Amino acid dipepetide frequency for Eilatimonas milleporae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.025AlaAla: 16.025 ± 0.162	1.107AlaCys: 1.107 ± 0.032	8.197AlaAsp: 8.197 ± 0.08	6.758AlaGlu: 6.758 ± 0.093	4.443AlaPhe: 4.443 ± 0.061	11.59AlaGly: 11.59 ± 0.153	2.368AlaHis: 2.368 ± 0.049	5.161AlaIle: 5.161 ± 0.07	3.017AlaLys: 3.017 ± 0.056	12.776AlaLeu: 12.776 ± 0.114	3.105AlaMet: 3.105 ± 0.053	2.632AlaAsn: 2.632 ± 0.055	5.467AlaPro: 5.467 ± 0.086	3.387AlaGln: 3.387 ± 0.061	8.717AlaArg: 8.717 ± 0.1	5.505AlaSer: 5.505 ± 0.07	5.403AlaThr: 5.403 ± 0.083	9.183AlaVal: 9.183 ± 0.098	1.354AlaTrp: 1.354 ± 0.033	2.635AlaTyr: 2.635 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.849CysAla: 0.849 ± 0.03	0.105CysCys: 0.105 ± 0.009	0.56CysAsp: 0.56 ± 0.021	0.358CysGlu: 0.358 ± 0.02	0.344CysPhe: 0.344 ± 0.017	0.833CysGly: 0.833 ± 0.028	0.267CysHis: 0.267 ± 0.016	0.362CysIle: 0.362 ± 0.017	0.179CysLys: 0.179 ± 0.012	0.891CysLeu: 0.891 ± 0.03	0.183CysMet: 0.183 ± 0.013	0.192CysAsn: 0.192 ± 0.013	0.473CysPro: 0.473 ± 0.019	0.24CysGln: 0.24 ± 0.013	0.709CysArg: 0.709 ± 0.027	0.348CysSer: 0.348 ± 0.02	0.427CysThr: 0.427 ± 0.02	0.56CysVal: 0.56 ± 0.023	0.088CysTrp: 0.088 ± 0.008	0.182CysTyr: 0.182 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.593AspAla: 7.593 ± 0.09	0.504AspCys: 0.504 ± 0.02	4.538AspAsp: 4.538 ± 0.134	3.408AspGlu: 3.408 ± 0.057	2.682AspPhe: 2.682 ± 0.055	7.261AspGly: 7.261 ± 0.116	1.494AspHis: 1.494 ± 0.037	4.096AspIle: 4.096 ± 0.061	1.694AspLys: 1.694 ± 0.04	6.525AspLeu: 6.525 ± 0.084	1.99AspMet: 1.99 ± 0.037	1.711AspAsn: 1.711 ± 0.048	3.615AspPro: 3.615 ± 0.059	1.675AspGln: 1.675 ± 0.039	5.427AspArg: 5.427 ± 0.077	2.968AspSer: 2.968 ± 0.057	4.42AspThr: 4.42 ± 0.085	4.517AspVal: 4.517 ± 0.061	1.161AspTrp: 1.161 ± 0.027	1.693AspTyr: 1.693 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.403GluAla: 6.403 ± 0.092	0.329GluCys: 0.329 ± 0.017	3.798GluAsp: 3.798 ± 0.063	3.092GluGlu: 3.092 ± 0.063	1.437GluPhe: 1.437 ± 0.037	4.084GluGly: 4.084 ± 0.061	1.013GluHis: 1.013 ± 0.027	3.066GluIle: 3.066 ± 0.051	2.38GluLys: 2.38 ± 0.051	4.119GluLeu: 4.119 ± 0.074	1.29GluMet: 1.29 ± 0.031	1.87GluAsn: 1.87 ± 0.039	2.167GluPro: 2.167 ± 0.064	1.932GluGln: 1.932 ± 0.046	4.539GluArg: 4.539 ± 0.06	2.204GluSer: 2.204 ± 0.041	4.265GluThr: 4.265 ± 0.06	3.211GluVal: 3.211 ± 0.06	0.599GluTrp: 0.599 ± 0.021	1.017GluTyr: 1.017 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.23PheAla: 4.23 ± 0.066	0.401PheCys: 0.401 ± 0.02	3.06PheAsp: 3.06 ± 0.068	2.259PheGlu: 2.259 ± 0.046	1.64PhePhe: 1.64 ± 0.039	3.602PheGly: 3.602 ± 0.063	0.766PheHis: 0.766 ± 0.026	1.783PheIle: 1.783 ± 0.041	0.91PheLys: 0.91 ± 0.027	3.619PheLeu: 3.619 ± 0.054	0.878PheMet: 0.878 ± 0.025	1.184PheAsn: 1.184 ± 0.033	1.516PhePro: 1.516 ± 0.037	1.113PheGln: 1.113 ± 0.03	2.304PheArg: 2.304 ± 0.039	2.369PheSer: 2.369 ± 0.056	2.287PheThr: 2.287 ± 0.052	2.559PheVal: 2.559 ± 0.048	0.53PheTrp: 0.53 ± 0.019	1.016PheTyr: 1.016 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.659GlyAla: 9.659 ± 0.113	0.75GlyCys: 0.75 ± 0.026	5.853GlyAsp: 5.853 ± 0.11	4.426GlyGlu: 4.426 ± 0.057	3.756GlyPhe: 3.756 ± 0.058	8.152GlyGly: 8.152 ± 0.142	2.052GlyHis: 2.052 ± 0.041	4.215GlyIle: 4.215 ± 0.067	2.705GlyLys: 2.705 ± 0.06	9.492GlyLeu: 9.492 ± 0.097	2.219GlyMet: 2.219 ± 0.049	2.44GlyAsn: 2.44 ± 0.08	3.904GlyPro: 3.904 ± 0.061	3.004GlyGln: 3.004 ± 0.047	6.749GlyArg: 6.749 ± 0.087	4.315GlySer: 4.315 ± 0.071	5.661GlyThr: 5.661 ± 0.118	6.154GlyVal: 6.154 ± 0.082	1.276GlyTrp: 1.276 ± 0.035	2.222GlyTyr: 2.222 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.306HisAla: 2.306 ± 0.048	0.226HisCys: 0.226 ± 0.014	1.39HisAsp: 1.39 ± 0.038	0.958HisGlu: 0.958 ± 0.028	0.89HisPhe: 0.89 ± 0.028	2.036HisGly: 2.036 ± 0.049	0.542HisHis: 0.542 ± 0.025	1.164HisIle: 1.164 ± 0.033	0.584HisLys: 0.584 ± 0.024	2.051HisLeu: 2.051 ± 0.043	0.668HisMet: 0.668 ± 0.025	0.48HisAsn: 0.48 ± 0.02	1.315HisPro: 1.315 ± 0.035	0.547HisGln: 0.547 ± 0.019	1.602HisArg: 1.602 ± 0.041	0.934HisSer: 0.934 ± 0.028	1.096HisThr: 1.096 ± 0.025	1.518HisVal: 1.518 ± 0.032	0.336HisTrp: 0.336 ± 0.017	0.547HisTyr: 0.547 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.467IleAla: 6.467 ± 0.071	0.443IleCys: 0.443 ± 0.02	3.708IleAsp: 3.708 ± 0.054	2.969IleGlu: 2.969 ± 0.061	1.719IlePhe: 1.719 ± 0.036	4.434IleGly: 4.434 ± 0.057	0.966IleHis: 0.966 ± 0.026	2.178IleIle: 2.178 ± 0.047	1.268IleLys: 1.268 ± 0.037	4.798IleLeu: 4.798 ± 0.059	0.987IleMet: 0.987 ± 0.028	1.506IleAsn: 1.506 ± 0.043	2.219IlePro: 2.219 ± 0.044	1.267IleGln: 1.267 ± 0.03	3.457IleArg: 3.457 ± 0.052	2.8IleSer: 2.8 ± 0.051	2.852IleThr: 2.852 ± 0.056	3.893IleVal: 3.893 ± 0.062	0.554IleTrp: 0.554 ± 0.023	1.087IleTyr: 1.087 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.812LysAla: 3.812 ± 0.059	0.164LysCys: 0.164 ± 0.013	1.854LysAsp: 1.854 ± 0.044	1.334LysGlu: 1.334 ± 0.04	0.732LysPhe: 0.732 ± 0.023	2.503LysGly: 2.503 ± 0.051	0.529LysHis: 0.529 ± 0.023	1.505LysIle: 1.505 ± 0.039	1.286LysLys: 1.286 ± 0.041	2.552LysLeu: 2.552 ± 0.054	0.642LysMet: 0.642 ± 0.028	0.877LysAsn: 0.877 ± 0.027	1.721LysPro: 1.721 ± 0.047	0.976LysGln: 0.976 ± 0.031	2.261LysArg: 2.261 ± 0.048	1.738LysSer: 1.738 ± 0.042	2.396LysThr: 2.396 ± 0.053	1.802LysVal: 1.802 ± 0.044	0.297LysTrp: 0.297 ± 0.014	0.615LysTyr: 0.615 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.189LeuAla: 12.189 ± 0.132	0.851LeuCys: 0.851 ± 0.029	6.767LeuAsp: 6.767 ± 0.094	5.279LeuGlu: 5.279 ± 0.075	3.817LeuPhe: 3.817 ± 0.063	7.641LeuGly: 7.641 ± 0.081	1.921LeuHis: 1.921 ± 0.042	5.028LeuIle: 5.028 ± 0.068	3.883LeuLys: 3.883 ± 0.073	8.712LeuLeu: 8.712 ± 0.107	2.524LeuMet: 2.524 ± 0.053	2.875LeuAsn: 2.875 ± 0.044	5.403LeuPro: 5.403 ± 0.07	2.593LeuGln: 2.593 ± 0.047	6.223LeuArg: 6.223 ± 0.076	7.022LeuSer: 7.022 ± 0.089	6.132LeuThr: 6.132 ± 0.087	6.697LeuVal: 6.697 ± 0.081	1.201LeuTrp: 1.201 ± 0.031	2.378LeuTyr: 2.378 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	3.375MetAla: 3.375 ± 0.054	0.147MetCys: 0.147 ± 0.011	1.559MetAsp: 1.559 ± 0.038	1.207MetGlu: 1.207 ± 0.029	0.619MetPhe: 0.619 ± 0.02	1.827MetGly: 1.827 ± 0.042	0.455MetHis: 0.455 ± 0.018	1.212MetIle: 1.212 ± 0.03	0.862MetLys: 0.862 ± 0.029	2.206MetLeu: 2.206 ± 0.042	0.657MetMet: 0.657 ± 0.026	0.674MetAsn: 0.674 ± 0.023	1.509MetPro: 1.509 ± 0.04	0.811MetGln: 0.811 ± 0.025	1.666MetArg: 1.666 ± 0.042	1.506MetSer: 1.506 ± 0.041	2.096MetThr: 2.096 ± 0.045	1.685MetVal: 1.685 ± 0.041	0.194MetTrp: 0.194 ± 0.012	0.284MetTyr: 0.284 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.055AsnAla: 3.055 ± 0.052	0.239AsnCys: 0.239 ± 0.014	1.714AsnAsp: 1.714 ± 0.057	1.181AsnGlu: 1.181 ± 0.034	1.005AsnPhe: 1.005 ± 0.035	2.571AsnGly: 2.571 ± 0.069	0.52AsnHis: 0.52 ± 0.019	1.554AsnIle: 1.554 ± 0.039	0.664AsnLys: 0.664 ± 0.025	2.516AsnLeu: 2.516 ± 0.046	0.641AsnMet: 0.641 ± 0.021	0.757AsnAsn: 0.757 ± 0.03	1.78AsnPro: 1.78 ± 0.044	0.745AsnGln: 0.745 ± 0.026	2.073AsnArg: 2.073 ± 0.037	1.292AsnSer: 1.292 ± 0.052	1.639AsnThr: 1.639 ± 0.047	1.855AsnVal: 1.855 ± 0.043	0.4AsnTrp: 0.4 ± 0.016	0.665AsnTyr: 0.665 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.065ProAla: 6.065 ± 0.076	0.379ProCys: 0.379 ± 0.016	4.524ProAsp: 4.524 ± 0.066	3.26ProGlu: 3.26 ± 0.065	2.035ProPhe: 2.035 ± 0.04	4.668ProGly: 4.668 ± 0.067	1.207ProHis: 1.207 ± 0.033	1.963ProIle: 1.963 ± 0.04	1.425ProLys: 1.425 ± 0.039	4.666ProLeu: 4.666 ± 0.062	1.164ProMet: 1.164 ± 0.034	1.175ProAsn: 1.175 ± 0.035	2.585ProPro: 2.585 ± 0.06	1.54ProGln: 1.54 ± 0.039	2.839ProArg: 2.839 ± 0.052	2.759ProSer: 2.759 ± 0.055	2.222ProThr: 2.222 ± 0.043	4.652ProVal: 4.652 ± 0.075	0.628ProTrp: 0.628 ± 0.025	1.228ProTyr: 1.228 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.978GlnAla: 3.978 ± 0.066	0.214GlnCys: 0.214 ± 0.015	1.894GlnAsp: 1.894 ± 0.041	1.477GlnGlu: 1.477 ± 0.041	1.061GlnPhe: 1.061 ± 0.034	2.368GlnGly: 2.368 ± 0.042	0.555GlnHis: 0.555 ± 0.02	1.646GlnIle: 1.646 ± 0.033	1.028GlnLys: 1.028 ± 0.033	2.476GlnLeu: 2.476 ± 0.044	0.779GlnMet: 0.779 ± 0.023	0.969GlnAsn: 0.969 ± 0.031	1.614GlnPro: 1.614 ± 0.037	1.09GlnGln: 1.09 ± 0.036	2.179GlnArg: 2.179 ± 0.045	1.864GlnSer: 1.864 ± 0.042	1.977GlnThr: 1.977 ± 0.04	2.069GlnVal: 2.069 ± 0.04	0.347GlnTrp: 0.347 ± 0.016	0.618GlnTyr: 0.618 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.848ArgAla: 7.848 ± 0.099	0.455ArgCys: 0.455 ± 0.024	4.896ArgAsp: 4.896 ± 0.064	3.567ArgGlu: 3.567 ± 0.073	3.209ArgPhe: 3.209 ± 0.062	4.883ArgGly: 4.883 ± 0.064	1.979ArgHis: 1.979 ± 0.046	3.919ArgIle: 3.919 ± 0.059	2.085ArgLys: 2.085 ± 0.047	8.711ArgLeu: 8.711 ± 0.105	1.77ArgMet: 1.77 ± 0.039	1.757ArgAsn: 1.757 ± 0.04	3.755ArgPro: 3.755 ± 0.065	2.83ArgGln: 2.83 ± 0.058	5.99ArgArg: 5.99 ± 0.091	3.454ArgSer: 3.454 ± 0.062	3.931ArgThr: 3.931 ± 0.069	4.733ArgVal: 4.733 ± 0.069	0.922ArgTrp: 0.922 ± 0.026	1.93ArgTyr: 1.93 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.974SerAla: 5.974 ± 0.075	0.38SerCys: 0.38 ± 0.017	3.662SerAsp: 3.662 ± 0.067	2.748SerGlu: 2.748 ± 0.044	2.203SerPhe: 2.203 ± 0.046	5.724SerGly: 5.724 ± 0.098	1.128SerHis: 1.128 ± 0.028	2.485SerIle: 2.485 ± 0.048	1.333SerLys: 1.333 ± 0.037	5.796SerLeu: 5.796 ± 0.079	1.225SerMet: 1.225 ± 0.034	1.342SerAsn: 1.342 ± 0.031	2.685SerPro: 2.685 ± 0.046	1.574SerGln: 1.574 ± 0.042	3.61SerArg: 3.61 ± 0.066	2.622SerSer: 2.622 ± 0.046	2.491SerThr: 2.491 ± 0.053	4.181SerVal: 4.181 ± 0.063	0.611SerTrp: 0.611 ± 0.022	1.25SerTyr: 1.25 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.432ThrAla: 7.432 ± 0.098	0.43ThrCys: 0.43 ± 0.02	3.946ThrAsp: 3.946 ± 0.072	2.714ThrGlu: 2.714 ± 0.05	2.024ThrPhe: 2.024 ± 0.042	6.387ThrGly: 6.387 ± 0.107	1.164ThrHis: 1.164 ± 0.027	2.816ThrIle: 2.816 ± 0.06	1.304ThrLys: 1.304 ± 0.034	6.568ThrLeu: 6.568 ± 0.09	1.148ThrMet: 1.148 ± 0.029	1.416ThrAsn: 1.416 ± 0.043	3.667ThrPro: 3.667 ± 0.064	1.56ThrGln: 1.56 ± 0.034	3.617ThrArg: 3.617 ± 0.057	2.758ThrSer: 2.758 ± 0.056	2.726ThrThr: 2.726 ± 0.061	5.34ThrVal: 5.34 ± 0.094	0.657ThrTrp: 0.657 ± 0.024	1.318ThrTyr: 1.318 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.025ValAla: 8.025 ± 0.087	0.643ValCys: 0.643 ± 0.025	4.7ValAsp: 4.7 ± 0.071	4.029ValGlu: 4.029 ± 0.058	2.945ValPhe: 2.945 ± 0.053	5.229ValGly: 5.229 ± 0.08	1.401ValHis: 1.401 ± 0.041	3.83ValIle: 3.83 ± 0.059	2.076ValLys: 2.076 ± 0.047	6.896ValLeu: 6.896 ± 0.09	1.806ValMet: 1.806 ± 0.041	2.073ValAsn: 2.073 ± 0.05	3.904ValPro: 3.904 ± 0.053	1.99ValGln: 1.99 ± 0.041	5.377ValArg: 5.377 ± 0.067	4.583ValSer: 4.583 ± 0.059	5.038ValThr: 5.038 ± 0.105	4.762ValVal: 4.762 ± 0.073	0.906ValTrp: 0.906 ± 0.03	1.523ValTyr: 1.523 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.211TrpAla: 1.211 ± 0.034	0.117TrpCys: 0.117 ± 0.01	0.707TrpAsp: 0.707 ± 0.024	0.48TrpGlu: 0.48 ± 0.02	0.474TrpPhe: 0.474 ± 0.022	0.861TrpGly: 0.861 ± 0.029	0.347TrpHis: 0.347 ± 0.015	0.607TrpIle: 0.607 ± 0.022	0.325TrpLys: 0.325 ± 0.015	1.45TrpLeu: 1.45 ± 0.037	0.345TrpMet: 0.345 ± 0.017	0.347TrpAsn: 0.347 ± 0.017	0.683TrpPro: 0.683 ± 0.027	0.597TrpGln: 0.597 ± 0.023	1.24TrpArg: 1.24 ± 0.037	0.75TrpSer: 0.75 ± 0.029	0.779TrpThr: 0.779 ± 0.029	0.793TrpVal: 0.793 ± 0.027	0.192TrpTrp: 0.192 ± 0.012	0.279TrpTyr: 0.279 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.333TyrAla: 2.333 ± 0.043	0.266TyrCys: 0.266 ± 0.016	1.643TyrAsp: 1.643 ± 0.039	1.311TyrGlu: 1.311 ± 0.037	0.994TyrPhe: 0.994 ± 0.029	2.35TyrGly: 2.35 ± 0.045	0.521TyrHis: 0.521 ± 0.023	0.982TyrIle: 0.982 ± 0.032	0.591TyrLys: 0.591 ± 0.024	2.315TyrLeu: 2.315 ± 0.043	0.529TyrMet: 0.529 ± 0.022	0.59TyrAsn: 0.59 ± 0.023	1.002TyrPro: 1.002 ± 0.032	0.729TyrGln: 0.729 ± 0.024	2.044TyrArg: 2.044 ± 0.046	1.236TyrSer: 1.236 ± 0.031	1.151TyrThr: 1.151 ± 0.031	1.57TyrVal: 1.57 ± 0.037	0.333TyrTrp: 0.333 ± 0.02	0.657TyrTyr: 0.657 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3747 proteins (1277968 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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