Amino acid dipepetide frequency for Methanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.938AlaAla: 2.938 ± 0.121
0.806AlaCys: 0.806 ± 0.055
2.647AlaAsp: 2.647 ± 0.085
3.937AlaGlu: 3.937 ± 0.104
2.22AlaPhe: 2.22 ± 0.076
3.428AlaGly: 3.428 ± 0.094
0.862AlaHis: 0.862 ± 0.034
6.043AlaIle: 6.043 ± 0.11
5.764AlaLys: 5.764 ± 0.123
5.766AlaLeu: 5.766 ± 0.118
1.526AlaMet: 1.526 ± 0.057
2.216AlaAsn: 2.216 ± 0.061
1.578AlaPro: 1.578 ± 0.056
0.858AlaGln: 0.858 ± 0.04
2.208AlaArg: 2.208 ± 0.08
2.527AlaSer: 2.527 ± 0.096
2.501AlaThr: 2.501 ± 0.072
3.813AlaVal: 3.813 ± 0.095
0.335AlaTrp: 0.335 ± 0.028
2.12AlaTyr: 2.12 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.758CysAla: 0.758 ± 0.045
0.221CysCys: 0.221 ± 0.021
0.74CysAsp: 0.74 ± 0.042
0.965CysGlu: 0.965 ± 0.045
0.367CysPhe: 0.367 ± 0.025
1.711CysGly: 1.711 ± 0.062
0.321CysHis: 0.321 ± 0.024
1.276CysIle: 1.276 ± 0.055
1.097CysLys: 1.097 ± 0.053
1.023CysLeu: 1.023 ± 0.044
0.315CysMet: 0.315 ± 0.024
0.654CysAsn: 0.654 ± 0.034
1.091CysPro: 1.091 ± 0.069
0.219CysGln: 0.219 ± 0.018
0.521CysArg: 0.521 ± 0.031
0.748CysSer: 0.748 ± 0.044
0.495CysThr: 0.495 ± 0.032
1.029CysVal: 1.029 ± 0.058
0.072CysTrp: 0.072 ± 0.011
0.548CysTyr: 0.548 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
3.297AspAla: 3.297 ± 0.089
0.594AspCys: 0.594 ± 0.036
3.008AspAsp: 3.008 ± 0.092
5.572AspGlu: 5.572 ± 0.106
2.551AspPhe: 2.551 ± 0.067
3.606AspGly: 3.606 ± 0.099
0.533AspHis: 0.533 ± 0.031
6.4AspIle: 6.4 ± 0.12
5.146AspLys: 5.146 ± 0.117
5.359AspLeu: 5.359 ± 0.105
1.175AspMet: 1.175 ± 0.052
2.395AspAsn: 2.395 ± 0.071
1.374AspPro: 1.374 ± 0.06
0.291AspGln: 0.291 ± 0.026
1.933AspArg: 1.933 ± 0.063
1.777AspSer: 1.777 ± 0.074
1.974AspThr: 1.974 ± 0.06
4.934AspVal: 4.934 ± 0.103
0.525AspTrp: 0.525 ± 0.035
2.559AspTyr: 2.559 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
3.674GluAla: 3.674 ± 0.106
0.983GluCys: 0.983 ± 0.043
4.785GluAsp: 4.785 ± 0.094
9.009GluGlu: 9.009 ± 0.173
3.775GluPhe: 3.775 ± 0.082
5.04GluGly: 5.04 ± 0.104
1.328GluHis: 1.328 ± 0.052
9.523GluIle: 9.523 ± 0.149
10.046GluLys: 10.046 ± 0.176
8.171GluLeu: 8.171 ± 0.19
2.158GluMet: 2.158 ± 0.077
5.287GluAsn: 5.287 ± 0.108
1.913GluPro: 1.913 ± 0.069
1.175GluGln: 1.175 ± 0.05
3.458GluArg: 3.458 ± 0.09
2.589GluSer: 2.589 ± 0.077
2.976GluThr: 2.976 ± 0.073
6.141GluVal: 6.141 ± 0.126
0.499GluTrp: 0.499 ± 0.035
3.428GluTyr: 3.428 ± 0.091
0.0GluXaa: 0.0 ± 0.0
Phe
2.176PheAla: 2.176 ± 0.076
0.704PheCys: 0.704 ± 0.039
2.535PheAsp: 2.535 ± 0.074
3.548PheGlu: 3.548 ± 0.088
1.466PhePhe: 1.466 ± 0.052
3.317PheGly: 3.317 ± 0.099
0.493PheHis: 0.493 ± 0.03
3.815PheIle: 3.815 ± 0.108
3.833PheLys: 3.833 ± 0.109
3.971PheLeu: 3.971 ± 0.111
0.957PheMet: 0.957 ± 0.043
2.146PheAsn: 2.146 ± 0.067
1.282PhePro: 1.282 ± 0.047
0.531PheGln: 0.531 ± 0.034
1.41PheArg: 1.41 ± 0.049
2.084PheSer: 2.084 ± 0.067
1.432PheThr: 1.432 ± 0.051
2.978PheVal: 2.978 ± 0.082
0.341PheTrp: 0.341 ± 0.027
1.641PheTyr: 1.641 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
3.702GlyAla: 3.702 ± 0.11
1.256GlyCys: 1.256 ± 0.06
3.664GlyAsp: 3.664 ± 0.097
4.777GlyGlu: 4.777 ± 0.1
2.924GlyPhe: 2.924 ± 0.077
4.499GlyGly: 4.499 ± 0.115
1.159GlyHis: 1.159 ± 0.046
7.328GlyIle: 7.328 ± 0.137
6.259GlyLys: 6.259 ± 0.115
5.351GlyLeu: 5.351 ± 0.118
1.596GlyMet: 1.596 ± 0.06
2.886GlyAsn: 2.886 ± 0.096
1.384GlyPro: 1.384 ± 0.06
0.909GlyGln: 0.909 ± 0.038
2.688GlyArg: 2.688 ± 0.08
2.934GlySer: 2.934 ± 0.089
3.169GlyThr: 3.169 ± 0.093
5.233GlyVal: 5.233 ± 0.123
0.527GlyTrp: 0.527 ± 0.037
2.944GlyTyr: 2.944 ± 0.08
0.0GlyXaa: 0.0 ± 0.0
His
0.935HisAla: 0.935 ± 0.038
0.309HisCys: 0.309 ± 0.024
0.69HisAsp: 0.69 ± 0.037
1.069HisGlu: 1.069 ± 0.05
0.588HisPhe: 0.588 ± 0.036
1.101HisGly: 1.101 ± 0.045
0.327HisHis: 0.327 ± 0.035
1.518HisIle: 1.518 ± 0.049
1.205HisLys: 1.205 ± 0.044
1.536HisLeu: 1.536 ± 0.057
0.277HisMet: 0.277 ± 0.022
0.79HisAsn: 0.79 ± 0.038
1.055HisPro: 1.055 ± 0.048
0.303HisGln: 0.303 ± 0.024
0.642HisArg: 0.642 ± 0.038
0.786HisSer: 0.786 ± 0.042
0.68HisThr: 0.68 ± 0.04
1.079HisVal: 1.079 ± 0.045
0.102HisTrp: 0.102 ± 0.014
0.752HisTyr: 0.752 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.989IleAla: 5.989 ± 0.125
1.33IleCys: 1.33 ± 0.056
5.784IleAsp: 5.784 ± 0.097
8.468IleGlu: 8.468 ± 0.158
3.907IlePhe: 3.907 ± 0.114
6.32IleGly: 6.32 ± 0.126
1.462IleHis: 1.462 ± 0.05
9.296IleIle: 9.296 ± 0.154
10.902IleLys: 10.902 ± 0.162
9.904IleLeu: 9.904 ± 0.183
2.046IleMet: 2.046 ± 0.066
5.513IleAsn: 5.513 ± 0.119
4.248IlePro: 4.248 ± 0.092
1.392IleGln: 1.392 ± 0.052
3.462IleArg: 3.462 ± 0.095
5.409IleSer: 5.409 ± 0.129
5.116IleThr: 5.116 ± 0.128
6.945IleVal: 6.945 ± 0.12
0.56IleTrp: 0.56 ± 0.035
3.899IleTyr: 3.899 ± 0.098
0.0IleXaa: 0.0 ± 0.0
Lys
4.627LysAla: 4.627 ± 0.094
1.32LysCys: 1.32 ± 0.059
6.155LysAsp: 6.155 ± 0.116
11.438LysGlu: 11.438 ± 0.199
3.588LysPhe: 3.588 ± 0.09
5.192LysGly: 5.192 ± 0.12
1.536LysHis: 1.536 ± 0.063
10.953LysIle: 10.953 ± 0.138
10.937LysLys: 10.937 ± 0.203
8.688LysLeu: 8.688 ± 0.157
2.667LysMet: 2.667 ± 0.079
6.626LysAsn: 6.626 ± 0.139
3.157LysPro: 3.157 ± 0.082
1.286LysGln: 1.286 ± 0.055
4.162LysArg: 4.162 ± 0.103
4.15LysSer: 4.15 ± 0.089
4.16LysThr: 4.16 ± 0.095
6.538LysVal: 6.538 ± 0.129
0.614LysTrp: 0.614 ± 0.036
4.673LysTyr: 4.673 ± 0.1
0.0LysXaa: 0.0 ± 0.0
Leu
5.154LeuAla: 5.154 ± 0.117
1.334LeuCys: 1.334 ± 0.055
5.036LeuAsp: 5.036 ± 0.103
7.196LeuGlu: 7.196 ± 0.152
3.672LeuPhe: 3.672 ± 0.093
5.758LeuGly: 5.758 ± 0.118
1.296LeuHis: 1.296 ± 0.051
8.789LeuIle: 8.789 ± 0.169
11.135LeuLys: 11.135 ± 0.187
7.525LeuLeu: 7.525 ± 0.138
2.375LeuMet: 2.375 ± 0.085
5.722LeuAsn: 5.722 ± 0.127
3.221LeuPro: 3.221 ± 0.079
1.292LeuGln: 1.292 ± 0.056
3.851LeuArg: 3.851 ± 0.101
5.407LeuSer: 5.407 ± 0.128
4.037LeuThr: 4.037 ± 0.085
5.108LeuVal: 5.108 ± 0.098
0.594LeuTrp: 0.594 ± 0.037
3.125LeuTyr: 3.125 ± 0.088
0.0LeuXaa: 0.0 ± 0.0
Met
1.488MetAla: 1.488 ± 0.06
0.339MetCys: 0.339 ± 0.023
1.582MetAsp: 1.582 ± 0.054
2.214MetGlu: 2.214 ± 0.063
0.842MetPhe: 0.842 ± 0.044
1.755MetGly: 1.755 ± 0.055
0.505MetHis: 0.505 ± 0.031
1.986MetIle: 1.986 ± 0.078
2.304MetLys: 2.304 ± 0.069
2.006MetLeu: 2.006 ± 0.054
0.554MetMet: 0.554 ± 0.035
1.053MetAsn: 1.053 ± 0.042
0.806MetPro: 0.806 ± 0.04
0.465MetGln: 0.465 ± 0.033
1.029MetArg: 1.029 ± 0.05
1.039MetSer: 1.039 ± 0.046
0.888MetThr: 0.888 ± 0.048
1.715MetVal: 1.715 ± 0.055
0.183MetTrp: 0.183 ± 0.02
0.642MetTyr: 0.642 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.365AsnAla: 3.365 ± 0.092
0.68AsnCys: 0.68 ± 0.04
2.212AsnAsp: 2.212 ± 0.073
4.326AsnGlu: 4.326 ± 0.1
2.18AsnPhe: 2.18 ± 0.072
3.183AsnGly: 3.183 ± 0.102
0.684AsnHis: 0.684 ± 0.036
5.776AsnIle: 5.776 ± 0.119
5.239AsnLys: 5.239 ± 0.119
5.098AsnLeu: 5.098 ± 0.112
1.131AsnMet: 1.131 ± 0.044
3.115AsnAsn: 3.115 ± 0.195
2.746AsnPro: 2.746 ± 0.081
0.838AsnGln: 0.838 ± 0.037
1.863AsnArg: 1.863 ± 0.072
2.276AsnSer: 2.276 ± 0.08
2.206AsnThr: 2.206 ± 0.087
3.704AsnVal: 3.704 ± 0.101
0.441AsnTrp: 0.441 ± 0.027
2.387AsnTyr: 2.387 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
1.544ProAla: 1.544 ± 0.059
0.479ProCys: 0.479 ± 0.03
1.687ProAsp: 1.687 ± 0.057
2.812ProGlu: 2.812 ± 0.07
1.613ProPhe: 1.613 ± 0.052
1.767ProGly: 1.767 ± 0.061
0.726ProHis: 0.726 ± 0.039
3.704ProIle: 3.704 ± 0.081
3.656ProLys: 3.656 ± 0.094
3.093ProLeu: 3.093 ± 0.08
0.822ProMet: 0.822 ± 0.04
1.992ProAsn: 1.992 ± 0.064
1.227ProPro: 1.227 ± 0.046
0.778ProGln: 0.778 ± 0.039
1.161ProArg: 1.161 ± 0.058
1.763ProSer: 1.763 ± 0.062
1.871ProThr: 1.871 ± 0.076
2.345ProVal: 2.345 ± 0.066
0.243ProTrp: 0.243 ± 0.022
1.693ProTyr: 1.693 ± 0.068
0.0ProXaa: 0.0 ± 0.0
Gln
0.704GlnAla: 0.704 ± 0.036
0.223GlnCys: 0.223 ± 0.022
0.507GlnAsp: 0.507 ± 0.036
0.929GlnGlu: 0.929 ± 0.043
0.582GlnPhe: 0.582 ± 0.037
0.748GlnGly: 0.748 ± 0.038
0.279GlnHis: 0.279 ± 0.025
1.556GlnIle: 1.556 ± 0.056
1.621GlnLys: 1.621 ± 0.067
1.312GlnLeu: 1.312 ± 0.05
0.505GlnMet: 0.505 ± 0.03
0.806GlnAsn: 0.806 ± 0.041
0.477GlnPro: 0.477 ± 0.029
0.417GlnGln: 0.417 ± 0.03
0.77GlnArg: 0.77 ± 0.04
0.716GlnSer: 0.716 ± 0.037
0.768GlnThr: 0.768 ± 0.039
0.884GlnVal: 0.884 ± 0.045
0.12GlnTrp: 0.12 ± 0.018
0.644GlnTyr: 0.644 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.23ArgAla: 2.23 ± 0.069
0.576ArgCys: 0.576 ± 0.035
2.128ArgAsp: 2.128 ± 0.065
3.867ArgGlu: 3.867 ± 0.095
1.643ArgPhe: 1.643 ± 0.061
2.619ArgGly: 2.619 ± 0.083
0.688ArgHis: 0.688 ± 0.04
3.949ArgIle: 3.949 ± 0.089
3.911ArgLys: 3.911 ± 0.107
2.97ArgLeu: 2.97 ± 0.077
1.055ArgMet: 1.055 ± 0.045
1.727ArgAsn: 1.727 ± 0.054
1.159ArgPro: 1.159 ± 0.052
0.578ArgGln: 0.578 ± 0.037
1.905ArgArg: 1.905 ± 0.074
1.123ArgSer: 1.123 ± 0.042
1.55ArgThr: 1.55 ± 0.057
2.786ArgVal: 2.786 ± 0.083
0.317ArgTrp: 0.317 ± 0.025
1.6ArgTyr: 1.6 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
2.479SerAla: 2.479 ± 0.078
0.554SerCys: 0.554 ± 0.032
2.351SerAsp: 2.351 ± 0.07
3.311SerGlu: 3.311 ± 0.089
1.877SerPhe: 1.877 ± 0.066
3.335SerGly: 3.335 ± 0.101
0.812SerHis: 0.812 ± 0.039
4.627SerIle: 4.627 ± 0.109
4.745SerLys: 4.745 ± 0.105
4.442SerLeu: 4.442 ± 0.112
1.031SerMet: 1.031 ± 0.045
2.359SerAsn: 2.359 ± 0.102
1.809SerPro: 1.809 ± 0.059
0.878SerGln: 0.878 ± 0.045
1.673SerArg: 1.673 ± 0.065
2.537SerSer: 2.537 ± 0.116
2.126SerThr: 2.126 ± 0.08
2.708SerVal: 2.708 ± 0.068
0.375SerTrp: 0.375 ± 0.03
1.963SerTyr: 1.963 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
2.328ThrAla: 2.328 ± 0.077
0.564ThrCys: 0.564 ± 0.039
1.821ThrAsp: 1.821 ± 0.065
2.519ThrGlu: 2.519 ± 0.081
1.851ThrPhe: 1.851 ± 0.069
2.948ThrGly: 2.948 ± 0.091
0.85ThrHis: 0.85 ± 0.041
4.495ThrIle: 4.495 ± 0.117
3.795ThrLys: 3.795 ± 0.102
4.388ThrLeu: 4.388 ± 0.096
0.794ThrMet: 0.794 ± 0.041
2.154ThrAsn: 2.154 ± 0.087
2.232ThrPro: 2.232 ± 0.068
0.736ThrGln: 0.736 ± 0.036
1.314ThrArg: 1.314 ± 0.055
2.278ThrSer: 2.278 ± 0.076
2.661ThrThr: 2.661 ± 0.099
2.974ThrVal: 2.974 ± 0.098
0.339ThrTrp: 0.339 ± 0.031
1.883ThrTyr: 1.883 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
3.923ValAla: 3.923 ± 0.111
1.171ValCys: 1.171 ± 0.06
4.759ValAsp: 4.759 ± 0.095
6.267ValGlu: 6.267 ± 0.116
2.85ValPhe: 2.85 ± 0.075
5.361ValGly: 5.361 ± 0.109
1.125ValHis: 1.125 ± 0.047
6.681ValIle: 6.681 ± 0.118
6.46ValLys: 6.46 ± 0.121
6.081ValLeu: 6.081 ± 0.118
1.432ValMet: 1.432 ± 0.058
3.251ValAsn: 3.251 ± 0.08
2.383ValPro: 2.383 ± 0.073
0.878ValGln: 0.878 ± 0.041
2.617ValArg: 2.617 ± 0.071
3.592ValSer: 3.592 ± 0.099
2.272ValThr: 2.272 ± 0.072
6.608ValVal: 6.608 ± 0.136
0.465ValTrp: 0.465 ± 0.032
2.718ValTyr: 2.718 ± 0.084
0.0ValXaa: 0.0 ± 0.0
Trp
0.419TrpAla: 0.419 ± 0.032
0.09TrpCys: 0.09 ± 0.014
0.491TrpAsp: 0.491 ± 0.032
0.642TrpGlu: 0.642 ± 0.039
0.299TrpPhe: 0.299 ± 0.029
0.513TrpGly: 0.513 ± 0.033
0.106TrpHis: 0.106 ± 0.014
0.674TrpIle: 0.674 ± 0.037
0.73TrpLys: 0.73 ± 0.037
0.499TrpLeu: 0.499 ± 0.032
0.187TrpMet: 0.187 ± 0.021
0.433TrpAsn: 0.433 ± 0.029
0.122TrpPro: 0.122 ± 0.014
0.138TrpGln: 0.138 ± 0.017
0.339TrpArg: 0.339 ± 0.029
0.273TrpSer: 0.273 ± 0.024
0.303TrpThr: 0.303 ± 0.027
0.457TrpVal: 0.457 ± 0.033
0.098TrpTrp: 0.098 ± 0.014
0.289TrpTyr: 0.289 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.363TyrAla: 2.363 ± 0.068
0.636TyrCys: 0.636 ± 0.034
2.423TyrAsp: 2.423 ± 0.073
3.091TyrGlu: 3.091 ± 0.092
1.865TyrPhe: 1.865 ± 0.058
2.988TyrGly: 2.988 ± 0.083
0.654TyrHis: 0.654 ± 0.039
3.562TyrIle: 3.562 ± 0.09
3.684TyrLys: 3.684 ± 0.095
4.446TyrLeu: 4.446 ± 0.105
0.79TyrMet: 0.79 ± 0.038
2.324TyrAsn: 2.324 ± 0.08
1.713TyrPro: 1.713 ± 0.054
0.606TyrGln: 0.606 ± 0.035
1.374TyrArg: 1.374 ± 0.057
1.986TyrSer: 1.986 ± 0.07
1.739TyrThr: 1.739 ± 0.068
2.914TyrVal: 2.914 ± 0.077
0.351TyrTrp: 0.351 ± 0.031
1.949TyrTyr: 1.949 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1753 proteins (501396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski