Amino acid dipepetide frequency for Roseovarius aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.816AlaAla: 13.816 ± 0.146
1.143AlaCys: 1.143 ± 0.033
6.743AlaAsp: 6.743 ± 0.081
7.353AlaGlu: 7.353 ± 0.082
4.103AlaPhe: 4.103 ± 0.06
9.345AlaGly: 9.345 ± 0.094
2.301AlaHis: 2.301 ± 0.043
5.874AlaIle: 5.874 ± 0.076
3.808AlaLys: 3.808 ± 0.052
12.366AlaLeu: 12.366 ± 0.124
3.519AlaMet: 3.519 ± 0.051
2.918AlaAsn: 2.918 ± 0.039
4.936AlaPro: 4.936 ± 0.061
4.099AlaGln: 4.099 ± 0.062
7.594AlaArg: 7.594 ± 0.089
5.631AlaSer: 5.631 ± 0.061
5.636AlaThr: 5.636 ± 0.066
7.434AlaVal: 7.434 ± 0.078
1.308AlaTrp: 1.308 ± 0.033
2.573AlaTyr: 2.573 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.099CysAla: 1.099 ± 0.027
0.147CysCys: 0.147 ± 0.01
0.684CysAsp: 0.684 ± 0.022
0.525CysGlu: 0.525 ± 0.017
0.409CysPhe: 0.409 ± 0.016
0.996CysGly: 0.996 ± 0.028
0.307CysHis: 0.307 ± 0.016
0.488CysIle: 0.488 ± 0.019
0.284CysLys: 0.284 ± 0.014
0.97CysLeu: 0.97 ± 0.028
0.213CysMet: 0.213 ± 0.011
0.286CysAsn: 0.286 ± 0.014
0.548CysPro: 0.548 ± 0.021
0.293CysGln: 0.293 ± 0.017
0.606CysArg: 0.606 ± 0.02
0.587CysSer: 0.587 ± 0.018
0.516CysThr: 0.516 ± 0.021
0.719CysVal: 0.719 ± 0.024
0.136CysTrp: 0.136 ± 0.012
0.287CysTyr: 0.287 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
6.854AspAla: 6.854 ± 0.078
0.584AspCys: 0.584 ± 0.022
3.683AspAsp: 3.683 ± 0.069
3.757AspGlu: 3.757 ± 0.058
2.449AspPhe: 2.449 ± 0.041
5.54AspGly: 5.54 ± 0.099
1.514AspHis: 1.514 ± 0.033
3.585AspIle: 3.585 ± 0.051
2.017AspLys: 2.017 ± 0.036
6.384AspLeu: 6.384 ± 0.065
1.725AspMet: 1.725 ± 0.036
1.602AspAsn: 1.602 ± 0.036
3.535AspPro: 3.535 ± 0.046
2.199AspGln: 2.199 ± 0.045
4.025AspArg: 4.025 ± 0.066
2.335AspSer: 2.335 ± 0.041
3.145AspThr: 3.145 ± 0.061
4.327AspVal: 4.327 ± 0.055
1.145AspTrp: 1.145 ± 0.031
1.655AspTyr: 1.655 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
7.369GluAla: 7.369 ± 0.075
0.446GluCys: 0.446 ± 0.018
3.394GluAsp: 3.394 ± 0.055
3.533GluGlu: 3.533 ± 0.048
2.2GluPhe: 2.2 ± 0.037
4.408GluGly: 4.408 ± 0.07
1.246GluHis: 1.246 ± 0.031
3.845GluIle: 3.845 ± 0.055
2.603GluLys: 2.603 ± 0.047
5.57GluLeu: 5.57 ± 0.073
1.971GluMet: 1.971 ± 0.036
2.132GluAsn: 2.132 ± 0.04
2.547GluPro: 2.547 ± 0.048
1.996GluGln: 1.996 ± 0.036
4.055GluArg: 4.055 ± 0.054
2.337GluSer: 2.337 ± 0.045
3.842GluThr: 3.842 ± 0.061
4.169GluVal: 4.169 ± 0.059
0.748GluTrp: 0.748 ± 0.024
1.184GluTyr: 1.184 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.171PheAla: 4.171 ± 0.059
0.536PheCys: 0.536 ± 0.019
3.049PheAsp: 3.049 ± 0.045
2.409PheGlu: 2.409 ± 0.04
1.544PhePhe: 1.544 ± 0.035
3.688PheGly: 3.688 ± 0.059
0.79PheHis: 0.79 ± 0.025
1.849PheIle: 1.849 ± 0.04
1.128PheLys: 1.128 ± 0.026
3.553PheLeu: 3.553 ± 0.052
0.93PheMet: 0.93 ± 0.028
1.196PheAsn: 1.196 ± 0.032
1.577PhePro: 1.577 ± 0.032
1.159PheGln: 1.159 ± 0.032
2.16PheArg: 2.16 ± 0.04
2.408PheSer: 2.408 ± 0.045
2.159PheThr: 2.159 ± 0.039
2.765PheVal: 2.765 ± 0.048
0.595PheTrp: 0.595 ± 0.019
1.057PheTyr: 1.057 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
8.663GlyAla: 8.663 ± 0.087
0.931GlyCys: 0.931 ± 0.026
4.828GlyAsp: 4.828 ± 0.074
4.601GlyGlu: 4.601 ± 0.067
3.71GlyPhe: 3.71 ± 0.066
7.062GlyGly: 7.062 ± 0.103
1.966GlyHis: 1.966 ± 0.034
4.584GlyIle: 4.584 ± 0.065
3.42GlyLys: 3.42 ± 0.05
8.56GlyLeu: 8.56 ± 0.09
2.569GlyMet: 2.569 ± 0.043
2.458GlyAsn: 2.458 ± 0.06
3.374GlyPro: 3.374 ± 0.049
3.11GlyGln: 3.11 ± 0.045
5.085GlyArg: 5.085 ± 0.063
4.402GlySer: 4.402 ± 0.064
4.494GlyThr: 4.494 ± 0.067
6.186GlyVal: 6.186 ± 0.07
1.441GlyTrp: 1.441 ± 0.035
2.394GlyTyr: 2.394 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.338HisAla: 2.338 ± 0.042
0.286HisCys: 0.286 ± 0.013
1.412HisAsp: 1.412 ± 0.038
1.215HisGlu: 1.215 ± 0.028
0.935HisPhe: 0.935 ± 0.026
1.917HisGly: 1.917 ± 0.041
0.625HisHis: 0.625 ± 0.026
1.106HisIle: 1.106 ± 0.031
0.642HisLys: 0.642 ± 0.021
2.196HisLeu: 2.196 ± 0.045
0.602HisMet: 0.602 ± 0.022
0.573HisAsn: 0.573 ± 0.021
1.39HisPro: 1.39 ± 0.031
0.734HisGln: 0.734 ± 0.021
1.39HisArg: 1.39 ± 0.03
1.089HisSer: 1.089 ± 0.029
0.934HisThr: 0.934 ± 0.026
1.507HisVal: 1.507 ± 0.033
0.392HisTrp: 0.392 ± 0.016
0.628HisTyr: 0.628 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.844IleAla: 6.844 ± 0.08
0.753IleCys: 0.753 ± 0.023
3.744IleAsp: 3.744 ± 0.049
3.828IleGlu: 3.828 ± 0.051
1.997IlePhe: 1.997 ± 0.048
4.947IleGly: 4.947 ± 0.069
1.007IleHis: 1.007 ± 0.026
2.589IleIle: 2.589 ± 0.048
1.727IleLys: 1.727 ± 0.037
4.92IleLeu: 4.92 ± 0.075
1.218IleMet: 1.218 ± 0.031
1.675IleAsn: 1.675 ± 0.037
2.463IlePro: 2.463 ± 0.044
1.345IleGln: 1.345 ± 0.031
3.39IleArg: 3.39 ± 0.054
3.619IleSer: 3.619 ± 0.058
3.108IleThr: 3.108 ± 0.047
3.904IleVal: 3.904 ± 0.059
0.829IleTrp: 0.829 ± 0.025
1.288IleTyr: 1.288 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
3.935LysAla: 3.935 ± 0.057
0.236LysCys: 0.236 ± 0.014
1.925LysAsp: 1.925 ± 0.042
1.779LysGlu: 1.779 ± 0.042
1.179LysPhe: 1.179 ± 0.032
2.8LysGly: 2.8 ± 0.049
0.791LysHis: 0.791 ± 0.024
2.002LysIle: 2.002 ± 0.039
1.493LysLys: 1.493 ± 0.037
3.496LysLeu: 3.496 ± 0.049
0.955LysMet: 0.955 ± 0.026
1.042LysAsn: 1.042 ± 0.026
2.037LysPro: 2.037 ± 0.038
1.104LysGln: 1.104 ± 0.028
2.43LysArg: 2.43 ± 0.043
2.226LysSer: 2.226 ± 0.042
2.209LysThr: 2.209 ± 0.044
2.415LysVal: 2.415 ± 0.041
0.468LysTrp: 0.468 ± 0.019
0.79LysTyr: 0.79 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
11.513LeuAla: 11.513 ± 0.109
1.015LeuCys: 1.015 ± 0.025
5.843LeuAsp: 5.843 ± 0.065
5.575LeuGlu: 5.575 ± 0.07
3.567LeuPhe: 3.567 ± 0.064
7.995LeuGly: 7.995 ± 0.086
1.966LeuHis: 1.966 ± 0.039
5.621LeuIle: 5.621 ± 0.076
3.71LeuLys: 3.71 ± 0.052
8.776LeuLeu: 8.776 ± 0.109
2.667LeuMet: 2.667 ± 0.045
3.1LeuAsn: 3.1 ± 0.048
5.234LeuPro: 5.234 ± 0.063
2.911LeuGln: 2.911 ± 0.056
6.561LeuArg: 6.561 ± 0.073
7.001LeuSer: 7.001 ± 0.082
5.985LeuThr: 5.985 ± 0.061
6.572LeuVal: 6.572 ± 0.083
1.28LeuTrp: 1.28 ± 0.034
2.0LeuTyr: 2.0 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
3.295MetAla: 3.295 ± 0.048
0.247MetCys: 0.247 ± 0.011
1.404MetAsp: 1.404 ± 0.034
1.307MetGlu: 1.307 ± 0.03
0.812MetPhe: 0.812 ± 0.025
2.273MetGly: 2.273 ± 0.039
0.519MetHis: 0.519 ± 0.02
1.67MetIle: 1.67 ± 0.037
1.184MetLys: 1.184 ± 0.029
2.709MetLeu: 2.709 ± 0.053
0.793MetMet: 0.793 ± 0.026
0.923MetAsn: 0.923 ± 0.026
1.514MetPro: 1.514 ± 0.027
1.075MetGln: 1.075 ± 0.026
1.883MetArg: 1.883 ± 0.037
1.888MetSer: 1.888 ± 0.035
1.968MetThr: 1.968 ± 0.033
1.913MetVal: 1.913 ± 0.038
0.247MetTrp: 0.247 ± 0.012
0.392MetTyr: 0.392 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.361AsnAla: 3.361 ± 0.046
0.337AsnCys: 0.337 ± 0.016
1.687AsnAsp: 1.687 ± 0.039
1.525AsnGlu: 1.525 ± 0.036
1.121AsnPhe: 1.121 ± 0.03
2.594AsnGly: 2.594 ± 0.056
0.618AsnHis: 0.618 ± 0.025
1.633AsnIle: 1.633 ± 0.034
0.866AsnLys: 0.866 ± 0.027
2.874AsnLeu: 2.874 ± 0.045
0.784AsnMet: 0.784 ± 0.025
0.853AsnAsn: 0.853 ± 0.028
1.983AsnPro: 1.983 ± 0.038
0.912AsnGln: 0.912 ± 0.025
1.869AsnArg: 1.869 ± 0.037
1.528AsnSer: 1.528 ± 0.032
1.59AsnThr: 1.59 ± 0.034
2.087AsnVal: 2.087 ± 0.034
0.561AsnTrp: 0.561 ± 0.02
0.73AsnTyr: 0.73 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
4.798ProAla: 4.798 ± 0.063
0.402ProCys: 0.402 ± 0.019
4.08ProAsp: 4.08 ± 0.055
3.98ProGlu: 3.98 ± 0.053
1.937ProPhe: 1.937 ± 0.037
4.259ProGly: 4.259 ± 0.068
1.098ProHis: 1.098 ± 0.03
2.317ProIle: 2.317 ± 0.044
1.805ProLys: 1.805 ± 0.04
4.382ProLeu: 4.382 ± 0.06
1.261ProMet: 1.261 ± 0.035
1.43ProAsn: 1.43 ± 0.034
2.082ProPro: 2.082 ± 0.042
1.58ProGln: 1.58 ± 0.039
2.505ProArg: 2.505 ± 0.047
2.493ProSer: 2.493 ± 0.044
2.345ProThr: 2.345 ± 0.036
4.084ProVal: 4.084 ± 0.053
0.639ProTrp: 0.639 ± 0.021
1.188ProTyr: 1.188 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.83GlnAla: 3.83 ± 0.058
0.257GlnCys: 0.257 ± 0.014
1.684GlnAsp: 1.684 ± 0.042
1.786GlnGlu: 1.786 ± 0.036
1.198GlnPhe: 1.198 ± 0.028
2.549GlnGly: 2.549 ± 0.042
0.704GlnHis: 0.704 ± 0.022
2.185GlnIle: 2.185 ± 0.042
1.198GlnLys: 1.198 ± 0.03
3.052GlnLeu: 3.052 ± 0.045
1.157GlnMet: 1.157 ± 0.032
1.074GlnAsn: 1.074 ± 0.028
1.582GlnPro: 1.582 ± 0.034
1.233GlnGln: 1.233 ± 0.04
2.195GlnArg: 2.195 ± 0.038
2.015GlnSer: 2.015 ± 0.04
1.908GlnThr: 1.908 ± 0.037
2.391GlnVal: 2.391 ± 0.043
0.415GlnTrp: 0.415 ± 0.017
0.634GlnTyr: 0.634 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
6.975ArgAla: 6.975 ± 0.078
0.548ArgCys: 0.548 ± 0.021
4.249ArgAsp: 4.249 ± 0.064
3.753ArgGlu: 3.753 ± 0.046
2.499ArgPhe: 2.499 ± 0.047
4.196ArgGly: 4.196 ± 0.061
1.634ArgHis: 1.634 ± 0.034
3.794ArgIle: 3.794 ± 0.055
2.457ArgLys: 2.457 ± 0.047
6.788ArgLeu: 6.788 ± 0.082
1.825ArgMet: 1.825 ± 0.037
1.99ArgAsn: 1.99 ± 0.043
2.908ArgPro: 2.908 ± 0.047
2.402ArgGln: 2.402 ± 0.044
4.608ArgArg: 4.608 ± 0.072
3.349ArgSer: 3.349 ± 0.048
2.875ArgThr: 2.875 ± 0.046
4.414ArgVal: 4.414 ± 0.058
0.891ArgTrp: 0.891 ± 0.024
1.616ArgTyr: 1.616 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.951SerAla: 5.951 ± 0.057
0.52SerCys: 0.52 ± 0.02
3.839SerAsp: 3.839 ± 0.055
3.239SerGlu: 3.239 ± 0.044
2.474SerPhe: 2.474 ± 0.045
5.603SerGly: 5.603 ± 0.075
1.215SerHis: 1.215 ± 0.031
2.865SerIle: 2.865 ± 0.051
1.857SerLys: 1.857 ± 0.038
5.23SerLeu: 5.23 ± 0.073
1.441SerMet: 1.441 ± 0.036
1.641SerAsn: 1.641 ± 0.028
2.625SerPro: 2.625 ± 0.045
1.772SerGln: 1.772 ± 0.042
3.3SerArg: 3.3 ± 0.056
2.879SerSer: 2.879 ± 0.047
2.753SerThr: 2.753 ± 0.041
4.014SerVal: 4.014 ± 0.056
0.788SerTrp: 0.788 ± 0.023
1.428SerTyr: 1.428 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
5.811ThrAla: 5.811 ± 0.057
0.565ThrCys: 0.565 ± 0.021
3.288ThrAsp: 3.288 ± 0.055
3.004ThrGlu: 3.004 ± 0.046
2.048ThrPhe: 2.048 ± 0.037
5.323ThrGly: 5.323 ± 0.068
1.214ThrHis: 1.214 ± 0.034
2.984ThrIle: 2.984 ± 0.046
1.67ThrLys: 1.67 ± 0.038
5.784ThrLeu: 5.784 ± 0.07
1.345ThrMet: 1.345 ± 0.03
1.454ThrAsn: 1.454 ± 0.034
3.246ThrPro: 3.246 ± 0.055
1.646ThrGln: 1.646 ± 0.036
3.455ThrArg: 3.455 ± 0.048
3.03ThrSer: 3.03 ± 0.049
2.894ThrThr: 2.894 ± 0.05
3.936ThrVal: 3.936 ± 0.053
0.693ThrTrp: 0.693 ± 0.022
1.41ThrTyr: 1.41 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
8.012ValAla: 8.012 ± 0.087
0.71ValCys: 0.71 ± 0.024
4.08ValAsp: 4.08 ± 0.055
4.364ValGlu: 4.364 ± 0.06
2.896ValPhe: 2.896 ± 0.047
5.232ValGly: 5.232 ± 0.064
1.375ValHis: 1.375 ± 0.029
4.372ValIle: 4.372 ± 0.06
2.265ValLys: 2.265 ± 0.046
7.172ValLeu: 7.172 ± 0.083
2.092ValMet: 2.092 ± 0.04
2.046ValAsn: 2.046 ± 0.04
3.258ValPro: 3.258 ± 0.043
2.051ValGln: 2.051 ± 0.042
4.031ValArg: 4.031 ± 0.05
4.436ValSer: 4.436 ± 0.066
4.557ValThr: 4.557 ± 0.071
5.478ValVal: 5.478 ± 0.076
0.94ValTrp: 0.94 ± 0.029
1.455ValTyr: 1.455 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.342TrpAla: 1.342 ± 0.03
0.159TrpCys: 0.159 ± 0.01
0.76TrpAsp: 0.76 ± 0.025
0.715TrpGlu: 0.715 ± 0.023
0.591TrpPhe: 0.591 ± 0.02
1.004TrpGly: 1.004 ± 0.027
0.398TrpHis: 0.398 ± 0.018
0.8TrpIle: 0.8 ± 0.026
0.483TrpLys: 0.483 ± 0.019
1.661TrpLeu: 1.661 ± 0.042
0.421TrpMet: 0.421 ± 0.018
0.456TrpAsn: 0.456 ± 0.017
0.698TrpPro: 0.698 ± 0.02
0.629TrpGln: 0.629 ± 0.023
0.991TrpArg: 0.991 ± 0.028
0.825TrpSer: 0.825 ± 0.024
0.732TrpThr: 0.732 ± 0.022
0.923TrpVal: 0.923 ± 0.029
0.204TrpTrp: 0.204 ± 0.013
0.337TrpTyr: 0.337 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.525TyrAla: 2.525 ± 0.045
0.278TyrCys: 0.278 ± 0.014
1.683TyrAsp: 1.683 ± 0.037
1.349TyrGlu: 1.349 ± 0.034
1.053TyrPhe: 1.053 ± 0.027
2.106TyrGly: 2.106 ± 0.041
0.623TyrHis: 0.623 ± 0.022
1.034TyrIle: 1.034 ± 0.028
0.696TyrLys: 0.696 ± 0.024
2.449TyrLeu: 2.449 ± 0.042
0.525TyrMet: 0.525 ± 0.023
0.664TyrAsn: 0.664 ± 0.02
1.127TyrPro: 1.127 ± 0.03
0.796TyrGln: 0.796 ± 0.025
1.638TyrArg: 1.638 ± 0.034
1.359TyrSer: 1.359 ± 0.037
1.152TyrThr: 1.152 ± 0.03
1.585TyrVal: 1.585 ± 0.035
0.406TyrTrp: 0.406 ± 0.016
0.632TyrTyr: 0.632 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4594 proteins (1411738 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski