268 ± 0.08
2.774GlnSer: 2.774 ± 0.06
3.038GlnThr: 3.038 ± 0.064
3.316GlnVal: 3.316 ± 0.063
0.77GlnTrp: 0.77 ± 0.031
1.481GlnTyr: 1.481 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
4.023ArgAla: 4.023 ± 0.063
0.503ArgCys: 0.503 ± 0.023
2.555ArgAsp: 2.555 ± 0.056
2.844ArgGlu: 2.844 ± 0.058
2.404ArgPhe: 2.404 ± 0.055
2.616ArgGly: 2.616 ± 0.053
1.456ArgHis: 1.456 ± 0.043
3.131ArgIle: 3.131 ± 0.057
2.086ArgLys: 2.086 ± 0.047
6.36ArgLeu: 6.36 ± 0.105
1.171ArgMet: 1.171 ± 0.035
1.535ArgAsn: 1.535 ± 0.039
1.787ArgPro: 1.787 ± 0.045
3.123ArgGln: 3.123 ± 0.061
2.598ArgArg: 2.598 ± 0.063
2.433ArgSer: 2.433 ± 0.046
2.202ArgThr: 2.202 ± 0.047
3.492ArgVal: 3.492 ± 0.056
0.724ArgTrp: 0.724 ± 0.031
1.937ArgTyr: 1.937 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.454SerAla: 5.454 ± 0.089
0.592SerCys: 0.592 ± 0.032
2.955SerAsp: 2.955 ± 0.058
3.118SerGlu: 3.118 ± 0.059
2.546SerPhe: 2.546 ± 0.052
4.147SerGly: 4.147 ± 0.092
1.571SerHis: 1.571 ± 0.04
3.53SerIle: 3.53 ± 0.054
2.64SerLys: 2.64 ± 0.052
7.202SerLeu: 7.202 ± 0.093
1.398SerMet: 1.398 ± 0.035
2.269SerAsn: 2.269 ± 0.065
2.748SerPro: 2.748 ± 0.05
3.305SerGln: 3.305 ± 0.06
2.815SerArg: 2.815 ± 0.046
3.925SerSer: 3.925 ± 0.088
3.517SerThr: 3.517 ± 0.08
4.141SerVal: 4.141 ± 0.068
0.763SerTrp: 0.763 ± 0.028
2.016SerTyr: 2.016 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
5.363ThrAla: 5.363 ± 0.112
0.461ThrCys: 0.461 ± 0.023
2.956ThrAsp: 2.956 ± 0.079
2.956ThrGlu: 2.956 ± 0.058
1.819ThrPhe: 1.819 ± 0.047
4.828ThrGly: 4.828 ± 0.158
1.406ThrHis: 1.406 ± 0.037
3.412ThrIle: 3.412 ± 0.072
2.107ThrLys: 2.107 ± 0.047
6.66ThrLeu: 6.66 ± 0.127
1.148ThrMet: 1.148 ± 0.034
2.207ThrAsn: 2.207 ± 0.102
3.148ThrPro: 3.148 ± 0.064
2.846ThrGln: 2.846 ± 0.063
2.487ThrArg: 2.487 ± 0.05
2.87ThrSer: 2.87 ± 0.06
3.555ThrThr: 3.555 ± 0.104
4.334ThrVal: 4.334 ± 0.102
0.802ThrTrp: 0.802 ± 0.028
1.513ThrTyr: 1.513 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
6.323ValAla: 6.323 ± 0.096
0.762ValCys: 0.762 ± 0.026
3.941ValAsp: 3.941 ± 0.063
3.785ValGlu: 3.785 ± 0.066
2.573ValPhe: 2.573 ± 0.055
4.548ValGly: 4.548 ± 0.091
1.296ValHis: 1.296 ± 0.036
4.474ValIle: 4.474 ± 0.066
3.262ValLys: 3.262 ± 0.055
7.379ValLeu: 7.379 ± 0.101
1.855ValMet: 1.855 ± 0.044
2.955ValAsn: 2.955 ± 0.064
2.656ValPro: 2.656 ± 0.06
2.695ValGln: 2.695 ± 0.061
3.198ValArg: 3.198 ± 0.046
4.567ValSer: 4.567 ± 0.075
3.935ValThr: 3.935 ± 0.083
5.082ValVal: 5.082 ± 0.086
0.908ValTrp: 0.908 ± 0.033
1.981ValTyr: 1.981 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.894TrpAla: 0.894 ± 0.032
0.16TrpCys: 0.16 ± 0.013
0.537TrpAsp: 0.537 ± 0.022
0.477TrpGlu: 0.477 ± 0.021
0.572TrpPhe: 0.572 ± 0.024
0.786TrpGly: 0.786 ± 0.028
0.432TrpHis: 0.432 ± 0.018
0.595TrpIle: 0.595 ± 0.022
0.406TrpLys: 0.406 ± 0.02
2.06TrpLeu: 2.06 ± 0.053
0.312TrpMet: 0.312 ± 0.018
0.35TrpAsn: 0.35 ± 0.018
0.553TrpPro: 0.553 ± 0.026
1.459TrpGln: 1.459 ± 0.047
0.872TrpArg: 0.872 ± 0.032
0.817TrpSer: 0.817 ± 0.032
0.598TrpThr: 0.598 ± 0.024
0.824TrpVal: 0.824 ± 0.033
0.23TrpTrp: 0.23 ± 0.016
0.388TrpTyr: 0.388 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.699TyrAla: 2.699 ± 0.051
0.357TyrCys: 0.357 ± 0.019
1.644TyrAsp: 1.644 ± 0.046
1.551TyrGlu: 1.551 ± 0.038
1.34TyrPhe: 1.34 ± 0.038
2.18TyrGly: 2.18 ± 0.052
0.812TyrHis: 0.812 ± 0.03
1.561TyrIle: 1.561 ± 0.043
1.248TyrLys: 1.248 ± 0.044
3.506TyrLeu: 3.506 ± 0.064
0.537TyrMet: 0.537 ± 0.024
1.047TyrAsn: 1.047 ± 0.037
1.376TyrPro: 1.376 ± 0.037
2.274TyrGln: 2.274 ± 0.052
1.837TyrArg: 1.837 ± 0.044
1.82TyrSer: 1.82 ± 0.052
1.538TyrThr: 1.538 ± 0.053
1.981TyrVal: 1.981 ± 0.043
0.511TyrTrp: 0.511 ± 0.024
1.065TyrTyr: 1.065 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3309 proteins (1093339 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski