Amino acid dipepetide frequency for Acidibacillus ferrooxidans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.015AlaAla: 9.015 ± 0.128	0.891AlaCys: 0.891 ± 0.035	4.203AlaAsp: 4.203 ± 0.074	4.994AlaGlu: 4.994 ± 0.094	3.954AlaPhe: 3.954 ± 0.067	6.767AlaGly: 6.767 ± 0.084	2.486AlaHis: 2.486 ± 0.053	6.001AlaIle: 6.001 ± 0.095	4.024AlaLys: 4.024 ± 0.08	11.467AlaLeu: 11.467 ± 0.121	2.978AlaMet: 2.978 ± 0.064	2.889AlaAsn: 2.889 ± 0.065	3.325AlaPro: 3.325 ± 0.069	3.944AlaGln: 3.944 ± 0.072	6.288AlaArg: 6.288 ± 0.102	5.874AlaSer: 5.874 ± 0.087	5.452AlaThr: 5.452 ± 0.095	7.552AlaVal: 7.552 ± 0.107	1.245AlaTrp: 1.245 ± 0.034	2.968AlaTyr: 2.968 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.852CysAla: 0.852 ± 0.032	0.105CysCys: 0.105 ± 0.014	0.566CysAsp: 0.566 ± 0.026	0.592CysGlu: 0.592 ± 0.024	0.305CysPhe: 0.305 ± 0.018	0.917CysGly: 0.917 ± 0.039	0.219CysHis: 0.219 ± 0.018	0.439CysIle: 0.439 ± 0.029	0.298CysLys: 0.298 ± 0.018	0.655CysLeu: 0.655 ± 0.026	0.174CysMet: 0.174 ± 0.014	0.229CysAsn: 0.229 ± 0.017	0.388CysPro: 0.388 ± 0.021	0.26CysGln: 0.26 ± 0.017	0.504CysArg: 0.504 ± 0.026	0.516CysSer: 0.516 ± 0.024	0.497CysThr: 0.497 ± 0.026	0.716CysVal: 0.716 ± 0.033	0.073CysTrp: 0.073 ± 0.009	0.207CysTyr: 0.207 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.367AspAla: 5.367 ± 0.086	0.383AspCys: 0.383 ± 0.02	2.504AspAsp: 2.504 ± 0.062	4.019AspGlu: 4.019 ± 0.077	1.809AspPhe: 1.809 ± 0.045	3.651AspGly: 3.651 ± 0.055	1.377AspHis: 1.377 ± 0.04	2.28AspIle: 2.28 ± 0.058	1.342AspLys: 1.342 ± 0.042	5.223AspLeu: 5.223 ± 0.096	1.111AspMet: 1.111 ± 0.04	0.961AspAsn: 0.961 ± 0.035	2.566AspPro: 2.566 ± 0.056	1.915AspGln: 1.915 ± 0.043	3.359AspArg: 3.359 ± 0.075	2.106AspSer: 2.106 ± 0.048	2.373AspThr: 2.373 ± 0.053	4.832AspVal: 4.832 ± 0.073	0.577AspTrp: 0.577 ± 0.026	1.304AspTyr: 1.304 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.65GluAla: 5.65 ± 0.11	0.408GluCys: 0.408 ± 0.025	2.813GluAsp: 2.813 ± 0.068	4.185GluGlu: 4.185 ± 0.08	1.778GluPhe: 1.778 ± 0.039	3.588GluGly: 3.588 ± 0.075	1.525GluHis: 1.525 ± 0.038	3.931GluIle: 3.931 ± 0.08	2.8GluLys: 2.8 ± 0.058	5.842GluLeu: 5.842 ± 0.083	1.918GluMet: 1.918 ± 0.049	1.85GluAsn: 1.85 ± 0.047	1.92GluPro: 1.92 ± 0.046	2.908GluGln: 2.908 ± 0.058	5.454GluArg: 5.454 ± 0.101	3.12GluSer: 3.12 ± 0.065	3.501GluThr: 3.501 ± 0.062	4.121GluVal: 4.121 ± 0.085	0.809GluTrp: 0.809 ± 0.034	1.343GluTyr: 1.343 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.105PheAla: 4.105 ± 0.07	0.411PheCys: 0.411 ± 0.023	2.082PheAsp: 2.082 ± 0.051	2.105PheGlu: 2.105 ± 0.049	1.857PhePhe: 1.857 ± 0.051	3.386PheGly: 3.386 ± 0.066	1.071PheHis: 1.071 ± 0.034	2.147PheIle: 2.147 ± 0.057	1.021PheLys: 1.021 ± 0.028	4.2PheLeu: 4.2 ± 0.075	1.004PheMet: 1.004 ± 0.033	1.006PheAsn: 1.006 ± 0.039	1.652PhePro: 1.652 ± 0.044	1.431PheGln: 1.431 ± 0.041	2.12PheArg: 2.12 ± 0.056	3.074PheSer: 3.074 ± 0.068	2.297PheThr: 2.297 ± 0.055	3.272PheVal: 3.272 ± 0.064	0.436PheTrp: 0.436 ± 0.021	1.308PheTyr: 1.308 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.698GlyAla: 6.698 ± 0.118	0.749GlyCys: 0.749 ± 0.033	3.409GlyAsp: 3.409 ± 0.068	3.91GlyGlu: 3.91 ± 0.08	3.346GlyPhe: 3.346 ± 0.073	5.573GlyGly: 5.573 ± 0.098	1.775GlyHis: 1.775 ± 0.04	5.323GlyIle: 5.323 ± 0.075	3.217GlyLys: 3.217 ± 0.065	7.149GlyLeu: 7.149 ± 0.092	2.409GlyMet: 2.409 ± 0.058	2.28GlyAsn: 2.28 ± 0.071	2.206GlyPro: 2.206 ± 0.052	2.868GlyGln: 2.868 ± 0.076	4.102GlyArg: 4.102 ± 0.071	4.411GlySer: 4.411 ± 0.074	4.533GlyThr: 4.533 ± 0.083	6.506GlyVal: 6.506 ± 0.092	0.945GlyTrp: 0.945 ± 0.031	2.722GlyTyr: 2.722 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.812HisAla: 2.812 ± 0.059	0.221HisCys: 0.221 ± 0.015	1.22HisAsp: 1.22 ± 0.038	1.444HisGlu: 1.444 ± 0.04	1.032HisPhe: 1.032 ± 0.034	1.918HisGly: 1.918 ± 0.05	0.844HisHis: 0.844 ± 0.034	1.25HisIle: 1.25 ± 0.034	0.731HisLys: 0.731 ± 0.033	2.75HisLeu: 2.75 ± 0.053	0.631HisMet: 0.631 ± 0.027	0.584HisAsn: 0.584 ± 0.026	1.57HisPro: 1.57 ± 0.051	0.899HisGln: 0.899 ± 0.035	1.587HisArg: 1.587 ± 0.048	1.333HisSer: 1.333 ± 0.041	1.406HisThr: 1.406 ± 0.038	2.309HisVal: 2.309 ± 0.059	0.289HisTrp: 0.289 ± 0.018	0.713HisTyr: 0.713 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.841IleAla: 6.841 ± 0.1	0.54IleCys: 0.54 ± 0.028	3.354IleAsp: 3.354 ± 0.071	3.752IleGlu: 3.752 ± 0.073	1.993IlePhe: 1.993 ± 0.052	5.146IleGly: 5.146 ± 0.085	1.648IleHis: 1.648 ± 0.043	2.761IleIle: 2.761 ± 0.059	1.931IleLys: 1.931 ± 0.051	6.167IleLeu: 6.167 ± 0.081	1.191IleMet: 1.191 ± 0.04	1.589IleAsn: 1.589 ± 0.047	3.084IlePro: 3.084 ± 0.06	2.024IleGln: 2.024 ± 0.05	3.706IleArg: 3.706 ± 0.075	3.604IleSer: 3.604 ± 0.079	3.185IleThr: 3.185 ± 0.06	4.952IleVal: 4.952 ± 0.081	0.573IleTrp: 0.573 ± 0.026	1.539IleTyr: 1.539 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.143LysAla: 3.143 ± 0.067	0.198LysCys: 0.198 ± 0.016	1.827LysAsp: 1.827 ± 0.046	2.608LysGlu: 2.608 ± 0.06	0.979LysPhe: 0.979 ± 0.036	2.564LysGly: 2.564 ± 0.056	0.91LysHis: 0.91 ± 0.036	2.049LysIle: 2.049 ± 0.054	2.115LysLys: 2.115 ± 0.053	3.381LysLeu: 3.381 ± 0.068	1.126LysMet: 1.126 ± 0.035	1.501LysAsn: 1.501 ± 0.045	1.746LysPro: 1.746 ± 0.045	1.571LysGln: 1.571 ± 0.043	3.372LysArg: 3.372 ± 0.066	2.296LysSer: 2.296 ± 0.051	2.658LysThr: 2.658 ± 0.05	2.272LysVal: 2.272 ± 0.065	0.457LysTrp: 0.457 ± 0.025	0.859LysTyr: 0.859 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	10.491LeuAla: 10.491 ± 0.129	1.041LeuCys: 1.041 ± 0.036	4.878LeuAsp: 4.878 ± 0.082	5.79LeuGlu: 5.79 ± 0.093	4.629LeuPhe: 4.629 ± 0.078	7.53LeuGly: 7.53 ± 0.116	2.77LeuHis: 2.77 ± 0.063	6.193LeuIle: 6.193 ± 0.096	3.749LeuLys: 3.749 ± 0.071	11.436LeuLeu: 11.436 ± 0.156	2.535LeuMet: 2.535 ± 0.05	2.873LeuAsn: 2.873 ± 0.066	4.916LeuPro: 4.916 ± 0.071	4.042LeuGln: 4.042 ± 0.068	7.294LeuArg: 7.294 ± 0.106	7.612LeuSer: 7.612 ± 0.111	6.485LeuThr: 6.485 ± 0.093	6.988LeuVal: 6.988 ± 0.1	1.048LeuTrp: 1.048 ± 0.035	2.951LeuTyr: 2.951 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.525MetAla: 2.525 ± 0.059	0.161MetCys: 0.161 ± 0.013	1.415MetAsp: 1.415 ± 0.043	1.514MetGlu: 1.514 ± 0.043	0.83MetPhe: 0.83 ± 0.031	1.872MetGly: 1.872 ± 0.042	0.606MetHis: 0.606 ± 0.029	1.893MetIle: 1.893 ± 0.054	1.4MetLys: 1.4 ± 0.039	2.628MetLeu: 2.628 ± 0.05	0.941MetMet: 0.941 ± 0.032	1.238MetAsn: 1.238 ± 0.035	1.153MetPro: 1.153 ± 0.039	1.04MetGln: 1.04 ± 0.034	2.093MetArg: 2.093 ± 0.053	1.782MetSer: 1.782 ± 0.051	1.783MetThr: 1.783 ± 0.048	1.914MetVal: 1.914 ± 0.048	0.276MetTrp: 0.276 ± 0.017	0.661MetTyr: 0.661 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.237AsnAla: 3.237 ± 0.073	0.215AsnCys: 0.215 ± 0.017	1.338AsnAsp: 1.338 ± 0.05	1.704AsnGlu: 1.704 ± 0.048	1.059AsnPhe: 1.059 ± 0.037	2.41AsnGly: 2.41 ± 0.072	0.861AsnHis: 0.861 ± 0.032	1.387AsnIle: 1.387 ± 0.037	0.934AsnLys: 0.934 ± 0.033	3.071AsnLeu: 3.071 ± 0.059	0.691AsnMet: 0.691 ± 0.029	0.772AsnAsn: 0.772 ± 0.034	1.954AsnPro: 1.954 ± 0.056	1.356AsnGln: 1.356 ± 0.043	1.981AsnArg: 1.981 ± 0.043	1.523AsnSer: 1.523 ± 0.05	1.596AsnThr: 1.596 ± 0.058	2.6AsnVal: 2.6 ± 0.062	0.382AsnTrp: 0.382 ± 0.023	0.826AsnTyr: 0.826 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.392ProAla: 3.392 ± 0.065	0.294ProCys: 0.294 ± 0.019	2.341ProAsp: 2.341 ± 0.063	2.695ProGlu: 2.695 ± 0.064	2.092ProPhe: 2.092 ± 0.051	3.143ProGly: 3.143 ± 0.07	1.152ProHis: 1.152 ± 0.037	2.627ProIle: 2.627 ± 0.052	1.573ProLys: 1.573 ± 0.042	4.688ProLeu: 4.688 ± 0.071	1.089ProMet: 1.089 ± 0.034	1.527ProAsn: 1.527 ± 0.04	1.513ProPro: 1.513 ± 0.051	1.58ProGln: 1.58 ± 0.051	2.132ProArg: 2.132 ± 0.05	2.997ProSer: 2.997 ± 0.071	2.422ProThr: 2.422 ± 0.059	3.361ProVal: 3.361 ± 0.065	0.526ProTrp: 0.526 ± 0.026	1.475ProTyr: 1.475 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.866GlnAla: 3.866 ± 0.066	0.289GlnCys: 0.289 ± 0.02	1.601GlnAsp: 1.601 ± 0.04	2.206GlnGlu: 2.206 ± 0.057	1.51GlnPhe: 1.51 ± 0.038	2.836GlnGly: 2.836 ± 0.06	0.819GlnHis: 0.819 ± 0.031	2.517GlnIle: 2.517 ± 0.051	1.713GlnLys: 1.713 ± 0.046	3.664GlnLeu: 3.664 ± 0.068	1.273GlnMet: 1.273 ± 0.041	1.369GlnAsn: 1.369 ± 0.043	1.502GlnPro: 1.502 ± 0.048	1.626GlnGln: 1.626 ± 0.047	2.43GlnArg: 2.43 ± 0.057	2.66GlnSer: 2.66 ± 0.063	2.586GlnThr: 2.586 ± 0.057	2.863GlnVal: 2.863 ± 0.055	0.497GlnTrp: 0.497 ± 0.025	1.015GlnTyr: 1.015 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	6.266ArgAla: 6.266 ± 0.096	0.532ArgCys: 0.532 ± 0.028	3.621ArgAsp: 3.621 ± 0.073	4.937ArgGlu: 4.937 ± 0.087	2.67ArgPhe: 2.67 ± 0.054	4.29ArgGly: 4.29 ± 0.07	1.49ArgHis: 1.49 ± 0.039	4.226ArgIle: 4.226 ± 0.081	2.654ArgLys: 2.654 ± 0.063	6.373ArgLeu: 6.373 ± 0.099	2.197ArgMet: 2.197 ± 0.057	1.842ArgAsn: 1.842 ± 0.05	2.291ArgPro: 2.291 ± 0.058	2.469ArgGln: 2.469 ± 0.046	4.083ArgArg: 4.083 ± 0.078	3.701ArgSer: 3.701 ± 0.068	3.282ArgThr: 3.282 ± 0.06	5.609ArgVal: 5.609 ± 0.079	0.573ArgTrp: 0.573 ± 0.027	1.942ArgTyr: 1.942 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.784SerAla: 5.784 ± 0.083	0.451SerCys: 0.451 ± 0.026	2.961SerAsp: 2.961 ± 0.058	3.383SerGlu: 3.383 ± 0.06	2.902SerPhe: 2.902 ± 0.057	5.197SerGly: 5.197 ± 0.089	1.513SerHis: 1.513 ± 0.042	3.886SerIle: 3.886 ± 0.069	1.964SerLys: 1.964 ± 0.047	6.791SerLeu: 6.791 ± 0.101	1.79SerMet: 1.79 ± 0.047	1.789SerAsn: 1.789 ± 0.055	2.631SerPro: 2.631 ± 0.072	2.28SerGln: 2.28 ± 0.057	3.479SerArg: 3.479 ± 0.057	4.053SerSer: 4.053 ± 0.088	3.509SerThr: 3.509 ± 0.071	5.128SerVal: 5.128 ± 0.09	0.75SerTrp: 0.75 ± 0.034	1.912SerTyr: 1.912 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.32ThrAla: 5.32 ± 0.089	0.468ThrCys: 0.468 ± 0.024	2.632ThrAsp: 2.632 ± 0.053	2.905ThrGlu: 2.905 ± 0.058	2.415ThrPhe: 2.415 ± 0.056	4.668ThrGly: 4.668 ± 0.086	1.465ThrHis: 1.465 ± 0.041	3.42ThrIle: 3.42 ± 0.054	1.965ThrLys: 1.965 ± 0.051	7.103ThrLeu: 7.103 ± 0.107	1.549ThrMet: 1.549 ± 0.044	1.663ThrAsn: 1.663 ± 0.047	3.091ThrPro: 3.091 ± 0.064	2.069ThrGln: 2.069 ± 0.049	3.365ThrArg: 3.365 ± 0.063	3.657ThrSer: 3.657 ± 0.076	3.204ThrThr: 3.204 ± 0.078	4.962ThrVal: 4.962 ± 0.094	0.731ThrTrp: 0.731 ± 0.027	1.788ThrTyr: 1.788 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	7.345ValAla: 7.345 ± 0.095	0.795ValCys: 0.795 ± 0.029	4.081ValAsp: 4.081 ± 0.068	4.434ValGlu: 4.434 ± 0.086	3.171ValPhe: 3.171 ± 0.07	5.411ValGly: 5.411 ± 0.077	1.939ValHis: 1.939 ± 0.044	5.072ValIle: 5.072 ± 0.077	2.941ValLys: 2.941 ± 0.06	8.081ValLeu: 8.081 ± 0.095	2.123ValMet: 2.123 ± 0.057	2.573ValAsn: 2.573 ± 0.062	3.333ValPro: 3.333 ± 0.067	2.743ValGln: 2.743 ± 0.06	4.893ValArg: 4.893 ± 0.074	5.509ValSer: 5.509 ± 0.089	5.417ValThr: 5.417 ± 0.101	6.05ValVal: 6.05 ± 0.092	0.937ValTrp: 0.937 ± 0.03	2.317ValTyr: 2.317 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.671TrpAla: 0.671 ± 0.031	0.113TrpCys: 0.113 ± 0.011	0.525TrpAsp: 0.525 ± 0.027	0.522TrpGlu: 0.522 ± 0.021	0.529TrpPhe: 0.529 ± 0.025	0.758TrpGly: 0.758 ± 0.034	0.298TrpHis: 0.298 ± 0.019	0.864TrpIle: 0.864 ± 0.03	0.438TrpLys: 0.438 ± 0.022	1.507TrpLeu: 1.507 ± 0.042	0.442TrpMet: 0.442 ± 0.026	0.491TrpAsn: 0.491 ± 0.026	0.419TrpPro: 0.419 ± 0.025	0.522TrpGln: 0.522 ± 0.027	0.76TrpArg: 0.76 ± 0.029	0.752TrpSer: 0.752 ± 0.026	0.61TrpThr: 0.61 ± 0.028	0.858TrpVal: 0.858 ± 0.033	0.219TrpTrp: 0.219 ± 0.017	0.358TrpTyr: 0.358 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.935TyrAla: 2.935 ± 0.06	0.248TyrCys: 0.248 ± 0.017	1.686TyrAsp: 1.686 ± 0.051	1.763TyrGlu: 1.763 ± 0.05	1.125TyrPhe: 1.125 ± 0.034	2.507TyrGly: 2.507 ± 0.056	0.776TyrHis: 0.776 ± 0.03	1.316TyrIle: 1.316 ± 0.041	0.822TyrLys: 0.822 ± 0.029	3.077TyrLeu: 3.077 ± 0.056	0.553TyrMet: 0.553 ± 0.026	0.871TyrAsn: 0.871 ± 0.043	1.359TyrPro: 1.359 ± 0.042	1.294TyrGln: 1.294 ± 0.04	2.044TyrArg: 2.044 ± 0.05	1.575TyrSer: 1.575 ± 0.048	1.643TyrThr: 1.643 ± 0.048	2.299TyrVal: 2.299 ± 0.044	0.313TyrTrp: 0.313 ± 0.02	0.78TyrTyr: 0.78 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2881 proteins (885484 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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