Amino acid dipepetide frequency for Arthrobacter silviterrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.331AlaAla: 22.331 ± 0.224	0.8AlaCys: 0.8 ± 0.029	6.844AlaAsp: 6.844 ± 0.086	7.387AlaGlu: 7.387 ± 0.098	3.728AlaPhe: 3.728 ± 0.066	14.168AlaGly: 14.168 ± 0.123	2.549AlaHis: 2.549 ± 0.048	5.148AlaIle: 5.148 ± 0.078	4.008AlaLys: 4.008 ± 0.081	13.652AlaLeu: 13.652 ± 0.141	3.079AlaMet: 3.079 ± 0.053	3.184AlaAsn: 3.184 ± 0.055	6.42AlaPro: 6.42 ± 0.098	4.314AlaGln: 4.314 ± 0.079	8.013AlaArg: 8.013 ± 0.086	7.06AlaSer: 7.06 ± 0.091	7.439AlaThr: 7.439 ± 0.08	11.902AlaVal: 11.902 ± 0.106	1.76AlaTrp: 1.76 ± 0.044	2.385AlaTyr: 2.385 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.765CysAla: 0.765 ± 0.025	0.062CysCys: 0.062 ± 0.007	0.326CysAsp: 0.326 ± 0.016	0.332CysGlu: 0.332 ± 0.016	0.196CysPhe: 0.196 ± 0.013	0.691CysGly: 0.691 ± 0.024	0.141CysHis: 0.141 ± 0.011	0.266CysIle: 0.266 ± 0.018	0.122CysLys: 0.122 ± 0.009	0.532CysLeu: 0.532 ± 0.021	0.103CysMet: 0.103 ± 0.008	0.146CysAsn: 0.146 ± 0.011	0.333CysPro: 0.333 ± 0.019	0.184CysGln: 0.184 ± 0.012	0.387CysArg: 0.387 ± 0.019	0.429CysSer: 0.429 ± 0.019	0.476CysThr: 0.476 ± 0.023	0.454CysVal: 0.454 ± 0.02	0.091CysTrp: 0.091 ± 0.009	0.129CysTyr: 0.129 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.29AspAla: 7.29 ± 0.097	0.312AspCys: 0.312 ± 0.018	2.787AspAsp: 2.787 ± 0.058	2.687AspGlu: 2.687 ± 0.054	1.87AspPhe: 1.87 ± 0.037	5.896AspGly: 5.896 ± 0.073	1.142AspHis: 1.142 ± 0.032	2.451AspIle: 2.451 ± 0.051	1.398AspLys: 1.398 ± 0.038	4.82AspLeu: 4.82 ± 0.062	0.969AspMet: 0.969 ± 0.026	1.202AspAsn: 1.202 ± 0.035	3.664AspPro: 3.664 ± 0.06	1.503AspGln: 1.503 ± 0.033	3.108AspArg: 3.108 ± 0.064	2.865AspSer: 2.865 ± 0.042	2.79AspThr: 2.79 ± 0.05	4.645AspVal: 4.645 ± 0.069	0.872AspTrp: 0.872 ± 0.027	1.246AspTyr: 1.246 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.32GluAla: 6.32 ± 0.089	0.275GluCys: 0.275 ± 0.015	2.536GluAsp: 2.536 ± 0.044	2.67GluGlu: 2.67 ± 0.056	1.724GluPhe: 1.724 ± 0.045	3.582GluGly: 3.582 ± 0.055	1.304GluHis: 1.304 ± 0.034	2.408GluIle: 2.408 ± 0.049	1.52GluLys: 1.52 ± 0.04	6.833GluLeu: 6.833 ± 0.085	0.975GluMet: 0.975 ± 0.028	1.378GluAsn: 1.378 ± 0.033	2.58GluPro: 2.58 ± 0.054	2.044GluGln: 2.044 ± 0.041	3.553GluArg: 3.553 ± 0.063	2.86GluSer: 2.86 ± 0.044	2.681GluThr: 2.681 ± 0.049	3.836GluVal: 3.836 ± 0.066	0.74GluTrp: 0.74 ± 0.025	0.949GluTyr: 0.949 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.146PheAla: 4.146 ± 0.059	0.244PheCys: 0.244 ± 0.012	2.089PheAsp: 2.089 ± 0.04	1.511PheGlu: 1.511 ± 0.034	1.111PhePhe: 1.111 ± 0.038	3.358PheGly: 3.358 ± 0.055	0.675PheHis: 0.675 ± 0.023	1.419PheIle: 1.419 ± 0.039	0.793PheLys: 0.793 ± 0.028	3.024PheLeu: 3.024 ± 0.056	0.655PheMet: 0.655 ± 0.023	0.95PheAsn: 0.95 ± 0.026	1.558PhePro: 1.558 ± 0.034	0.818PheGln: 0.818 ± 0.027	1.773PheArg: 1.773 ± 0.043	2.019PheSer: 2.019 ± 0.04	2.295PheThr: 2.295 ± 0.049	2.439PheVal: 2.439 ± 0.048	0.489PheTrp: 0.489 ± 0.025	0.686PheTyr: 0.686 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.044GlyAla: 11.044 ± 0.114	0.661GlyCys: 0.661 ± 0.023	4.158GlyAsp: 4.158 ± 0.068	4.326GlyGlu: 4.326 ± 0.06	3.269GlyPhe: 3.269 ± 0.063	8.378GlyGly: 8.378 ± 0.102	2.2GlyHis: 2.2 ± 0.043	4.654GlyIle: 4.654 ± 0.071	3.024GlyLys: 3.024 ± 0.053	9.622GlyLeu: 9.622 ± 0.09	2.261GlyMet: 2.261 ± 0.043	2.419GlyAsn: 2.419 ± 0.048	4.607GlyPro: 4.607 ± 0.067	3.189GlyGln: 3.189 ± 0.053	6.146GlyArg: 6.146 ± 0.076	5.755GlySer: 5.755 ± 0.077	6.646GlyThr: 6.646 ± 0.086	7.352GlyVal: 7.352 ± 0.082	1.737GlyTrp: 1.737 ± 0.037	2.31GlyTyr: 2.31 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.473HisAla: 2.473 ± 0.048	0.147HisCys: 0.147 ± 0.011	1.203HisAsp: 1.203 ± 0.034	1.112HisGlu: 1.112 ± 0.027	0.727HisPhe: 0.727 ± 0.021	2.2HisGly: 2.2 ± 0.049	0.65HisHis: 0.65 ± 0.026	0.872HisIle: 0.872 ± 0.022	0.482HisLys: 0.482 ± 0.019	2.082HisLeu: 2.082 ± 0.043	0.402HisMet: 0.402 ± 0.018	0.487HisAsn: 0.487 ± 0.018	1.51HisPro: 1.51 ± 0.034	0.736HisGln: 0.736 ± 0.026	1.481HisArg: 1.481 ± 0.036	1.224HisSer: 1.224 ± 0.029	1.121HisThr: 1.121 ± 0.028	1.73HisVal: 1.73 ± 0.042	0.335HisTrp: 0.335 ± 0.017	0.526HisTyr: 0.526 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.748IleAla: 5.748 ± 0.083	0.303IleCys: 0.303 ± 0.018	2.601IleAsp: 2.601 ± 0.046	2.157IleGlu: 2.157 ± 0.044	1.437IlePhe: 1.437 ± 0.045	4.096IleGly: 4.096 ± 0.07	0.872IleHis: 0.872 ± 0.029	1.932IleIle: 1.932 ± 0.045	1.303IleLys: 1.303 ± 0.032	3.841IleLeu: 3.841 ± 0.063	0.849IleMet: 0.849 ± 0.032	1.323IleAsn: 1.323 ± 0.037	2.452IlePro: 2.452 ± 0.045	1.115IleGln: 1.115 ± 0.031	2.408IleArg: 2.408 ± 0.047	2.636IleSer: 2.636 ± 0.048	2.741IleThr: 2.741 ± 0.052	3.595IleVal: 3.595 ± 0.052	0.47IleTrp: 0.47 ± 0.021	0.918IleTyr: 0.918 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.733LysAla: 3.733 ± 0.063	0.119LysCys: 0.119 ± 0.01	1.621LysAsp: 1.621 ± 0.04	1.277LysGlu: 1.277 ± 0.034	0.858LysPhe: 0.858 ± 0.029	2.111LysGly: 2.111 ± 0.044	0.598LysHis: 0.598 ± 0.021	1.316LysIle: 1.316 ± 0.034	1.021LysLys: 1.021 ± 0.033	2.766LysLeu: 2.766 ± 0.045	0.699LysMet: 0.699 ± 0.023	0.878LysAsn: 0.878 ± 0.028	1.596LysPro: 1.596 ± 0.039	0.835LysGln: 0.835 ± 0.027	1.608LysArg: 1.608 ± 0.041	1.758LysSer: 1.758 ± 0.039	1.699LysThr: 1.699 ± 0.038	2.485LysVal: 2.485 ± 0.052	0.341LysTrp: 0.341 ± 0.016	0.721LysTyr: 0.721 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	15.787LeuAla: 15.787 ± 0.144	0.683LeuCys: 0.683 ± 0.024	6.179LeuAsp: 6.179 ± 0.071	5.304LeuGlu: 5.304 ± 0.075	3.005LeuPhe: 3.005 ± 0.064	9.497LeuGly: 9.497 ± 0.106	2.013LeuHis: 2.013 ± 0.045	3.998LeuIle: 3.998 ± 0.065	2.637LeuLys: 2.637 ± 0.05	10.439LeuLeu: 10.439 ± 0.126	2.077LeuMet: 2.077 ± 0.043	2.545LeuAsn: 2.545 ± 0.042	5.852LeuPro: 5.852 ± 0.062	2.794LeuGln: 2.794 ± 0.049	6.538LeuArg: 6.538 ± 0.085	5.965LeuSer: 5.965 ± 0.068	5.763LeuThr: 5.763 ± 0.072	8.651LeuVal: 8.651 ± 0.094	1.323LeuTrp: 1.323 ± 0.039	1.679LeuTyr: 1.679 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.995MetAla: 2.995 ± 0.057	0.128MetCys: 0.128 ± 0.011	1.144MetAsp: 1.144 ± 0.03	0.962MetGlu: 0.962 ± 0.029	0.614MetPhe: 0.614 ± 0.021	1.875MetGly: 1.875 ± 0.042	0.413MetHis: 0.413 ± 0.021	0.842MetIle: 0.842 ± 0.026	0.659MetLys: 0.659 ± 0.025	2.031MetLeu: 2.031 ± 0.04	0.437MetMet: 0.437 ± 0.019	0.661MetAsn: 0.661 ± 0.022	1.195MetPro: 1.195 ± 0.031	0.535MetGln: 0.535 ± 0.023	1.142MetArg: 1.142 ± 0.026	1.556MetSer: 1.556 ± 0.032	1.528MetThr: 1.528 ± 0.036	1.855MetVal: 1.855 ± 0.036	0.232MetTrp: 0.232 ± 0.012	0.349MetTyr: 0.349 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.14AsnAla: 3.14 ± 0.053	0.181AsnCys: 0.181 ± 0.012	1.397AsnAsp: 1.397 ± 0.034	1.103AsnGlu: 1.103 ± 0.033	0.88AsnPhe: 0.88 ± 0.026	2.51AsnGly: 2.51 ± 0.044	0.582AsnHis: 0.582 ± 0.02	1.131AsnIle: 1.131 ± 0.032	0.739AsnLys: 0.739 ± 0.026	2.338AsnLeu: 2.338 ± 0.042	0.539AsnMet: 0.539 ± 0.018	0.802AsnAsn: 0.802 ± 0.028	1.937AsnPro: 1.937 ± 0.037	0.818AsnGln: 0.818 ± 0.028	1.508AsnArg: 1.508 ± 0.039	1.515AsnSer: 1.515 ± 0.039	1.594AsnThr: 1.594 ± 0.041	1.999AsnVal: 1.999 ± 0.041	0.407AsnTrp: 0.407 ± 0.018	0.683AsnTyr: 0.683 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	8.517ProAla: 8.517 ± 0.102	0.224ProCys: 0.224 ± 0.013	3.413ProAsp: 3.413 ± 0.065	3.559ProGlu: 3.559 ± 0.06	1.662ProPhe: 1.662 ± 0.038	6.053ProGly: 6.053 ± 0.093	1.146ProHis: 1.146 ± 0.034	1.734ProIle: 1.734 ± 0.039	1.344ProLys: 1.344 ± 0.038	5.003ProLeu: 5.003 ± 0.072	1.13ProMet: 1.13 ± 0.028	1.316ProAsn: 1.316 ± 0.033	2.373ProPro: 2.373 ± 0.056	1.704ProGln: 1.704 ± 0.041	2.833ProArg: 2.833 ± 0.053	3.25ProSer: 3.25 ± 0.054	3.001ProThr: 3.001 ± 0.05	4.873ProVal: 4.873 ± 0.064	0.858ProTrp: 0.858 ± 0.029	1.112ProTyr: 1.112 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.338GlnAla: 4.338 ± 0.08	0.175GlnCys: 0.175 ± 0.012	1.511GlnAsp: 1.511 ± 0.042	1.489GlnGlu: 1.489 ± 0.038	0.975GlnPhe: 0.975 ± 0.03	2.56GlnGly: 2.56 ± 0.043	0.702GlnHis: 0.702 ± 0.023	1.33GlnIle: 1.33 ± 0.039	0.861GlnLys: 0.861 ± 0.028	3.869GlnLeu: 3.869 ± 0.056	0.643GlnMet: 0.643 ± 0.024	0.711GlnAsn: 0.711 ± 0.025	1.717GlnPro: 1.717 ± 0.044	1.33GlnGln: 1.33 ± 0.04	2.197GlnArg: 2.197 ± 0.045	1.654GlnSer: 1.654 ± 0.041	1.423GlnThr: 1.423 ± 0.03	2.498GlnVal: 2.498 ± 0.046	0.608GlnTrp: 0.608 ± 0.022	0.664GlnTyr: 0.664 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.009ArgAla: 7.009 ± 0.094	0.32ArgCys: 0.32 ± 0.016	3.257ArgAsp: 3.257 ± 0.056	3.553ArgGlu: 3.553 ± 0.063	1.98ArgPhe: 1.98 ± 0.04	4.75ArgGly: 4.75 ± 0.064	1.64ArgHis: 1.64 ± 0.038	3.079ArgIle: 3.079 ± 0.056	1.867ArgLys: 1.867 ± 0.04	6.645ArgLeu: 6.645 ± 0.087	1.397ArgMet: 1.397 ± 0.035	1.726ArgAsn: 1.726 ± 0.043	3.322ArgPro: 3.322 ± 0.061	2.259ArgGln: 2.259 ± 0.047	5.243ArgArg: 5.243 ± 0.078	3.557ArgSer: 3.557 ± 0.059	3.782ArgThr: 3.782 ± 0.06	4.44ArgVal: 4.44 ± 0.061	1.039ArgTrp: 1.039 ± 0.029	1.394ArgTyr: 1.394 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	7.482SerAla: 7.482 ± 0.08	0.379SerCys: 0.379 ± 0.016	2.63SerAsp: 2.63 ± 0.046	2.543SerGlu: 2.543 ± 0.041	1.916SerPhe: 1.916 ± 0.039	5.978SerGly: 5.978 ± 0.073	1.235SerHis: 1.235 ± 0.035	2.502SerIle: 2.502 ± 0.054	1.549SerLys: 1.549 ± 0.038	5.906SerLeu: 5.906 ± 0.065	1.362SerMet: 1.362 ± 0.031	1.528SerAsn: 1.528 ± 0.034	3.349SerPro: 3.349 ± 0.052	1.714SerGln: 1.714 ± 0.037	3.626SerArg: 3.626 ± 0.052	3.507SerSer: 3.507 ± 0.06	3.682SerThr: 3.682 ± 0.054	4.653SerVal: 4.653 ± 0.065	0.968SerTrp: 0.968 ± 0.028	1.483SerTyr: 1.483 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	8.22ThrAla: 8.22 ± 0.102	0.301ThrCys: 0.301 ± 0.016	2.996ThrAsp: 2.996 ± 0.048	2.731ThrGlu: 2.731 ± 0.044	2.016ThrPhe: 2.016 ± 0.044	6.142ThrGly: 6.142 ± 0.077	1.174ThrHis: 1.174 ± 0.033	2.651ThrIle: 2.651 ± 0.046	1.525ThrLys: 1.525 ± 0.038	5.917ThrLeu: 5.917 ± 0.071	1.185ThrMet: 1.185 ± 0.032	1.403ThrAsn: 1.403 ± 0.038	3.934ThrPro: 3.934 ± 0.076	1.577ThrGln: 1.577 ± 0.037	3.058ThrArg: 3.058 ± 0.05	3.343ThrSer: 3.343 ± 0.05	3.825ThrThr: 3.825 ± 0.074	5.64ThrVal: 5.64 ± 0.084	0.819ThrTrp: 0.819 ± 0.027	1.151ThrTyr: 1.151 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	10.883ValAla: 10.883 ± 0.098	0.583ValCys: 0.583 ± 0.021	4.881ValAsp: 4.881 ± 0.068	4.464ValGlu: 4.464 ± 0.069	2.696ValPhe: 2.696 ± 0.042	6.742ValGly: 6.742 ± 0.077	1.768ValHis: 1.768 ± 0.037	3.659ValIle: 3.659 ± 0.069	2.258ValLys: 2.258 ± 0.049	9.284ValLeu: 9.284 ± 0.098	1.7ValMet: 1.7 ± 0.037	2.124ValAsn: 2.124 ± 0.042	4.857ValPro: 4.857 ± 0.068	2.407ValGln: 2.407 ± 0.041	5.098ValArg: 5.098 ± 0.07	4.877ValSer: 4.877 ± 0.067	4.989ValThr: 4.989 ± 0.074	8.155ValVal: 8.155 ± 0.103	1.015ValTrp: 1.015 ± 0.032	1.468ValTyr: 1.468 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.577TrpAla: 1.577 ± 0.04	0.115TrpCys: 0.115 ± 0.011	0.796TrpAsp: 0.796 ± 0.026	0.651TrpGlu: 0.651 ± 0.023	0.546TrpPhe: 0.546 ± 0.021	1.083TrpGly: 1.083 ± 0.033	0.352TrpHis: 0.352 ± 0.017	0.706TrpIle: 0.706 ± 0.027	0.407TrpLys: 0.407 ± 0.02	1.851TrpLeu: 1.851 ± 0.041	0.345TrpMet: 0.345 ± 0.013	0.493TrpAsn: 0.493 ± 0.023	0.722TrpPro: 0.722 ± 0.027	0.617TrpGln: 0.617 ± 0.024	1.085TrpArg: 1.085 ± 0.032	0.826TrpSer: 0.826 ± 0.028	0.922TrpThr: 0.922 ± 0.031	1.058TrpVal: 1.058 ± 0.032	0.316TrpTrp: 0.316 ± 0.016	0.288TrpTyr: 0.288 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.374TyrAla: 2.374 ± 0.047	0.152TyrCys: 0.152 ± 0.013	1.148TyrAsp: 1.148 ± 0.034	0.951TyrGlu: 0.951 ± 0.031	0.842TyrPhe: 0.842 ± 0.031	2.088TyrGly: 2.088 ± 0.049	0.343TyrHis: 0.343 ± 0.016	0.701TyrIle: 0.701 ± 0.027	0.526TyrLys: 0.526 ± 0.024	2.277TyrLeu: 2.277 ± 0.044	0.345TyrMet: 0.345 ± 0.019	0.529TyrAsn: 0.529 ± 0.02	1.123TyrPro: 1.123 ± 0.035	0.764TyrGln: 0.764 ± 0.025	1.455TyrArg: 1.455 ± 0.033	1.335TyrSer: 1.335 ± 0.037	1.21TyrThr: 1.21 ± 0.034	1.644TyrVal: 1.644 ± 0.033	0.336TyrTrp: 0.336 ± 0.02	0.513TyrTyr: 0.513 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3795 proteins (1248229 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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