Amino acid dipepetide frequency for Avibacterium endocarditidis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.662AlaAla: 6.662 ± 0.163
0.93AlaCys: 0.93 ± 0.049
4.414AlaAsp: 4.414 ± 0.1
6.467AlaGlu: 6.467 ± 0.135
3.603AlaPhe: 3.603 ± 0.1
5.717AlaGly: 5.717 ± 0.117
1.539AlaHis: 1.539 ± 0.057
6.046AlaIle: 6.046 ± 0.124
5.76AlaLys: 5.76 ± 0.117
10.383AlaLeu: 10.383 ± 0.171
2.617AlaMet: 2.617 ± 0.086
3.783AlaAsn: 3.783 ± 0.104
2.737AlaPro: 2.737 ± 0.076
4.779AlaGln: 4.779 ± 0.12
3.489AlaArg: 3.489 ± 0.097
4.148AlaSer: 4.148 ± 0.091
4.247AlaThr: 4.247 ± 0.104
6.089AlaVal: 6.089 ± 0.144
0.934AlaTrp: 0.934 ± 0.045
2.482AlaTyr: 2.482 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
0.85CysAla: 0.85 ± 0.041
0.185CysCys: 0.185 ± 0.024
0.556CysAsp: 0.556 ± 0.037
0.661CysGlu: 0.661 ± 0.038
0.49CysPhe: 0.49 ± 0.034
1.082CysGly: 1.082 ± 0.05
0.268CysHis: 0.268 ± 0.028
0.575CysIle: 0.575 ± 0.035
0.474CysLys: 0.474 ± 0.032
1.05CysLeu: 1.05 ± 0.054
0.198CysMet: 0.198 ± 0.024
0.384CysAsn: 0.384 ± 0.027
0.442CysPro: 0.442 ± 0.039
0.612CysGln: 0.612 ± 0.034
0.451CysArg: 0.451 ± 0.032
0.642CysSer: 0.642 ± 0.032
0.505CysThr: 0.505 ± 0.035
0.713CysVal: 0.713 ± 0.038
0.118CysTrp: 0.118 ± 0.016
0.378CysTyr: 0.378 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.48AspAla: 3.48 ± 0.093
0.612AspCys: 0.612 ± 0.039
2.402AspAsp: 2.402 ± 0.077
3.678AspGlu: 3.678 ± 0.109
2.493AspPhe: 2.493 ± 0.082
3.143AspGly: 3.143 ± 0.113
0.981AspHis: 0.981 ± 0.051
3.495AspIle: 3.495 ± 0.096
3.364AspLys: 3.364 ± 0.095
5.084AspLeu: 5.084 ± 0.107
1.054AspMet: 1.054 ± 0.042
2.349AspAsn: 2.349 ± 0.078
2.149AspPro: 2.149 ± 0.075
1.844AspGln: 1.844 ± 0.062
2.216AspArg: 2.216 ± 0.073
2.452AspSer: 2.452 ± 0.078
2.128AspThr: 2.128 ± 0.072
3.474AspVal: 3.474 ± 0.095
0.779AspTrp: 0.779 ± 0.037
2.25AspTyr: 2.25 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
4.549GluAla: 4.549 ± 0.121
0.432GluCys: 0.432 ± 0.03
2.385GluAsp: 2.385 ± 0.078
3.826GluGlu: 3.826 ± 0.113
2.359GluPhe: 2.359 ± 0.071
3.328GluGly: 3.328 ± 0.098
1.254GluHis: 1.254 ± 0.057
4.753GluIle: 4.753 ± 0.116
5.221GluLys: 5.221 ± 0.125
6.366GluLeu: 6.366 ± 0.117
1.964GluMet: 1.964 ± 0.07
3.955GluAsn: 3.955 ± 0.104
1.962GluPro: 1.962 ± 0.062
4.605GluGln: 4.605 ± 0.115
3.18GluArg: 3.18 ± 0.102
2.858GluSer: 2.858 ± 0.08
2.965GluThr: 2.965 ± 0.088
4.043GluVal: 4.043 ± 0.099
0.61GluTrp: 0.61 ± 0.038
1.703GluTyr: 1.703 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
4.03PheAla: 4.03 ± 0.11
0.573PheCys: 0.573 ± 0.035
2.673PheAsp: 2.673 ± 0.076
2.415PheGlu: 2.415 ± 0.082
1.919PhePhe: 1.919 ± 0.087
3.255PheGly: 3.255 ± 0.093
0.885PheHis: 0.885 ± 0.039
3.074PheIle: 3.074 ± 0.087
2.042PheLys: 2.042 ± 0.062
4.017PheLeu: 4.017 ± 0.121
1.058PheMet: 1.058 ± 0.052
2.278PheAsn: 2.278 ± 0.086
1.518PhePro: 1.518 ± 0.07
1.58PheGln: 1.58 ± 0.056
1.505PheArg: 1.505 ± 0.058
3.225PheSer: 3.225 ± 0.093
2.265PheThr: 2.265 ± 0.073
2.748PheVal: 2.748 ± 0.093
0.603PheTrp: 0.603 ± 0.042
1.602PheTyr: 1.602 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
5.249GlyAla: 5.249 ± 0.121
0.859GlyCys: 0.859 ± 0.048
3.308GlyAsp: 3.308 ± 0.093
4.584GlyGlu: 4.584 ± 0.125
3.21GlyPhe: 3.21 ± 0.091
4.697GlyGly: 4.697 ± 0.113
1.333GlyHis: 1.333 ± 0.054
5.35GlyIle: 5.35 ± 0.115
4.897GlyLys: 4.897 ± 0.103
6.945GlyLeu: 6.945 ± 0.138
1.726GlyMet: 1.726 ± 0.073
2.797GlyAsn: 2.797 ± 0.108
1.234GlyPro: 1.234 ± 0.046
2.63GlyGln: 2.63 ± 0.076
2.943GlyArg: 2.943 ± 0.085
3.433GlySer: 3.433 ± 0.094
3.405GlyThr: 3.405 ± 0.102
5.232GlyVal: 5.232 ± 0.111
0.889GlyTrp: 0.889 ± 0.041
2.606GlyTyr: 2.606 ± 0.082
0.002GlyXaa: 0.002 ± 0.002
His
1.183HisAla: 1.183 ± 0.048
0.386HisCys: 0.386 ± 0.032
0.726HisAsp: 0.726 ± 0.044
0.728HisGlu: 0.728 ± 0.041
1.413HisPhe: 1.413 ± 0.063
1.17HisGly: 1.17 ± 0.053
0.706HisHis: 0.706 ± 0.043
1.735HisIle: 1.735 ± 0.069
1.129HisLys: 1.129 ± 0.056
2.458HisLeu: 2.458 ± 0.072
0.326HisMet: 0.326 ± 0.027
0.979HisAsn: 0.979 ± 0.041
1.031HisPro: 1.031 ± 0.045
1.295HisGln: 1.295 ± 0.047
1.108HisArg: 1.108 ± 0.05
1.567HisSer: 1.567 ± 0.067
1.011HisThr: 1.011 ± 0.048
0.698HisVal: 0.698 ± 0.036
0.371HisTrp: 0.371 ± 0.031
0.992HisTyr: 0.992 ± 0.053
0.0HisXaa: 0.0 ± 0.0
Ile
6.78IleAla: 6.78 ± 0.144
0.831IleCys: 0.831 ± 0.042
3.888IleAsp: 3.888 ± 0.097
4.539IleGlu: 4.539 ± 0.113
2.651IlePhe: 2.651 ± 0.082
4.936IleGly: 4.936 ± 0.127
1.344IleHis: 1.344 ± 0.057
4.393IleIle: 4.393 ± 0.116
3.542IleLys: 3.542 ± 0.09
6.177IleLeu: 6.177 ± 0.132
1.335IleMet: 1.335 ± 0.062
3.124IleAsn: 3.124 ± 0.092
2.883IlePro: 2.883 ± 0.084
2.823IleGln: 2.823 ± 0.081
2.916IleArg: 2.916 ± 0.086
4.401IleSer: 4.401 ± 0.106
3.787IleThr: 3.787 ± 0.1
4.395IleVal: 4.395 ± 0.104
0.676IleTrp: 0.676 ± 0.042
2.012IleTyr: 2.012 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
5.264LysAla: 5.264 ± 0.127
0.417LysCys: 0.417 ± 0.03
3.014LysAsp: 3.014 ± 0.09
3.755LysGlu: 3.755 ± 0.101
1.967LysPhe: 1.967 ± 0.077
3.864LysGly: 3.864 ± 0.111
1.202LysHis: 1.202 ± 0.055
3.849LysIle: 3.849 ± 0.107
3.465LysLys: 3.465 ± 0.096
5.93LysLeu: 5.93 ± 0.105
1.814LysMet: 1.814 ± 0.062
3.055LysAsn: 3.055 ± 0.086
2.503LysPro: 2.503 ± 0.075
3.399LysGln: 3.399 ± 0.091
2.834LysArg: 2.834 ± 0.086
3.139LysSer: 3.139 ± 0.086
3.263LysThr: 3.263 ± 0.081
4.056LysVal: 4.056 ± 0.104
0.666LysTrp: 0.666 ± 0.035
1.677LysTyr: 1.677 ± 0.074
0.0LysXaa: 0.0 ± 0.0
Leu
10.146LeuAla: 10.146 ± 0.182
1.226LeuCys: 1.226 ± 0.055
5.603LeuAsp: 5.603 ± 0.099
5.524LeuGlu: 5.524 ± 0.125
4.749LeuPhe: 4.749 ± 0.132
7.54LeuGly: 7.54 ± 0.146
1.979LeuHis: 1.979 ± 0.064
6.686LeuIle: 6.686 ± 0.163
5.773LeuLys: 5.773 ± 0.105
11.271LeuLeu: 11.271 ± 0.228
2.54LeuMet: 2.54 ± 0.089
5.082LeuAsn: 5.082 ± 0.124
4.846LeuPro: 4.846 ± 0.106
4.863LeuGln: 4.863 ± 0.123
4.719LeuArg: 4.719 ± 0.112
7.181LeuSer: 7.181 ± 0.146
5.872LeuThr: 5.872 ± 0.106
6.406LeuVal: 6.406 ± 0.125
1.181LeuTrp: 1.181 ± 0.057
2.742LeuTyr: 2.742 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
2.604MetAla: 2.604 ± 0.083
0.215MetCys: 0.215 ± 0.02
0.994MetAsp: 0.994 ± 0.046
1.207MetGlu: 1.207 ± 0.051
0.827MetPhe: 0.827 ± 0.042
1.584MetGly: 1.584 ± 0.063
0.374MetHis: 0.374 ± 0.029
1.507MetIle: 1.507 ± 0.065
1.743MetLys: 1.743 ± 0.064
2.802MetLeu: 2.802 ± 0.1
0.651MetMet: 0.651 ± 0.037
1.224MetAsn: 1.224 ± 0.05
1.204MetPro: 1.204 ± 0.044
1.361MetGln: 1.361 ± 0.058
1.108MetArg: 1.108 ± 0.055
1.385MetSer: 1.385 ± 0.055
1.408MetThr: 1.408 ± 0.055
1.505MetVal: 1.505 ± 0.063
0.182MetTrp: 0.182 ± 0.019
0.507MetTyr: 0.507 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
4.343AsnAla: 4.343 ± 0.122
0.41AsnCys: 0.41 ± 0.033
2.211AsnAsp: 2.211 ± 0.067
2.834AsnGlu: 2.834 ± 0.072
1.782AsnPhe: 1.782 ± 0.065
3.532AsnGly: 3.532 ± 0.106
1.02AsnHis: 1.02 ± 0.05
3.188AsnIle: 3.188 ± 0.095
2.583AsnLys: 2.583 ± 0.075
4.693AsnLeu: 4.693 ± 0.108
1.026AsnMet: 1.026 ± 0.053
2.254AsnAsn: 2.254 ± 0.103
2.555AsnPro: 2.555 ± 0.078
2.523AsnGln: 2.523 ± 0.074
2.01AsnArg: 2.01 ± 0.078
2.561AsnSer: 2.561 ± 0.09
2.216AsnThr: 2.216 ± 0.097
3.205AsnVal: 3.205 ± 0.082
0.599AsnTrp: 0.599 ± 0.036
1.587AsnTyr: 1.587 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
3.255ProAla: 3.255 ± 0.092
0.367ProCys: 0.367 ± 0.025
1.954ProAsp: 1.954 ± 0.056
3.102ProGlu: 3.102 ± 0.089
1.919ProPhe: 1.919 ± 0.063
1.507ProGly: 1.507 ± 0.068
1.106ProHis: 1.106 ± 0.055
2.731ProIle: 2.731 ± 0.077
2.209ProLys: 2.209 ± 0.077
4.064ProLeu: 4.064 ± 0.095
1.076ProMet: 1.076 ± 0.046
2.323ProAsn: 2.323 ± 0.073
1.161ProPro: 1.161 ± 0.053
2.226ProGln: 2.226 ± 0.071
1.316ProArg: 1.316 ± 0.059
2.186ProSer: 2.186 ± 0.076
2.302ProThr: 2.302 ± 0.063
2.778ProVal: 2.778 ± 0.077
0.429ProTrp: 0.429 ± 0.029
1.434ProTyr: 1.434 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
5.168GlnAla: 5.168 ± 0.118
0.464GlnCys: 0.464 ± 0.034
2.553GlnAsp: 2.553 ± 0.068
2.924GlnGlu: 2.924 ± 0.085
2.117GlnPhe: 2.117 ± 0.073
3.738GlnGly: 3.738 ± 0.108
1.389GlnHis: 1.389 ± 0.066
3.227GlnIle: 3.227 ± 0.09
2.896GlnLys: 2.896 ± 0.086
5.372GlnLeu: 5.372 ± 0.133
1.108GlnMet: 1.108 ± 0.055
2.508GlnAsn: 2.508 ± 0.069
2.196GlnPro: 2.196 ± 0.082
4.517GlnGln: 4.517 ± 0.133
2.673GlnArg: 2.673 ± 0.079
2.916GlnSer: 2.916 ± 0.09
2.353GlnThr: 2.353 ± 0.075
3.132GlnVal: 3.132 ± 0.091
0.865GlnTrp: 0.865 ± 0.048
1.572GlnTyr: 1.572 ± 0.063
0.0GlnXaa: 0.0 ± 0.0
Arg
3.341ArgAla: 3.341 ± 0.089
0.485ArgCys: 0.485 ± 0.027
1.988ArgAsp: 1.988 ± 0.076
3.031ArgGlu: 3.031 ± 0.08
2.308ArgPhe: 2.308 ± 0.064
2.585ArgGly: 2.585 ± 0.082
1.039ArgHis: 1.039 ± 0.051
3.07ArgIle: 3.07 ± 0.08
2.533ArgLys: 2.533 ± 0.079
5.103ArgLeu: 5.103 ± 0.114
0.979ArgMet: 0.979 ± 0.039
2.074ArgAsn: 2.074 ± 0.084
1.627ArgPro: 1.627 ± 0.069
2.417ArgGln: 2.417 ± 0.074
2.16ArgArg: 2.16 ± 0.072
2.222ArgSer: 2.222 ± 0.072
2.297ArgThr: 2.297 ± 0.069
2.836ArgVal: 2.836 ± 0.091
0.56ArgTrp: 0.56 ± 0.04
1.868ArgTyr: 1.868 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.496SerAla: 5.496 ± 0.121
0.526SerCys: 0.526 ± 0.041
2.643SerAsp: 2.643 ± 0.082
3.454SerGlu: 3.454 ± 0.093
2.475SerPhe: 2.475 ± 0.075
4.013SerGly: 4.013 ± 0.097
1.307SerHis: 1.307 ± 0.054
3.465SerIle: 3.465 ± 0.094
2.858SerLys: 2.858 ± 0.089
6.28SerLeu: 6.28 ± 0.126
1.346SerMet: 1.346 ± 0.058
2.25SerAsn: 2.25 ± 0.076
2.469SerPro: 2.469 ± 0.079
3.122SerGln: 3.122 ± 0.107
2.45SerArg: 2.45 ± 0.073
3.22SerSer: 3.22 ± 0.107
2.828SerThr: 2.828 ± 0.08
3.686SerVal: 3.686 ± 0.096
0.702SerTrp: 0.702 ± 0.036
1.823SerTyr: 1.823 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.715ThrAla: 4.715 ± 0.097
0.436ThrCys: 0.436 ± 0.028
2.469ThrAsp: 2.469 ± 0.078
3.027ThrGlu: 3.027 ± 0.089
2.233ThrPhe: 2.233 ± 0.066
3.963ThrGly: 3.963 ± 0.101
1.028ThrHis: 1.028 ± 0.046
3.165ThrIle: 3.165 ± 0.086
2.463ThrLys: 2.463 ± 0.078
6.007ThrLeu: 6.007 ± 0.128
1.054ThrMet: 1.054 ± 0.039
1.986ThrAsn: 1.986 ± 0.083
2.617ThrPro: 2.617 ± 0.079
2.72ThrGln: 2.72 ± 0.086
1.971ThrArg: 1.971 ± 0.058
2.639ThrSer: 2.639 ± 0.078
2.821ThrThr: 2.821 ± 0.085
3.478ThrVal: 3.478 ± 0.088
0.545ThrTrp: 0.545 ± 0.033
1.505ThrTyr: 1.505 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
6.089ValAla: 6.089 ± 0.129
0.676ValCys: 0.676 ± 0.034
3.476ValAsp: 3.476 ± 0.093
4.438ValGlu: 4.438 ± 0.111
2.54ValPhe: 2.54 ± 0.086
4.594ValGly: 4.594 ± 0.11
1.056ValHis: 1.056 ± 0.05
4.64ValIle: 4.64 ± 0.11
4.118ValLys: 4.118 ± 0.104
6.613ValLeu: 6.613 ± 0.119
1.683ValMet: 1.683 ± 0.063
3.053ValAsn: 3.053 ± 0.082
2.499ValPro: 2.499 ± 0.071
2.956ValGln: 2.956 ± 0.081
3.014ValArg: 3.014 ± 0.086
4.023ValSer: 4.023 ± 0.091
3.244ValThr: 3.244 ± 0.106
4.901ValVal: 4.901 ± 0.119
0.689ValTrp: 0.689 ± 0.039
1.806ValTyr: 1.806 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.876TrpAla: 0.876 ± 0.045
0.144TrpCys: 0.144 ± 0.019
0.494TrpAsp: 0.494 ± 0.032
0.586TrpGlu: 0.586 ± 0.031
0.569TrpPhe: 0.569 ± 0.034
0.743TrpGly: 0.743 ± 0.044
0.341TrpHis: 0.341 ± 0.026
0.724TrpIle: 0.724 ± 0.039
0.706TrpLys: 0.706 ± 0.037
1.735TrpLeu: 1.735 ± 0.05
0.228TrpMet: 0.228 ± 0.023
0.485TrpAsn: 0.485 ± 0.037
0.208TrpPro: 0.208 ± 0.022
1.26TrpGln: 1.26 ± 0.059
0.653TrpArg: 0.653 ± 0.039
0.474TrpSer: 0.474 ± 0.03
0.509TrpThr: 0.509 ± 0.035
0.814TrpVal: 0.814 ± 0.043
0.191TrpTrp: 0.191 ± 0.023
0.363TrpTyr: 0.363 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.744TyrAla: 2.744 ± 0.081
0.462TyrCys: 0.462 ± 0.036
1.675TyrAsp: 1.675 ± 0.07
1.539TyrGlu: 1.539 ± 0.056
1.642TyrPhe: 1.642 ± 0.078
2.34TyrGly: 2.34 ± 0.064
0.859TyrHis: 0.859 ± 0.047
1.758TyrIle: 1.758 ± 0.062
1.355TyrLys: 1.355 ± 0.054
3.581TyrLeu: 3.581 ± 0.102
0.605TyrMet: 0.605 ± 0.038
1.189TyrAsn: 1.189 ± 0.055
1.602TyrPro: 1.602 ± 0.071
2.153TyrGln: 2.153 ± 0.081
1.812TyrArg: 1.812 ± 0.061
1.741TyrSer: 1.741 ± 0.066
1.417TyrThr: 1.417 ± 0.055
1.919TyrVal: 1.919 ± 0.067
0.511TyrTrp: 0.511 ± 0.033
1.138TyrTyr: 1.138 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.002XaaIle: 0.002 ± 0.002
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.004
Statistics based on 1713 proteins (465782 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski