Amino acid dipepetide frequency for Mycolicibacter sinensis (strain JDM601) (Mycobacterium sinense)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.313AlaAla: 22.313 ± 0.245	0.943AlaCys: 0.943 ± 0.03	9.034AlaAsp: 9.034 ± 0.092	8.219AlaGlu: 8.219 ± 0.084	3.41AlaPhe: 3.41 ± 0.049	14.379AlaGly: 14.379 ± 0.296	2.586AlaHis: 2.586 ± 0.05	4.98AlaIle: 4.98 ± 0.067	2.96AlaLys: 2.96 ± 0.056	13.037AlaLeu: 13.037 ± 0.133	3.012AlaMet: 3.012 ± 0.051	2.631AlaAsn: 2.631 ± 0.052	6.565AlaPro: 6.565 ± 0.106	4.23AlaGln: 4.23 ± 0.06	8.66AlaArg: 8.66 ± 0.098	5.622AlaSer: 5.622 ± 0.067	7.569AlaThr: 7.569 ± 0.086	11.955AlaVal: 11.955 ± 0.13	1.642AlaTrp: 1.642 ± 0.041	2.26AlaTyr: 2.26 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.08CysAla: 1.08 ± 0.031	0.095CysCys: 0.095 ± 0.008	0.54CysAsp: 0.54 ± 0.021	0.399CysGlu: 0.399 ± 0.019	0.235CysPhe: 0.235 ± 0.012	0.921CysGly: 0.921 ± 0.03	0.189CysHis: 0.189 ± 0.01	0.26CysIle: 0.26 ± 0.013	0.132CysLys: 0.132 ± 0.01	0.619CysLeu: 0.619 ± 0.02	0.125CysMet: 0.125 ± 0.009	0.16CysAsn: 0.16 ± 0.011	0.493CysPro: 0.493 ± 0.02	0.222CysGln: 0.222 ± 0.013	0.627CysArg: 0.627 ± 0.021	0.443CysSer: 0.443 ± 0.02	0.458CysThr: 0.458 ± 0.02	0.61CysVal: 0.61 ± 0.021	0.137CysTrp: 0.137 ± 0.009	0.195CysTyr: 0.195 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.094AspAla: 8.094 ± 0.09	0.454AspCys: 0.454 ± 0.019	4.377AspAsp: 4.377 ± 0.069	3.916AspGlu: 3.916 ± 0.062	1.836AspPhe: 1.836 ± 0.037	6.674AspGly: 6.674 ± 0.193	1.438AspHis: 1.438 ± 0.04	2.573AspIle: 2.573 ± 0.049	1.215AspLys: 1.215 ± 0.033	5.808AspLeu: 5.808 ± 0.064	1.025AspMet: 1.025 ± 0.024	1.241AspAsn: 1.241 ± 0.033	4.53AspPro: 4.53 ± 0.059	1.743AspGln: 1.743 ± 0.038	4.387AspArg: 4.387 ± 0.063	2.784AspSer: 2.784 ± 0.053	3.325AspThr: 3.325 ± 0.053	5.06AspVal: 5.06 ± 0.064	1.011AspTrp: 1.011 ± 0.031	1.533AspTyr: 1.533 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.262GluAla: 6.262 ± 0.087	0.327GluCys: 0.327 ± 0.015	2.252GluAsp: 2.252 ± 0.046	2.365GluGlu: 2.365 ± 0.043	1.847GluPhe: 1.847 ± 0.036	3.084GluGly: 3.084 ± 0.05	1.62GluHis: 1.62 ± 0.039	2.599GluIle: 2.599 ± 0.049	1.197GluLys: 1.197 ± 0.035	6.859GluLeu: 6.859 ± 0.084	1.043GluMet: 1.043 ± 0.028	1.035GluAsn: 1.035 ± 0.029	3.094GluPro: 3.094 ± 0.059	2.4GluGln: 2.4 ± 0.04	4.244GluArg: 4.244 ± 0.062	2.585GluSer: 2.585 ± 0.041	2.548GluThr: 2.548 ± 0.046	4.296GluVal: 4.296 ± 0.057	0.713GluTrp: 0.713 ± 0.024	1.082GluTyr: 1.082 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.099PheAla: 4.099 ± 0.06	0.326PheCys: 0.326 ± 0.017	2.503PheAsp: 2.503 ± 0.051	1.518PheGlu: 1.518 ± 0.033	0.951PhePhe: 0.951 ± 0.03	3.576PheGly: 3.576 ± 0.051	0.611PheHis: 0.611 ± 0.022	1.063PheIle: 1.063 ± 0.026	0.511PheLys: 0.511 ± 0.02	2.452PheLeu: 2.452 ± 0.048	0.516PheMet: 0.516 ± 0.024	0.805PheAsn: 0.805 ± 0.024	1.454PhePro: 1.454 ± 0.036	0.669PheGln: 0.669 ± 0.021	1.602PheArg: 1.602 ± 0.04	1.655PheSer: 1.655 ± 0.035	2.089PheThr: 2.089 ± 0.042	2.333PheVal: 2.333 ± 0.038	0.43PheTrp: 0.43 ± 0.019	0.732PheTyr: 0.732 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.631GlyAla: 11.631 ± 0.262	0.837GlyCys: 0.837 ± 0.029	5.639GlyAsp: 5.639 ± 0.151	4.631GlyGlu: 4.631 ± 0.062	3.082GlyPhe: 3.082 ± 0.048	10.706GlyGly: 10.706 ± 0.707	2.101GlyHis: 2.101 ± 0.046	4.149GlyIle: 4.149 ± 0.062	2.275GlyLys: 2.275 ± 0.046	8.833GlyLeu: 8.833 ± 0.099	2.295GlyMet: 2.295 ± 0.039	2.547GlyAsn: 2.547 ± 0.17	4.801GlyPro: 4.801 ± 0.062	2.987GlyGln: 2.987 ± 0.053	6.524GlyArg: 6.524 ± 0.071	5.732GlySer: 5.732 ± 0.116	5.718GlyThr: 5.718 ± 0.15	7.822GlyVal: 7.822 ± 0.094	1.677GlyTrp: 1.677 ± 0.036	2.569GlyTyr: 2.569 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.483HisAla: 2.483 ± 0.043	0.227HisCys: 0.227 ± 0.014	1.356HisAsp: 1.356 ± 0.035	1.036HisGlu: 1.036 ± 0.029	0.69HisPhe: 0.69 ± 0.023	2.237HisGly: 2.237 ± 0.052	0.685HisHis: 0.685 ± 0.023	0.84HisIle: 0.84 ± 0.03	0.349HisLys: 0.349 ± 0.013	2.041HisLeu: 2.041 ± 0.045	0.315HisMet: 0.315 ± 0.017	0.506HisAsn: 0.506 ± 0.017	1.667HisPro: 1.667 ± 0.037	0.697HisGln: 0.697 ± 0.025	1.996HisArg: 1.996 ± 0.043	1.05HisSer: 1.05 ± 0.03	1.222HisThr: 1.222 ± 0.032	1.549HisVal: 1.549 ± 0.031	0.398HisTrp: 0.398 ± 0.018	0.573HisTyr: 0.573 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.222IleAla: 6.222 ± 0.079	0.398IleCys: 0.398 ± 0.017	3.408IleAsp: 3.408 ± 0.056	2.519IleGlu: 2.519 ± 0.047	1.017IlePhe: 1.017 ± 0.03	4.468IleGly: 4.468 ± 0.061	0.816IleHis: 0.816 ± 0.025	1.421IleIle: 1.421 ± 0.034	0.866IleLys: 0.866 ± 0.026	2.74IleLeu: 2.74 ± 0.047	0.624IleMet: 0.624 ± 0.025	1.186IleAsn: 1.186 ± 0.031	2.331IlePro: 2.331 ± 0.044	0.91IleGln: 0.91 ± 0.028	2.536IleArg: 2.536 ± 0.041	2.257IleSer: 2.257 ± 0.045	2.824IleThr: 2.824 ± 0.046	3.21IleVal: 3.21 ± 0.051	0.488IleTrp: 0.488 ± 0.021	0.795IleTyr: 0.795 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.533LysAla: 2.533 ± 0.043	0.102LysCys: 0.102 ± 0.009	0.963LysAsp: 0.963 ± 0.032	0.862LysGlu: 0.862 ± 0.028	0.588LysPhe: 0.588 ± 0.021	1.467LysGly: 1.467 ± 0.051	0.463LysHis: 0.463 ± 0.018	0.977LysIle: 0.977 ± 0.032	0.598LysLys: 0.598 ± 0.032	2.14LysLeu: 2.14 ± 0.045	0.478LysMet: 0.478 ± 0.02	0.47LysAsn: 0.47 ± 0.018	1.398LysPro: 1.398 ± 0.04	0.684LysGln: 0.684 ± 0.025	1.507LysArg: 1.507 ± 0.039	1.111LysSer: 1.111 ± 0.028	1.288LysThr: 1.288 ± 0.038	1.82LysVal: 1.82 ± 0.039	0.277LysTrp: 0.277 ± 0.015	0.443LysTyr: 0.443 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.556LeuAla: 14.556 ± 0.13	0.802LeuCys: 0.802 ± 0.026	6.364LeuAsp: 6.364 ± 0.081	4.247LeuGlu: 4.247 ± 0.061	2.702LeuPhe: 2.702 ± 0.052	8.941LeuGly: 8.941 ± 0.087	2.057LeuHis: 2.057 ± 0.039	4.008LeuIle: 4.008 ± 0.055	1.66LeuLys: 1.66 ± 0.043	9.826LeuLeu: 9.826 ± 0.105	1.743LeuMet: 1.743 ± 0.037	2.14LeuAsn: 2.14 ± 0.045	5.953LeuPro: 5.953 ± 0.072	2.639LeuGln: 2.639 ± 0.044	7.622LeuArg: 7.622 ± 0.096	5.489LeuSer: 5.489 ± 0.072	6.277LeuThr: 6.277 ± 0.07	8.063LeuVal: 8.063 ± 0.087	1.174LeuTrp: 1.174 ± 0.032	1.6LeuTyr: 1.6 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.756MetAla: 2.756 ± 0.05	0.176MetCys: 0.176 ± 0.011	0.922MetAsp: 0.922 ± 0.027	0.662MetGlu: 0.662 ± 0.022	0.667MetPhe: 0.667 ± 0.023	1.549MetGly: 1.549 ± 0.035	0.415MetHis: 0.415 ± 0.015	0.909MetIle: 0.909 ± 0.024	0.421MetLys: 0.421 ± 0.016	2.227MetLeu: 2.227 ± 0.046	0.469MetMet: 0.469 ± 0.02	0.489MetAsn: 0.489 ± 0.017	1.219MetPro: 1.219 ± 0.03	0.588MetGln: 0.588 ± 0.022	1.421MetArg: 1.421 ± 0.029	1.468MetSer: 1.468 ± 0.033	1.726MetThr: 1.726 ± 0.032	1.645MetVal: 1.645 ± 0.035	0.295MetTrp: 0.295 ± 0.016	0.348MetTyr: 0.348 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.741AsnAla: 2.741 ± 0.052	0.194AsnCys: 0.194 ± 0.012	1.149AsnAsp: 1.149 ± 0.026	0.962AsnGlu: 0.962 ± 0.026	0.686AsnPhe: 0.686 ± 0.022	2.699AsnGly: 2.699 ± 0.169	0.467AsnHis: 0.467 ± 0.02	0.951AsnIle: 0.951 ± 0.029	0.418AsnLys: 0.418 ± 0.019	2.052AsnLeu: 2.052 ± 0.05	0.438AsnMet: 0.438 ± 0.02	0.556AsnAsn: 0.556 ± 0.019	1.764AsnPro: 1.764 ± 0.037	0.636AsnGln: 0.636 ± 0.026	1.536AsnArg: 1.536 ± 0.036	1.098AsnSer: 1.098 ± 0.029	1.344AsnThr: 1.344 ± 0.037	1.665AsnVal: 1.665 ± 0.035	0.383AsnTrp: 0.383 ± 0.018	0.551AsnTyr: 0.551 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.948ProAla: 7.948 ± 0.113	0.297ProCys: 0.297 ± 0.014	4.513ProAsp: 4.513 ± 0.059	3.755ProGlu: 3.755 ± 0.059	1.62ProPhe: 1.62 ± 0.036	6.096ProGly: 6.096 ± 0.085	1.179ProHis: 1.179 ± 0.033	2.092ProIle: 2.092 ± 0.041	1.211ProLys: 1.211 ± 0.034	4.927ProLeu: 4.927 ± 0.061	1.238ProMet: 1.238 ± 0.031	1.211ProAsn: 1.211 ± 0.031	3.781ProPro: 3.781 ± 0.098	1.824ProGln: 1.824 ± 0.036	3.448ProArg: 3.448 ± 0.054	2.799ProSer: 2.799 ± 0.058	3.19ProThr: 3.19 ± 0.051	5.08ProVal: 5.08 ± 0.075	0.832ProTrp: 0.832 ± 0.025	1.183ProTyr: 1.183 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.92GlnAla: 3.92 ± 0.062	0.229GlnCys: 0.229 ± 0.013	1.227GlnAsp: 1.227 ± 0.032	1.024GlnGlu: 1.024 ± 0.028	0.94GlnPhe: 0.94 ± 0.026	2.044GlnGly: 2.044 ± 0.045	0.81GlnHis: 0.81 ± 0.024	1.51GlnIle: 1.51 ± 0.034	0.545GlnLys: 0.545 ± 0.019	3.879GlnLeu: 3.879 ± 0.065	0.601GlnMet: 0.601 ± 0.02	0.601GlnAsn: 0.601 ± 0.023	1.914GlnPro: 1.914 ± 0.042	1.454GlnGln: 1.454 ± 0.038	2.961GlnArg: 2.961 ± 0.048	1.347GlnSer: 1.347 ± 0.034	1.592GlnThr: 1.592 ± 0.03	2.655GlnVal: 2.655 ± 0.046	0.563GlnTrp: 0.563 ± 0.019	0.615GlnTyr: 0.615 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.427ArgAla: 8.427 ± 0.106	0.616ArgCys: 0.616 ± 0.022	4.207ArgAsp: 4.207 ± 0.061	3.667ArgGlu: 3.667 ± 0.053	2.418ArgPhe: 2.418 ± 0.045	5.296ArgGly: 5.296 ± 0.072	1.768ArgHis: 1.768 ± 0.036	3.296ArgIle: 3.296 ± 0.047	1.444ArgLys: 1.444 ± 0.035	7.614ArgLeu: 7.614 ± 0.101	1.765ArgMet: 1.765 ± 0.037	1.633ArgAsn: 1.633 ± 0.039	3.989ArgPro: 3.989 ± 0.066	2.265ArgGln: 2.265 ± 0.041	6.675ArgArg: 6.675 ± 0.095	3.933ArgSer: 3.933 ± 0.056	3.902ArgThr: 3.902 ± 0.057	5.431ArgVal: 5.431 ± 0.075	1.372ArgTrp: 1.372 ± 0.036	1.93ArgTyr: 1.93 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.944SerAla: 6.944 ± 0.076	0.402SerCys: 0.402 ± 0.021	3.073SerAsp: 3.073 ± 0.049	2.45SerGlu: 2.45 ± 0.047	1.591SerPhe: 1.591 ± 0.035	5.956SerGly: 5.956 ± 0.114	1.011SerHis: 1.011 ± 0.03	2.003SerIle: 2.003 ± 0.04	1.017SerLys: 1.017 ± 0.029	4.483SerLeu: 4.483 ± 0.062	1.264SerMet: 1.264 ± 0.032	1.01SerAsn: 1.01 ± 0.027	2.981SerPro: 2.981 ± 0.044	1.469SerGln: 1.469 ± 0.03	3.536SerArg: 3.536 ± 0.051	2.892SerSer: 2.892 ± 0.052	3.222SerThr: 3.222 ± 0.055	4.225SerVal: 4.225 ± 0.056	0.933SerTrp: 0.933 ± 0.023	1.287SerTyr: 1.287 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	8.394ThrAla: 8.394 ± 0.09	0.397ThrCys: 0.397 ± 0.016	3.797ThrAsp: 3.797 ± 0.055	3.21ThrGlu: 3.21 ± 0.052	1.686ThrPhe: 1.686 ± 0.036	6.52ThrGly: 6.52 ± 0.136	1.118ThrHis: 1.118 ± 0.029	2.296ThrIle: 2.296 ± 0.053	1.124ThrLys: 1.124 ± 0.033	5.441ThrLeu: 5.441 ± 0.065	1.211ThrMet: 1.211 ± 0.032	1.217ThrAsn: 1.217 ± 0.034	3.657ThrPro: 3.657 ± 0.064	1.474ThrGln: 1.474 ± 0.032	3.537ThrArg: 3.537 ± 0.056	2.903ThrSer: 2.903 ± 0.059	3.753ThrThr: 3.753 ± 0.102	5.846ThrVal: 5.846 ± 0.067	0.783ThrTrp: 0.783 ± 0.023	1.162ThrTyr: 1.162 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	11.586ValAla: 11.586 ± 0.127	0.722ValCys: 0.722 ± 0.024	5.513ValAsp: 5.513 ± 0.067	4.322ValGlu: 4.322 ± 0.059	2.61ValPhe: 2.61 ± 0.05	6.904ValGly: 6.904 ± 0.082	1.723ValHis: 1.723 ± 0.033	3.856ValIle: 3.856 ± 0.052	1.595ValLys: 1.595 ± 0.04	8.648ValLeu: 8.648 ± 0.1	1.575ValMet: 1.575 ± 0.037	1.976ValAsn: 1.976 ± 0.04	4.518ValPro: 4.518 ± 0.061	2.102ValGln: 2.102 ± 0.04	5.71ValArg: 5.71 ± 0.078	4.569ValSer: 4.569 ± 0.06	5.428ValThr: 5.428 ± 0.069	8.001ValVal: 8.001 ± 0.094	0.962ValTrp: 0.962 ± 0.031	1.57ValTyr: 1.57 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.577TrpAla: 1.577 ± 0.039	0.172TrpCys: 0.172 ± 0.011	0.797TrpAsp: 0.797 ± 0.028	0.666TrpGlu: 0.666 ± 0.022	0.516TrpPhe: 0.516 ± 0.021	0.985TrpGly: 0.985 ± 0.029	0.364TrpHis: 0.364 ± 0.016	0.608TrpIle: 0.608 ± 0.02	0.282TrpLys: 0.282 ± 0.015	1.777TrpLeu: 1.777 ± 0.04	0.355TrpMet: 0.355 ± 0.013	0.402TrpAsn: 0.402 ± 0.019	0.842TrpPro: 0.842 ± 0.026	0.679TrpGln: 0.679 ± 0.021	1.258TrpArg: 1.258 ± 0.033	0.922TrpSer: 0.922 ± 0.028	0.857TrpThr: 0.857 ± 0.026	1.08TrpVal: 1.08 ± 0.03	0.344TrpTrp: 0.344 ± 0.016	0.302TrpTyr: 0.302 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.44TyrAla: 2.44 ± 0.039	0.225TyrCys: 0.225 ± 0.014	1.39TyrAsp: 1.39 ± 0.036	1.023TyrGlu: 1.023 ± 0.027	0.799TyrPhe: 0.799 ± 0.025	2.057TyrGly: 2.057 ± 0.039	0.495TyrHis: 0.495 ± 0.02	0.644TyrIle: 0.644 ± 0.021	0.348TyrLys: 0.348 ± 0.017	2.463TyrLeu: 2.463 ± 0.046	0.282TyrMet: 0.282 ± 0.016	0.473TyrAsn: 0.473 ± 0.02	1.273TyrPro: 1.273 ± 0.031	0.759TyrGln: 0.759 ± 0.024	1.863TyrArg: 1.863 ± 0.041	1.091TyrSer: 1.091 ± 0.031	1.194TyrThr: 1.194 ± 0.026	1.542TyrVal: 1.542 ± 0.034	0.371TyrTrp: 0.371 ± 0.015	0.496TyrTyr: 0.496 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4332 proteins (1398531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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