Amino acid dipepetide frequency for Vibrio sp. C7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.117AlaAla: 7.117 ± 0.091	0.906AlaCys: 0.906 ± 0.028	4.271AlaAsp: 4.271 ± 0.054	5.219AlaGlu: 5.219 ± 0.064	3.39AlaPhe: 3.39 ± 0.054	5.569AlaGly: 5.569 ± 0.077	1.686AlaHis: 1.686 ± 0.033	5.865AlaIle: 5.865 ± 0.079	4.603AlaLys: 4.603 ± 0.062	9.497AlaLeu: 9.497 ± 0.088	2.907AlaMet: 2.907 ± 0.043	3.478AlaAsn: 3.478 ± 0.049	2.814AlaPro: 2.814 ± 0.049	3.905AlaGln: 3.905 ± 0.057	3.609AlaArg: 3.609 ± 0.051	5.481AlaSer: 5.481 ± 0.07	4.616AlaThr: 4.616 ± 0.059	5.668AlaVal: 5.668 ± 0.069	0.96AlaTrp: 0.96 ± 0.028	2.322AlaTyr: 2.322 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.824CysAla: 0.824 ± 0.027	0.197CysCys: 0.197 ± 0.013	0.564CysAsp: 0.564 ± 0.019	0.62CysGlu: 0.62 ± 0.022	0.497CysPhe: 0.497 ± 0.019	0.873CysGly: 0.873 ± 0.025	0.367CysHis: 0.367 ± 0.018	0.587CysIle: 0.587 ± 0.02	0.409CysLys: 0.409 ± 0.019	1.049CysLeu: 1.049 ± 0.024	0.338CysMet: 0.338 ± 0.017	0.359CysAsn: 0.359 ± 0.017	0.422CysPro: 0.422 ± 0.018	0.468CysGln: 0.468 ± 0.019	0.526CysArg: 0.526 ± 0.019	0.807CysSer: 0.807 ± 0.025	0.525CysThr: 0.525 ± 0.02	0.701CysVal: 0.701 ± 0.021	0.152CysTrp: 0.152 ± 0.011	0.335CysTyr: 0.335 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.323AspAla: 4.323 ± 0.061	0.55AspCys: 0.55 ± 0.019	3.152AspAsp: 3.152 ± 0.059	4.018AspGlu: 4.018 ± 0.063	2.504AspPhe: 2.504 ± 0.044	3.872AspGly: 3.872 ± 0.074	1.12AspHis: 1.12 ± 0.028	4.062AspIle: 4.062 ± 0.056	3.1AspLys: 3.1 ± 0.045	5.105AspLeu: 5.105 ± 0.068	1.46AspMet: 1.46 ± 0.036	2.489AspAsn: 2.489 ± 0.046	1.909AspPro: 1.909 ± 0.04	2.002AspGln: 2.002 ± 0.043	2.229AspArg: 2.229 ± 0.04	3.534AspSer: 3.534 ± 0.053	2.851AspThr: 2.851 ± 0.052	4.032AspVal: 4.032 ± 0.064	0.915AspTrp: 0.915 ± 0.028	2.172AspTyr: 2.172 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.416GluAla: 5.416 ± 0.068	0.556GluCys: 0.556 ± 0.02	2.938GluAsp: 2.938 ± 0.055	4.148GluGlu: 4.148 ± 0.064	2.536GluPhe: 2.536 ± 0.045	3.789GluGly: 3.789 ± 0.056	1.67GluHis: 1.67 ± 0.033	3.742GluIle: 3.742 ± 0.052	3.598GluLys: 3.598 ± 0.051	7.311GluLeu: 7.311 ± 0.084	1.828GluMet: 1.828 ± 0.037	2.582GluAsn: 2.582 ± 0.05	2.084GluPro: 2.084 ± 0.042	4.123GluGln: 4.123 ± 0.059	3.671GluArg: 3.671 ± 0.051	4.059GluSer: 4.059 ± 0.053	3.231GluThr: 3.231 ± 0.053	4.648GluVal: 4.648 ± 0.069	0.824GluTrp: 0.824 ± 0.024	1.843GluTyr: 1.843 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.586PheAla: 3.586 ± 0.052	0.508PheCys: 0.508 ± 0.019	2.939PheAsp: 2.939 ± 0.047	2.693PheGlu: 2.693 ± 0.048	1.609PhePhe: 1.609 ± 0.035	3.279PheGly: 3.279 ± 0.056	0.852PheHis: 0.852 ± 0.023	2.668PheIle: 2.668 ± 0.047	1.917PheLys: 1.917 ± 0.035	3.345PheLeu: 3.345 ± 0.063	1.154PheMet: 1.154 ± 0.026	2.07PheAsn: 2.07 ± 0.042	1.365PhePro: 1.365 ± 0.034	1.291PheGln: 1.291 ± 0.029	1.444PheArg: 1.444 ± 0.033	3.282PheSer: 3.282 ± 0.049	2.433PheThr: 2.433 ± 0.048	3.013PheVal: 3.013 ± 0.047	0.508PheTrp: 0.508 ± 0.019	1.283PheTyr: 1.283 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.265GlyAla: 5.265 ± 0.06	0.867GlyCys: 0.867 ± 0.025	3.762GlyAsp: 3.762 ± 0.066	4.496GlyGlu: 4.496 ± 0.066	3.2GlyPhe: 3.2 ± 0.05	4.706GlyGly: 4.706 ± 0.074	1.538GlyHis: 1.538 ± 0.034	4.555GlyIle: 4.555 ± 0.067	3.668GlyLys: 3.668 ± 0.051	6.779GlyLeu: 6.779 ± 0.085	2.135GlyMet: 2.135 ± 0.05	2.548GlyAsn: 2.548 ± 0.048	1.476GlyPro: 1.476 ± 0.032	2.825GlyGln: 2.825 ± 0.043	3.066GlyArg: 3.066 ± 0.049	4.106GlySer: 4.106 ± 0.062	3.417GlyThr: 3.417 ± 0.047	5.184GlyVal: 5.184 ± 0.061	0.984GlyTrp: 0.984 ± 0.029	2.634GlyTyr: 2.634 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	1.602HisAla: 1.602 ± 0.033	0.347HisCys: 0.347 ± 0.016	1.168HisAsp: 1.168 ± 0.032	1.163HisGlu: 1.163 ± 0.031	1.062HisPhe: 1.062 ± 0.03	1.513HisGly: 1.513 ± 0.034	0.75HisHis: 0.75 ± 0.023	1.33HisIle: 1.33 ± 0.028	1.033HisLys: 1.033 ± 0.028	2.254HisLeu: 2.254 ± 0.04	0.563HisMet: 0.563 ± 0.022	0.892HisAsn: 0.892 ± 0.023	1.099HisPro: 1.099 ± 0.029	1.24HisGln: 1.24 ± 0.03	1.11HisArg: 1.11 ± 0.03	1.57HisSer: 1.57 ± 0.029	1.135HisThr: 1.135 ± 0.029	1.288HisVal: 1.288 ± 0.029	0.401HisTrp: 0.401 ± 0.016	0.931HisTyr: 0.931 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.263IleAla: 6.263 ± 0.076	0.663IleCys: 0.663 ± 0.022	4.255IleAsp: 4.255 ± 0.053	5.05IleGlu: 5.05 ± 0.061	2.166IlePhe: 2.166 ± 0.046	4.519IleGly: 4.519 ± 0.059	1.251IleHis: 1.251 ± 0.029	3.342IleIle: 3.342 ± 0.056	3.211IleLys: 3.211 ± 0.05	5.033IleLeu: 5.033 ± 0.071	1.424IleMet: 1.424 ± 0.034	2.945IleAsn: 2.945 ± 0.048	2.568IlePro: 2.568 ± 0.039	2.25IleGln: 2.25 ± 0.036	2.692IleArg: 2.692 ± 0.053	4.449IleSer: 4.449 ± 0.067	3.665IleThr: 3.665 ± 0.051	4.302IleVal: 4.302 ± 0.059	0.622IleTrp: 0.622 ± 0.023	1.693IleTyr: 1.693 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.589LysAla: 4.589 ± 0.068	0.356LysCys: 0.356 ± 0.015	2.537LysAsp: 2.537 ± 0.042	3.421LysGlu: 3.421 ± 0.053	1.52LysPhe: 1.52 ± 0.034	3.32LysGly: 3.32 ± 0.05	1.293LysHis: 1.293 ± 0.029	2.654LysIle: 2.654 ± 0.037	2.734LysLys: 2.734 ± 0.053	5.176LysLeu: 5.176 ± 0.061	1.478LysMet: 1.478 ± 0.036	1.927LysAsn: 1.927 ± 0.036	2.343LysPro: 2.343 ± 0.042	2.877LysGln: 2.877 ± 0.046	2.82LysArg: 2.82 ± 0.043	3.262LysSer: 3.262 ± 0.045	2.712LysThr: 2.712 ± 0.053	3.8LysVal: 3.8 ± 0.054	0.578LysTrp: 0.578 ± 0.023	1.375LysTyr: 1.375 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	9.216LeuAla: 9.216 ± 0.098	1.124LeuCys: 1.124 ± 0.033	5.784LeuAsp: 5.784 ± 0.067	6.404LeuGlu: 6.404 ± 0.064	4.215LeuPhe: 4.215 ± 0.068	6.88LeuGly: 6.88 ± 0.084	1.938LeuHis: 1.938 ± 0.039	6.183LeuIle: 6.183 ± 0.08	5.309LeuLys: 5.309 ± 0.068	9.875LeuLeu: 9.875 ± 0.091	2.947LeuMet: 2.947 ± 0.048	4.685LeuAsn: 4.685 ± 0.056	4.54LeuPro: 4.54 ± 0.057	3.412LeuGln: 3.412 ± 0.051	4.328LeuArg: 4.328 ± 0.054	8.183LeuSer: 8.183 ± 0.075	6.017LeuThr: 6.017 ± 0.07	7.149LeuVal: 7.149 ± 0.076	1.079LeuTrp: 1.079 ± 0.029	2.55LeuTyr: 2.55 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.604MetAla: 2.604 ± 0.044	0.235MetCys: 0.235 ± 0.015	1.409MetAsp: 1.409 ± 0.034	1.424MetGlu: 1.424 ± 0.032	1.086MetPhe: 1.086 ± 0.027	1.934MetGly: 1.934 ± 0.038	0.52MetHis: 0.52 ± 0.018	1.733MetIle: 1.733 ± 0.033	1.704MetLys: 1.704 ± 0.038	3.086MetLeu: 3.086 ± 0.051	0.962MetMet: 0.962 ± 0.028	1.294MetAsn: 1.294 ± 0.031	1.348MetPro: 1.348 ± 0.028	1.203MetGln: 1.203 ± 0.027	1.353MetArg: 1.353 ± 0.03	2.24MetSer: 2.24 ± 0.036	1.879MetThr: 1.879 ± 0.036	2.118MetVal: 2.118 ± 0.038	0.262MetTrp: 0.262 ± 0.014	0.637MetTyr: 0.637 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.374AsnAla: 3.374 ± 0.046	0.364AsnCys: 0.364 ± 0.018	2.415AsnAsp: 2.415 ± 0.044	2.548AsnGlu: 2.548 ± 0.045	1.586AsnPhe: 1.586 ± 0.031	3.005AsnGly: 3.005 ± 0.052	1.054AsnHis: 1.054 ± 0.029	2.75AsnIle: 2.75 ± 0.044	2.103AsnLys: 2.103 ± 0.041	3.946AsnLeu: 3.946 ± 0.059	1.092AsnMet: 1.092 ± 0.024	1.879AsnAsn: 1.879 ± 0.041	2.038AsnPro: 2.038 ± 0.039	2.234AsnGln: 2.234 ± 0.038	2.05AsnArg: 2.05 ± 0.036	2.636AsnSer: 2.636 ± 0.043	2.308AsnThr: 2.308 ± 0.043	2.796AsnVal: 2.796 ± 0.041	0.561AsnTrp: 0.561 ± 0.021	1.38AsnTyr: 1.38 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.835ProAla: 2.835 ± 0.05	0.354ProCys: 0.354 ± 0.014	2.14ProAsp: 2.14 ± 0.036	3.1ProGlu: 3.1 ± 0.055	1.674ProPhe: 1.674 ± 0.035	1.963ProGly: 1.963 ± 0.043	0.831ProHis: 0.831 ± 0.022	2.407ProIle: 2.407 ± 0.04	1.918ProLys: 1.918 ± 0.035	4.011ProLeu: 4.011 ± 0.062	1.178ProMet: 1.178 ± 0.031	1.72ProAsn: 1.72 ± 0.037	1.076ProPro: 1.076 ± 0.03	1.685ProGln: 1.685 ± 0.039	1.395ProArg: 1.395 ± 0.036	2.667ProSer: 2.667 ± 0.047	2.22ProThr: 2.22 ± 0.038	2.952ProVal: 2.952 ± 0.048	0.508ProTrp: 0.508 ± 0.018	1.219ProTyr: 1.219 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.308GlnAla: 4.308 ± 0.062	0.418GlnCys: 0.418 ± 0.016	2.056GlnAsp: 2.056 ± 0.038	2.69GlnGlu: 2.69 ± 0.054	1.78GlnPhe: 1.78 ± 0.033	2.952GlnGly: 2.952 ± 0.043	1.134GlnHis: 1.134 ± 0.026	2.511GlnIle: 2.511 ± 0.039	1.95GlnLys: 1.95 ± 0.039	4.953GlnLeu: 4.953 ± 0.056	1.236GlnMet: 1.236 ± 0.029	1.588GlnAsn: 1.588 ± 0.033	1.777GlnPro: 1.777 ± 0.033	2.833GlnGln: 2.833 ± 0.048	2.387GlnArg: 2.387 ± 0.042	2.999GlnSer: 2.999 ± 0.042	2.327GlnThr: 2.327 ± 0.041	3.273GlnVal: 3.273 ± 0.049	0.729GlnTrp: 0.729 ± 0.022	1.458GlnTyr: 1.458 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.496ArgAla: 3.496 ± 0.057	0.559ArgCys: 0.559 ± 0.021	2.5ArgAsp: 2.5 ± 0.042	3.058ArgGlu: 3.058 ± 0.045	2.243ArgPhe: 2.243 ± 0.039	2.584ArgGly: 2.584 ± 0.047	1.128ArgHis: 1.128 ± 0.027	2.876ArgIle: 2.876 ± 0.047	2.366ArgLys: 2.366 ± 0.044	4.942ArgLeu: 4.942 ± 0.065	1.374ArgMet: 1.374 ± 0.032	1.877ArgAsn: 1.877 ± 0.037	1.591ArgPro: 1.591 ± 0.033	2.195ArgGln: 2.195 ± 0.043	2.368ArgArg: 2.368 ± 0.048	2.939ArgSer: 2.939 ± 0.05	2.191ArgThr: 2.191 ± 0.039	3.364ArgVal: 3.364 ± 0.041	0.688ArgTrp: 0.688 ± 0.022	1.767ArgTyr: 1.767 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.321SerAla: 5.321 ± 0.054	0.697SerCys: 0.697 ± 0.023	3.873SerAsp: 3.873 ± 0.064	4.229SerGlu: 4.229 ± 0.052	2.978SerPhe: 2.978 ± 0.049	4.956SerGly: 4.956 ± 0.062	1.6SerHis: 1.6 ± 0.035	4.455SerIle: 4.455 ± 0.067	3.315SerLys: 3.315 ± 0.052	7.263SerLeu: 7.263 ± 0.078	2.157SerMet: 2.157 ± 0.041	2.911SerAsn: 2.911 ± 0.046	2.391SerPro: 2.391 ± 0.037	3.221SerGln: 3.221 ± 0.053	3.068SerArg: 3.068 ± 0.045	4.829SerSer: 4.829 ± 0.08	3.715SerThr: 3.715 ± 0.051	5.017SerVal: 5.017 ± 0.062	0.884SerTrp: 0.884 ± 0.027	2.127SerTyr: 2.127 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.34ThrAla: 4.34 ± 0.059	0.505ThrCys: 0.505 ± 0.018	2.957ThrAsp: 2.957 ± 0.049	3.139ThrGlu: 3.139 ± 0.05	2.234ThrPhe: 2.234 ± 0.043	3.858ThrGly: 3.858 ± 0.052	1.315ThrHis: 1.315 ± 0.032	3.539ThrIle: 3.539 ± 0.051	2.437ThrLys: 2.437 ± 0.044	6.43ThrLeu: 6.43 ± 0.072	1.447ThrMet: 1.447 ± 0.032	2.131ThrAsn: 2.131 ± 0.04	2.688ThrPro: 2.688 ± 0.044	2.561ThrGln: 2.561 ± 0.044	2.343ThrArg: 2.343 ± 0.043	3.662ThrSer: 3.662 ± 0.052	3.165ThrThr: 3.165 ± 0.051	4.04ThrVal: 4.04 ± 0.054	0.62ThrTrp: 0.62 ± 0.02	1.539ThrTyr: 1.539 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.367ValAla: 6.367 ± 0.079	0.813ValCys: 0.813 ± 0.023	4.302ValAsp: 4.302 ± 0.059	5.048ValGlu: 5.048 ± 0.069	2.932ValPhe: 2.932 ± 0.047	4.741ValGly: 4.741 ± 0.065	1.286ValHis: 1.286 ± 0.03	4.819ValIle: 4.819 ± 0.057	3.541ValLys: 3.541 ± 0.052	6.699ValLeu: 6.699 ± 0.068	2.195ValMet: 2.195 ± 0.039	3.045ValAsn: 3.045 ± 0.045	2.572ValPro: 2.572 ± 0.046	2.321ValGln: 2.321 ± 0.04	3.134ValArg: 3.134 ± 0.047	5.308ValSer: 5.308 ± 0.059	4.386ValThr: 4.386 ± 0.065	5.687ValVal: 5.687 ± 0.071	0.788ValTrp: 0.788 ± 0.026	1.872ValTyr: 1.872 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.815TrpAla: 0.815 ± 0.023	0.203TrpCys: 0.203 ± 0.013	0.642TrpAsp: 0.642 ± 0.024	0.538TrpGlu: 0.538 ± 0.02	0.617TrpPhe: 0.617 ± 0.02	0.813TrpGly: 0.813 ± 0.024	0.356TrpHis: 0.356 ± 0.016	0.649TrpIle: 0.649 ± 0.023	0.552TrpLys: 0.552 ± 0.022	1.761TrpLeu: 1.761 ± 0.038	0.445TrpMet: 0.445 ± 0.019	0.509TrpAsn: 0.509 ± 0.022	0.424TrpPro: 0.424 ± 0.017	0.804TrpGln: 0.804 ± 0.022	0.707TrpArg: 0.707 ± 0.021	0.846TrpSer: 0.846 ± 0.023	0.571TrpThr: 0.571 ± 0.021	0.899TrpVal: 0.899 ± 0.024	0.214TrpTrp: 0.214 ± 0.013	0.396TrpTyr: 0.396 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.219TyrAla: 2.219 ± 0.039	0.399TyrCys: 0.399 ± 0.016	1.736TyrAsp: 1.736 ± 0.033	1.59TyrGlu: 1.59 ± 0.033	1.411TyrPhe: 1.411 ± 0.032	2.088TyrGly: 2.088 ± 0.042	0.763TyrHis: 0.763 ± 0.022	1.636TyrIle: 1.636 ± 0.035	1.304TyrLys: 1.304 ± 0.03	3.305TyrLeu: 3.305 ± 0.048	0.71TyrMet: 0.71 ± 0.02	1.19TyrAsn: 1.19 ± 0.029	1.327TyrPro: 1.327 ± 0.032	1.905TyrGln: 1.905 ± 0.041	1.809TyrArg: 1.809 ± 0.034	2.15TyrSer: 2.15 ± 0.04	1.586TyrThr: 1.586 ± 0.037	1.923TyrVal: 1.923 ± 0.034	0.486TyrTrp: 0.486 ± 0.021	1.08TyrTyr: 1.08 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7458 proteins (1439835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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