Amino acid dipepetide frequency for SAR202 cluster bacterium AD-804-J14_MRT_500m

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.285AlaAla: 7.285 ± 0.153
0.881AlaCys: 0.881 ± 0.041
4.161AlaAsp: 4.161 ± 0.085
4.6AlaGlu: 4.6 ± 0.11
3.073AlaPhe: 3.073 ± 0.085
6.9AlaGly: 6.9 ± 0.12
1.736AlaHis: 1.736 ± 0.058
5.734AlaIle: 5.734 ± 0.12
3.263AlaLys: 3.263 ± 0.083
8.296AlaLeu: 8.296 ± 0.134
2.404AlaMet: 2.404 ± 0.086
2.609AlaAsn: 2.609 ± 0.07
2.939AlaPro: 2.939 ± 0.081
2.759AlaGln: 2.759 ± 0.066
4.518AlaArg: 4.518 ± 0.102
5.278AlaSer: 5.278 ± 0.108
4.674AlaThr: 4.674 ± 0.108
6.441AlaVal: 6.441 ± 0.129
0.898AlaTrp: 0.898 ± 0.04
2.228AlaTyr: 2.228 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.808CysAla: 0.808 ± 0.056
0.133CysCys: 0.133 ± 0.019
0.517CysAsp: 0.517 ± 0.033
0.498CysGlu: 0.498 ± 0.035
0.381CysPhe: 0.381 ± 0.026
1.121CysGly: 1.121 ± 0.05
0.322CysHis: 0.322 ± 0.027
0.601CysIle: 0.601 ± 0.037
0.344CysLys: 0.344 ± 0.029
0.908CysLeu: 0.908 ± 0.042
0.217CysMet: 0.217 ± 0.021
0.336CysAsn: 0.336 ± 0.028
0.562CysPro: 0.562 ± 0.035
0.398CysGln: 0.398 ± 0.027
0.627CysArg: 0.627 ± 0.039
0.681CysSer: 0.681 ± 0.036
0.617CysThr: 0.617 ± 0.036
0.644CysVal: 0.644 ± 0.038
0.15CysTrp: 0.15 ± 0.033
0.297CysTyr: 0.297 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.112AspAla: 4.112 ± 0.092
0.525AspCys: 0.525 ± 0.031
2.845AspAsp: 2.845 ± 0.088
3.522AspGlu: 3.522 ± 0.085
2.185AspPhe: 2.185 ± 0.067
4.772AspGly: 4.772 ± 0.121
1.332AspHis: 1.332 ± 0.058
3.903AspIle: 3.903 ± 0.09
1.956AspLys: 1.956 ± 0.066
6.35AspLeu: 6.35 ± 0.106
1.597AspMet: 1.597 ± 0.054
1.861AspAsn: 1.861 ± 0.061
3.44AspPro: 3.44 ± 0.082
2.124AspGln: 2.124 ± 0.075
3.561AspArg: 3.561 ± 0.089
3.637AspSer: 3.637 ± 0.091
2.823AspThr: 2.823 ± 0.085
4.545AspVal: 4.545 ± 0.103
0.802AspTrp: 0.802 ± 0.044
1.818AspTyr: 1.818 ± 0.066
0.0AspXaa: 0.0 ± 0.0
Glu
5.047GluAla: 5.047 ± 0.114
0.519GluCys: 0.519 ± 0.037
3.425GluAsp: 3.425 ± 0.083
4.153GluGlu: 4.153 ± 0.104
2.083GluPhe: 2.083 ± 0.064
4.387GluGly: 4.387 ± 0.104
1.435GluHis: 1.435 ± 0.056
4.44GluIle: 4.44 ± 0.103
2.339GluLys: 2.339 ± 0.064
6.156GluLeu: 6.156 ± 0.125
1.8GluMet: 1.8 ± 0.065
2.169GluAsn: 2.169 ± 0.061
2.458GluPro: 2.458 ± 0.068
2.142GluGln: 2.142 ± 0.069
3.684GluArg: 3.684 ± 0.092
3.868GluSer: 3.868 ± 0.09
3.188GluThr: 3.188 ± 0.084
4.411GluVal: 4.411 ± 0.101
0.742GluTrp: 0.742 ± 0.04
1.781GluTyr: 1.781 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
2.802PheAla: 2.802 ± 0.092
0.506PheCys: 0.506 ± 0.031
2.382PheAsp: 2.382 ± 0.069
2.068PheGlu: 2.068 ± 0.067
1.498PhePhe: 1.498 ± 0.07
3.39PheGly: 3.39 ± 0.103
0.959PheHis: 0.959 ± 0.037
2.054PheIle: 2.054 ± 0.067
1.402PheLys: 1.402 ± 0.046
3.628PheLeu: 3.628 ± 0.105
0.865PheMet: 0.865 ± 0.041
1.404PheAsn: 1.404 ± 0.043
1.97PhePro: 1.97 ± 0.067
1.267PheGln: 1.267 ± 0.054
1.966PheArg: 1.966 ± 0.059
2.759PheSer: 2.759 ± 0.075
2.079PheThr: 2.079 ± 0.061
2.616PheVal: 2.616 ± 0.076
0.611PheTrp: 0.611 ± 0.036
1.082PheTyr: 1.082 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
6.402GlyAla: 6.402 ± 0.131
0.886GlyCys: 0.886 ± 0.048
4.245GlyAsp: 4.245 ± 0.089
4.299GlyGlu: 4.299 ± 0.106
3.659GlyPhe: 3.659 ± 0.086
6.748GlyGly: 6.748 ± 0.177
2.103GlyHis: 2.103 ± 0.068
6.301GlyIle: 6.301 ± 0.117
3.589GlyLys: 3.589 ± 0.093
8.167GlyLeu: 8.167 ± 0.138
2.486GlyMet: 2.486 ± 0.074
2.911GlyAsn: 2.911 ± 0.078
3.45GlyPro: 3.45 ± 0.092
2.855GlyGln: 2.855 ± 0.081
5.028GlyArg: 5.028 ± 0.109
5.709GlySer: 5.709 ± 0.114
4.711GlyThr: 4.711 ± 0.115
6.383GlyVal: 6.383 ± 0.131
1.392GlyTrp: 1.392 ± 0.062
2.628GlyTyr: 2.628 ± 0.072
0.0GlyXaa: 0.0 ± 0.0
His
1.628HisAla: 1.628 ± 0.061
0.316HisCys: 0.316 ± 0.028
1.095HisAsp: 1.095 ± 0.046
1.158HisGlu: 1.158 ± 0.048
0.834HisPhe: 0.834 ± 0.045
2.04HisGly: 2.04 ± 0.061
0.625HisHis: 0.625 ± 0.037
1.589HisIle: 1.589 ± 0.053
0.752HisLys: 0.752 ± 0.037
2.337HisLeu: 2.337 ± 0.071
0.603HisMet: 0.603 ± 0.032
0.789HisAsn: 0.789 ± 0.04
1.693HisPro: 1.693 ± 0.06
0.824HisGln: 0.824 ± 0.042
1.544HisArg: 1.544 ± 0.065
1.408HisSer: 1.408 ± 0.053
1.183HisThr: 1.183 ± 0.051
1.539HisVal: 1.539 ± 0.057
0.336HisTrp: 0.336 ± 0.024
0.748HisTyr: 0.748 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.729IleAla: 5.729 ± 0.109
0.699IleCys: 0.699 ± 0.038
4.208IleAsp: 4.208 ± 0.085
3.981IleGlu: 3.981 ± 0.097
2.421IlePhe: 2.421 ± 0.084
5.762IleGly: 5.762 ± 0.115
1.349IleHis: 1.349 ± 0.051
3.747IleIle: 3.747 ± 0.094
2.72IleLys: 2.72 ± 0.087
5.887IleLeu: 5.887 ± 0.105
1.449IleMet: 1.449 ± 0.057
2.519IleAsn: 2.519 ± 0.075
3.637IlePro: 3.637 ± 0.089
2.224IleGln: 2.224 ± 0.073
3.747IleArg: 3.747 ± 0.077
5.0IleSer: 5.0 ± 0.101
3.667IleThr: 3.667 ± 0.087
4.827IleVal: 4.827 ± 0.106
0.808IleTrp: 0.808 ± 0.042
1.728IleTyr: 1.728 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
3.3LysAla: 3.3 ± 0.086
0.328LysCys: 0.328 ± 0.035
2.487LysAsp: 2.487 ± 0.073
2.757LysGlu: 2.757 ± 0.085
1.248LysPhe: 1.248 ± 0.045
3.022LysGly: 3.022 ± 0.078
0.744LysHis: 0.744 ± 0.038
2.673LysIle: 2.673 ± 0.078
1.517LysLys: 1.517 ± 0.063
3.786LysLeu: 3.786 ± 0.084
1.015LysMet: 1.015 ± 0.038
1.525LysAsn: 1.525 ± 0.057
1.952LysPro: 1.952 ± 0.061
1.347LysGln: 1.347 ± 0.049
2.349LysArg: 2.349 ± 0.071
2.663LysSer: 2.663 ± 0.074
2.271LysThr: 2.271 ± 0.074
3.003LysVal: 3.003 ± 0.066
0.476LysTrp: 0.476 ± 0.027
1.129LysTyr: 1.129 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
8.743LeuAla: 8.743 ± 0.152
0.998LeuCys: 0.998 ± 0.045
6.211LeuAsp: 6.211 ± 0.117
6.482LeuGlu: 6.482 ± 0.124
3.284LeuPhe: 3.284 ± 0.091
8.681LeuGly: 8.681 ± 0.145
2.015LeuHis: 2.015 ± 0.073
5.777LeuIle: 5.777 ± 0.125
4.221LeuLys: 4.221 ± 0.09
8.63LeuLeu: 8.63 ± 0.195
2.427LeuMet: 2.427 ± 0.068
3.446LeuAsn: 3.446 ± 0.08
4.6LeuPro: 4.6 ± 0.102
3.009LeuGln: 3.009 ± 0.082
5.348LeuArg: 5.348 ± 0.117
7.062LeuSer: 7.062 ± 0.112
5.328LeuThr: 5.328 ± 0.104
7.265LeuVal: 7.265 ± 0.139
1.062LeuTrp: 1.062 ± 0.05
2.189LeuTyr: 2.189 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.691MetAla: 2.691 ± 0.086
0.228MetCys: 0.228 ± 0.021
1.552MetAsp: 1.552 ± 0.062
1.599MetGlu: 1.599 ± 0.057
0.847MetPhe: 0.847 ± 0.042
2.341MetGly: 2.341 ± 0.067
0.494MetHis: 0.494 ± 0.03
1.701MetIle: 1.701 ± 0.058
1.123MetLys: 1.123 ± 0.049
2.241MetLeu: 2.241 ± 0.075
0.699MetMet: 0.699 ± 0.04
0.896MetAsn: 0.896 ± 0.038
1.517MetPro: 1.517 ± 0.052
0.728MetGln: 0.728 ± 0.036
1.464MetArg: 1.464 ± 0.06
1.769MetSer: 1.769 ± 0.056
1.66MetThr: 1.66 ± 0.057
2.124MetVal: 2.124 ± 0.071
0.32MetTrp: 0.32 ± 0.025
0.574MetTyr: 0.574 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
2.864AsnAla: 2.864 ± 0.071
0.408AsnCys: 0.408 ± 0.034
1.919AsnAsp: 1.919 ± 0.065
1.785AsnGlu: 1.785 ± 0.053
1.248AsnPhe: 1.248 ± 0.047
2.856AsnGly: 2.856 ± 0.075
0.875AsnHis: 0.875 ± 0.042
2.486AsnIle: 2.486 ± 0.068
1.183AsnLys: 1.183 ± 0.052
3.911AsnLeu: 3.911 ± 0.084
0.974AsnMet: 0.974 ± 0.044
1.394AsnAsn: 1.394 ± 0.055
2.456AsnPro: 2.456 ± 0.077
1.308AsnGln: 1.308 ± 0.052
2.349AsnArg: 2.349 ± 0.067
2.259AsnSer: 2.259 ± 0.063
1.747AsnThr: 1.747 ± 0.068
2.591AsnVal: 2.591 ± 0.069
0.553AsnTrp: 0.553 ± 0.031
0.994AsnTyr: 0.994 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
3.263ProAla: 3.263 ± 0.091
0.385ProCys: 0.385 ± 0.028
3.491ProAsp: 3.491 ± 0.092
3.464ProGlu: 3.464 ± 0.086
1.917ProPhe: 1.917 ± 0.069
4.237ProGly: 4.237 ± 0.086
1.293ProHis: 1.293 ± 0.054
3.14ProIle: 3.14 ± 0.079
1.99ProLys: 1.99 ± 0.063
4.262ProLeu: 4.262 ± 0.092
1.33ProMet: 1.33 ± 0.044
2.038ProAsn: 2.038 ± 0.073
2.175ProPro: 2.175 ± 0.085
1.64ProGln: 1.64 ± 0.055
2.38ProArg: 2.38 ± 0.065
3.499ProSer: 3.499 ± 0.094
2.972ProThr: 2.972 ± 0.113
3.727ProVal: 3.727 ± 0.086
0.761ProTrp: 0.761 ± 0.037
1.462ProTyr: 1.462 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
3.005GlnAla: 3.005 ± 0.076
0.314GlnCys: 0.314 ± 0.025
1.775GlnAsp: 1.775 ± 0.056
2.288GlnGlu: 2.288 ± 0.07
1.211GlnPhe: 1.211 ± 0.051
2.749GlnGly: 2.749 ± 0.077
0.732GlnHis: 0.732 ± 0.044
2.435GlnIle: 2.435 ± 0.077
1.394GlnLys: 1.394 ± 0.05
3.153GlnLeu: 3.153 ± 0.078
1.035GlnMet: 1.035 ± 0.047
1.263GlnAsn: 1.263 ± 0.057
1.468GlnPro: 1.468 ± 0.049
1.341GlnGln: 1.341 ± 0.054
2.269GlnArg: 2.269 ± 0.07
2.036GlnSer: 2.036 ± 0.065
1.892GlnThr: 1.892 ± 0.061
2.554GlnVal: 2.554 ± 0.068
0.502GlnTrp: 0.502 ± 0.03
0.867GlnTyr: 0.867 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
4.174ArgAla: 4.174 ± 0.106
0.648ArgCys: 0.648 ± 0.034
3.202ArgAsp: 3.202 ± 0.076
3.557ArgGlu: 3.557 ± 0.085
2.392ArgPhe: 2.392 ± 0.069
4.243ArgGly: 4.243 ± 0.089
1.33ArgHis: 1.33 ± 0.05
4.053ArgIle: 4.053 ± 0.083
2.232ArgLys: 2.232 ± 0.072
6.008ArgLeu: 6.008 ± 0.113
1.656ArgMet: 1.656 ± 0.063
2.154ArgAsn: 2.154 ± 0.06
2.685ArgPro: 2.685 ± 0.072
2.165ArgGln: 2.165 ± 0.066
3.839ArgArg: 3.839 ± 0.109
3.971ArgSer: 3.971 ± 0.094
2.966ArgThr: 2.966 ± 0.074
4.085ArgVal: 4.085 ± 0.084
0.785ArgTrp: 0.785 ± 0.04
1.886ArgTyr: 1.886 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
5.123SerAla: 5.123 ± 0.106
0.656SerCys: 0.656 ± 0.037
4.139SerAsp: 4.139 ± 0.093
3.925SerGlu: 3.925 ± 0.099
2.544SerPhe: 2.544 ± 0.078
6.057SerGly: 6.057 ± 0.118
1.632SerHis: 1.632 ± 0.058
4.288SerIle: 4.288 ± 0.107
2.892SerLys: 2.892 ± 0.077
6.58SerLeu: 6.58 ± 0.133
1.753SerMet: 1.753 ± 0.055
2.523SerAsn: 2.523 ± 0.08
3.511SerPro: 3.511 ± 0.071
2.382SerGln: 2.382 ± 0.064
3.85SerArg: 3.85 ± 0.102
4.803SerSer: 4.803 ± 0.107
3.837SerThr: 3.837 ± 0.105
4.893SerVal: 4.893 ± 0.106
0.875SerTrp: 0.875 ± 0.042
1.933SerTyr: 1.933 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.36ThrAla: 4.36 ± 0.109
0.543ThrCys: 0.543 ± 0.043
2.974ThrAsp: 2.974 ± 0.092
2.94ThrGlu: 2.94 ± 0.077
2.099ThrPhe: 2.099 ± 0.067
5.237ThrGly: 5.237 ± 0.141
1.291ThrHis: 1.291 ± 0.054
3.786ThrIle: 3.786 ± 0.102
2.04ThrLys: 2.04 ± 0.074
5.244ThrLeu: 5.244 ± 0.105
1.349ThrMet: 1.349 ± 0.053
2.136ThrAsn: 2.136 ± 0.069
3.358ThrPro: 3.358 ± 0.138
1.673ThrGln: 1.673 ± 0.056
2.989ThrArg: 2.989 ± 0.084
3.782ThrSer: 3.782 ± 0.096
3.54ThrThr: 3.54 ± 0.124
4.147ThrVal: 4.147 ± 0.104
0.722ThrTrp: 0.722 ± 0.039
1.503ThrTyr: 1.503 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
6.275ValAla: 6.275 ± 0.12
0.738ValCys: 0.738 ± 0.034
4.649ValAsp: 4.649 ± 0.102
4.729ValGlu: 4.729 ± 0.103
2.788ValPhe: 2.788 ± 0.076
5.902ValGly: 5.902 ± 0.112
1.605ValHis: 1.605 ± 0.057
4.957ValIle: 4.957 ± 0.094
3.032ValLys: 3.032 ± 0.077
7.242ValLeu: 7.242 ± 0.149
1.859ValMet: 1.859 ± 0.06
2.675ValAsn: 2.675 ± 0.069
3.538ValPro: 3.538 ± 0.084
2.39ValGln: 2.39 ± 0.074
3.95ValArg: 3.95 ± 0.079
5.229ValSer: 5.229 ± 0.094
4.372ValThr: 4.372 ± 0.104
6.207ValVal: 6.207 ± 0.128
0.806ValTrp: 0.806 ± 0.041
1.933ValTyr: 1.933 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
1.041TrpAla: 1.041 ± 0.039
0.15TrpCys: 0.15 ± 0.016
0.791TrpAsp: 0.791 ± 0.041
0.849TrpGlu: 0.849 ± 0.041
0.488TrpPhe: 0.488 ± 0.032
1.144TrpGly: 1.144 ± 0.06
0.385TrpHis: 0.385 ± 0.03
0.779TrpIle: 0.779 ± 0.039
0.521TrpLys: 0.521 ± 0.033
1.273TrpLeu: 1.273 ± 0.048
0.402TrpMet: 0.402 ± 0.024
0.486TrpAsn: 0.486 ± 0.033
0.555TrpPro: 0.555 ± 0.031
0.549TrpGln: 0.549 ± 0.032
0.703TrpArg: 0.703 ± 0.039
0.873TrpSer: 0.873 ± 0.044
0.728TrpThr: 0.728 ± 0.043
0.937TrpVal: 0.937 ± 0.045
0.223TrpTrp: 0.223 ± 0.022
0.344TrpTyr: 0.344 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.023TyrAla: 2.023 ± 0.056
0.301TyrCys: 0.301 ± 0.025
1.644TyrAsp: 1.644 ± 0.056
1.574TyrGlu: 1.574 ± 0.055
1.107TyrPhe: 1.107 ± 0.052
2.363TyrGly: 2.363 ± 0.066
0.787TyrHis: 0.787 ± 0.037
1.664TyrIle: 1.664 ± 0.059
1.086TyrLys: 1.086 ± 0.045
2.72TyrLeu: 2.72 ± 0.077
0.648TyrMet: 0.648 ± 0.032
1.027TyrAsn: 1.027 ± 0.053
1.46TyrPro: 1.46 ± 0.055
1.158TyrGln: 1.158 ± 0.048
1.865TyrArg: 1.865 ± 0.054
1.908TyrSer: 1.908 ± 0.067
1.459TyrThr: 1.459 ± 0.064
1.937TyrVal: 1.937 ± 0.061
0.394TyrTrp: 0.394 ± 0.029
0.847TyrTyr: 0.847 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1639 proteins (512167 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski