Amino acid dipepetide frequency for Candidimonas bauzanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.638AlaAla: 17.638 ± 0.173
1.313AlaCys: 1.313 ± 0.028
6.39AlaAsp: 6.39 ± 0.069
5.751AlaGlu: 5.751 ± 0.074
3.943AlaPhe: 3.943 ± 0.053
11.757AlaGly: 11.757 ± 0.133
2.515AlaHis: 2.515 ± 0.038
6.255AlaIle: 6.255 ± 0.066
3.431AlaLys: 3.431 ± 0.055
14.409AlaLeu: 14.409 ± 0.123
3.483AlaMet: 3.483 ± 0.055
2.911AlaAsn: 2.911 ± 0.056
5.839AlaPro: 5.839 ± 0.081
5.697AlaGln: 5.697 ± 0.063
8.561AlaArg: 8.561 ± 0.079
7.039AlaSer: 7.039 ± 0.087
5.394AlaThr: 5.394 ± 0.067
8.296AlaVal: 8.296 ± 0.082
1.78AlaTrp: 1.78 ± 0.04
2.78AlaTyr: 2.78 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.2CysAla: 1.2 ± 0.027
0.154CysCys: 0.154 ± 0.01
0.504CysAsp: 0.504 ± 0.019
0.435CysGlu: 0.435 ± 0.017
0.338CysPhe: 0.338 ± 0.014
0.967CysGly: 0.967 ± 0.028
0.237CysHis: 0.237 ± 0.012
0.419CysIle: 0.419 ± 0.017
0.218CysLys: 0.218 ± 0.012
0.918CysLeu: 0.918 ± 0.023
0.213CysMet: 0.213 ± 0.011
0.25CysAsn: 0.25 ± 0.013
0.508CysPro: 0.508 ± 0.019
0.275CysGln: 0.275 ± 0.013
0.586CysArg: 0.586 ± 0.022
0.535CysSer: 0.535 ± 0.02
0.389CysThr: 0.389 ± 0.016
0.707CysVal: 0.707 ± 0.021
0.128CysTrp: 0.128 ± 0.009
0.237CysTyr: 0.237 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.437AspAla: 6.437 ± 0.074
0.479AspCys: 0.479 ± 0.02
2.644AspAsp: 2.644 ± 0.046
2.952AspGlu: 2.952 ± 0.046
2.085AspPhe: 2.085 ± 0.038
4.488AspGly: 4.488 ± 0.071
1.126AspHis: 1.126 ± 0.029
3.071AspIle: 3.071 ± 0.049
1.718AspLys: 1.718 ± 0.037
5.441AspLeu: 5.441 ± 0.061
1.346AspMet: 1.346 ± 0.027
1.314AspAsn: 1.314 ± 0.03
2.93AspPro: 2.93 ± 0.044
1.808AspGln: 1.808 ± 0.032
3.179AspArg: 3.179 ± 0.04
2.601AspSer: 2.601 ± 0.043
2.641AspThr: 2.641 ± 0.053
3.876AspVal: 3.876 ± 0.052
0.905AspTrp: 0.905 ± 0.027
1.594AspTyr: 1.594 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
5.814GluAla: 5.814 ± 0.074
0.38GluCys: 0.38 ± 0.014
2.147GluAsp: 2.147 ± 0.036
2.298GluGlu: 2.298 ± 0.041
1.779GluPhe: 1.779 ± 0.034
3.413GluGly: 3.413 ± 0.051
1.34GluHis: 1.34 ± 0.029
3.052GluIle: 3.052 ± 0.046
2.014GluLys: 2.014 ± 0.042
5.665GluLeu: 5.665 ± 0.071
1.242GluMet: 1.242 ± 0.027
1.564GluAsn: 1.564 ± 0.031
2.528GluPro: 2.528 ± 0.047
2.552GluGln: 2.552 ± 0.042
4.085GluArg: 4.085 ± 0.063
2.738GluSer: 2.738 ± 0.041
2.492GluThr: 2.492 ± 0.037
3.404GluVal: 3.404 ± 0.047
0.671GluTrp: 0.671 ± 0.019
1.184GluTyr: 1.184 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.916PheAla: 3.916 ± 0.052
0.386PheCys: 0.386 ± 0.017
2.401PheAsp: 2.401 ± 0.043
1.949PheGlu: 1.949 ± 0.032
1.358PhePhe: 1.358 ± 0.032
3.357PheGly: 3.357 ± 0.051
0.752PheHis: 0.752 ± 0.023
1.814PheIle: 1.814 ± 0.033
1.184PheLys: 1.184 ± 0.027
3.202PheLeu: 3.202 ± 0.052
0.856PheMet: 0.856 ± 0.024
1.161PheAsn: 1.161 ± 0.025
1.581PhePro: 1.581 ± 0.038
1.141PheGln: 1.141 ± 0.025
1.848PheArg: 1.848 ± 0.039
2.445PheSer: 2.445 ± 0.042
1.837PheThr: 1.837 ± 0.036
2.537PheVal: 2.537 ± 0.041
0.519PheTrp: 0.519 ± 0.021
0.934PheTyr: 0.934 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
9.838GlyAla: 9.838 ± 0.123
0.889GlyCys: 0.889 ± 0.025
4.002GlyAsp: 4.002 ± 0.08
4.081GlyGlu: 4.081 ± 0.059
3.172GlyPhe: 3.172 ± 0.046
7.27GlyGly: 7.27 ± 0.137
1.859GlyHis: 1.859 ± 0.038
4.726GlyIle: 4.726 ± 0.064
3.593GlyLys: 3.593 ± 0.049
9.285GlyLeu: 9.285 ± 0.089
2.498GlyMet: 2.498 ± 0.04
2.34GlyAsn: 2.34 ± 0.065
3.257GlyPro: 3.257 ± 0.049
3.454GlyGln: 3.454 ± 0.044
5.569GlyArg: 5.569 ± 0.067
4.992GlySer: 4.992 ± 0.111
4.202GlyThr: 4.202 ± 0.078
6.281GlyVal: 6.281 ± 0.07
1.327GlyTrp: 1.327 ± 0.033
2.592GlyTyr: 2.592 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.683HisAla: 2.683 ± 0.045
0.259HisCys: 0.259 ± 0.013
1.184HisAsp: 1.184 ± 0.029
1.147HisGlu: 1.147 ± 0.024
0.792HisPhe: 0.792 ± 0.021
2.0HisGly: 2.0 ± 0.042
0.564HisHis: 0.564 ± 0.022
1.243HisIle: 1.243 ± 0.027
0.572HisLys: 0.572 ± 0.018
2.04HisLeu: 2.04 ± 0.034
0.516HisMet: 0.516 ± 0.018
0.519HisAsn: 0.519 ± 0.017
1.453HisPro: 1.453 ± 0.029
0.734HisGln: 0.734 ± 0.021
1.301HisArg: 1.301 ± 0.03
1.146HisSer: 1.146 ± 0.026
1.01HisThr: 1.01 ± 0.027
1.503HisVal: 1.503 ± 0.028
0.362HisTrp: 0.362 ± 0.015
0.629HisTyr: 0.629 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.806IleAla: 6.806 ± 0.071
0.503IleCys: 0.503 ± 0.019
3.351IleAsp: 3.351 ± 0.042
3.295IleGlu: 3.295 ± 0.044
1.65IlePhe: 1.65 ± 0.032
4.647IleGly: 4.647 ± 0.064
1.004IleHis: 1.004 ± 0.022
2.28IleIle: 2.28 ± 0.043
1.824IleLys: 1.824 ± 0.036
4.55IleLeu: 4.55 ± 0.062
1.08IleMet: 1.08 ± 0.025
1.659IleAsn: 1.659 ± 0.034
2.458IlePro: 2.458 ± 0.039
1.682IleGln: 1.682 ± 0.03
3.06IleArg: 3.06 ± 0.045
3.19IleSer: 3.19 ± 0.046
2.736IleThr: 2.736 ± 0.044
4.103IleVal: 4.103 ± 0.052
0.571IleTrp: 0.571 ± 0.019
1.132IleTyr: 1.132 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
3.926LysAla: 3.926 ± 0.058
0.16LysCys: 0.16 ± 0.011
1.653LysAsp: 1.653 ± 0.035
1.699LysGlu: 1.699 ± 0.035
0.974LysPhe: 0.974 ± 0.026
2.443LysGly: 2.443 ± 0.038
0.676LysHis: 0.676 ± 0.019
1.737LysIle: 1.737 ± 0.039
1.445LysLys: 1.445 ± 0.036
3.393LysLeu: 3.393 ± 0.045
0.815LysMet: 0.815 ± 0.023
1.028LysAsn: 1.028 ± 0.025
1.894LysPro: 1.894 ± 0.04
1.343LysGln: 1.343 ± 0.03
2.217LysArg: 2.217 ± 0.035
1.894LysSer: 1.894 ± 0.029
1.932LysThr: 1.932 ± 0.038
2.465LysVal: 2.465 ± 0.046
0.418LysTrp: 0.418 ± 0.017
0.745LysTyr: 0.745 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
15.248LeuAla: 15.248 ± 0.139
1.029LeuCys: 1.029 ± 0.027
6.063LeuAsp: 6.063 ± 0.062
5.334LeuGlu: 5.334 ± 0.059
3.709LeuPhe: 3.709 ± 0.055
8.979LeuGly: 8.979 ± 0.094
2.17LeuHis: 2.17 ± 0.039
5.08LeuIle: 5.08 ± 0.056
3.505LeuLys: 3.505 ± 0.052
11.318LeuLeu: 11.318 ± 0.114
2.483LeuMet: 2.483 ± 0.044
2.959LeuAsn: 2.959 ± 0.047
5.864LeuPro: 5.864 ± 0.068
3.664LeuGln: 3.664 ± 0.055
7.55LeuArg: 7.55 ± 0.077
6.752LeuSer: 6.752 ± 0.07
5.268LeuThr: 5.268 ± 0.078
7.296LeuVal: 7.296 ± 0.072
1.245LeuTrp: 1.245 ± 0.033
2.321LeuTyr: 2.321 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.219MetAla: 3.219 ± 0.038
0.179MetCys: 0.179 ± 0.012
1.154MetAsp: 1.154 ± 0.029
1.059MetGlu: 1.059 ± 0.024
0.732MetPhe: 0.732 ± 0.023
1.902MetGly: 1.902 ± 0.04
0.529MetHis: 0.529 ± 0.02
1.149MetIle: 1.149 ± 0.028
1.034MetLys: 1.034 ± 0.026
2.851MetLeu: 2.851 ± 0.048
0.637MetMet: 0.637 ± 0.021
0.869MetAsn: 0.869 ± 0.022
1.505MetPro: 1.505 ± 0.031
1.103MetGln: 1.103 ± 0.024
1.707MetArg: 1.707 ± 0.032
1.72MetSer: 1.72 ± 0.036
1.483MetThr: 1.483 ± 0.031
1.725MetVal: 1.725 ± 0.038
0.21MetTrp: 0.21 ± 0.01
0.432MetTyr: 0.432 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.215AsnAla: 3.215 ± 0.068
0.235AsnCys: 0.235 ± 0.013
1.4AsnAsp: 1.4 ± 0.037
1.285AsnGlu: 1.285 ± 0.027
1.018AsnPhe: 1.018 ± 0.027
2.405AsnGly: 2.405 ± 0.052
0.563AsnHis: 0.563 ± 0.018
1.619AsnIle: 1.619 ± 0.031
0.896AsnLys: 0.896 ± 0.024
2.767AsnLeu: 2.767 ± 0.045
0.682AsnMet: 0.682 ± 0.022
0.842AsnAsn: 0.842 ± 0.03
1.866AsnPro: 1.866 ± 0.035
0.954AsnGln: 0.954 ± 0.025
1.803AsnArg: 1.803 ± 0.034
1.462AsnSer: 1.462 ± 0.04
1.54AsnThr: 1.54 ± 0.037
2.005AsnVal: 2.005 ± 0.045
0.424AsnTrp: 0.424 ± 0.016
0.789AsnTyr: 0.789 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.952ProAla: 6.952 ± 0.087
0.386ProCys: 0.386 ± 0.017
3.267ProAsp: 3.267 ± 0.049
3.191ProGlu: 3.191 ± 0.055
1.808ProPhe: 1.808 ± 0.037
4.801ProGly: 4.801 ± 0.061
0.994ProHis: 0.994 ± 0.024
2.181ProIle: 2.181 ± 0.036
1.433ProLys: 1.433 ± 0.031
5.029ProLeu: 5.029 ± 0.077
1.258ProMet: 1.258 ± 0.031
1.255ProAsn: 1.255 ± 0.028
2.404ProPro: 2.404 ± 0.045
2.052ProGln: 2.052 ± 0.038
2.929ProArg: 2.929 ± 0.042
2.874ProSer: 2.874 ± 0.047
2.097ProThr: 2.097 ± 0.032
3.954ProVal: 3.954 ± 0.048
0.757ProTrp: 0.757 ± 0.021
1.423ProTyr: 1.423 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
6.071GlnAla: 6.071 ± 0.074
0.279GlnCys: 0.279 ± 0.012
1.873GlnAsp: 1.873 ± 0.037
1.922GlnGlu: 1.922 ± 0.041
1.244GlnPhe: 1.244 ± 0.029
3.223GlnGly: 3.223 ± 0.049
0.883GlnHis: 0.883 ± 0.024
1.985GlnIle: 1.985 ± 0.039
1.212GlnLys: 1.212 ± 0.027
3.974GlnLeu: 3.974 ± 0.05
0.942GlnMet: 0.942 ± 0.021
0.958GlnAsn: 0.958 ± 0.023
1.988GlnPro: 1.988 ± 0.037
1.848GlnGln: 1.848 ± 0.038
3.029GlnArg: 3.029 ± 0.047
2.046GlnSer: 2.046 ± 0.031
1.871GlnThr: 1.871 ± 0.039
2.852GlnVal: 2.852 ± 0.044
0.639GlnTrp: 0.639 ± 0.021
0.932GlnTyr: 0.932 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.134ArgAla: 7.134 ± 0.08
0.563ArgCys: 0.563 ± 0.02
3.449ArgAsp: 3.449 ± 0.047
3.673ArgGlu: 3.673 ± 0.057
2.36ArgPhe: 2.36 ± 0.037
4.592ArgGly: 4.592 ± 0.055
1.833ArgHis: 1.833 ± 0.037
3.839ArgIle: 3.839 ± 0.052
2.318ArgLys: 2.318 ± 0.041
7.745ArgLeu: 7.745 ± 0.083
1.785ArgMet: 1.785 ± 0.032
2.001ArgAsn: 2.001 ± 0.037
3.225ArgPro: 3.225 ± 0.05
3.286ArgGln: 3.286 ± 0.056
4.98ArgArg: 4.98 ± 0.07
3.648ArgSer: 3.648 ± 0.048
2.716ArgThr: 2.716 ± 0.04
4.514ArgVal: 4.514 ± 0.052
0.986ArgTrp: 0.986 ± 0.028
2.115ArgTyr: 2.115 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.705SerAla: 6.705 ± 0.083
0.487SerCys: 0.487 ± 0.019
2.864SerAsp: 2.864 ± 0.047
2.534SerGlu: 2.534 ± 0.041
2.196SerPhe: 2.196 ± 0.037
5.877SerGly: 5.877 ± 0.085
1.235SerHis: 1.235 ± 0.025
3.145SerIle: 3.145 ± 0.055
1.702SerLys: 1.702 ± 0.031
6.391SerLeu: 6.391 ± 0.068
1.559SerMet: 1.559 ± 0.029
1.562SerAsn: 1.562 ± 0.038
2.951SerPro: 2.951 ± 0.048
2.094SerGln: 2.094 ± 0.035
3.806SerArg: 3.806 ± 0.054
3.547SerSer: 3.547 ± 0.066
2.867SerThr: 2.867 ± 0.048
4.198SerVal: 4.198 ± 0.058
0.833SerTrp: 0.833 ± 0.022
1.525SerTyr: 1.525 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.409ThrAla: 5.409 ± 0.075
0.385ThrCys: 0.385 ± 0.016
2.344ThrAsp: 2.344 ± 0.046
2.178ThrGlu: 2.178 ± 0.038
1.635ThrPhe: 1.635 ± 0.032
4.562ThrGly: 4.562 ± 0.081
1.096ThrHis: 1.096 ± 0.027
2.557ThrIle: 2.557 ± 0.045
1.097ThrLys: 1.097 ± 0.031
6.148ThrLeu: 6.148 ± 0.073
1.1ThrMet: 1.1 ± 0.025
1.18ThrAsn: 1.18 ± 0.029
3.159ThrPro: 3.159 ± 0.047
1.822ThrGln: 1.822 ± 0.035
3.086ThrArg: 3.086 ± 0.045
2.699ThrSer: 2.699 ± 0.05
2.437ThrThr: 2.437 ± 0.057
3.984ThrVal: 3.984 ± 0.057
0.595ThrTrp: 0.595 ± 0.019
1.057ThrTyr: 1.057 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
8.847ValAla: 8.847 ± 0.087
0.725ValCys: 0.725 ± 0.023
3.885ValAsp: 3.885 ± 0.052
3.749ValGlu: 3.749 ± 0.055
2.84ValPhe: 2.84 ± 0.049
5.291ValGly: 5.291 ± 0.064
1.443ValHis: 1.443 ± 0.032
3.688ValIle: 3.688 ± 0.053
2.41ValLys: 2.41 ± 0.043
8.107ValLeu: 8.107 ± 0.087
1.795ValMet: 1.795 ± 0.032
2.27ValAsn: 2.27 ± 0.048
3.635ValPro: 3.635 ± 0.049
2.611ValGln: 2.611 ± 0.046
4.393ValArg: 4.393 ± 0.051
4.486ValSer: 4.486 ± 0.062
3.551ValThr: 3.551 ± 0.049
5.771ValVal: 5.771 ± 0.075
0.931ValTrp: 0.931 ± 0.024
1.675ValTyr: 1.675 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.266TrpAla: 1.266 ± 0.032
0.135TrpCys: 0.135 ± 0.008
0.617TrpAsp: 0.617 ± 0.021
0.552TrpGlu: 0.552 ± 0.017
0.547TrpPhe: 0.547 ± 0.019
0.913TrpGly: 0.913 ± 0.024
0.353TrpHis: 0.353 ± 0.013
0.697TrpIle: 0.697 ± 0.022
0.447TrpLys: 0.447 ± 0.014
1.997TrpLeu: 1.997 ± 0.044
0.399TrpMet: 0.399 ± 0.016
0.469TrpAsn: 0.469 ± 0.015
0.687TrpPro: 0.687 ± 0.024
0.704TrpGln: 0.704 ± 0.022
1.212TrpArg: 1.212 ± 0.033
0.802TrpSer: 0.802 ± 0.023
0.675TrpThr: 0.675 ± 0.022
0.895TrpVal: 0.895 ± 0.026
0.222TrpTrp: 0.222 ± 0.011
0.331TrpTyr: 0.331 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.858TyrAla: 2.858 ± 0.047
0.296TyrCys: 0.296 ± 0.014
1.443TyrAsp: 1.443 ± 0.033
1.28TyrGlu: 1.28 ± 0.03
0.995TyrPhe: 0.995 ± 0.024
2.34TyrGly: 2.34 ± 0.039
0.486TyrHis: 0.486 ± 0.017
1.041TyrIle: 1.041 ± 0.027
0.801TyrLys: 0.801 ± 0.023
2.61TyrLeu: 2.61 ± 0.046
0.511TyrMet: 0.511 ± 0.018
0.661TyrAsn: 0.661 ± 0.021
1.313TyrPro: 1.313 ± 0.031
0.947TyrGln: 0.947 ± 0.025
1.862TyrArg: 1.862 ± 0.034
1.463TyrSer: 1.463 ± 0.034
1.389TyrThr: 1.389 ± 0.027
1.736TyrVal: 1.736 ± 0.034
0.398TyrTrp: 0.398 ± 0.018
0.655TyrTyr: 0.655 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5118 proteins (1690431 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski