Amino acid dipepetide frequency for Listeria virus P61

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.752AlaAla: 0.752 ± 0.325
0.301AlaCys: 0.301 ± 0.077
3.282AlaAsp: 3.282 ± 0.312
4.435AlaGlu: 4.435 ± 0.374
2.055AlaPhe: 2.055 ± 0.192
3.859AlaGly: 3.859 ± 0.532
0.927AlaHis: 0.927 ± 0.142
4.034AlaIle: 4.034 ± 0.336
4.66AlaLys: 4.66 ± 0.323
5.487AlaLeu: 5.487 ± 0.407
1.503AlaMet: 1.503 ± 0.257
3.508AlaAsn: 3.508 ± 0.3
1.754AlaPro: 1.754 ± 0.284
2.23AlaGln: 2.23 ± 0.267
2.631AlaArg: 2.631 ± 0.295
4.46AlaSer: 4.46 ± 0.381
3.934AlaThr: 3.934 ± 0.331
4.209AlaVal: 4.209 ± 0.297
0.376AlaTrp: 0.376 ± 0.085
2.881AlaTyr: 2.881 ± 0.284
0.05AlaXaa: 0.05 ± 0.049
Cys
0.226CysAla: 0.226 ± 0.077
0.125CysCys: 0.125 ± 0.048
0.326CysAsp: 0.326 ± 0.107
0.401CysGlu: 0.401 ± 0.105
0.326CysPhe: 0.326 ± 0.087
0.451CysGly: 0.451 ± 0.11
0.175CysHis: 0.175 ± 0.064
0.326CysIle: 0.326 ± 0.093
0.551CysLys: 0.551 ± 0.109
0.501CysLeu: 0.501 ± 0.107
0.1CysMet: 0.1 ± 0.047
0.401CysAsn: 0.401 ± 0.09
0.301CysPro: 0.301 ± 0.098
0.251CysGln: 0.251 ± 0.08
0.276CysArg: 0.276 ± 0.091
0.526CysSer: 0.526 ± 0.127
0.226CysThr: 0.226 ± 0.068
0.476CysVal: 0.476 ± 0.112
0.0CysTrp: 0.0 ± 0.0
0.426CysTyr: 0.426 ± 0.121
0.0CysXaa: 0.0 ± 0.0
Asp
2.255AspAla: 2.255 ± 0.257
0.501AspCys: 0.501 ± 0.118
2.606AspAsp: 2.606 ± 0.294
4.034AspGlu: 4.034 ± 0.331
2.982AspPhe: 2.982 ± 0.252
3.383AspGly: 3.383 ± 0.309
0.451AspHis: 0.451 ± 0.097
4.56AspIle: 4.56 ± 0.343
5.913AspLys: 5.913 ± 0.445
5.487AspLeu: 5.487 ± 0.273
1.553AspMet: 1.553 ± 0.188
4.26AspAsn: 4.26 ± 0.298
1.528AspPro: 1.528 ± 0.165
1.428AspGln: 1.428 ± 0.266
2.606AspArg: 2.606 ± 0.277
4.209AspSer: 4.209 ± 0.322
3.583AspThr: 3.583 ± 0.29
3.758AspVal: 3.758 ± 0.328
0.727AspTrp: 0.727 ± 0.144
3.558AspTyr: 3.558 ± 0.331
0.0AspXaa: 0.0 ± 0.0
Glu
5.537GluAla: 5.537 ± 0.381
0.426GluCys: 0.426 ± 0.106
5.362GluAsp: 5.362 ± 0.451
9.271GluGlu: 9.271 ± 0.697
3.032GluPhe: 3.032 ± 0.285
4.385GluGly: 4.385 ± 0.372
1.153GluHis: 1.153 ± 0.182
4.786GluIle: 4.786 ± 0.353
7.767GluLys: 7.767 ± 0.557
7.918GluLeu: 7.918 ± 0.567
1.904GluMet: 1.904 ± 0.242
4.26GluAsn: 4.26 ± 0.285
1.629GluPro: 1.629 ± 0.242
2.806GluGln: 2.806 ± 0.28
3.533GluArg: 3.533 ± 0.313
4.585GluSer: 4.585 ± 0.34
4.059GluThr: 4.059 ± 0.376
6.439GluVal: 6.439 ± 0.426
0.702GluTrp: 0.702 ± 0.155
3.032GluTyr: 3.032 ± 0.326
0.025GluXaa: 0.025 ± 0.024
Phe
1.729PheAla: 1.729 ± 0.191
0.276PheCys: 0.276 ± 0.095
2.18PheAsp: 2.18 ± 0.228
2.581PheGlu: 2.581 ± 0.245
1.579PhePhe: 1.579 ± 0.154
2.28PheGly: 2.28 ± 0.275
0.702PheHis: 0.702 ± 0.135
2.856PheIle: 2.856 ± 0.286
2.631PheLys: 2.631 ± 0.203
3.984PheLeu: 3.984 ± 0.364
1.027PheMet: 1.027 ± 0.172
2.33PheAsn: 2.33 ± 0.277
1.077PhePro: 1.077 ± 0.169
1.128PheGln: 1.128 ± 0.156
1.353PheArg: 1.353 ± 0.161
3.182PheSer: 3.182 ± 0.322
2.556PheThr: 2.556 ± 0.248
3.332PheVal: 3.332 ± 0.299
0.226PheTrp: 0.226 ± 0.071
2.23PheTyr: 2.23 ± 0.278
0.0PheXaa: 0.0 ± 0.0
Gly
3.733GlyAla: 3.733 ± 0.737
0.551GlyCys: 0.551 ± 0.121
3.834GlyAsp: 3.834 ± 0.374
4.084GlyGlu: 4.084 ± 0.293
2.08GlyPhe: 2.08 ± 0.216
4.711GlyGly: 4.711 ± 0.808
0.827GlyHis: 0.827 ± 0.119
4.335GlyIle: 4.335 ± 0.353
5.262GlyLys: 5.262 ± 0.477
4.109GlyLeu: 4.109 ± 0.369
1.704GlyMet: 1.704 ± 0.259
3.758GlyAsn: 3.758 ± 0.288
0.025GlyPro: 0.025 ± 0.026
1.528GlyGln: 1.528 ± 0.231
2.255GlyArg: 2.255 ± 0.239
4.184GlySer: 4.184 ± 0.437
3.909GlyThr: 3.909 ± 0.399
4.585GlyVal: 4.585 ± 0.319
0.626GlyTrp: 0.626 ± 0.141
2.806GlyTyr: 2.806 ± 0.222
0.05GlyXaa: 0.05 ± 0.049
His
0.802HisAla: 0.802 ± 0.132
0.2HisCys: 0.2 ± 0.066
0.902HisAsp: 0.902 ± 0.168
0.952HisGlu: 0.952 ± 0.138
0.526HisPhe: 0.526 ± 0.11
0.852HisGly: 0.852 ± 0.145
0.276HisHis: 0.276 ± 0.091
1.203HisIle: 1.203 ± 0.242
1.253HisLys: 1.253 ± 0.171
1.328HisLeu: 1.328 ± 0.171
0.301HisMet: 0.301 ± 0.085
0.626HisAsn: 0.626 ± 0.115
0.451HisPro: 0.451 ± 0.107
0.401HisGln: 0.401 ± 0.103
0.651HisArg: 0.651 ± 0.133
1.002HisSer: 1.002 ± 0.173
1.027HisThr: 1.027 ± 0.182
1.128HisVal: 1.128 ± 0.186
0.276HisTrp: 0.276 ± 0.108
0.852HisTyr: 0.852 ± 0.165
0.0HisXaa: 0.0 ± 0.0
Ile
4.51IleAla: 4.51 ± 0.361
0.401IleCys: 0.401 ± 0.101
4.009IleAsp: 4.009 ± 0.349
5.437IleGlu: 5.437 ± 0.424
1.804IlePhe: 1.804 ± 0.23
3.733IleGly: 3.733 ± 0.358
1.102IleHis: 1.102 ± 0.18
4.786IleIle: 4.786 ± 0.417
5.262IleLys: 5.262 ± 0.409
5.312IleLeu: 5.312 ± 0.35
1.904IleMet: 1.904 ± 0.212
3.633IleAsn: 3.633 ± 0.344
2.38IlePro: 2.38 ± 0.249
2.355IleGln: 2.355 ± 0.209
3.157IleArg: 3.157 ± 0.293
4.66IleSer: 4.66 ± 0.357
4.109IleThr: 4.109 ± 0.403
4.886IleVal: 4.886 ± 0.367
0.526IleTrp: 0.526 ± 0.141
2.305IleTyr: 2.305 ± 0.229
0.025IleXaa: 0.025 ± 0.024
Lys
4.861LysAla: 4.861 ± 0.375
0.376LysCys: 0.376 ± 0.129
5.487LysAsp: 5.487 ± 0.379
9.822LysGlu: 9.822 ± 0.687
3.032LysPhe: 3.032 ± 0.253
5.187LysGly: 5.187 ± 0.389
1.403LysHis: 1.403 ± 0.182
4.786LysIle: 4.786 ± 0.348
8.82LysLys: 8.82 ± 0.606
6.615LysLeu: 6.615 ± 0.404
2.03LysMet: 2.03 ± 0.23
4.911LysAsn: 4.911 ± 0.344
2.606LysPro: 2.606 ± 0.232
3.232LysGln: 3.232 ± 0.3
3.182LysArg: 3.182 ± 0.308
4.635LysSer: 4.635 ± 0.322
4.56LysThr: 4.56 ± 0.421
6.439LysVal: 6.439 ± 0.474
0.852LysTrp: 0.852 ± 0.145
3.257LysTyr: 3.257 ± 0.251
0.0LysXaa: 0.0 ± 0.0
Leu
6.214LeuAla: 6.214 ± 0.398
0.626LeuCys: 0.626 ± 0.114
5.938LeuAsp: 5.938 ± 0.378
7.191LeuGlu: 7.191 ± 0.431
3.408LeuPhe: 3.408 ± 0.291
5.337LeuGly: 5.337 ± 0.395
0.877LeuHis: 0.877 ± 0.176
4.285LeuIle: 4.285 ± 0.365
6.465LeuLys: 6.465 ± 0.425
6.815LeuLeu: 6.815 ± 0.471
1.954LeuMet: 1.954 ± 0.216
4.836LeuAsn: 4.836 ± 0.354
3.257LeuPro: 3.257 ± 0.361
3.057LeuGln: 3.057 ± 0.29
3.733LeuArg: 3.733 ± 0.352
5.512LeuSer: 5.512 ± 0.407
5.112LeuThr: 5.112 ± 0.356
6.414LeuVal: 6.414 ± 0.458
0.827LeuTrp: 0.827 ± 0.136
3.232LeuTyr: 3.232 ± 0.291
0.05LeuXaa: 0.05 ± 0.049
Met
1.704MetAla: 1.704 ± 0.201
0.15MetCys: 0.15 ± 0.074
0.902MetAsp: 0.902 ± 0.138
1.829MetGlu: 1.829 ± 0.237
1.102MetPhe: 1.102 ± 0.142
1.077MetGly: 1.077 ± 0.211
0.15MetHis: 0.15 ± 0.059
1.353MetIle: 1.353 ± 0.197
2.18MetLys: 2.18 ± 0.254
2.155MetLeu: 2.155 ± 0.236
0.351MetMet: 0.351 ± 0.092
1.403MetAsn: 1.403 ± 0.201
1.027MetPro: 1.027 ± 0.145
0.902MetGln: 0.902 ± 0.148
1.278MetArg: 1.278 ± 0.173
2.08MetSer: 2.08 ± 0.186
1.979MetThr: 1.979 ± 0.223
1.403MetVal: 1.403 ± 0.191
0.301MetTrp: 0.301 ± 0.087
1.052MetTyr: 1.052 ± 0.16
0.0MetXaa: 0.0 ± 0.0
Asn
2.806AsnAla: 2.806 ± 0.296
0.2AsnCys: 0.2 ± 0.066
2.456AsnAsp: 2.456 ± 0.218
3.633AsnGlu: 3.633 ± 0.32
2.23AsnPhe: 2.23 ± 0.212
3.433AsnGly: 3.433 ± 0.329
1.027AsnHis: 1.027 ± 0.163
4.36AsnIle: 4.36 ± 0.422
5.537AsnLys: 5.537 ± 0.339
4.736AsnLeu: 4.736 ± 0.396
1.804AsnMet: 1.804 ± 0.184
3.458AsnAsn: 3.458 ± 0.317
2.105AsnPro: 2.105 ± 0.244
1.729AsnGln: 1.729 ± 0.197
2.43AsnArg: 2.43 ± 0.243
3.708AsnSer: 3.708 ± 0.353
3.884AsnThr: 3.884 ± 0.33
3.408AsnVal: 3.408 ± 0.304
0.752AsnTrp: 0.752 ± 0.124
2.556AsnTyr: 2.556 ± 0.235
0.025AsnXaa: 0.025 ± 0.027
Pro
1.629ProAla: 1.629 ± 0.253
0.1ProCys: 0.1 ± 0.049
1.929ProAsp: 1.929 ± 0.221
2.456ProGlu: 2.456 ± 0.211
1.228ProPhe: 1.228 ± 0.151
0.426ProGly: 0.426 ± 0.117
0.401ProHis: 0.401 ± 0.101
1.729ProIle: 1.729 ± 0.218
2.756ProLys: 2.756 ± 0.313
2.456ProLeu: 2.456 ± 0.276
0.852ProMet: 0.852 ± 0.141
1.553ProAsn: 1.553 ± 0.191
0.752ProPro: 0.752 ± 0.152
1.178ProGln: 1.178 ± 0.21
0.952ProArg: 0.952 ± 0.154
2.18ProSer: 2.18 ± 0.283
2.305ProThr: 2.305 ± 0.326
1.879ProVal: 1.879 ± 0.274
0.226ProTrp: 0.226 ± 0.073
1.428ProTyr: 1.428 ± 0.214
0.0ProXaa: 0.0 ± 0.0
Gln
2.831GlnAla: 2.831 ± 0.46
0.1GlnCys: 0.1 ± 0.046
1.779GlnAsp: 1.779 ± 0.211
2.806GlnGlu: 2.806 ± 0.299
1.178GlnPhe: 1.178 ± 0.17
2.305GlnGly: 2.305 ± 0.228
0.401GlnHis: 0.401 ± 0.097
1.704GlnIle: 1.704 ± 0.203
2.606GlnLys: 2.606 ± 0.314
3.107GlnLeu: 3.107 ± 0.284
0.852GlnMet: 0.852 ± 0.144
1.353GlnAsn: 1.353 ± 0.183
0.927GlnPro: 0.927 ± 0.292
2.305GlnGln: 2.305 ± 0.957
1.403GlnArg: 1.403 ± 0.208
2.155GlnSer: 2.155 ± 0.289
1.929GlnThr: 1.929 ± 0.197
2.731GlnVal: 2.731 ± 0.272
0.125GlnTrp: 0.125 ± 0.059
1.303GlnTyr: 1.303 ± 0.194
0.025GlnXaa: 0.025 ± 0.024
Arg
2.581ArgAla: 2.581 ± 0.317
0.15ArgCys: 0.15 ± 0.052
2.856ArgAsp: 2.856 ± 0.271
3.708ArgGlu: 3.708 ± 0.362
1.654ArgPhe: 1.654 ± 0.2
2.405ArgGly: 2.405 ± 0.276
0.677ArgHis: 0.677 ± 0.119
2.907ArgIle: 2.907 ± 0.253
3.633ArgLys: 3.633 ± 0.296
3.733ArgLeu: 3.733 ± 0.281
0.977ArgMet: 0.977 ± 0.153
2.706ArgAsn: 2.706 ± 0.255
0.677ArgPro: 0.677 ± 0.124
1.428ArgGln: 1.428 ± 0.203
1.353ArgArg: 1.353 ± 0.188
1.979ArgSer: 1.979 ± 0.241
2.355ArgThr: 2.355 ± 0.216
3.358ArgVal: 3.358 ± 0.293
0.301ArgTrp: 0.301 ± 0.094
1.779ArgTyr: 1.779 ± 0.226
0.0ArgXaa: 0.0 ± 0.0
Ser
3.784SerAla: 3.784 ± 0.305
0.401SerCys: 0.401 ± 0.115
3.658SerAsp: 3.658 ± 0.323
4.184SerGlu: 4.184 ± 0.347
3.007SerPhe: 3.007 ± 0.277
3.533SerGly: 3.533 ± 0.407
1.228SerHis: 1.228 ± 0.16
5.337SerIle: 5.337 ± 0.384
6.064SerLys: 6.064 ± 0.432
6.289SerLeu: 6.289 ± 0.428
1.754SerMet: 1.754 ± 0.19
3.383SerAsn: 3.383 ± 0.321
1.954SerPro: 1.954 ± 0.227
2.03SerGln: 2.03 ± 0.234
3.307SerArg: 3.307 ± 0.329
5.061SerSer: 5.061 ± 0.55
4.109SerThr: 4.109 ± 0.337
4.936SerVal: 4.936 ± 0.354
0.802SerTrp: 0.802 ± 0.161
3.132SerTyr: 3.132 ± 0.323
0.0SerXaa: 0.0 ± 0.0
Thr
4.109ThrAla: 4.109 ± 0.398
0.301ThrCys: 0.301 ± 0.084
3.608ThrAsp: 3.608 ± 0.312
5.061ThrGlu: 5.061 ± 0.359
3.157ThrPhe: 3.157 ± 0.265
4.435ThrGly: 4.435 ± 0.368
1.128ThrHis: 1.128 ± 0.173
4.385ThrIle: 4.385 ± 0.363
4.635ThrLys: 4.635 ± 0.357
5.086ThrLeu: 5.086 ± 0.405
1.102ThrMet: 1.102 ± 0.151
2.932ThrAsn: 2.932 ± 0.293
2.305ThrPro: 2.305 ± 0.263
1.503ThrGln: 1.503 ± 0.203
2.03ThrArg: 2.03 ± 0.225
4.435ThrSer: 4.435 ± 0.325
4.009ThrThr: 4.009 ± 0.314
5.086ThrVal: 5.086 ± 0.387
0.702ThrTrp: 0.702 ± 0.15
2.907ThrTyr: 2.907 ± 0.323
0.075ThrXaa: 0.075 ± 0.057
Val
4.535ValAla: 4.535 ± 0.28
0.501ValCys: 0.501 ± 0.116
4.861ValAsp: 4.861 ± 0.303
6.214ValGlu: 6.214 ± 0.437
2.907ValPhe: 2.907 ± 0.326
4.009ValGly: 4.009 ± 0.341
1.027ValHis: 1.027 ± 0.16
5.112ValIle: 5.112 ± 0.404
5.738ValLys: 5.738 ± 0.397
5.437ValLeu: 5.437 ± 0.46
1.478ValMet: 1.478 ± 0.221
3.809ValAsn: 3.809 ± 0.353
2.305ValPro: 2.305 ± 0.252
2.456ValGln: 2.456 ± 0.285
2.631ValArg: 2.631 ± 0.24
5.713ValSer: 5.713 ± 0.373
5.337ValThr: 5.337 ± 0.507
5.237ValVal: 5.237 ± 0.356
0.752ValTrp: 0.752 ± 0.136
3.207ValTyr: 3.207 ± 0.319
0.0ValXaa: 0.0 ± 0.0
Trp
0.451TrpAla: 0.451 ± 0.119
0.15TrpCys: 0.15 ± 0.062
0.752TrpAsp: 0.752 ± 0.159
0.952TrpGlu: 0.952 ± 0.168
0.326TrpPhe: 0.326 ± 0.082
0.777TrpGly: 0.777 ± 0.17
0.276TrpHis: 0.276 ± 0.079
0.451TrpIle: 0.451 ± 0.09
0.651TrpLys: 0.651 ± 0.131
0.802TrpLeu: 0.802 ± 0.121
0.05TrpMet: 0.05 ± 0.036
0.551TrpAsn: 0.551 ± 0.13
0.0TrpPro: 0.0 ± 0.0
0.301TrpGln: 0.301 ± 0.085
0.175TrpArg: 0.175 ± 0.065
0.476TrpSer: 0.476 ± 0.11
0.727TrpThr: 0.727 ± 0.155
0.802TrpVal: 0.802 ± 0.13
0.276TrpTrp: 0.276 ± 0.091
0.727TrpTyr: 0.727 ± 0.151
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.255TyrAla: 2.255 ± 0.204
0.551TyrCys: 0.551 ± 0.114
2.656TyrAsp: 2.656 ± 0.223
3.533TyrGlu: 3.533 ± 0.309
1.629TyrPhe: 1.629 ± 0.217
2.38TyrGly: 2.38 ± 0.286
0.802TyrHis: 0.802 ± 0.175
2.957TyrIle: 2.957 ± 0.295
3.708TyrLys: 3.708 ± 0.273
3.708TyrLeu: 3.708 ± 0.358
1.153TyrMet: 1.153 ± 0.147
2.606TyrAsn: 2.606 ± 0.203
1.353TyrPro: 1.353 ± 0.175
1.629TyrGln: 1.629 ± 0.291
2.28TyrArg: 2.28 ± 0.221
3.207TyrSer: 3.207 ± 0.269
3.207TyrThr: 3.207 ± 0.311
2.756TyrVal: 2.756 ± 0.257
0.301TyrTrp: 0.301 ± 0.075
2.08TyrTyr: 2.08 ± 0.232
0.025TyrXaa: 0.025 ± 0.024
Xaa
0.025XaaAla: 0.025 ± 0.024
0.0XaaCys: 0.0 ± 0.0
0.025XaaAsp: 0.025 ± 0.024
0.025XaaGlu: 0.025 ± 0.024
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.05XaaIle: 0.05 ± 0.037
0.0XaaLys: 0.0 ± 0.0
0.075XaaLeu: 0.075 ± 0.073
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.05XaaGln: 0.05 ± 0.049
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.075XaaThr: 0.075 ± 0.057
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.025XaaTyr: 0.025 ± 0.024
0.326XaaXaa: 0.326 ± 0.318
Statistics based on 190 proteins (39911 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski