Amino acid dipepetide frequency for Mesonia phycicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.91AlaAla: 3.91 ± 0.082
0.525AlaCys: 0.525 ± 0.024
3.012AlaAsp: 3.012 ± 0.059
4.434AlaGlu: 4.434 ± 0.073
3.038AlaPhe: 3.038 ± 0.053
3.851AlaGly: 3.851 ± 0.073
1.062AlaHis: 1.062 ± 0.035
5.259AlaIle: 5.259 ± 0.08
4.874AlaLys: 4.874 ± 0.096
5.588AlaLeu: 5.588 ± 0.088
1.343AlaMet: 1.343 ± 0.041
3.509AlaAsn: 3.509 ± 0.072
1.674AlaPro: 1.674 ± 0.037
2.468AlaGln: 2.468 ± 0.051
1.877AlaArg: 1.877 ± 0.049
4.098AlaSer: 4.098 ± 0.07
3.525AlaThr: 3.525 ± 0.066
3.775AlaVal: 3.775 ± 0.075
0.577AlaTrp: 0.577 ± 0.026
2.554AlaTyr: 2.554 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.392CysAla: 0.392 ± 0.021
0.094CysCys: 0.094 ± 0.011
0.404CysAsp: 0.404 ± 0.023
0.471CysGlu: 0.471 ± 0.026
0.391CysPhe: 0.391 ± 0.019
0.557CysGly: 0.557 ± 0.026
0.162CysHis: 0.162 ± 0.014
0.557CysIle: 0.557 ± 0.026
0.503CysLys: 0.503 ± 0.024
0.639CysLeu: 0.639 ± 0.029
0.126CysMet: 0.126 ± 0.013
0.4CysAsn: 0.4 ± 0.021
0.316CysPro: 0.316 ± 0.021
0.233CysGln: 0.233 ± 0.017
0.15CysArg: 0.15 ± 0.011
0.537CysSer: 0.537 ± 0.028
0.412CysThr: 0.412 ± 0.024
0.421CysVal: 0.421 ± 0.022
0.064CysTrp: 0.064 ± 0.007
0.315CysTyr: 0.315 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.484AspAla: 3.484 ± 0.066
0.415AspCys: 0.415 ± 0.026
2.688AspAsp: 2.688 ± 0.071
3.764AspGlu: 3.764 ± 0.064
3.632AspPhe: 3.632 ± 0.065
3.259AspGly: 3.259 ± 0.071
0.849AspHis: 0.849 ± 0.031
4.254AspIle: 4.254 ± 0.066
4.077AspLys: 4.077 ± 0.065
5.251AspLeu: 5.251 ± 0.069
0.937AspMet: 0.937 ± 0.032
3.266AspAsn: 3.266 ± 0.06
1.545AspPro: 1.545 ± 0.044
1.654AspGln: 1.654 ± 0.033
1.695AspArg: 1.695 ± 0.041
3.038AspSer: 3.038 ± 0.059
2.673AspThr: 2.673 ± 0.062
3.366AspVal: 3.366 ± 0.08
0.762AspTrp: 0.762 ± 0.03
2.904AspTyr: 2.904 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.501GluAla: 4.501 ± 0.076
0.316GluCys: 0.316 ± 0.02
4.174GluAsp: 4.174 ± 0.068
6.527GluGlu: 6.527 ± 0.109
3.193GluPhe: 3.193 ± 0.053
3.843GluGly: 3.843 ± 0.071
1.134GluHis: 1.134 ± 0.036
6.28GluIle: 6.28 ± 0.097
6.709GluLys: 6.709 ± 0.099
6.484GluLeu: 6.484 ± 0.083
1.592GluMet: 1.592 ± 0.043
5.536GluAsn: 5.536 ± 0.082
1.596GluPro: 1.596 ± 0.039
2.455GluGln: 2.455 ± 0.052
2.359GluArg: 2.359 ± 0.054
3.419GluSer: 3.419 ± 0.068
3.725GluThr: 3.725 ± 0.061
5.03GluVal: 5.03 ± 0.076
0.622GluTrp: 0.622 ± 0.026
2.524GluTyr: 2.524 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
2.899PheAla: 2.899 ± 0.065
0.465PheCys: 0.465 ± 0.026
2.974PheAsp: 2.974 ± 0.048
3.338PheGlu: 3.338 ± 0.054
2.798PhePhe: 2.798 ± 0.065
3.29PheGly: 3.29 ± 0.063
0.84PheHis: 0.84 ± 0.03
4.134PheIle: 4.134 ± 0.076
4.072PheLys: 4.072 ± 0.059
4.967PheLeu: 4.967 ± 0.102
1.036PheMet: 1.036 ± 0.036
3.508PheAsn: 3.508 ± 0.066
1.623PhePro: 1.623 ± 0.039
1.905PheGln: 1.905 ± 0.051
1.431PheArg: 1.431 ± 0.036
4.176PheSer: 4.176 ± 0.082
3.356PheThr: 3.356 ± 0.058
2.858PheVal: 2.858 ± 0.061
0.553PheTrp: 0.553 ± 0.029
2.363PheTyr: 2.363 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
3.858GlyAla: 3.858 ± 0.073
0.513GlyCys: 0.513 ± 0.028
3.25GlyAsp: 3.25 ± 0.071
3.942GlyGlu: 3.942 ± 0.067
3.461GlyPhe: 3.461 ± 0.059
4.163GlyGly: 4.163 ± 0.083
1.006GlyHis: 1.006 ± 0.034
4.835GlyIle: 4.835 ± 0.088
4.746GlyLys: 4.746 ± 0.065
5.42GlyLeu: 5.42 ± 0.084
1.413GlyMet: 1.413 ± 0.035
3.503GlyAsn: 3.503 ± 0.074
1.162GlyPro: 1.162 ± 0.036
1.657GlyGln: 1.657 ± 0.046
1.831GlyArg: 1.831 ± 0.047
3.909GlySer: 3.909 ± 0.077
3.544GlyThr: 3.544 ± 0.085
4.262GlyVal: 4.262 ± 0.076
0.692GlyTrp: 0.692 ± 0.026
2.711GlyTyr: 2.711 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
0.814HisAla: 0.814 ± 0.03
0.155HisCys: 0.155 ± 0.012
0.697HisAsp: 0.697 ± 0.026
0.93HisGlu: 0.93 ± 0.035
1.099HisPhe: 1.099 ± 0.036
0.929HisGly: 0.929 ± 0.034
0.481HisHis: 0.481 ± 0.029
1.4HisIle: 1.4 ± 0.037
1.191HisLys: 1.191 ± 0.036
1.872HisLeu: 1.872 ± 0.046
0.279HisMet: 0.279 ± 0.015
0.911HisAsn: 0.911 ± 0.029
0.845HisPro: 0.845 ± 0.032
0.906HisGln: 0.906 ± 0.031
0.607HisArg: 0.607 ± 0.025
1.035HisSer: 1.035 ± 0.035
0.952HisThr: 0.952 ± 0.034
0.797HisVal: 0.797 ± 0.031
0.186HisTrp: 0.186 ± 0.013
0.836HisTyr: 0.836 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
5.443IleAla: 5.443 ± 0.072
0.688IleCys: 0.688 ± 0.027
4.864IleAsp: 4.864 ± 0.072
6.095IleGlu: 6.095 ± 0.081
3.855IlePhe: 3.855 ± 0.073
4.775IleGly: 4.775 ± 0.082
1.283IleHis: 1.283 ± 0.037
6.173IleIle: 6.173 ± 0.09
6.218IleLys: 6.218 ± 0.082
7.358IleLeu: 7.358 ± 0.105
1.19IleMet: 1.19 ± 0.038
5.124IleAsn: 5.124 ± 0.076
3.211IlePro: 3.211 ± 0.065
2.779IleGln: 2.779 ± 0.059
2.201IleArg: 2.201 ± 0.047
5.87IleSer: 5.87 ± 0.085
5.107IleThr: 5.107 ± 0.07
4.412IleVal: 4.412 ± 0.074
0.668IleTrp: 0.668 ± 0.026
3.114IleTyr: 3.114 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.737LysAla: 4.737 ± 0.086
0.355LysCys: 0.355 ± 0.021
4.527LysAsp: 4.527 ± 0.081
7.065LysGlu: 7.065 ± 0.093
3.344LysPhe: 3.344 ± 0.058
4.147LysGly: 4.147 ± 0.075
1.387LysHis: 1.387 ± 0.038
6.897LysIle: 6.897 ± 0.096
7.878LysLys: 7.878 ± 0.108
7.181LysLeu: 7.181 ± 0.105
1.972LysMet: 1.972 ± 0.049
6.039LysAsn: 6.039 ± 0.086
2.308LysPro: 2.308 ± 0.053
2.911LysGln: 2.911 ± 0.062
2.719LysArg: 2.719 ± 0.06
4.639LysSer: 4.639 ± 0.07
4.692LysThr: 4.692 ± 0.069
4.717LysVal: 4.717 ± 0.078
0.76LysTrp: 0.76 ± 0.029
3.285LysTyr: 3.285 ± 0.064
0.0LysXaa: 0.0 ± 0.0
Leu
6.003LeuAla: 6.003 ± 0.094
0.611LeuCys: 0.611 ± 0.026
5.074LeuAsp: 5.074 ± 0.075
6.684LeuGlu: 6.684 ± 0.082
4.884LeuPhe: 4.884 ± 0.092
5.621LeuGly: 5.621 ± 0.093
1.531LeuHis: 1.531 ± 0.042
7.247LeuIle: 7.247 ± 0.104
8.127LeuLys: 8.127 ± 0.108
8.705LeuLeu: 8.705 ± 0.131
1.976LeuMet: 1.976 ± 0.045
6.001LeuAsn: 6.001 ± 0.08
3.568LeuPro: 3.568 ± 0.062
3.733LeuGln: 3.733 ± 0.065
2.904LeuArg: 2.904 ± 0.067
6.664LeuSer: 6.664 ± 0.096
5.119LeuThr: 5.119 ± 0.073
5.466LeuVal: 5.466 ± 0.091
0.73LeuTrp: 0.73 ± 0.028
3.262LeuTyr: 3.262 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
1.397MetAla: 1.397 ± 0.04
0.134MetCys: 0.134 ± 0.012
0.904MetAsp: 0.904 ± 0.031
1.173MetGlu: 1.173 ± 0.035
0.798MetPhe: 0.798 ± 0.031
1.23MetGly: 1.23 ± 0.038
0.364MetHis: 0.364 ± 0.018
1.401MetIle: 1.401 ± 0.041
2.139MetLys: 2.139 ± 0.042
1.9MetLeu: 1.9 ± 0.047
0.513MetMet: 0.513 ± 0.026
1.199MetAsn: 1.199 ± 0.035
0.766MetPro: 0.766 ± 0.029
0.826MetGln: 0.826 ± 0.029
0.712MetArg: 0.712 ± 0.026
1.349MetSer: 1.349 ± 0.037
0.931MetThr: 0.931 ± 0.031
1.29MetVal: 1.29 ± 0.038
0.136MetTrp: 0.136 ± 0.011
0.652MetTyr: 0.652 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.567AsnAla: 3.567 ± 0.058
0.446AsnCys: 0.446 ± 0.025
3.001AsnAsp: 3.001 ± 0.07
3.914AsnGlu: 3.914 ± 0.071
3.696AsnPhe: 3.696 ± 0.07
3.925AsnGly: 3.925 ± 0.093
1.148AsnHis: 1.148 ± 0.041
5.19AsnIle: 5.19 ± 0.079
4.927AsnLys: 4.927 ± 0.078
6.222AsnLeu: 6.222 ± 0.085
1.155AsnMet: 1.155 ± 0.034
4.466AsnAsn: 4.466 ± 0.095
2.666AsnPro: 2.666 ± 0.063
2.571AsnGln: 2.571 ± 0.054
2.09AsnArg: 2.09 ± 0.043
4.329AsnSer: 4.329 ± 0.082
3.924AsnThr: 3.924 ± 0.083
3.386AsnVal: 3.386 ± 0.074
0.866AsnTrp: 0.866 ± 0.035
3.404AsnTyr: 3.404 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
1.738ProAla: 1.738 ± 0.042
0.207ProCys: 0.207 ± 0.015
1.759ProAsp: 1.759 ± 0.041
2.807ProGlu: 2.807 ± 0.061
1.77ProPhe: 1.77 ± 0.041
1.71ProGly: 1.71 ± 0.043
0.554ProHis: 0.554 ± 0.022
2.55ProIle: 2.55 ± 0.049
2.483ProLys: 2.483 ± 0.055
2.923ProLeu: 2.923 ± 0.055
0.599ProMet: 0.599 ± 0.025
2.156ProAsn: 2.156 ± 0.051
0.748ProPro: 0.748 ± 0.027
1.289ProGln: 1.289 ± 0.043
0.773ProArg: 0.773 ± 0.03
2.129ProSer: 2.129 ± 0.053
1.957ProThr: 1.957 ± 0.052
2.166ProVal: 2.166 ± 0.049
0.282ProTrp: 0.282 ± 0.019
1.44ProTyr: 1.44 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.193GlnAla: 2.193 ± 0.053
0.151GlnCys: 0.151 ± 0.013
1.879GlnAsp: 1.879 ± 0.047
2.937GlnGlu: 2.937 ± 0.062
1.72GlnPhe: 1.72 ± 0.043
1.772GlnGly: 1.772 ± 0.046
0.696GlnHis: 0.696 ± 0.027
2.835GlnIle: 2.835 ± 0.052
3.272GlnLys: 3.272 ± 0.071
3.976GlnLeu: 3.976 ± 0.077
0.769GlnMet: 0.769 ± 0.026
2.399GlnAsn: 2.399 ± 0.055
1.184GlnPro: 1.184 ± 0.034
1.832GlnGln: 1.832 ± 0.049
1.197GlnArg: 1.197 ± 0.036
1.859GlnSer: 1.859 ± 0.047
1.999GlnThr: 1.999 ± 0.054
2.172GlnVal: 2.172 ± 0.052
0.335GlnTrp: 0.335 ± 0.019
1.356GlnTyr: 1.356 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
1.842ArgAla: 1.842 ± 0.045
0.156ArgCys: 0.156 ± 0.014
1.633ArgAsp: 1.633 ± 0.047
2.279ArgGlu: 2.279 ± 0.061
1.679ArgPhe: 1.679 ± 0.043
1.774ArgGly: 1.774 ± 0.042
0.507ArgHis: 0.507 ± 0.027
2.462ArgIle: 2.462 ± 0.049
2.806ArgLys: 2.806 ± 0.055
2.962ArgLeu: 2.962 ± 0.06
0.801ArgMet: 0.801 ± 0.031
1.941ArgAsn: 1.941 ± 0.052
0.935ArgPro: 0.935 ± 0.033
0.95ArgGln: 0.95 ± 0.03
1.131ArgArg: 1.131 ± 0.039
1.72ArgSer: 1.72 ± 0.043
1.585ArgThr: 1.585 ± 0.043
1.947ArgVal: 1.947 ± 0.044
0.336ArgTrp: 0.336 ± 0.017
1.405ArgTyr: 1.405 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
3.852SerAla: 3.852 ± 0.068
0.644SerCys: 0.644 ± 0.029
3.174SerAsp: 3.174 ± 0.059
4.175SerGlu: 4.175 ± 0.07
3.927SerPhe: 3.927 ± 0.065
4.319SerGly: 4.319 ± 0.082
0.981SerHis: 0.981 ± 0.035
5.562SerIle: 5.562 ± 0.076
4.976SerLys: 4.976 ± 0.089
6.364SerLeu: 6.364 ± 0.091
1.131SerMet: 1.131 ± 0.034
4.069SerAsn: 4.069 ± 0.071
1.937SerPro: 1.937 ± 0.044
2.138SerGln: 2.138 ± 0.045
1.858SerArg: 1.858 ± 0.046
4.961SerSer: 4.961 ± 0.109
3.965SerThr: 3.965 ± 0.079
3.995SerVal: 3.995 ± 0.069
0.703SerTrp: 0.703 ± 0.032
2.948SerTyr: 2.948 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
3.545ThrAla: 3.545 ± 0.067
0.339ThrCys: 0.339 ± 0.019
3.152ThrAsp: 3.152 ± 0.082
3.971ThrGlu: 3.971 ± 0.065
2.86ThrPhe: 2.86 ± 0.053
3.936ThrGly: 3.936 ± 0.08
0.991ThrHis: 0.991 ± 0.033
4.752ThrIle: 4.752 ± 0.073
3.946ThrLys: 3.946 ± 0.064
5.345ThrLeu: 5.345 ± 0.075
0.836ThrMet: 0.836 ± 0.025
3.535ThrAsn: 3.535 ± 0.074
2.341ThrPro: 2.341 ± 0.05
2.082ThrGln: 2.082 ± 0.06
1.563ThrArg: 1.563 ± 0.045
4.134ThrSer: 4.134 ± 0.086
3.715ThrThr: 3.715 ± 0.089
3.664ThrVal: 3.664 ± 0.076
0.539ThrTrp: 0.539 ± 0.022
2.557ThrTyr: 2.557 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
3.828ValAla: 3.828 ± 0.069
0.518ValCys: 0.518 ± 0.027
3.468ValAsp: 3.468 ± 0.071
4.405ValGlu: 4.405 ± 0.068
3.325ValPhe: 3.325 ± 0.066
3.656ValGly: 3.656 ± 0.073
0.864ValHis: 0.864 ± 0.03
4.913ValIle: 4.913 ± 0.082
4.597ValLys: 4.597 ± 0.072
5.659ValLeu: 5.659 ± 0.084
1.222ValMet: 1.222 ± 0.035
3.828ValAsn: 3.828 ± 0.071
1.91ValPro: 1.91 ± 0.049
1.771ValGln: 1.771 ± 0.043
1.795ValArg: 1.795 ± 0.048
4.284ValSer: 4.284 ± 0.079
3.605ValThr: 3.605 ± 0.083
4.086ValVal: 4.086 ± 0.073
0.553ValTrp: 0.553 ± 0.026
2.481ValTyr: 2.481 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.555TrpAla: 0.555 ± 0.026
0.092TrpCys: 0.092 ± 0.009
0.619TrpAsp: 0.619 ± 0.027
0.677TrpGlu: 0.677 ± 0.03
0.547TrpPhe: 0.547 ± 0.025
0.581TrpGly: 0.581 ± 0.025
0.196TrpHis: 0.196 ± 0.013
0.736TrpIle: 0.736 ± 0.029
0.735TrpLys: 0.735 ± 0.03
0.983TrpLeu: 0.983 ± 0.036
0.27TrpMet: 0.27 ± 0.017
0.624TrpAsn: 0.624 ± 0.027
0.233TrpPro: 0.233 ± 0.017
0.436TrpGln: 0.436 ± 0.021
0.376TrpArg: 0.376 ± 0.019
0.612TrpSer: 0.612 ± 0.032
0.476TrpThr: 0.476 ± 0.026
0.644TrpVal: 0.644 ± 0.027
0.137TrpTrp: 0.137 ± 0.013
0.451TrpTyr: 0.451 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.394TyrAla: 2.394 ± 0.045
0.322TyrCys: 0.322 ± 0.021
2.259TyrAsp: 2.259 ± 0.055
2.431TyrGlu: 2.431 ± 0.059
2.571TyrPhe: 2.571 ± 0.049
2.538TyrGly: 2.538 ± 0.054
0.891TyrHis: 0.891 ± 0.03
2.993TyrIle: 2.993 ± 0.049
3.285TyrLys: 3.285 ± 0.067
4.114TyrLeu: 4.114 ± 0.063
0.653TyrMet: 0.653 ± 0.025
2.879TyrAsn: 2.879 ± 0.069
1.47TyrPro: 1.47 ± 0.034
1.938TyrGln: 1.938 ± 0.05
1.579TyrArg: 1.579 ± 0.043
2.915TyrSer: 2.915 ± 0.057
2.541TyrThr: 2.541 ± 0.055
2.314TyrVal: 2.314 ± 0.053
0.477TyrTrp: 0.477 ± 0.021
2.155TyrTyr: 2.155 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2974 proteins (992302 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski