Amino acid dipepetide frequency for Ralstonia virus RSA1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.896AlaAla: 20.896 ± 2.012
1.346AlaCys: 1.346 ± 0.323
8.073AlaAsp: 8.073 ± 0.986
7.044AlaGlu: 7.044 ± 0.802
3.404AlaPhe: 3.404 ± 0.673
12.506AlaGly: 12.506 ± 1.071
2.533AlaHis: 2.533 ± 0.556
4.987AlaIle: 4.987 ± 0.662
4.274AlaLys: 4.274 ± 0.76
11.952AlaLeu: 11.952 ± 1.014
3.245AlaMet: 3.245 ± 0.433
3.878AlaAsn: 3.878 ± 0.568
4.828AlaPro: 4.828 ± 0.535
5.145AlaGln: 5.145 ± 0.672
9.261AlaArg: 9.261 ± 0.885
6.016AlaSer: 6.016 ± 0.706
7.044AlaThr: 7.044 ± 0.851
8.944AlaVal: 8.944 ± 1.14
2.533AlaTrp: 2.533 ± 0.471
2.929AlaTyr: 2.929 ± 0.409
0.0AlaXaa: 0.0 ± 0.0
Cys
1.425CysAla: 1.425 ± 0.354
0.0CysCys: 0.0 ± 0.0
0.317CysAsp: 0.317 ± 0.169
0.95CysGlu: 0.95 ± 0.336
0.079CysPhe: 0.079 ± 0.073
0.95CysGly: 0.95 ± 0.276
0.158CysHis: 0.158 ± 0.127
0.871CysIle: 0.871 ± 0.282
0.317CysLys: 0.317 ± 0.191
0.712CysLeu: 0.712 ± 0.255
0.396CysMet: 0.396 ± 0.133
0.079CysAsn: 0.079 ± 0.077
1.108CysPro: 1.108 ± 0.357
0.158CysGln: 0.158 ± 0.113
1.266CysArg: 1.266 ± 0.328
0.95CysSer: 0.95 ± 0.282
0.396CysThr: 0.396 ± 0.173
0.871CysVal: 0.871 ± 0.274
0.079CysTrp: 0.079 ± 0.08
0.317CysTyr: 0.317 ± 0.15
0.0CysXaa: 0.0 ± 0.0
Asp
8.073AspAla: 8.073 ± 0.775
0.396AspCys: 0.396 ± 0.17
2.77AspAsp: 2.77 ± 0.573
2.691AspGlu: 2.691 ± 0.397
1.425AspPhe: 1.425 ± 0.366
5.62AspGly: 5.62 ± 0.72
0.792AspHis: 0.792 ± 0.345
2.137AspIle: 2.137 ± 0.499
2.375AspLys: 2.375 ± 0.566
6.016AspLeu: 6.016 ± 0.507
1.187AspMet: 1.187 ± 0.328
2.137AspAsn: 2.137 ± 0.48
2.929AspPro: 2.929 ± 0.425
3.008AspGln: 3.008 ± 0.407
4.195AspArg: 4.195 ± 0.583
1.662AspSer: 1.662 ± 0.399
3.878AspThr: 3.878 ± 0.729
3.483AspVal: 3.483 ± 0.501
0.792AspTrp: 0.792 ± 0.33
1.346AspTyr: 1.346 ± 0.369
0.0AspXaa: 0.0 ± 0.0
Glu
5.461GluAla: 5.461 ± 0.67
0.792GluCys: 0.792 ± 0.309
2.295GluAsp: 2.295 ± 0.377
2.216GluGlu: 2.216 ± 0.498
1.504GluPhe: 1.504 ± 0.324
3.562GluGly: 3.562 ± 0.507
0.95GluHis: 0.95 ± 0.288
2.137GluIle: 2.137 ± 0.521
2.137GluLys: 2.137 ± 0.478
6.016GluLeu: 6.016 ± 0.929
1.108GluMet: 1.108 ± 0.278
1.346GluAsn: 1.346 ± 0.359
2.216GluPro: 2.216 ± 0.47
2.295GluGln: 2.295 ± 0.571
5.541GluArg: 5.541 ± 0.766
2.137GluSer: 2.137 ± 0.446
2.295GluThr: 2.295 ± 0.363
4.432GluVal: 4.432 ± 0.871
1.029GluTrp: 1.029 ± 0.302
1.425GluTyr: 1.425 ± 0.329
0.0GluXaa: 0.0 ± 0.0
Phe
4.116PheAla: 4.116 ± 0.704
0.396PheCys: 0.396 ± 0.197
2.295PheAsp: 2.295 ± 0.485
1.504PheGlu: 1.504 ± 0.317
1.187PhePhe: 1.187 ± 0.322
2.454PheGly: 2.454 ± 0.543
0.396PheHis: 0.396 ± 0.188
1.346PheIle: 1.346 ± 0.304
1.108PheLys: 1.108 ± 0.312
2.137PheLeu: 2.137 ± 0.314
0.554PheMet: 0.554 ± 0.201
0.95PheAsn: 0.95 ± 0.284
1.187PhePro: 1.187 ± 0.297
1.029PheGln: 1.029 ± 0.286
2.216PheArg: 2.216 ± 0.587
2.454PheSer: 2.454 ± 0.637
1.583PheThr: 1.583 ± 0.343
1.979PheVal: 1.979 ± 0.378
0.712PheTrp: 0.712 ± 0.226
0.712PheTyr: 0.712 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
9.498GlyAla: 9.498 ± 1.225
1.346GlyCys: 1.346 ± 0.265
5.224GlyAsp: 5.224 ± 0.695
3.641GlyGlu: 3.641 ± 0.583
2.216GlyPhe: 2.216 ± 0.39
7.678GlyGly: 7.678 ± 0.885
1.425GlyHis: 1.425 ± 0.396
3.562GlyIle: 3.562 ± 0.791
3.562GlyLys: 3.562 ± 0.504
6.016GlyLeu: 6.016 ± 0.859
1.741GlyMet: 1.741 ± 0.374
2.375GlyAsn: 2.375 ± 0.39
3.008GlyPro: 3.008 ± 0.549
2.929GlyGln: 2.929 ± 0.469
7.044GlyArg: 7.044 ± 1.063
3.404GlySer: 3.404 ± 0.632
5.224GlyThr: 5.224 ± 0.868
6.57GlyVal: 6.57 ± 0.71
1.82GlyTrp: 1.82 ± 0.341
2.849GlyTyr: 2.849 ± 0.401
0.0GlyXaa: 0.0 ± 0.0
His
2.929HisAla: 2.929 ± 0.722
0.712HisCys: 0.712 ± 0.25
1.741HisAsp: 1.741 ± 0.333
0.792HisGlu: 0.792 ± 0.243
0.475HisPhe: 0.475 ± 0.229
2.058HisGly: 2.058 ± 0.494
1.029HisHis: 1.029 ± 0.389
0.95HisIle: 0.95 ± 0.263
0.871HisLys: 0.871 ± 0.315
2.058HisLeu: 2.058 ± 0.497
0.712HisMet: 0.712 ± 0.247
0.475HisAsn: 0.475 ± 0.2
1.346HisPro: 1.346 ± 0.355
0.792HisGln: 0.792 ± 0.282
1.425HisArg: 1.425 ± 0.367
1.266HisSer: 1.266 ± 0.312
0.871HisThr: 0.871 ± 0.3
1.741HisVal: 1.741 ± 0.376
0.317HisTrp: 0.317 ± 0.159
0.396HisTyr: 0.396 ± 0.162
0.0HisXaa: 0.0 ± 0.0
Ile
5.382IleAla: 5.382 ± 0.712
0.317IleCys: 0.317 ± 0.191
3.483IleAsp: 3.483 ± 0.627
3.008IleGlu: 3.008 ± 0.485
0.554IlePhe: 0.554 ± 0.203
4.274IleGly: 4.274 ± 0.683
0.712IleHis: 0.712 ± 0.223
1.346IleIle: 1.346 ± 0.36
1.9IleLys: 1.9 ± 0.33
3.008IleLeu: 3.008 ± 0.52
0.396IleMet: 0.396 ± 0.18
1.662IleAsn: 1.662 ± 0.403
1.346IlePro: 1.346 ± 0.385
1.187IleGln: 1.187 ± 0.273
2.929IleArg: 2.929 ± 0.428
1.425IleSer: 1.425 ± 0.439
3.641IleThr: 3.641 ± 0.693
2.77IleVal: 2.77 ± 0.482
0.237IleTrp: 0.237 ± 0.126
0.396IleTyr: 0.396 ± 0.161
0.0IleXaa: 0.0 ± 0.0
Lys
5.62LysAla: 5.62 ± 0.893
0.317LysCys: 0.317 ± 0.163
1.504LysAsp: 1.504 ± 0.337
2.058LysGlu: 2.058 ± 0.374
1.108LysPhe: 1.108 ± 0.317
2.691LysGly: 2.691 ± 0.381
0.712LysHis: 0.712 ± 0.217
1.029LysIle: 1.029 ± 0.26
2.137LysLys: 2.137 ± 0.556
3.404LysLeu: 3.404 ± 0.534
0.712LysMet: 0.712 ± 0.24
0.871LysAsn: 0.871 ± 0.263
1.9LysPro: 1.9 ± 0.394
1.662LysGln: 1.662 ± 0.431
3.404LysArg: 3.404 ± 0.637
1.741LysSer: 1.741 ± 0.454
2.216LysThr: 2.216 ± 0.394
2.77LysVal: 2.77 ± 0.758
0.396LysTrp: 0.396 ± 0.203
0.871LysTyr: 0.871 ± 0.256
0.0LysXaa: 0.0 ± 0.0
Leu
12.902LeuAla: 12.902 ± 1.092
1.187LeuCys: 1.187 ± 0.417
4.591LeuAsp: 4.591 ± 0.576
5.62LeuGlu: 5.62 ± 0.777
3.245LeuPhe: 3.245 ± 0.621
6.016LeuGly: 6.016 ± 0.757
2.691LeuHis: 2.691 ± 0.543
3.008LeuIle: 3.008 ± 0.455
3.878LeuLys: 3.878 ± 0.794
7.282LeuLeu: 7.282 ± 0.861
1.82LeuMet: 1.82 ± 0.394
2.691LeuAsn: 2.691 ± 0.372
5.145LeuPro: 5.145 ± 0.818
3.245LeuGln: 3.245 ± 0.514
7.282LeuArg: 7.282 ± 0.871
5.224LeuSer: 5.224 ± 0.728
5.066LeuThr: 5.066 ± 0.787
6.807LeuVal: 6.807 ± 0.898
0.95LeuTrp: 0.95 ± 0.234
2.375LeuTyr: 2.375 ± 0.346
0.0LeuXaa: 0.0 ± 0.0
Met
2.612MetAla: 2.612 ± 0.456
0.079MetCys: 0.079 ± 0.077
1.108MetAsp: 1.108 ± 0.346
1.029MetGlu: 1.029 ± 0.312
0.396MetPhe: 0.396 ± 0.167
0.792MetGly: 0.792 ± 0.241
0.554MetHis: 0.554 ± 0.211
0.554MetIle: 0.554 ± 0.201
0.95MetLys: 0.95 ± 0.279
2.375MetLeu: 2.375 ± 0.388
0.475MetMet: 0.475 ± 0.205
0.792MetAsn: 0.792 ± 0.234
1.266MetPro: 1.266 ± 0.291
0.554MetGln: 0.554 ± 0.166
1.583MetArg: 1.583 ± 0.284
1.662MetSer: 1.662 ± 0.338
1.82MetThr: 1.82 ± 0.315
1.583MetVal: 1.583 ± 0.273
0.158MetTrp: 0.158 ± 0.129
0.475MetTyr: 0.475 ± 0.18
0.0MetXaa: 0.0 ± 0.0
Asn
4.037AsnAla: 4.037 ± 0.446
0.158AsnCys: 0.158 ± 0.099
2.058AsnAsp: 2.058 ± 0.513
1.266AsnGlu: 1.266 ± 0.294
0.871AsnPhe: 0.871 ± 0.22
2.77AsnGly: 2.77 ± 0.516
0.95AsnHis: 0.95 ± 0.221
1.108AsnIle: 1.108 ± 0.267
0.95AsnLys: 0.95 ± 0.33
2.612AsnLeu: 2.612 ± 0.538
0.554AsnMet: 0.554 ± 0.173
0.712AsnAsn: 0.712 ± 0.19
2.691AsnPro: 2.691 ± 0.513
1.266AsnGln: 1.266 ± 0.297
1.266AsnArg: 1.266 ± 0.32
1.187AsnSer: 1.187 ± 0.38
1.583AsnThr: 1.583 ± 0.371
2.058AsnVal: 2.058 ± 0.334
0.317AsnTrp: 0.317 ± 0.142
0.871AsnTyr: 0.871 ± 0.316
0.0AsnXaa: 0.0 ± 0.0
Pro
5.62ProAla: 5.62 ± 0.907
0.554ProCys: 0.554 ± 0.248
3.087ProAsp: 3.087 ± 0.453
2.929ProGlu: 2.929 ± 0.41
1.583ProPhe: 1.583 ± 0.374
4.116ProGly: 4.116 ± 0.63
0.95ProHis: 0.95 ± 0.294
2.375ProIle: 2.375 ± 0.448
1.029ProLys: 1.029 ± 0.257
4.432ProLeu: 4.432 ± 0.615
0.95ProMet: 0.95 ± 0.251
1.187ProAsn: 1.187 ± 0.331
2.454ProPro: 2.454 ± 0.541
1.583ProGln: 1.583 ± 0.362
3.72ProArg: 3.72 ± 0.652
2.612ProSer: 2.612 ± 0.472
2.454ProThr: 2.454 ± 0.466
3.878ProVal: 3.878 ± 0.474
1.266ProTrp: 1.266 ± 0.31
1.266ProTyr: 1.266 ± 0.363
0.0ProXaa: 0.0 ± 0.0
Gln
5.699GlnAla: 5.699 ± 0.651
0.554GlnCys: 0.554 ± 0.217
1.346GlnAsp: 1.346 ± 0.321
1.82GlnGlu: 1.82 ± 0.44
1.425GlnPhe: 1.425 ± 0.313
1.662GlnGly: 1.662 ± 0.392
0.95GlnHis: 0.95 ± 0.304
1.504GlnIle: 1.504 ± 0.418
0.95GlnLys: 0.95 ± 0.32
5.066GlnLeu: 5.066 ± 0.494
0.475GlnMet: 0.475 ± 0.184
0.95GlnAsn: 0.95 ± 0.297
1.583GlnPro: 1.583 ± 0.423
1.662GlnGln: 1.662 ± 0.406
4.274GlnArg: 4.274 ± 0.769
1.662GlnSer: 1.662 ± 0.405
2.058GlnThr: 2.058 ± 0.459
3.324GlnVal: 3.324 ± 0.555
0.95GlnTrp: 0.95 ± 0.237
1.266GlnTyr: 1.266 ± 0.36
0.0GlnXaa: 0.0 ± 0.0
Arg
9.261ArgAla: 9.261 ± 0.984
0.95ArgCys: 0.95 ± 0.347
4.195ArgAsp: 4.195 ± 0.56
3.958ArgGlu: 3.958 ± 0.518
2.058ArgPhe: 2.058 ± 0.305
6.411ArgGly: 6.411 ± 0.796
2.058ArgHis: 2.058 ± 0.489
3.878ArgIle: 3.878 ± 0.517
2.77ArgLys: 2.77 ± 0.507
7.678ArgLeu: 7.678 ± 0.911
1.82ArgMet: 1.82 ± 0.361
2.295ArgAsn: 2.295 ± 0.454
3.72ArgPro: 3.72 ± 0.597
3.404ArgGln: 3.404 ± 0.498
8.469ArgArg: 8.469 ± 1.323
3.958ArgSer: 3.958 ± 0.535
4.195ArgThr: 4.195 ± 0.466
7.519ArgVal: 7.519 ± 0.901
1.266ArgTrp: 1.266 ± 0.463
2.375ArgTyr: 2.375 ± 0.442
0.0ArgXaa: 0.0 ± 0.0
Ser
6.411SerAla: 6.411 ± 0.875
0.475SerCys: 0.475 ± 0.168
2.849SerAsp: 2.849 ± 0.595
2.137SerGlu: 2.137 ± 0.446
1.9SerPhe: 1.9 ± 0.42
4.037SerGly: 4.037 ± 0.754
1.266SerHis: 1.266 ± 0.378
2.454SerIle: 2.454 ± 0.5
1.82SerLys: 1.82 ± 0.331
4.116SerLeu: 4.116 ± 0.554
1.187SerMet: 1.187 ± 0.313
1.583SerAsn: 1.583 ± 0.344
3.008SerPro: 3.008 ± 0.578
1.425SerGln: 1.425 ± 0.303
3.404SerArg: 3.404 ± 0.62
3.641SerSer: 3.641 ± 0.617
2.533SerThr: 2.533 ± 0.519
4.432SerVal: 4.432 ± 0.563
0.871SerTrp: 0.871 ± 0.294
0.633SerTyr: 0.633 ± 0.195
0.0SerXaa: 0.0 ± 0.0
Thr
7.994ThrAla: 7.994 ± 0.841
0.712ThrCys: 0.712 ± 0.315
3.008ThrAsp: 3.008 ± 0.622
1.82ThrGlu: 1.82 ± 0.409
1.741ThrPhe: 1.741 ± 0.474
5.62ThrGly: 5.62 ± 0.624
1.187ThrHis: 1.187 ± 0.269
2.691ThrIle: 2.691 ± 0.494
1.82ThrLys: 1.82 ± 0.416
4.67ThrLeu: 4.67 ± 0.642
1.187ThrMet: 1.187 ± 0.259
1.979ThrAsn: 1.979 ± 0.49
2.612ThrPro: 2.612 ± 0.52
1.82ThrGln: 1.82 ± 0.313
4.512ThrArg: 4.512 ± 0.694
3.641ThrSer: 3.641 ± 0.5
4.828ThrThr: 4.828 ± 0.853
4.828ThrVal: 4.828 ± 0.664
0.871ThrTrp: 0.871 ± 0.311
1.583ThrTyr: 1.583 ± 0.422
0.0ThrXaa: 0.0 ± 0.0
Val
8.548ValAla: 8.548 ± 1.101
0.475ValCys: 0.475 ± 0.176
4.67ValAsp: 4.67 ± 0.708
4.274ValGlu: 4.274 ± 0.488
3.087ValPhe: 3.087 ± 0.54
5.224ValGly: 5.224 ± 0.847
2.295ValHis: 2.295 ± 0.677
2.612ValIle: 2.612 ± 0.403
2.454ValLys: 2.454 ± 0.548
7.361ValLeu: 7.361 ± 0.846
1.504ValMet: 1.504 ± 0.349
2.137ValAsn: 2.137 ± 0.491
4.116ValPro: 4.116 ± 0.581
3.641ValGln: 3.641 ± 0.535
6.253ValArg: 6.253 ± 0.576
3.958ValSer: 3.958 ± 0.54
4.907ValThr: 4.907 ± 0.568
6.016ValVal: 6.016 ± 1.155
1.425ValTrp: 1.425 ± 0.269
1.662ValTyr: 1.662 ± 0.388
0.0ValXaa: 0.0 ± 0.0
Trp
1.425TrpAla: 1.425 ± 0.336
0.317TrpCys: 0.317 ± 0.152
0.633TrpAsp: 0.633 ± 0.194
0.871TrpGlu: 0.871 ± 0.234
0.396TrpPhe: 0.396 ± 0.196
0.712TrpGly: 0.712 ± 0.212
0.633TrpHis: 0.633 ± 0.271
0.792TrpIle: 0.792 ± 0.227
0.792TrpLys: 0.792 ± 0.264
2.216TrpLeu: 2.216 ± 0.387
0.396TrpMet: 0.396 ± 0.192
0.712TrpAsn: 0.712 ± 0.277
0.554TrpPro: 0.554 ± 0.171
0.871TrpGln: 0.871 ± 0.309
1.583TrpArg: 1.583 ± 0.342
1.108TrpSer: 1.108 ± 0.293
0.792TrpThr: 0.792 ± 0.269
1.187TrpVal: 1.187 ± 0.366
0.237TrpTrp: 0.237 ± 0.137
0.475TrpTyr: 0.475 ± 0.21
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.929TyrAla: 2.929 ± 0.451
0.317TyrCys: 0.317 ± 0.154
1.662TyrAsp: 1.662 ± 0.416
1.266TyrGlu: 1.266 ± 0.306
1.662TyrPhe: 1.662 ± 0.414
1.979TyrGly: 1.979 ± 0.413
0.712TyrHis: 0.712 ± 0.233
0.633TyrIle: 0.633 ± 0.218
1.029TyrLys: 1.029 ± 0.403
1.9TyrLeu: 1.9 ± 0.464
0.317TyrMet: 0.317 ± 0.136
0.475TyrAsn: 0.475 ± 0.199
1.108TyrPro: 1.108 ± 0.278
1.504TyrGln: 1.504 ± 0.292
2.612TyrArg: 2.612 ± 0.436
0.475TyrSer: 0.475 ± 0.241
1.741TyrThr: 1.741 ± 0.373
1.425TyrVal: 1.425 ± 0.375
0.475TyrTrp: 0.475 ± 0.209
1.029TyrTyr: 1.029 ± 0.32
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (12635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski