Amino acid dipepetide frequency for Streptococcus phage Javan349

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.041AlaAla: 4.041 ± 1.006
0.172AlaCys: 0.172 ± 0.111
4.384AlaAsp: 4.384 ± 0.741
4.384AlaGlu: 4.384 ± 0.686
2.493AlaPhe: 2.493 ± 0.453
4.728AlaGly: 4.728 ± 0.657
0.602AlaHis: 0.602 ± 0.2
4.47AlaIle: 4.47 ± 0.876
5.588AlaLys: 5.588 ± 1.113
6.104AlaLeu: 6.104 ± 0.794
2.149AlaMet: 2.149 ± 0.416
3.955AlaAsn: 3.955 ± 0.652
1.805AlaPro: 1.805 ± 0.396
2.235AlaGln: 2.235 ± 0.357
3.181AlaArg: 3.181 ± 0.498
5.244AlaSer: 5.244 ± 0.893
4.298AlaThr: 4.298 ± 0.554
4.127AlaVal: 4.127 ± 0.803
0.86AlaTrp: 0.86 ± 0.356
2.235AlaTyr: 2.235 ± 0.435
0.0AlaXaa: 0.0 ± 0.0
Cys
0.172CysAla: 0.172 ± 0.113
0.086CysCys: 0.086 ± 0.076
0.086CysAsp: 0.086 ± 0.098
0.602CysGlu: 0.602 ± 0.295
0.086CysPhe: 0.086 ± 0.084
0.602CysGly: 0.602 ± 0.43
0.258CysHis: 0.258 ± 0.158
0.602CysIle: 0.602 ± 0.286
0.774CysLys: 0.774 ± 0.254
0.516CysLeu: 0.516 ± 0.221
0.086CysMet: 0.086 ± 0.093
0.086CysAsn: 0.086 ± 0.104
0.172CysPro: 0.172 ± 0.119
0.43CysGln: 0.43 ± 0.206
0.172CysArg: 0.172 ± 0.12
0.344CysSer: 0.344 ± 0.172
0.258CysThr: 0.258 ± 0.149
0.086CysVal: 0.086 ± 0.078
0.086CysTrp: 0.086 ± 0.1
0.258CysTyr: 0.258 ± 0.194
0.0CysXaa: 0.0 ± 0.0
Asp
2.923AspAla: 2.923 ± 0.521
0.516AspCys: 0.516 ± 0.275
3.353AspAsp: 3.353 ± 0.558
4.9AspGlu: 4.9 ± 0.738
3.267AspPhe: 3.267 ± 0.554
5.674AspGly: 5.674 ± 0.941
0.688AspHis: 0.688 ± 0.241
4.728AspIle: 4.728 ± 0.647
5.244AspLys: 5.244 ± 0.572
5.416AspLeu: 5.416 ± 0.625
1.805AspMet: 1.805 ± 0.412
2.493AspAsn: 2.493 ± 0.482
1.633AspPro: 1.633 ± 0.362
1.376AspGln: 1.376 ± 0.347
1.719AspArg: 1.719 ± 0.404
3.783AspSer: 3.783 ± 0.465
3.783AspThr: 3.783 ± 0.582
3.783AspVal: 3.783 ± 0.588
0.86AspTrp: 0.86 ± 0.299
3.181AspTyr: 3.181 ± 0.617
0.0AspXaa: 0.0 ± 0.0
Glu
5.158GluAla: 5.158 ± 0.96
0.688GluCys: 0.688 ± 0.361
3.869GluAsp: 3.869 ± 0.59
6.018GluGlu: 6.018 ± 1.02
4.127GluPhe: 4.127 ± 0.695
2.665GluGly: 2.665 ± 0.479
0.946GluHis: 0.946 ± 0.325
5.502GluIle: 5.502 ± 0.693
7.393GluLys: 7.393 ± 1.006
6.792GluLeu: 6.792 ± 0.55
2.149GluMet: 2.149 ± 0.632
4.986GluAsn: 4.986 ± 0.747
2.235GluPro: 2.235 ± 0.435
2.493GluGln: 2.493 ± 0.57
3.611GluArg: 3.611 ± 0.459
3.611GluSer: 3.611 ± 0.577
3.611GluThr: 3.611 ± 0.521
5.588GluVal: 5.588 ± 0.668
1.118GluTrp: 1.118 ± 0.281
2.063GluTyr: 2.063 ± 0.328
0.0GluXaa: 0.0 ± 0.0
Phe
3.267PheAla: 3.267 ± 0.549
0.344PheCys: 0.344 ± 0.194
4.127PheAsp: 4.127 ± 0.722
2.837PheGlu: 2.837 ± 0.604
1.805PhePhe: 1.805 ± 0.375
2.321PheGly: 2.321 ± 0.562
0.602PheHis: 0.602 ± 0.196
3.009PheIle: 3.009 ± 0.67
4.041PheLys: 4.041 ± 0.53
3.009PheLeu: 3.009 ± 0.684
1.547PheMet: 1.547 ± 0.389
2.149PheAsn: 2.149 ± 0.483
1.032PhePro: 1.032 ± 0.374
1.891PheGln: 1.891 ± 0.551
2.579PheArg: 2.579 ± 0.537
3.353PheSer: 3.353 ± 0.479
2.321PheThr: 2.321 ± 0.476
2.493PheVal: 2.493 ± 0.623
0.602PheTrp: 0.602 ± 0.25
1.719PheTyr: 1.719 ± 0.407
0.0PheXaa: 0.0 ± 0.0
Gly
3.439GlyAla: 3.439 ± 0.475
0.43GlyCys: 0.43 ± 0.212
3.525GlyAsp: 3.525 ± 0.537
4.213GlyGlu: 4.213 ± 0.564
4.127GlyPhe: 4.127 ± 0.951
3.869GlyGly: 3.869 ± 0.855
0.602GlyHis: 0.602 ± 0.415
4.384GlyIle: 4.384 ± 0.541
5.932GlyLys: 5.932 ± 0.945
6.104GlyLeu: 6.104 ± 0.874
1.547GlyMet: 1.547 ± 0.359
4.298GlyAsn: 4.298 ± 0.625
1.118GlyPro: 1.118 ± 0.3
2.665GlyGln: 2.665 ± 0.543
3.095GlyArg: 3.095 ± 0.586
4.213GlySer: 4.213 ± 0.914
3.697GlyThr: 3.697 ± 0.79
4.127GlyVal: 4.127 ± 0.591
1.633GlyTrp: 1.633 ± 0.552
2.407GlyTyr: 2.407 ± 0.542
0.0GlyXaa: 0.0 ± 0.0
His
0.946HisAla: 0.946 ± 0.27
0.172HisCys: 0.172 ± 0.127
1.376HisAsp: 1.376 ± 0.486
1.29HisGlu: 1.29 ± 0.379
0.43HisPhe: 0.43 ± 0.213
1.376HisGly: 1.376 ± 0.308
0.086HisHis: 0.086 ± 0.104
0.774HisIle: 0.774 ± 0.28
0.774HisLys: 0.774 ± 0.224
1.547HisLeu: 1.547 ± 0.402
0.344HisMet: 0.344 ± 0.158
0.946HisAsn: 0.946 ± 0.278
0.774HisPro: 0.774 ± 0.214
0.774HisGln: 0.774 ± 0.229
0.43HisArg: 0.43 ± 0.185
1.29HisSer: 1.29 ± 0.44
1.032HisThr: 1.032 ± 0.253
0.688HisVal: 0.688 ± 0.306
0.0HisTrp: 0.0 ± 0.0
0.258HisTyr: 0.258 ± 0.143
0.0HisXaa: 0.0 ± 0.0
Ile
4.728IleAla: 4.728 ± 0.998
0.516IleCys: 0.516 ± 0.219
4.814IleAsp: 4.814 ± 0.639
5.244IleGlu: 5.244 ± 0.763
3.439IlePhe: 3.439 ± 0.535
4.814IleGly: 4.814 ± 0.679
1.032IleHis: 1.032 ± 0.322
3.611IleIle: 3.611 ± 0.514
6.706IleLys: 6.706 ± 0.814
4.9IleLeu: 4.9 ± 0.696
1.032IleMet: 1.032 ± 0.335
3.353IleAsn: 3.353 ± 0.432
2.665IlePro: 2.665 ± 0.623
2.149IleGln: 2.149 ± 0.403
3.611IleArg: 3.611 ± 0.598
3.869IleSer: 3.869 ± 0.8
3.955IleThr: 3.955 ± 0.678
4.384IleVal: 4.384 ± 0.548
0.43IleTrp: 0.43 ± 0.227
1.719IleTyr: 1.719 ± 0.408
0.0IleXaa: 0.0 ± 0.0
Lys
6.792LysAla: 6.792 ± 1.294
0.172LysCys: 0.172 ± 0.113
4.814LysAsp: 4.814 ± 0.648
7.651LysGlu: 7.651 ± 0.806
2.923LysPhe: 2.923 ± 0.487
4.213LysGly: 4.213 ± 0.487
1.633LysHis: 1.633 ± 0.473
6.276LysIle: 6.276 ± 0.901
5.502LysLys: 5.502 ± 0.814
6.276LysLeu: 6.276 ± 0.634
2.751LysMet: 2.751 ± 0.412
5.76LysAsn: 5.76 ± 0.674
2.923LysPro: 2.923 ± 0.521
3.525LysGln: 3.525 ± 0.463
3.439LysArg: 3.439 ± 0.743
5.588LysSer: 5.588 ± 0.711
6.104LysThr: 6.104 ± 0.742
5.932LysVal: 5.932 ± 0.702
1.204LysTrp: 1.204 ± 0.34
2.407LysTyr: 2.407 ± 0.38
0.0LysXaa: 0.0 ± 0.0
Leu
6.62LeuAla: 6.62 ± 0.795
0.43LeuCys: 0.43 ± 0.215
5.33LeuAsp: 5.33 ± 0.776
6.964LeuGlu: 6.964 ± 0.844
3.439LeuPhe: 3.439 ± 0.727
5.674LeuGly: 5.674 ± 0.909
1.29LeuHis: 1.29 ± 0.352
4.556LeuIle: 4.556 ± 0.706
7.307LeuLys: 7.307 ± 0.8
6.62LeuLeu: 6.62 ± 1.087
1.891LeuMet: 1.891 ± 0.431
4.556LeuAsn: 4.556 ± 0.626
2.149LeuPro: 2.149 ± 0.439
2.063LeuGln: 2.063 ± 0.441
4.041LeuArg: 4.041 ± 0.489
5.76LeuSer: 5.76 ± 0.914
5.416LeuThr: 5.416 ± 0.865
3.869LeuVal: 3.869 ± 0.529
0.344LeuTrp: 0.344 ± 0.18
3.611LeuTyr: 3.611 ± 0.541
0.0LeuXaa: 0.0 ± 0.0
Met
1.891MetAla: 1.891 ± 0.318
0.0MetCys: 0.0 ± 0.0
1.29MetAsp: 1.29 ± 0.364
1.805MetGlu: 1.805 ± 0.432
0.602MetPhe: 0.602 ± 0.186
1.29MetGly: 1.29 ± 0.395
0.086MetHis: 0.086 ± 0.077
1.719MetIle: 1.719 ± 0.423
1.805MetLys: 1.805 ± 0.358
1.805MetLeu: 1.805 ± 0.397
0.258MetMet: 0.258 ± 0.135
1.29MetAsn: 1.29 ± 0.281
1.204MetPro: 1.204 ± 0.361
1.204MetGln: 1.204 ± 0.276
1.461MetArg: 1.461 ± 0.334
2.149MetSer: 2.149 ± 0.435
2.149MetThr: 2.149 ± 0.472
1.719MetVal: 1.719 ± 0.446
0.258MetTrp: 0.258 ± 0.172
0.946MetTyr: 0.946 ± 0.251
0.0MetXaa: 0.0 ± 0.0
Asn
3.095AsnAla: 3.095 ± 0.769
0.516AsnCys: 0.516 ± 0.209
3.095AsnAsp: 3.095 ± 0.496
4.298AsnGlu: 4.298 ± 0.929
2.149AsnPhe: 2.149 ± 0.365
6.018AsnGly: 6.018 ± 0.784
0.774AsnHis: 0.774 ± 0.285
3.009AsnIle: 3.009 ± 0.462
4.814AsnLys: 4.814 ± 0.645
4.127AsnLeu: 4.127 ± 0.501
0.946AsnMet: 0.946 ± 0.25
3.869AsnAsn: 3.869 ± 0.57
2.149AsnPro: 2.149 ± 0.342
2.493AsnGln: 2.493 ± 0.416
2.493AsnArg: 2.493 ± 0.467
3.611AsnSer: 3.611 ± 0.69
2.837AsnThr: 2.837 ± 0.404
3.955AsnVal: 3.955 ± 0.581
0.86AsnTrp: 0.86 ± 0.304
2.407AsnTyr: 2.407 ± 0.388
0.0AsnXaa: 0.0 ± 0.0
Pro
2.063ProAla: 2.063 ± 0.423
0.172ProCys: 0.172 ± 0.129
1.719ProAsp: 1.719 ± 0.319
1.633ProGlu: 1.633 ± 0.427
1.032ProPhe: 1.032 ± 0.259
0.946ProGly: 0.946 ± 0.28
0.602ProHis: 0.602 ± 0.214
2.321ProIle: 2.321 ± 0.571
3.181ProLys: 3.181 ± 0.506
1.891ProLeu: 1.891 ± 0.407
0.688ProMet: 0.688 ± 0.26
1.633ProAsn: 1.633 ± 0.339
0.516ProPro: 0.516 ± 0.215
0.946ProGln: 0.946 ± 0.269
1.719ProArg: 1.719 ± 0.462
1.547ProSer: 1.547 ± 0.394
2.665ProThr: 2.665 ± 0.506
1.461ProVal: 1.461 ± 0.285
0.258ProTrp: 0.258 ± 0.13
1.29ProTyr: 1.29 ± 0.361
0.0ProXaa: 0.0 ± 0.0
Gln
2.665GlnAla: 2.665 ± 0.644
0.258GlnCys: 0.258 ± 0.144
1.204GlnAsp: 1.204 ± 0.395
3.181GlnGlu: 3.181 ± 0.468
1.805GlnPhe: 1.805 ± 0.398
2.751GlnGly: 2.751 ± 0.551
0.602GlnHis: 0.602 ± 0.213
2.407GlnIle: 2.407 ± 0.434
2.579GlnLys: 2.579 ± 0.439
3.439GlnLeu: 3.439 ± 0.572
0.774GlnMet: 0.774 ± 0.253
2.321GlnAsn: 2.321 ± 0.413
0.774GlnPro: 0.774 ± 0.301
1.977GlnGln: 1.977 ± 0.431
2.579GlnArg: 2.579 ± 0.349
1.719GlnSer: 1.719 ± 0.41
2.407GlnThr: 2.407 ± 0.377
2.063GlnVal: 2.063 ± 0.408
0.258GlnTrp: 0.258 ± 0.147
1.29GlnTyr: 1.29 ± 0.396
0.0GlnXaa: 0.0 ± 0.0
Arg
2.407ArgAla: 2.407 ± 0.485
0.086ArgCys: 0.086 ± 0.087
2.923ArgAsp: 2.923 ± 0.545
2.923ArgGlu: 2.923 ± 0.427
2.321ArgPhe: 2.321 ± 0.478
2.665ArgGly: 2.665 ± 0.518
0.688ArgHis: 0.688 ± 0.239
2.837ArgIle: 2.837 ± 0.456
3.439ArgLys: 3.439 ± 0.676
4.642ArgLeu: 4.642 ± 0.562
1.29ArgMet: 1.29 ± 0.314
2.665ArgAsn: 2.665 ± 0.509
1.204ArgPro: 1.204 ± 0.388
1.977ArgGln: 1.977 ± 0.388
1.977ArgArg: 1.977 ± 0.441
2.837ArgSer: 2.837 ± 0.56
2.837ArgThr: 2.837 ± 0.465
2.063ArgVal: 2.063 ± 0.608
0.946ArgTrp: 0.946 ± 0.361
2.063ArgTyr: 2.063 ± 0.498
0.0ArgXaa: 0.0 ± 0.0
Ser
4.384SerAla: 4.384 ± 0.468
0.43SerCys: 0.43 ± 0.249
5.158SerAsp: 5.158 ± 0.714
4.384SerGlu: 4.384 ± 0.705
2.579SerPhe: 2.579 ± 0.464
4.213SerGly: 4.213 ± 0.698
1.204SerHis: 1.204 ± 0.31
4.213SerIle: 4.213 ± 0.593
5.416SerLys: 5.416 ± 0.723
4.9SerLeu: 4.9 ± 0.775
1.547SerMet: 1.547 ± 0.322
4.384SerAsn: 4.384 ± 0.533
1.891SerPro: 1.891 ± 0.408
2.665SerGln: 2.665 ± 0.464
2.149SerArg: 2.149 ± 0.52
5.33SerSer: 5.33 ± 0.866
3.869SerThr: 3.869 ± 0.825
4.213SerVal: 4.213 ± 0.63
0.774SerTrp: 0.774 ± 0.238
2.149SerTyr: 2.149 ± 0.412
0.0SerXaa: 0.0 ± 0.0
Thr
5.416ThrAla: 5.416 ± 1.126
0.0ThrCys: 0.0 ± 0.0
2.579ThrAsp: 2.579 ± 0.442
4.384ThrGlu: 4.384 ± 0.59
3.181ThrPhe: 3.181 ± 0.563
5.244ThrGly: 5.244 ± 0.763
1.118ThrHis: 1.118 ± 0.244
5.072ThrIle: 5.072 ± 0.968
5.502ThrLys: 5.502 ± 0.704
5.244ThrLeu: 5.244 ± 0.622
1.29ThrMet: 1.29 ± 0.392
3.095ThrAsn: 3.095 ± 0.5
1.376ThrPro: 1.376 ± 0.366
1.461ThrGln: 1.461 ± 0.426
1.805ThrArg: 1.805 ± 0.498
4.213ThrSer: 4.213 ± 0.491
3.869ThrThr: 3.869 ± 0.789
4.384ThrVal: 4.384 ± 0.591
0.946ThrTrp: 0.946 ± 0.316
2.149ThrTyr: 2.149 ± 0.467
0.0ThrXaa: 0.0 ± 0.0
Val
4.47ValAla: 4.47 ± 0.607
0.172ValCys: 0.172 ± 0.11
4.298ValAsp: 4.298 ± 0.459
4.127ValGlu: 4.127 ± 0.765
2.235ValPhe: 2.235 ± 0.473
3.611ValGly: 3.611 ± 0.536
0.86ValHis: 0.86 ± 0.298
4.127ValIle: 4.127 ± 0.623
5.932ValLys: 5.932 ± 0.741
4.298ValLeu: 4.298 ± 0.661
1.719ValMet: 1.719 ± 0.397
3.525ValAsn: 3.525 ± 0.552
1.204ValPro: 1.204 ± 0.351
2.235ValGln: 2.235 ± 0.519
2.235ValArg: 2.235 ± 0.49
4.642ValSer: 4.642 ± 0.667
4.213ValThr: 4.213 ± 0.543
3.697ValVal: 3.697 ± 0.568
0.516ValTrp: 0.516 ± 0.311
2.407ValTyr: 2.407 ± 0.505
0.0ValXaa: 0.0 ± 0.0
Trp
0.516TrpAla: 0.516 ± 0.163
0.0TrpCys: 0.0 ± 0.0
0.602TrpAsp: 0.602 ± 0.264
0.946TrpGlu: 0.946 ± 0.257
0.688TrpPhe: 0.688 ± 0.306
0.688TrpGly: 0.688 ± 0.24
0.172TrpHis: 0.172 ± 0.161
0.86TrpIle: 0.86 ± 0.28
1.118TrpLys: 1.118 ± 0.285
1.29TrpLeu: 1.29 ± 0.33
0.172TrpMet: 0.172 ± 0.127
0.774TrpAsn: 0.774 ± 0.278
0.172TrpPro: 0.172 ± 0.116
0.602TrpGln: 0.602 ± 0.25
0.688TrpArg: 0.688 ± 0.226
1.032TrpSer: 1.032 ± 0.322
0.86TrpThr: 0.86 ± 0.4
0.602TrpVal: 0.602 ± 0.252
0.344TrpTrp: 0.344 ± 0.227
0.516TrpTyr: 0.516 ± 0.357
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.149TyrAla: 2.149 ± 0.435
0.602TyrCys: 0.602 ± 0.274
2.579TyrAsp: 2.579 ± 0.513
2.837TyrGlu: 2.837 ± 0.498
2.321TyrPhe: 2.321 ± 0.523
2.063TyrGly: 2.063 ± 0.47
1.461TyrHis: 1.461 ± 0.328
2.493TyrIle: 2.493 ± 0.596
2.837TyrLys: 2.837 ± 0.357
3.009TyrLeu: 3.009 ± 0.533
0.86TyrMet: 0.86 ± 0.256
1.376TyrAsn: 1.376 ± 0.348
1.29TyrPro: 1.29 ± 0.361
1.891TyrGln: 1.891 ± 0.438
1.805TyrArg: 1.805 ± 0.467
1.719TyrSer: 1.719 ± 0.422
2.149TyrThr: 2.149 ± 0.404
1.29TyrVal: 1.29 ± 0.353
0.344TyrTrp: 0.344 ± 0.176
1.891TyrTyr: 1.891 ± 0.412
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (11633 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski