Amino acid dipepetide frequency for Lentimonas sp. CC11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.615AlaAla: 9.615 ± 0.123	1.076AlaCys: 1.076 ± 0.027	5.601AlaAsp: 5.601 ± 0.062	6.373AlaGlu: 6.373 ± 0.074	3.642AlaPhe: 3.642 ± 0.058	7.0AlaGly: 7.0 ± 0.084	1.883AlaHis: 1.883 ± 0.04	5.325AlaIle: 5.325 ± 0.072	4.334AlaLys: 4.334 ± 0.07	9.778AlaLeu: 9.778 ± 0.126	2.186AlaMet: 2.186 ± 0.046	3.213AlaAsn: 3.213 ± 0.053	3.968AlaPro: 3.968 ± 0.067	3.56AlaGln: 3.56 ± 0.053	4.51AlaArg: 4.51 ± 0.063	5.765AlaSer: 5.765 ± 0.067	5.334AlaThr: 5.334 ± 0.069	6.125AlaVal: 6.125 ± 0.082	1.302AlaTrp: 1.302 ± 0.03	2.688AlaTyr: 2.688 ± 0.04	0.001AlaXaa: 0.001 ± 0.001
Cys	1.067CysAla: 1.067 ± 0.028	0.169CysCys: 0.169 ± 0.011	0.596CysAsp: 0.596 ± 0.022	0.627CysGlu: 0.627 ± 0.024	0.472CysPhe: 0.472 ± 0.02	0.963CysGly: 0.963 ± 0.028	0.3CysHis: 0.3 ± 0.017	0.648CysIle: 0.648 ± 0.021	0.374CysLys: 0.374 ± 0.018	1.095CysLeu: 1.095 ± 0.028	0.241CysMet: 0.241 ± 0.014	0.317CysAsn: 0.317 ± 0.017	0.519CysPro: 0.519 ± 0.021	0.321CysGln: 0.321 ± 0.014	0.553CysArg: 0.553 ± 0.019	0.758CysSer: 0.758 ± 0.023	0.523CysThr: 0.523 ± 0.019	0.736CysVal: 0.736 ± 0.026	0.14CysTrp: 0.14 ± 0.011	0.371CysTyr: 0.371 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.095AspAla: 6.095 ± 0.07	0.593AspCys: 0.593 ± 0.02	3.329AspAsp: 3.329 ± 0.066	3.841AspGlu: 3.841 ± 0.054	2.842AspPhe: 2.842 ± 0.051	5.055AspGly: 5.055 ± 0.078	1.258AspHis: 1.258 ± 0.035	3.124AspIle: 3.124 ± 0.05	2.144AspLys: 2.144 ± 0.042	5.896AspLeu: 5.896 ± 0.064	1.23AspMet: 1.23 ± 0.029	2.005AspAsn: 2.005 ± 0.041	3.026AspPro: 3.026 ± 0.052	2.203AspGln: 2.203 ± 0.042	2.946AspArg: 2.946 ± 0.048	3.654AspSer: 3.654 ± 0.065	3.285AspThr: 3.285 ± 0.06	3.85AspVal: 3.85 ± 0.063	1.201AspTrp: 1.201 ± 0.031	2.264AspTyr: 2.264 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.842GluAla: 6.842 ± 0.086	0.537GluCys: 0.537 ± 0.021	3.469GluAsp: 3.469 ± 0.053	3.693GluGlu: 3.693 ± 0.068	2.423GluPhe: 2.423 ± 0.043	4.413GluGly: 4.413 ± 0.056	1.405GluHis: 1.405 ± 0.035	3.892GluIle: 3.892 ± 0.053	2.938GluLys: 2.938 ± 0.055	6.766GluLeu: 6.766 ± 0.07	1.609GluMet: 1.609 ± 0.034	2.319GluAsn: 2.319 ± 0.048	2.572GluPro: 2.572 ± 0.042	2.794GluGln: 2.794 ± 0.044	3.854GluArg: 3.854 ± 0.063	4.082GluSer: 4.082 ± 0.057	3.61GluThr: 3.61 ± 0.06	4.471GluVal: 4.471 ± 0.063	1.052GluTrp: 1.052 ± 0.029	1.686GluTyr: 1.686 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.582PheAla: 3.582 ± 0.048	0.549PheCys: 0.549 ± 0.02	2.967PheAsp: 2.967 ± 0.048	2.815PheGlu: 2.815 ± 0.046	1.873PhePhe: 1.873 ± 0.036	3.24PheGly: 3.24 ± 0.053	0.825PheHis: 0.825 ± 0.027	2.428PheIle: 2.428 ± 0.046	1.967PheLys: 1.967 ± 0.04	3.518PheLeu: 3.518 ± 0.053	0.938PheMet: 0.938 ± 0.026	1.726PheAsn: 1.726 ± 0.034	1.705PhePro: 1.705 ± 0.033	1.239PheGln: 1.239 ± 0.033	1.896PheArg: 1.896 ± 0.037	2.987PheSer: 2.987 ± 0.041	2.601PheThr: 2.601 ± 0.048	2.591PheVal: 2.591 ± 0.049	0.579PheTrp: 0.579 ± 0.02	1.344PheTyr: 1.344 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.475GlyAla: 6.475 ± 0.084	0.943GlyCys: 0.943 ± 0.028	4.503GlyAsp: 4.503 ± 0.069	4.489GlyGlu: 4.489 ± 0.061	3.404GlyPhe: 3.404 ± 0.055	5.982GlyGly: 5.982 ± 0.099	1.729GlyHis: 1.729 ± 0.039	4.544GlyIle: 4.544 ± 0.065	3.973GlyLys: 3.973 ± 0.067	6.981GlyLeu: 6.981 ± 0.083	1.967GlyMet: 1.967 ± 0.035	2.87GlyAsn: 2.87 ± 0.055	2.269GlyPro: 2.269 ± 0.044	2.672GlyGln: 2.672 ± 0.042	3.805GlyArg: 3.805 ± 0.059	4.973GlySer: 4.973 ± 0.072	4.297GlyThr: 4.297 ± 0.071	5.25GlyVal: 5.25 ± 0.074	1.196GlyTrp: 1.196 ± 0.033	2.755GlyTyr: 2.755 ± 0.045	0.001GlyXaa: 0.001 ± 0.001
His	1.998HisAla: 1.998 ± 0.037	0.307HisCys: 0.307 ± 0.014	1.187HisAsp: 1.187 ± 0.035	1.221HisGlu: 1.221 ± 0.029	1.118HisPhe: 1.118 ± 0.029	1.688HisGly: 1.688 ± 0.037	0.64HisHis: 0.64 ± 0.022	1.173HisIle: 1.173 ± 0.027	0.766HisLys: 0.766 ± 0.023	2.147HisLeu: 2.147 ± 0.043	0.461HisMet: 0.461 ± 0.018	0.773HisAsn: 0.773 ± 0.025	1.319HisPro: 1.319 ± 0.029	0.737HisGln: 0.737 ± 0.022	1.178HisArg: 1.178 ± 0.032	1.409HisSer: 1.409 ± 0.032	1.22HisThr: 1.22 ± 0.031	1.295HisVal: 1.295 ± 0.035	0.414HisTrp: 0.414 ± 0.015	0.829HisTyr: 0.829 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.646IleAla: 5.646 ± 0.074	0.766IleCys: 0.766 ± 0.025	4.071IleAsp: 4.071 ± 0.064	4.537IleGlu: 4.537 ± 0.068	2.247IlePhe: 2.247 ± 0.044	4.444IleGly: 4.444 ± 0.056	1.265IleHis: 1.265 ± 0.031	3.107IleIle: 3.107 ± 0.063	2.45IleLys: 2.45 ± 0.043	5.289IleLeu: 5.289 ± 0.067	1.022IleMet: 1.022 ± 0.024	2.225IleAsn: 2.225 ± 0.043	2.715IlePro: 2.715 ± 0.046	2.147IleGln: 2.147 ± 0.038	3.126IleArg: 3.126 ± 0.054	3.679IleSer: 3.679 ± 0.052	3.406IleThr: 3.406 ± 0.064	3.906IleVal: 3.906 ± 0.058	0.656IleTrp: 0.656 ± 0.024	1.713IleTyr: 1.713 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.416LysAla: 4.416 ± 0.073	0.32LysCys: 0.32 ± 0.015	2.649LysAsp: 2.649 ± 0.047	2.93LysGlu: 2.93 ± 0.054	1.421LysPhe: 1.421 ± 0.033	3.329LysGly: 3.329 ± 0.066	1.127LysHis: 1.127 ± 0.029	2.545LysIle: 2.545 ± 0.048	2.852LysLys: 2.852 ± 0.072	4.353LysLeu: 4.353 ± 0.056	1.206LysMet: 1.206 ± 0.029	1.837LysAsn: 1.837 ± 0.042	2.271LysPro: 2.271 ± 0.045	2.042LysGln: 2.042 ± 0.042	2.672LysArg: 2.672 ± 0.048	2.913LysSer: 2.913 ± 0.048	2.733LysThr: 2.733 ± 0.043	3.039LysVal: 3.039 ± 0.056	0.715LysTrp: 0.715 ± 0.027	1.302LysTyr: 1.302 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	8.954LeuAla: 8.954 ± 0.111	1.234LeuCys: 1.234 ± 0.029	5.65LeuAsp: 5.65 ± 0.068	6.135LeuGlu: 6.135 ± 0.078	3.905LeuPhe: 3.905 ± 0.057	6.813LeuGly: 6.813 ± 0.085	1.96LeuHis: 1.96 ± 0.043	5.78LeuIle: 5.78 ± 0.081	5.189LeuLys: 5.189 ± 0.072	9.697LeuLeu: 9.697 ± 0.114	2.144LeuMet: 2.144 ± 0.043	3.921LeuAsn: 3.921 ± 0.053	5.035LeuPro: 5.035 ± 0.068	3.397LeuGln: 3.397 ± 0.054	5.161LeuArg: 5.161 ± 0.071	7.251LeuSer: 7.251 ± 0.096	5.674LeuThr: 5.674 ± 0.071	5.958LeuVal: 5.958 ± 0.064	1.141LeuTrp: 1.141 ± 0.034	2.676LeuTyr: 2.676 ± 0.045	0.001LeuXaa: 0.001 ± 0.001
Met	2.033MetAla: 2.033 ± 0.04	0.181MetCys: 0.181 ± 0.012	1.275MetAsp: 1.275 ± 0.031	1.294MetGlu: 1.294 ± 0.034	0.677MetPhe: 0.677 ± 0.022	1.625MetGly: 1.625 ± 0.035	0.552MetHis: 0.552 ± 0.02	1.364MetIle: 1.364 ± 0.036	1.5MetLys: 1.5 ± 0.03	2.21MetLeu: 2.21 ± 0.043	0.562MetMet: 0.562 ± 0.025	1.047MetAsn: 1.047 ± 0.026	1.207MetPro: 1.207 ± 0.029	0.891MetGln: 0.891 ± 0.027	1.311MetArg: 1.311 ± 0.031	1.58MetSer: 1.58 ± 0.036	1.433MetThr: 1.433 ± 0.033	1.502MetVal: 1.502 ± 0.03	0.232MetTrp: 0.232 ± 0.013	0.416MetTyr: 0.416 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.377AsnAla: 3.377 ± 0.048	0.408AsnCys: 0.408 ± 0.022	2.182AsnAsp: 2.182 ± 0.054	2.158AsnGlu: 2.158 ± 0.041	1.531AsnPhe: 1.531 ± 0.033	3.245AsnGly: 3.245 ± 0.061	0.829AsnHis: 0.829 ± 0.024	2.118AsnIle: 2.118 ± 0.041	1.513AsnLys: 1.513 ± 0.036	3.506AsnLeu: 3.506 ± 0.046	0.789AsnMet: 0.789 ± 0.025	1.422AsnAsn: 1.422 ± 0.043	2.33AsnPro: 2.33 ± 0.039	1.411AsnGln: 1.411 ± 0.03	1.939AsnArg: 1.939 ± 0.034	2.304AsnSer: 2.304 ± 0.051	2.324AsnThr: 2.324 ± 0.044	2.342AsnVal: 2.342 ± 0.042	0.647AsnTrp: 0.647 ± 0.022	1.288AsnTyr: 1.288 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.111ProAla: 4.111 ± 0.053	0.336ProCys: 0.336 ± 0.017	2.99ProAsp: 2.99 ± 0.054	4.199ProGlu: 4.199 ± 0.057	1.993ProPhe: 1.993 ± 0.041	2.856ProGly: 2.856 ± 0.051	1.086ProHis: 1.086 ± 0.03	2.549ProIle: 2.549 ± 0.039	2.31ProLys: 2.31 ± 0.046	4.038ProLeu: 4.038 ± 0.047	0.954ProMet: 0.954 ± 0.025	1.927ProAsn: 1.927 ± 0.034	1.495ProPro: 1.495 ± 0.041	1.642ProGln: 1.642 ± 0.039	1.96ProArg: 1.96 ± 0.037	3.061ProSer: 3.061 ± 0.048	2.725ProThr: 2.725 ± 0.046	3.177ProVal: 3.177 ± 0.047	0.63ProTrp: 0.63 ± 0.023	1.377ProTyr: 1.377 ± 0.037	0.001ProXaa: 0.001 ± 0.001
Gln	3.7GlnAla: 3.7 ± 0.05	0.314GlnCys: 0.314 ± 0.017	1.715GlnAsp: 1.715 ± 0.034	1.885GlnGlu: 1.885 ± 0.039	1.426GlnPhe: 1.426 ± 0.03	2.387GlnGly: 2.387 ± 0.035	0.858GlnHis: 0.858 ± 0.021	2.237GlnIle: 2.237 ± 0.039	1.678GlnLys: 1.678 ± 0.037	4.057GlnLeu: 4.057 ± 0.059	0.988GlnMet: 0.988 ± 0.023	1.286GlnAsn: 1.286 ± 0.029	1.711GlnPro: 1.711 ± 0.037	1.72GlnGln: 1.72 ± 0.039	2.257GlnArg: 2.257 ± 0.044	2.578GlnSer: 2.578 ± 0.044	2.101GlnThr: 2.101 ± 0.041	2.416GlnVal: 2.416 ± 0.05	0.591GlnTrp: 0.591 ± 0.023	0.974GlnTyr: 0.974 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	4.321ArgAla: 4.321 ± 0.061	0.511ArgCys: 0.511 ± 0.019	2.8ArgAsp: 2.8 ± 0.045	3.432ArgGlu: 3.432 ± 0.055	2.466ArgPhe: 2.466 ± 0.041	3.322ArgGly: 3.322 ± 0.053	1.128ArgHis: 1.128 ± 0.03	3.501ArgIle: 3.501 ± 0.048	2.588ArgLys: 2.588 ± 0.039	5.2ArgLeu: 5.2 ± 0.075	1.433ArgMet: 1.433 ± 0.033	1.895ArgAsn: 1.895 ± 0.035	2.171ArgPro: 2.171 ± 0.041	1.826ArgGln: 1.826 ± 0.042	3.019ArgArg: 3.019 ± 0.058	3.363ArgSer: 3.363 ± 0.054	2.633ArgThr: 2.633 ± 0.043	3.592ArgVal: 3.592 ± 0.055	0.817ArgTrp: 0.817 ± 0.027	1.974ArgTyr: 1.974 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.975SerAla: 5.975 ± 0.081	0.619SerCys: 0.619 ± 0.02	4.078SerAsp: 4.078 ± 0.057	4.046SerGlu: 4.046 ± 0.058	2.755SerPhe: 2.755 ± 0.053	5.757SerGly: 5.757 ± 0.089	1.336SerHis: 1.336 ± 0.028	4.058SerIle: 4.058 ± 0.061	3.019SerLys: 3.019 ± 0.05	6.235SerLeu: 6.235 ± 0.07	1.571SerMet: 1.571 ± 0.032	2.52SerAsn: 2.52 ± 0.047	2.881SerPro: 2.881 ± 0.044	2.256SerGln: 2.256 ± 0.041	3.145SerArg: 3.145 ± 0.051	4.509SerSer: 4.509 ± 0.075	3.589SerThr: 3.589 ± 0.063	4.545SerVal: 4.545 ± 0.065	0.928SerTrp: 0.928 ± 0.028	2.084SerTyr: 2.084 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	5.029ThrAla: 5.029 ± 0.069	0.57ThrCys: 0.57 ± 0.019	3.505ThrAsp: 3.505 ± 0.058	3.517ThrGlu: 3.517 ± 0.055	2.394ThrPhe: 2.394 ± 0.041	4.669ThrGly: 4.669 ± 0.066	1.214ThrHis: 1.214 ± 0.032	3.553ThrIle: 3.553 ± 0.063	2.265ThrLys: 2.265 ± 0.043	6.062ThrLeu: 6.062 ± 0.078	1.083ThrMet: 1.083 ± 0.03	2.032ThrAsn: 2.032 ± 0.046	3.213ThrPro: 3.213 ± 0.051	1.963ThrGln: 1.963 ± 0.039	2.604ThrArg: 2.604 ± 0.044	3.572ThrSer: 3.572 ± 0.066	3.411ThrThr: 3.411 ± 0.065	4.214ThrVal: 4.214 ± 0.073	0.809ThrTrp: 0.809 ± 0.026	1.762ThrTyr: 1.762 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	6.298ValAla: 6.298 ± 0.076	0.829ValCys: 0.829 ± 0.026	4.338ValAsp: 4.338 ± 0.063	4.555ValGlu: 4.555 ± 0.052	2.794ValPhe: 2.794 ± 0.045	4.8ValGly: 4.8 ± 0.066	1.322ValHis: 1.322 ± 0.035	3.973ValIle: 3.973 ± 0.05	2.809ValLys: 2.809 ± 0.047	6.377ValLeu: 6.377 ± 0.075	1.475ValMet: 1.475 ± 0.035	2.469ValAsn: 2.469 ± 0.039	2.899ValPro: 2.899 ± 0.046	2.133ValGln: 2.133 ± 0.036	3.369ValArg: 3.369 ± 0.06	4.603ValSer: 4.603 ± 0.064	3.95ValThr: 3.95 ± 0.063	4.968ValVal: 4.968 ± 0.072	0.875ValTrp: 0.875 ± 0.022	1.876ValTyr: 1.876 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.082TrpAla: 1.082 ± 0.027	0.173TrpCys: 0.173 ± 0.01	0.898TrpAsp: 0.898 ± 0.026	0.827TrpGlu: 0.827 ± 0.027	0.618TrpPhe: 0.618 ± 0.021	1.027TrpGly: 1.027 ± 0.03	0.435TrpHis: 0.435 ± 0.017	0.887TrpIle: 0.887 ± 0.028	0.803TrpLys: 0.803 ± 0.026	1.505TrpLeu: 1.505 ± 0.039	0.427TrpMet: 0.427 ± 0.017	0.629TrpAsn: 0.629 ± 0.022	0.643TrpPro: 0.643 ± 0.021	0.67TrpGln: 0.67 ± 0.024	0.813TrpArg: 0.813 ± 0.024	0.921TrpSer: 0.921 ± 0.027	0.799TrpThr: 0.799 ± 0.025	0.908TrpVal: 0.908 ± 0.026	0.241TrpTrp: 0.241 ± 0.013	0.398TrpTyr: 0.398 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.666TyrAla: 2.666 ± 0.048	0.356TyrCys: 0.356 ± 0.018	2.036TyrAsp: 2.036 ± 0.041	1.853TyrGlu: 1.853 ± 0.041	1.37TyrPhe: 1.37 ± 0.031	2.463TyrGly: 2.463 ± 0.039	0.729TyrHis: 0.729 ± 0.025	1.61TyrIle: 1.61 ± 0.036	1.201TyrLys: 1.201 ± 0.031	2.967TyrLeu: 2.967 ± 0.053	0.603TyrMet: 0.603 ± 0.02	1.228TyrAsn: 1.228 ± 0.033	1.465TyrPro: 1.465 ± 0.032	1.256TyrGln: 1.256 ± 0.03	1.874TyrArg: 1.874 ± 0.037	1.942TyrSer: 1.942 ± 0.039	1.793TyrThr: 1.793 ± 0.038	1.827TyrVal: 1.827 ± 0.035	0.538TyrTrp: 0.538 ± 0.02	1.133TyrTyr: 1.133 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.054XaaXaa: 0.054 ± 0.031

Statistics based on 4076 proteins (1428820 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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