Amino acid dipepetide frequency for Pseudomonas agarici

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.494AlaAla: 11.494 ± 0.118	1.179AlaCys: 1.179 ± 0.028	5.668AlaAsp: 5.668 ± 0.063	6.145AlaGlu: 6.145 ± 0.071	3.67AlaPhe: 3.67 ± 0.05	8.33AlaGly: 8.33 ± 0.082	2.243AlaHis: 2.243 ± 0.04	5.242AlaIle: 5.242 ± 0.063	3.749AlaLys: 3.749 ± 0.078	13.424AlaLeu: 13.424 ± 0.116	2.692AlaMet: 2.692 ± 0.045	3.009AlaAsn: 3.009 ± 0.05	4.58AlaPro: 4.58 ± 0.075	5.219AlaGln: 5.219 ± 0.067	7.01AlaArg: 7.01 ± 0.076	6.22AlaSer: 6.22 ± 0.073	4.868AlaThr: 4.868 ± 0.057	7.2AlaVal: 7.2 ± 0.074	1.484AlaTrp: 1.484 ± 0.035	2.498AlaTyr: 2.498 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.125CysAla: 1.125 ± 0.029	0.141CysCys: 0.141 ± 0.009	0.527CysAsp: 0.527 ± 0.019	0.585CysGlu: 0.585 ± 0.02	0.36CysPhe: 0.36 ± 0.016	0.917CysGly: 0.917 ± 0.027	0.26CysHis: 0.26 ± 0.014	0.438CysIle: 0.438 ± 0.015	0.291CysLys: 0.291 ± 0.014	1.189CysLeu: 1.189 ± 0.03	0.194CysMet: 0.194 ± 0.011	0.274CysAsn: 0.274 ± 0.014	0.469CysPro: 0.469 ± 0.02	0.398CysGln: 0.398 ± 0.017	0.653CysArg: 0.653 ± 0.021	0.619CysSer: 0.619 ± 0.022	0.456CysThr: 0.456 ± 0.019	0.711CysVal: 0.711 ± 0.024	0.148CysTrp: 0.148 ± 0.008	0.255CysTyr: 0.255 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.29AspAla: 5.29 ± 0.061	0.56AspCys: 0.56 ± 0.019	2.802AspAsp: 2.802 ± 0.053	3.362AspGlu: 3.362 ± 0.048	2.203AspPhe: 2.203 ± 0.042	4.267AspGly: 4.267 ± 0.058	1.183AspHis: 1.183 ± 0.03	2.918AspIle: 2.918 ± 0.047	2.018AspLys: 2.018 ± 0.045	6.046AspLeu: 6.046 ± 0.072	1.165AspMet: 1.165 ± 0.027	1.749AspAsn: 1.749 ± 0.037	2.902AspPro: 2.902 ± 0.052	2.187AspGln: 2.187 ± 0.04	3.105AspArg: 3.105 ± 0.044	3.174AspSer: 3.174 ± 0.051	2.58AspThr: 2.58 ± 0.044	3.299AspVal: 3.299 ± 0.057	0.958AspTrp: 0.958 ± 0.027	1.752AspTyr: 1.752 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.151GluAla: 6.151 ± 0.075	0.435GluCys: 0.435 ± 0.018	2.471GluAsp: 2.471 ± 0.041	3.048GluGlu: 3.048 ± 0.06	1.792GluPhe: 1.792 ± 0.037	3.807GluGly: 3.807 ± 0.059	1.695GluHis: 1.695 ± 0.034	2.853GluIle: 2.853 ± 0.043	2.187GluLys: 2.187 ± 0.045	7.031GluLeu: 7.031 ± 0.077	1.29GluMet: 1.29 ± 0.031	1.606GluAsn: 1.606 ± 0.035	2.508GluPro: 2.508 ± 0.046	3.666GluGln: 3.666 ± 0.06	4.739GluArg: 4.739 ± 0.067	2.82GluSer: 2.82 ± 0.046	2.593GluThr: 2.593 ± 0.047	4.079GluVal: 4.079 ± 0.053	0.696GluTrp: 0.696 ± 0.02	1.255GluTyr: 1.255 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.957PheAla: 3.957 ± 0.054	0.458PheCys: 0.458 ± 0.019	2.51PheAsp: 2.51 ± 0.042	2.154PheGlu: 2.154 ± 0.037	1.542PhePhe: 1.542 ± 0.036	3.172PheGly: 3.172 ± 0.05	0.748PheHis: 0.748 ± 0.025	1.97PheIle: 1.97 ± 0.04	1.369PheLys: 1.369 ± 0.032	3.332PheLeu: 3.332 ± 0.052	0.809PheMet: 0.809 ± 0.022	1.395PheAsn: 1.395 ± 0.027	1.462PhePro: 1.462 ± 0.033	1.268PheGln: 1.268 ± 0.027	1.809PheArg: 1.809 ± 0.038	2.735PheSer: 2.735 ± 0.045	1.886PheThr: 1.886 ± 0.039	2.464PheVal: 2.464 ± 0.046	0.564PheTrp: 0.564 ± 0.02	1.07PheTyr: 1.07 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	7.216GlyAla: 7.216 ± 0.073	0.923GlyCys: 0.923 ± 0.026	3.818GlyAsp: 3.818 ± 0.048	4.606GlyGlu: 4.606 ± 0.058	3.227GlyPhe: 3.227 ± 0.057	5.966GlyGly: 5.966 ± 0.091	1.872GlyHis: 1.872 ± 0.034	4.131GlyIle: 4.131 ± 0.06	3.345GlyLys: 3.345 ± 0.052	9.231GlyLeu: 9.231 ± 0.097	2.042GlyMet: 2.042 ± 0.039	2.43GlyAsn: 2.43 ± 0.055	2.633GlyPro: 2.633 ± 0.046	3.671GlyGln: 3.671 ± 0.055	4.749GlyArg: 4.749 ± 0.058	4.577GlySer: 4.577 ± 0.065	3.76GlyThr: 3.76 ± 0.059	5.902GlyVal: 5.902 ± 0.067	1.325GlyTrp: 1.325 ± 0.027	2.448GlyTyr: 2.448 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.208HisAla: 2.208 ± 0.042	0.346HisCys: 0.346 ± 0.016	1.243HisAsp: 1.243 ± 0.03	1.257HisGlu: 1.257 ± 0.032	1.012HisPhe: 1.012 ± 0.026	1.988HisGly: 1.988 ± 0.037	0.647HisHis: 0.647 ± 0.025	1.066HisIle: 1.066 ± 0.026	0.709HisLys: 0.709 ± 0.019	2.713HisLeu: 2.713 ± 0.042	0.512HisMet: 0.512 ± 0.021	0.686HisAsn: 0.686 ± 0.023	1.448HisPro: 1.448 ± 0.036	1.006HisGln: 1.006 ± 0.026	1.404HisArg: 1.404 ± 0.028	1.344HisSer: 1.344 ± 0.028	0.987HisThr: 0.987 ± 0.026	1.33HisVal: 1.33 ± 0.027	0.472HisTrp: 0.472 ± 0.017	0.8HisTyr: 0.8 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.944IleAla: 5.944 ± 0.072	0.544IleCys: 0.544 ± 0.02	3.475IleAsp: 3.475 ± 0.049	3.549IleGlu: 3.549 ± 0.053	1.58IlePhe: 1.58 ± 0.033	4.658IleGly: 4.658 ± 0.061	1.087IleHis: 1.087 ± 0.03	2.262IleIle: 2.262 ± 0.053	1.93IleLys: 1.93 ± 0.041	4.436IleLeu: 4.436 ± 0.062	0.87IleMet: 0.87 ± 0.026	1.885IleAsn: 1.885 ± 0.039	2.275IlePro: 2.275 ± 0.042	1.725IleGln: 1.725 ± 0.038	3.086IleArg: 3.086 ± 0.046	3.196IleSer: 3.196 ± 0.056	2.597IleThr: 2.597 ± 0.044	3.343IleVal: 3.343 ± 0.048	0.524IleTrp: 0.524 ± 0.019	1.206IleTyr: 1.206 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.065LysAla: 4.065 ± 0.061	0.201LysCys: 0.201 ± 0.014	1.898LysAsp: 1.898 ± 0.047	1.783LysGlu: 1.783 ± 0.037	0.977LysPhe: 0.977 ± 0.031	2.637LysGly: 2.637 ± 0.048	0.818LysHis: 0.818 ± 0.025	1.87LysIle: 1.87 ± 0.042	1.465LysLys: 1.465 ± 0.04	4.001LysLeu: 4.001 ± 0.062	0.781LysMet: 0.781 ± 0.024	1.165LysAsn: 1.165 ± 0.033	2.032LysPro: 2.032 ± 0.043	1.608LysGln: 1.608 ± 0.036	2.341LysArg: 2.341 ± 0.04	2.067LysSer: 2.067 ± 0.04	1.982LysThr: 1.982 ± 0.04	2.813LysVal: 2.813 ± 0.055	0.366LysTrp: 0.366 ± 0.015	0.734LysTyr: 0.734 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.58LeuAla: 13.58 ± 0.121	1.253LeuCys: 1.253 ± 0.033	6.901LeuAsp: 6.901 ± 0.082	6.612LeuGlu: 6.612 ± 0.072	4.281LeuPhe: 4.281 ± 0.063	9.153LeuGly: 9.153 ± 0.096	2.511LeuHis: 2.511 ± 0.041	5.887LeuIle: 5.887 ± 0.062	4.636LeuLys: 4.636 ± 0.072	13.616LeuLeu: 13.616 ± 0.137	2.57LeuMet: 2.57 ± 0.047	3.846LeuAsn: 3.846 ± 0.054	6.364LeuPro: 6.364 ± 0.072	4.773LeuGln: 4.773 ± 0.07	7.542LeuArg: 7.542 ± 0.088	7.836LeuSer: 7.836 ± 0.078	5.854LeuThr: 5.854 ± 0.067	7.682LeuVal: 7.682 ± 0.077	1.361LeuTrp: 1.361 ± 0.035	2.68LeuTyr: 2.68 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.53MetAla: 2.53 ± 0.039	0.174MetCys: 0.174 ± 0.012	1.019MetAsp: 1.019 ± 0.027	0.934MetGlu: 0.934 ± 0.027	0.707MetPhe: 0.707 ± 0.023	1.603MetGly: 1.603 ± 0.034	0.498MetHis: 0.498 ± 0.017	1.203MetIle: 1.203 ± 0.031	0.874MetLys: 0.874 ± 0.025	2.584MetLeu: 2.584 ± 0.036	0.5MetMet: 0.5 ± 0.017	0.856MetAsn: 0.856 ± 0.024	1.252MetPro: 1.252 ± 0.029	0.992MetGln: 0.992 ± 0.025	1.46MetArg: 1.46 ± 0.028	1.767MetSer: 1.767 ± 0.033	1.45MetThr: 1.45 ± 0.032	1.506MetVal: 1.506 ± 0.029	0.156MetTrp: 0.156 ± 0.01	0.36MetTyr: 0.36 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.135AsnAla: 3.135 ± 0.053	0.283AsnCys: 0.283 ± 0.015	1.694AsnAsp: 1.694 ± 0.034	1.558AsnGlu: 1.558 ± 0.029	1.131AsnPhe: 1.131 ± 0.025	2.656AsnGly: 2.656 ± 0.046	0.68AsnHis: 0.68 ± 0.021	1.602AsnIle: 1.602 ± 0.037	1.05AsnLys: 1.05 ± 0.03	3.592AsnLeu: 3.592 ± 0.047	0.622AsnMet: 0.622 ± 0.022	1.11AsnAsn: 1.11 ± 0.033	1.989AsnPro: 1.989 ± 0.037	1.353AsnGln: 1.353 ± 0.032	1.932AsnArg: 1.932 ± 0.034	1.709AsnSer: 1.709 ± 0.036	1.558AsnThr: 1.558 ± 0.037	2.044AsnVal: 2.044 ± 0.038	0.489AsnTrp: 0.489 ± 0.018	0.879AsnTyr: 0.879 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	5.2ProAla: 5.2 ± 0.071	0.388ProCys: 0.388 ± 0.015	2.786ProAsp: 2.786 ± 0.048	3.083ProGlu: 3.083 ± 0.049	1.803ProPhe: 1.803 ± 0.037	3.889ProGly: 3.889 ± 0.052	1.078ProHis: 1.078 ± 0.028	2.201ProIle: 2.201 ± 0.044	1.655ProLys: 1.655 ± 0.038	5.799ProLeu: 5.799 ± 0.077	1.135ProMet: 1.135 ± 0.027	1.402ProAsn: 1.402 ± 0.031	2.063ProPro: 2.063 ± 0.044	2.37ProGln: 2.37 ± 0.044	2.62ProArg: 2.62 ± 0.049	2.843ProSer: 2.843 ± 0.045	2.383ProThr: 2.383 ± 0.037	3.773ProVal: 3.773 ± 0.052	0.707ProTrp: 0.707 ± 0.021	1.222ProTyr: 1.222 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	5.923GlnAla: 5.923 ± 0.083	0.333GlnCys: 0.333 ± 0.015	1.94GlnAsp: 1.94 ± 0.036	2.001GlnGlu: 2.001 ± 0.038	1.345GlnPhe: 1.345 ± 0.029	3.348GlnGly: 3.348 ± 0.046	1.119GlnHis: 1.119 ± 0.029	2.236GlnIle: 2.236 ± 0.045	1.412GlnLys: 1.412 ± 0.034	5.689GlnLeu: 5.689 ± 0.089	1.061GlnMet: 1.061 ± 0.023	1.177GlnAsn: 1.177 ± 0.028	2.337GlnPro: 2.337 ± 0.041	2.604GlnGln: 2.604 ± 0.058	3.563GlnArg: 3.563 ± 0.06	2.473GlnSer: 2.473 ± 0.039	2.126GlnThr: 2.126 ± 0.042	3.708GlnVal: 3.708 ± 0.056	0.735GlnTrp: 0.735 ± 0.024	1.014GlnTyr: 1.014 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	5.861ArgAla: 5.861 ± 0.069	0.625ArgCys: 0.625 ± 0.02	3.405ArgAsp: 3.405 ± 0.048	4.187ArgGlu: 4.187 ± 0.059	2.735ArgPhe: 2.735 ± 0.048	4.094ArgGly: 4.094 ± 0.056	1.785ArgHis: 1.785 ± 0.038	3.46ArgIle: 3.46 ± 0.049	2.045ArgLys: 2.045 ± 0.043	8.605ArgLeu: 8.605 ± 0.102	1.52ArgMet: 1.52 ± 0.033	1.991ArgAsn: 1.991 ± 0.035	2.76ArgPro: 2.76 ± 0.048	3.733ArgGln: 3.733 ± 0.059	4.403ArgArg: 4.403 ± 0.063	3.389ArgSer: 3.389 ± 0.051	2.721ArgThr: 2.721 ± 0.044	4.402ArgVal: 4.402 ± 0.056	1.045ArgTrp: 1.045 ± 0.031	2.035ArgTyr: 2.035 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.156SerAla: 6.156 ± 0.07	0.507SerCys: 0.507 ± 0.018	3.033SerAsp: 3.033 ± 0.047	3.198SerGlu: 3.198 ± 0.06	2.305SerPhe: 2.305 ± 0.043	5.256SerGly: 5.256 ± 0.068	1.434SerHis: 1.434 ± 0.03	2.999SerIle: 2.999 ± 0.048	1.961SerLys: 1.961 ± 0.035	7.404SerLeu: 7.404 ± 0.083	1.356SerMet: 1.356 ± 0.032	1.86SerAsn: 1.86 ± 0.038	2.794SerPro: 2.794 ± 0.045	2.561SerGln: 2.561 ± 0.045	3.854SerArg: 3.854 ± 0.048	3.719SerSer: 3.719 ± 0.059	3.031SerThr: 3.031 ± 0.047	4.23SerVal: 4.23 ± 0.056	0.822SerTrp: 0.822 ± 0.022	1.593SerTyr: 1.593 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.06ThrAla: 5.06 ± 0.07	0.496ThrCys: 0.496 ± 0.02	2.463ThrAsp: 2.463 ± 0.043	2.407ThrGlu: 2.407 ± 0.041	1.878ThrPhe: 1.878 ± 0.035	4.031ThrGly: 4.031 ± 0.054	1.141ThrHis: 1.141 ± 0.026	2.052ThrIle: 2.052 ± 0.039	1.145ThrLys: 1.145 ± 0.028	6.799ThrLeu: 6.799 ± 0.066	0.818ThrMet: 0.818 ± 0.024	1.185ThrAsn: 1.185 ± 0.03	3.148ThrPro: 3.148 ± 0.048	2.173ThrGln: 2.173 ± 0.04	3.054ThrArg: 3.054 ± 0.049	2.743ThrSer: 2.743 ± 0.051	2.486ThrThr: 2.486 ± 0.049	3.662ThrVal: 3.662 ± 0.051	0.708ThrTrp: 0.708 ± 0.021	1.266ThrTyr: 1.266 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.476ValAla: 7.476 ± 0.077	0.696ValCys: 0.696 ± 0.023	3.921ValAsp: 3.921 ± 0.052	4.432ValGlu: 4.432 ± 0.06	2.557ValPhe: 2.557 ± 0.042	5.2ValGly: 5.2 ± 0.062	1.404ValHis: 1.404 ± 0.033	3.926ValIle: 3.926 ± 0.053	2.435ValLys: 2.435 ± 0.048	8.143ValLeu: 8.143 ± 0.072	1.675ValMet: 1.675 ± 0.035	2.205ValAsn: 2.205 ± 0.038	3.356ValPro: 3.356 ± 0.047	2.693ValGln: 2.693 ± 0.044	4.267ValArg: 4.267 ± 0.058	4.396ValSer: 4.396 ± 0.056	3.544ValThr: 3.544 ± 0.049	5.27ValVal: 5.27 ± 0.069	0.818ValTrp: 0.818 ± 0.026	1.597ValTyr: 1.597 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.126TrpAla: 1.126 ± 0.028	0.166TrpCys: 0.166 ± 0.01	0.579TrpAsp: 0.579 ± 0.015	0.56TrpGlu: 0.56 ± 0.02	0.529TrpPhe: 0.529 ± 0.02	0.847TrpGly: 0.847 ± 0.022	0.394TrpHis: 0.394 ± 0.015	0.725TrpIle: 0.725 ± 0.023	0.479TrpLys: 0.479 ± 0.018	2.158TrpLeu: 2.158 ± 0.043	0.34TrpMet: 0.34 ± 0.015	0.455TrpAsn: 0.455 ± 0.019	0.683TrpPro: 0.683 ± 0.023	0.886TrpGln: 0.886 ± 0.026	1.154TrpArg: 1.154 ± 0.03	0.859TrpSer: 0.859 ± 0.022	0.603TrpThr: 0.603 ± 0.017	0.923TrpVal: 0.923 ± 0.026	0.217TrpTrp: 0.217 ± 0.013	0.343TrpTyr: 0.343 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.427TyrAla: 2.427 ± 0.041	0.304TyrCys: 0.304 ± 0.015	1.364TyrAsp: 1.364 ± 0.034	1.261TyrGlu: 1.261 ± 0.033	1.039TyrPhe: 1.039 ± 0.031	2.056TyrGly: 2.056 ± 0.038	0.58TyrHis: 0.58 ± 0.019	1.132TyrIle: 1.132 ± 0.027	0.845TyrLys: 0.845 ± 0.025	3.147TyrLeu: 3.147 ± 0.049	0.471TyrMet: 0.471 ± 0.019	0.78TyrAsn: 0.78 ± 0.024	1.348TyrPro: 1.348 ± 0.027	1.257TyrGln: 1.257 ± 0.029	2.056TyrArg: 2.056 ± 0.036	1.587TyrSer: 1.587 ± 0.033	1.252TyrThr: 1.252 ± 0.031	1.669TyrVal: 1.669 ± 0.038	0.431TyrTrp: 0.431 ± 0.017	0.716TyrTyr: 0.716 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4626 proteins (1550874 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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