Amino acid dipepetide frequency for Chryseotalea sanaruensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.253AlaAla: 5.253 ± 0.098
0.658AlaCys: 0.658 ± 0.026
3.763AlaAsp: 3.763 ± 0.061
4.391AlaGlu: 4.391 ± 0.063
3.562AlaPhe: 3.562 ± 0.055
5.064AlaGly: 5.064 ± 0.081
1.183AlaHis: 1.183 ± 0.032
5.46AlaIle: 5.46 ± 0.067
4.593AlaLys: 4.593 ± 0.074
7.252AlaLeu: 7.252 ± 0.085
1.75AlaMet: 1.75 ± 0.042
3.682AlaAsn: 3.682 ± 0.064
2.205AlaPro: 2.205 ± 0.056
2.767AlaGln: 2.767 ± 0.054
2.437AlaArg: 2.437 ± 0.042
4.833AlaSer: 4.833 ± 0.074
4.133AlaThr: 4.133 ± 0.086
4.507AlaVal: 4.507 ± 0.074
0.773AlaTrp: 0.773 ± 0.028
2.772AlaTyr: 2.772 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.496CysAla: 0.496 ± 0.019
0.095CysCys: 0.095 ± 0.008
0.382CysAsp: 0.382 ± 0.018
0.47CysGlu: 0.47 ± 0.02
0.358CysPhe: 0.358 ± 0.015
0.545CysGly: 0.545 ± 0.022
0.161CysHis: 0.161 ± 0.011
0.554CysIle: 0.554 ± 0.02
0.42CysLys: 0.42 ± 0.02
0.728CysLeu: 0.728 ± 0.023
0.17CysMet: 0.17 ± 0.012
0.368CysAsn: 0.368 ± 0.017
0.277CysPro: 0.277 ± 0.017
0.223CysGln: 0.223 ± 0.013
0.253CysArg: 0.253 ± 0.014
0.521CysSer: 0.521 ± 0.028
0.44CysThr: 0.44 ± 0.018
0.437CysVal: 0.437 ± 0.023
0.084CysTrp: 0.084 ± 0.009
0.278CysTyr: 0.278 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
3.725AspAla: 3.725 ± 0.051
0.372AspCys: 0.372 ± 0.017
2.592AspAsp: 2.592 ± 0.047
3.531AspGlu: 3.531 ± 0.057
3.317AspPhe: 3.317 ± 0.05
3.587AspGly: 3.587 ± 0.072
0.897AspHis: 0.897 ± 0.024
3.837AspIle: 3.837 ± 0.051
3.832AspLys: 3.832 ± 0.06
5.122AspLeu: 5.122 ± 0.074
1.122AspMet: 1.122 ± 0.026
2.724AspAsn: 2.724 ± 0.049
2.014AspPro: 2.014 ± 0.048
1.874AspGln: 1.874 ± 0.038
2.078AspArg: 2.078 ± 0.042
3.104AspSer: 3.104 ± 0.054
2.401AspThr: 2.401 ± 0.04
3.361AspVal: 3.361 ± 0.057
0.679AspTrp: 0.679 ± 0.023
2.463AspTyr: 2.463 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
4.784GluAla: 4.784 ± 0.068
0.282GluCys: 0.282 ± 0.016
2.995GluAsp: 2.995 ± 0.048
4.536GluGlu: 4.536 ± 0.072
2.758GluPhe: 2.758 ± 0.051
3.773GluGly: 3.773 ± 0.061
1.104GluHis: 1.104 ± 0.032
4.775GluIle: 4.775 ± 0.059
5.357GluLys: 5.357 ± 0.087
6.325GluLeu: 6.325 ± 0.085
1.494GluMet: 1.494 ± 0.042
3.577GluAsn: 3.577 ± 0.053
1.675GluPro: 1.675 ± 0.04
2.548GluGln: 2.548 ± 0.05
2.852GluArg: 2.852 ± 0.056
3.568GluSer: 3.568 ± 0.06
3.178GluThr: 3.178 ± 0.048
4.456GluVal: 4.456 ± 0.06
0.7GluTrp: 0.7 ± 0.025
2.144GluTyr: 2.144 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.317PheAla: 3.317 ± 0.056
0.414PheCys: 0.414 ± 0.016
3.067PheAsp: 3.067 ± 0.045
3.101PheGlu: 3.101 ± 0.054
2.635PhePhe: 2.635 ± 0.058
3.37PheGly: 3.37 ± 0.057
0.84PheHis: 0.84 ± 0.028
3.67PheIle: 3.67 ± 0.057
3.185PheLys: 3.185 ± 0.059
4.491PheLeu: 4.491 ± 0.074
1.083PheMet: 1.083 ± 0.028
2.958PheAsn: 2.958 ± 0.052
1.632PhePro: 1.632 ± 0.035
1.664PheGln: 1.664 ± 0.035
1.812PheArg: 1.812 ± 0.042
3.959PheSer: 3.959 ± 0.055
3.354PheThr: 3.354 ± 0.058
3.203PheVal: 3.203 ± 0.049
0.604PheTrp: 0.604 ± 0.026
2.111PheTyr: 2.111 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.41GlyAla: 4.41 ± 0.08
0.591GlyCys: 0.591 ± 0.029
3.272GlyAsp: 3.272 ± 0.052
3.702GlyGlu: 3.702 ± 0.051
3.575GlyPhe: 3.575 ± 0.056
4.74GlyGly: 4.74 ± 0.103
1.075GlyHis: 1.075 ± 0.035
5.239GlyIle: 5.239 ± 0.068
4.982GlyLys: 4.982 ± 0.068
6.268GlyLeu: 6.268 ± 0.082
1.633GlyMet: 1.633 ± 0.043
3.629GlyAsn: 3.629 ± 0.083
1.432GlyPro: 1.432 ± 0.037
2.099GlyGln: 2.099 ± 0.048
2.477GlyArg: 2.477 ± 0.043
4.389GlySer: 4.389 ± 0.086
4.074GlyThr: 4.074 ± 0.1
4.367GlyVal: 4.367 ± 0.073
0.821GlyTrp: 0.821 ± 0.029
2.667GlyTyr: 2.667 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
1.209HisAla: 1.209 ± 0.036
0.165HisCys: 0.165 ± 0.013
0.886HisAsp: 0.886 ± 0.027
1.12HisGlu: 1.12 ± 0.029
1.101HisPhe: 1.101 ± 0.028
1.095HisGly: 1.095 ± 0.031
0.509HisHis: 0.509 ± 0.023
1.215HisIle: 1.215 ± 0.03
1.073HisLys: 1.073 ± 0.029
1.768HisLeu: 1.768 ± 0.042
0.36HisMet: 0.36 ± 0.017
0.848HisAsn: 0.848 ± 0.024
0.904HisPro: 0.904 ± 0.028
0.745HisGln: 0.745 ± 0.027
0.765HisArg: 0.765 ± 0.026
1.02HisSer: 1.02 ± 0.029
1.026HisThr: 1.026 ± 0.03
1.054HisVal: 1.054 ± 0.03
0.222HisTrp: 0.222 ± 0.013
0.847HisTyr: 0.847 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.572IleAla: 5.572 ± 0.072
0.601IleCys: 0.601 ± 0.025
4.41IleAsp: 4.41 ± 0.054
4.971IleGlu: 4.971 ± 0.072
3.424IlePhe: 3.424 ± 0.062
4.988IleGly: 4.988 ± 0.069
1.343IleHis: 1.343 ± 0.03
5.318IleIle: 5.318 ± 0.074
5.046IleLys: 5.046 ± 0.071
6.55IleLeu: 6.55 ± 0.085
1.365IleMet: 1.365 ± 0.038
4.223IleAsn: 4.223 ± 0.053
2.932IlePro: 2.932 ± 0.05
2.585IleGln: 2.585 ± 0.046
3.047IleArg: 3.047 ± 0.047
5.372IleSer: 5.372 ± 0.075
4.751IleThr: 4.751 ± 0.075
4.802IleVal: 4.802 ± 0.066
0.693IleTrp: 0.693 ± 0.024
2.553IleTyr: 2.553 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
5.025LysAla: 5.025 ± 0.085
0.309LysCys: 0.309 ± 0.015
3.823LysAsp: 3.823 ± 0.067
5.297LysGlu: 5.297 ± 0.079
2.581LysPhe: 2.581 ± 0.042
4.244LysGly: 4.244 ± 0.07
1.306LysHis: 1.306 ± 0.036
5.121LysIle: 5.121 ± 0.075
5.71LysLys: 5.71 ± 0.091
6.381LysLeu: 6.381 ± 0.089
1.732LysMet: 1.732 ± 0.039
4.011LysAsn: 4.011 ± 0.058
2.431LysPro: 2.431 ± 0.051
2.949LysGln: 2.949 ± 0.053
3.153LysArg: 3.153 ± 0.053
4.326LysSer: 4.326 ± 0.073
3.856LysThr: 3.856 ± 0.062
4.582LysVal: 4.582 ± 0.068
0.665LysTrp: 0.665 ± 0.023
2.415LysTyr: 2.415 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
6.964LeuAla: 6.964 ± 0.082
0.719LeuCys: 0.719 ± 0.024
4.874LeuAsp: 4.874 ± 0.064
5.55LeuGlu: 5.55 ± 0.08
4.7LeuPhe: 4.7 ± 0.072
5.839LeuGly: 5.839 ± 0.072
1.785LeuHis: 1.785 ± 0.037
7.182LeuIle: 7.182 ± 0.089
7.207LeuLys: 7.207 ± 0.106
9.927LeuLeu: 9.927 ± 0.102
2.224LeuMet: 2.224 ± 0.041
5.491LeuAsn: 5.491 ± 0.071
3.896LeuPro: 3.896 ± 0.055
3.851LeuGln: 3.851 ± 0.061
3.915LeuArg: 3.915 ± 0.056
7.518LeuSer: 7.518 ± 0.086
5.926LeuThr: 5.926 ± 0.075
6.048LeuVal: 6.048 ± 0.072
0.87LeuTrp: 0.87 ± 0.029
3.232LeuTyr: 3.232 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
1.814MetAla: 1.814 ± 0.04
0.129MetCys: 0.129 ± 0.01
1.132MetAsp: 1.132 ± 0.032
1.38MetGlu: 1.38 ± 0.032
0.809MetPhe: 0.809 ± 0.027
1.483MetGly: 1.483 ± 0.035
0.438MetHis: 0.438 ± 0.02
1.496MetIle: 1.496 ± 0.036
1.879MetLys: 1.879 ± 0.036
2.245MetLeu: 2.245 ± 0.041
0.611MetMet: 0.611 ± 0.022
1.192MetAsn: 1.192 ± 0.026
0.964MetPro: 0.964 ± 0.028
0.893MetGln: 0.893 ± 0.026
1.119MetArg: 1.119 ± 0.028
1.355MetSer: 1.355 ± 0.031
1.127MetThr: 1.127 ± 0.032
1.444MetVal: 1.444 ± 0.038
0.188MetTrp: 0.188 ± 0.011
0.602MetTyr: 0.602 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.819AsnAla: 3.819 ± 0.06
0.368AsnCys: 0.368 ± 0.02
2.88AsnAsp: 2.88 ± 0.044
3.406AsnGlu: 3.406 ± 0.05
2.844AsnPhe: 2.844 ± 0.053
3.823AsnGly: 3.823 ± 0.092
0.919AsnHis: 0.919 ± 0.025
3.999AsnIle: 3.999 ± 0.052
3.49AsnLys: 3.49 ± 0.054
5.161AsnLeu: 5.161 ± 0.077
1.174AsnMet: 1.174 ± 0.03
3.312AsnAsn: 3.312 ± 0.072
2.601AsnPro: 2.601 ± 0.052
2.114AsnGln: 2.114 ± 0.041
2.201AsnArg: 2.201 ± 0.039
3.456AsnSer: 3.456 ± 0.058
3.324AsnThr: 3.324 ± 0.068
3.282AsnVal: 3.282 ± 0.051
0.76AsnTrp: 0.76 ± 0.023
2.46AsnTyr: 2.46 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
2.76ProAla: 2.76 ± 0.058
0.217ProCys: 0.217 ± 0.012
2.208ProAsp: 2.208 ± 0.042
2.649ProGlu: 2.649 ± 0.042
1.879ProPhe: 1.879 ± 0.043
2.376ProGly: 2.376 ± 0.052
0.606ProHis: 0.606 ± 0.023
2.552ProIle: 2.552 ± 0.049
2.011ProLys: 2.011 ± 0.041
3.254ProLeu: 3.254 ± 0.05
0.699ProMet: 0.699 ± 0.022
1.883ProAsn: 1.883 ± 0.048
0.985ProPro: 0.985 ± 0.035
1.211ProGln: 1.211 ± 0.03
1.108ProArg: 1.108 ± 0.029
2.326ProSer: 2.326 ± 0.045
2.04ProThr: 2.04 ± 0.055
2.783ProVal: 2.783 ± 0.063
0.377ProTrp: 0.377 ± 0.015
1.324ProTyr: 1.324 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
2.726GlnAla: 2.726 ± 0.051
0.181GlnCys: 0.181 ± 0.012
1.688GlnAsp: 1.688 ± 0.036
2.421GlnGlu: 2.421 ± 0.048
1.737GlnPhe: 1.737 ± 0.036
2.068GlnGly: 2.068 ± 0.04
0.84GlnHis: 0.84 ± 0.023
2.437GlnIle: 2.437 ± 0.047
2.575GlnLys: 2.575 ± 0.054
3.999GlnLeu: 3.999 ± 0.061
0.859GlnMet: 0.859 ± 0.025
2.058GlnAsn: 2.058 ± 0.046
1.293GlnPro: 1.293 ± 0.037
2.085GlnGln: 2.085 ± 0.053
1.767GlnArg: 1.767 ± 0.04
2.399GlnSer: 2.399 ± 0.045
2.039GlnThr: 2.039 ± 0.043
2.397GlnVal: 2.397 ± 0.047
0.471GlnTrp: 0.471 ± 0.018
1.521GlnTyr: 1.521 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.431ArgAla: 2.431 ± 0.041
0.242ArgCys: 0.242 ± 0.015
2.044ArgAsp: 2.044 ± 0.04
2.628ArgGlu: 2.628 ± 0.046
2.175ArgPhe: 2.175 ± 0.039
2.159ArgGly: 2.159 ± 0.048
0.688ArgHis: 0.688 ± 0.021
3.44ArgIle: 3.44 ± 0.051
3.107ArgLys: 3.107 ± 0.059
3.98ArgLeu: 3.98 ± 0.055
1.126ArgMet: 1.126 ± 0.031
2.232ArgAsn: 2.232 ± 0.042
1.256ArgPro: 1.256 ± 0.037
1.484ArgGln: 1.484 ± 0.036
1.426ArgArg: 1.426 ± 0.038
2.46ArgSer: 2.46 ± 0.044
2.149ArgThr: 2.149 ± 0.042
2.477ArgVal: 2.477 ± 0.045
0.481ArgTrp: 0.481 ± 0.02
1.794ArgTyr: 1.794 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
4.544SerAla: 4.544 ± 0.059
0.55SerCys: 0.55 ± 0.02
3.329SerAsp: 3.329 ± 0.05
3.539SerGlu: 3.539 ± 0.056
3.921SerPhe: 3.921 ± 0.064
4.899SerGly: 4.899 ± 0.08
1.076SerHis: 1.076 ± 0.028
5.706SerIle: 5.706 ± 0.068
4.193SerLys: 4.193 ± 0.069
6.987SerLeu: 6.987 ± 0.073
1.368SerMet: 1.368 ± 0.032
3.526SerAsn: 3.526 ± 0.057
2.359SerPro: 2.359 ± 0.047
2.145SerGln: 2.145 ± 0.043
2.483SerArg: 2.483 ± 0.042
4.551SerSer: 4.551 ± 0.083
3.935SerThr: 3.935 ± 0.069
4.477SerVal: 4.477 ± 0.073
0.754SerTrp: 0.754 ± 0.025
2.55SerTyr: 2.55 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
4.136ThrAla: 4.136 ± 0.083
0.39ThrCys: 0.39 ± 0.019
3.105ThrAsp: 3.105 ± 0.054
3.433ThrGlu: 3.433 ± 0.058
3.065ThrPhe: 3.065 ± 0.055
4.195ThrGly: 4.195 ± 0.076
1.004ThrHis: 1.004 ± 0.028
4.663ThrIle: 4.663 ± 0.078
3.39ThrLys: 3.39 ± 0.057
5.884ThrLeu: 5.884 ± 0.061
0.978ThrMet: 0.978 ± 0.027
3.082ThrAsn: 3.082 ± 0.075
2.377ThrPro: 2.377 ± 0.061
2.049ThrGln: 2.049 ± 0.039
1.954ThrArg: 1.954 ± 0.036
3.84ThrSer: 3.84 ± 0.072
3.725ThrThr: 3.725 ± 0.095
3.898ThrVal: 3.898 ± 0.086
0.68ThrTrp: 0.68 ± 0.03
2.267ThrTyr: 2.267 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
4.715ValAla: 4.715 ± 0.077
0.569ValCys: 0.569 ± 0.024
3.463ValAsp: 3.463 ± 0.049
3.92ValGlu: 3.92 ± 0.063
3.087ValPhe: 3.087 ± 0.043
4.108ValGly: 4.108 ± 0.064
1.088ValHis: 1.088 ± 0.027
4.731ValIle: 4.731 ± 0.067
4.548ValLys: 4.548 ± 0.07
6.436ValLeu: 6.436 ± 0.076
1.526ValMet: 1.526 ± 0.03
3.729ValAsn: 3.729 ± 0.07
2.289ValPro: 2.289 ± 0.046
2.075ValGln: 2.075 ± 0.039
2.637ValArg: 2.637 ± 0.045
4.672ValSer: 4.672 ± 0.071
3.631ValThr: 3.631 ± 0.079
4.663ValVal: 4.663 ± 0.07
0.742ValTrp: 0.742 ± 0.024
2.393ValTyr: 2.393 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.655TrpAla: 0.655 ± 0.026
0.096TrpCys: 0.096 ± 0.008
0.576TrpAsp: 0.576 ± 0.022
0.655TrpGlu: 0.655 ± 0.023
0.564TrpPhe: 0.564 ± 0.024
0.69TrpGly: 0.69 ± 0.023
0.229TrpHis: 0.229 ± 0.014
0.841TrpIle: 0.841 ± 0.03
0.789TrpLys: 0.789 ± 0.024
1.157TrpLeu: 1.157 ± 0.034
0.319TrpMet: 0.319 ± 0.017
0.627TrpAsn: 0.627 ± 0.02
0.31TrpPro: 0.31 ± 0.015
0.522TrpGln: 0.522 ± 0.02
0.521TrpArg: 0.521 ± 0.019
0.728TrpSer: 0.728 ± 0.023
0.647TrpThr: 0.647 ± 0.024
0.685TrpVal: 0.685 ± 0.022
0.167TrpTrp: 0.167 ± 0.012
0.433TrpTyr: 0.433 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.683TyrAla: 2.683 ± 0.048
0.31TyrCys: 0.31 ± 0.014
2.145TyrAsp: 2.145 ± 0.04
2.181TyrGlu: 2.181 ± 0.042
2.379TyrPhe: 2.379 ± 0.043
2.394TyrGly: 2.394 ± 0.045
0.842TyrHis: 0.842 ± 0.025
2.312TyrIle: 2.312 ± 0.041
2.531TyrLys: 2.531 ± 0.048
3.803TyrLeu: 3.803 ± 0.066
0.706TyrMet: 0.706 ± 0.025
2.239TyrAsn: 2.239 ± 0.049
1.416TyrPro: 1.416 ± 0.033
1.678TyrGln: 1.678 ± 0.038
1.776TyrArg: 1.776 ± 0.04
2.493TyrSer: 2.493 ± 0.045
2.356TyrThr: 2.356 ± 0.045
2.101TyrVal: 2.101 ± 0.033
0.481TyrTrp: 0.481 ± 0.02
1.811TyrTyr: 1.811 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3948 proteins (1390093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski